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6PUH
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BU of 6puh by Molmil
Structure of human MAIT A-F7 TCR in complex with human MR1-Ribityl-less
Descriptor: 6-methyl-5-[(1E)-3-oxobut-1-en-1-yl]pyrimidine-2,4(1H,3H)-dione, Beta-2-microglobulin, Human TCR alpha chain, ...
Authors:Awad, W, Keller, A.N, Rossjohn, J.
Deposit date:2019-07-18
Release date:2020-02-19
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:The molecular basis underpinning the potency and specificity of MAIT cell antigens.
Nat.Immunol., 21, 2020
6D29
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BU of 6d29 by Molmil
HLA-B*57:01 presenting TSMSFVPRPW
Descriptor: Beta-2-microglobulin, HLA class I histocompatibility antigen, B-57 alpha chain, ...
Authors:Vivian, J.P, Rossjohn, J.
Deposit date:2018-04-13
Release date:2018-10-03
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:A subset of HLA-I peptides are not genomically templated: Evidence for cis- and trans-spliced peptide ligands.
Sci Immunol, 3, 2018
1RUL
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BU of 1rul by Molmil
Crystal Structure (D) of u.v.-irradiated cationic cyclization antibody 4C6 Fab at pH 5.6 with a data set collected at SSRL beamline 11-1.
Descriptor: ACETATE ION, BENZOIC ACID, GLYCEROL, ...
Authors:Zhu, X, Wentworth Jr, P, Wentworth, A.D, Eschenmoser, A, Lerner, R.A, Wilson, I.A.
Deposit date:2003-12-11
Release date:2004-03-02
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Probing the antibody-catalyzed water-oxidation pathway at atomic resolution.
Proc.Natl.Acad.Sci.USA, 110, 2004
8F7M
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BU of 8f7m by Molmil
Crystal Structure of HLA-B*57:01-TW10-T242N complex
Descriptor: ACETATE ION, Beta-2-microglobulin, DI(HYDROXYETHYL)ETHER, ...
Authors:Chatzileontiadou, D.S.M, Lobos, C.A, Gras, S.
Deposit date:2022-11-18
Release date:2024-06-05
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Crystal Structure of HLA-B*57:01-TW10-T242N complex
To Be Published
6ULI
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BU of 6uli by Molmil
Molecular basis for tumor infiltrating TCR recognition of hotspot KRAS-G12D mutation
Descriptor: Beta-2-microglobulin, GLY-ALA-ASP-GLY-VAL-GLY-LYS-SER-ALA, HLA class I antigen
Authors:Sun, P.D, Sim, M.J.W.
Deposit date:2019-10-08
Release date:2020-05-27
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:High-affinity oligoclonal TCRs define effective adoptive T cell therapy targeting mutant KRAS-G12D.
Proc.Natl.Acad.Sci.USA, 117, 2020
4Z76
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BU of 4z76 by Molmil
Weak TCR binding to an unstable insulin epitope drives type 1 diabetes
Descriptor: 1,2-ETHANEDIOL, Beta-2-microglobulin, GLYCEROL, ...
Authors:Rizkallah, P.J, Cole, D.K.
Deposit date:2015-04-06
Release date:2015-06-24
Last modified:2015-08-12
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Distortion of the Major Histocompatibility Complex Class I Binding Groove to Accommodate an Insulin-derived 10-Mer Peptide.
J.Biol.Chem., 290, 2015
3H7B
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BU of 3h7b by Molmil
Human Class I MHC HLA-A2 in complex with the Tel1p peptide
Descriptor: Beta-2-microglobulin, GLYCEROL, HLA class I histocompatibility antigen, ...
Authors:Borbulevych, O.Y, Baker, B.M.
Deposit date:2009-04-24
Release date:2010-01-12
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:T cell receptor cross-reactivity directed by antigen-dependent tuning of peptide-MHC molecular flexibility.
Immunity, 31, 2009
7WT3
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BU of 7wt3 by Molmil
Crystal structure of HLA-A*2402 complexed with 4-mer lipopeptide
Descriptor: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 4-mer lipopeptide, ...
Authors:Asa, M, Morita, D, Sugita, M.
Deposit date:2022-02-03
Release date:2022-06-22
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.887655 Å)
Cite:Crystal structures of N-myristoylated lipopeptide-bound HLA class I complexes indicate reorganization of B-pocket architecture upon ligand binding.
J.Biol.Chem., 298, 2022
5HYE
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BU of 5hye by Molmil
Glycosylated Knob-Knob Fc fragment (P212121)
Descriptor: Ig gamma-1 chain C region, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-beta-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-beta-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Kuglstatter, A, Stihle, M, Benz, J.
Deposit date:2016-02-01
Release date:2017-02-01
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Structural differences between glycosylated, disulfide-linked heterodimeric Knob-into-Hole Fc fragment and its homodimeric Knob-Knob and Hole-Hole side products.
Protein Eng. Des. Sel., 30, 2017
7ZUC
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BU of 7zuc by Molmil
Human Major Histocompatibility Complex A2 allele presenting LLLGIGILV
Descriptor: 1,2-ETHANEDIOL, Beta-2-microglobulin, LEU-LEU-LEU-GLY-ILE-GLY-ILE-LEU-VAL, ...
Authors:Rizkallah, P.J, Wall, A, Sewell, A.K, Fuller, A.
Deposit date:2022-05-12
Release date:2023-05-24
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Targeting of multiple tumor-associated antigens by individual T cell receptors during successful cancer immunotherapy.
Cell, 186, 2023
6PBH
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BU of 6pbh by Molmil
Crystal Structure of HLA-A*68:01 in complex with NP145-156, a 12 mer influenza peptide
Descriptor: Beta-2-microglobulin, HLA class I histocompatibility antigen, A-68 alpha chain, ...
Authors:Gras, S.
Deposit date:2019-06-13
Release date:2019-12-11
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Challenging immunodominance of influenza-specific CD8+T cell responses restricted by the risk-associated HLA-A*68:01 allomorph.
Nat Commun, 10, 2019
6C5I
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BU of 6c5i by Molmil
Unliganded S25-5 Fab
Descriptor: 2-(2-METHOXYETHOXY)ETHANOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ...
Authors:Evans, S.V, Haji-Ghassemi, O.
Deposit date:2018-01-16
Release date:2019-01-09
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Subtle Changes in the Combining Site of the Chlamydiaceae-Specific mAb S25-23 Increase the Antibody-Carbohydrate Binding Affinity by an Order of Magnitude.
Biochemistry, 58, 2019
6W9U
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BU of 6w9u by Molmil
Structure of human MAIT A-F7 TCR in complex with patient MR1-R9H-Ac-6-FP
Descriptor: 1-[[6-(1-$l^{1}-oxidanylethyl)-4-$l^{3}-oxidanylidene-2,3,6,8~{a}-tetrahydropteridin-2-yl]-$l^{2}-azanyl]ethanone, Beta-2-microglobulin, CHLORIDE ION, ...
Authors:Awad, W, Rossjohn, J.
Deposit date:2020-03-23
Release date:2020-08-05
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Absence of mucosal-associated invariant T cells in a person with a homozygous point mutation in MR1 .
Sci Immunol, 5, 2020
6G9Q
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BU of 6g9q by Molmil
Ternary complex of P14 TCR with murine MHC class I H-2 Db in complex with self-antigen derived from dopamine monooxygenase.
Descriptor: Beta-2-microglobulin, Dopamine beta-hydroxylase, GLYCEROL, ...
Authors:Achour, A, Sandalova, T, Allerbring, E.
Deposit date:2018-04-11
Release date:2019-04-24
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Structural basis for CD8+ T cells auto-reactivity in LCMV infection
to be published
3MYJ
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BU of 3myj by Molmil
Human Class I MHC HLA-A2 in complex with the WT-1 (126-134) (R1Y) peptide variant.
Descriptor: Beta-2-microglobulin, GLYCEROL, HLA class I histocompatibility antigen, ...
Authors:Borbulevych, O.Y, Baker, B.M.
Deposit date:2010-05-10
Release date:2010-08-18
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Structures of native and affinity-enhanced WT1 epitopes bound to HLA-A*0201: Implications for WT1-based cancer therapeutics.
Mol.Immunol., 47, 2010
2OK0
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BU of 2ok0 by Molmil
Fab ED10-DNA complex
Descriptor: 5'-D(*TP*C)-3', Fab ED10 heavy chain, Fab ED10 light chain
Authors:Stanfield, R.L, Sanguineti, S, Wilson, I.A, de Prat-Gay, G.
Deposit date:2007-01-15
Release date:2007-06-12
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Specific recognition of a DNA immunogen by its elicited antibody
J.Mol.Biol., 370, 2007
2P5E
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BU of 2p5e by Molmil
Crystal Structures of High Affinity Human T-Cell Receptors Bound to pMHC Reveal Native Diagonal Binding Geometry
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Beta-2-microglobulin, Cancer/testis antigen 1B, ...
Authors:Sami, M, Rizkallah, P.J, Dunn, S, Li, Y, Moysey, R, Vuidepot, A, Baston, E, Todorov, P, Molloy, P, Gao, F, Boulter, J.M, Jakobsen, B.K.
Deposit date:2007-03-15
Release date:2007-09-25
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Crystal structures of high affinity human T-cell receptors bound to peptide major histocompatibility complex reveal native diagonal binding geometry
Protein Eng.Des.Sel., 20, 2007
7EJL
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BU of 7ejl by Molmil
Complex Structure of HLA-A*2402 with the Peptide from HCoV(CoV-2) spike protein
Descriptor: 9-mer peptide from the HCoV spike protein, Beta-2-microglobulin, MHC class I antigen
Authors:Murayama, K, Kato-Murayama, M, Shirouzu, M.
Deposit date:2021-04-02
Release date:2022-01-26
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Identification of TCR repertoires in functionally competent cytotoxic T cells cross-reactive to SARS-CoV-2.
Commun Biol, 4, 2021
7WT4
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BU of 7wt4 by Molmil
Crystal structure of HLA-A*2402 complexed with 8-mer Influenza PB1 peptide
Descriptor: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, ...
Authors:Asa, M, Morita, D, Sugita, M.
Deposit date:2022-02-03
Release date:2022-06-22
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.89459145 Å)
Cite:Crystal structures of N-myristoylated lipopeptide-bound HLA class I complexes indicate reorganization of B-pocket architecture upon ligand binding.
J.Biol.Chem., 298, 2022
6KVM
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BU of 6kvm by Molmil
Crystal structure of Chicken MHC Class II for 1.9 angstrom
Descriptor: GLYCEROL, MHC class II alpha chain, MHC class II beta chain 2, ...
Authors:Zhang, L, Xia, C.
Deposit date:2019-09-04
Release date:2019-12-25
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.897 Å)
Cite:A Newly Recognized Pairing Mechanism of the alpha- and beta-Chains of the Chicken Peptide-MHC Class II Complex.
J Immunol., 204, 2020
6BJ3
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BU of 6bj3 by Molmil
TCR55 in complex with HIV(Pol448-456)/HLA-B35
Descriptor: 1,2-ETHANEDIOL, Beta-2-microglobulin, HIV Pol B35 peptide, ...
Authors:Jude, K.M, Sibener, L.V, Garcia, K.C.
Deposit date:2017-11-03
Release date:2018-07-25
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.898 Å)
Cite:Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding.
Cell, 174, 2018
5W0D
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BU of 5w0d by Molmil
Inferred precursor (UCA) of the human antibody lineage K03.12 in complex with influenza hemagglutinin H1 Solomon Islands/03/2006
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ...
Authors:McCarthy, K.R, Harrison, S.C.
Deposit date:2017-05-30
Release date:2018-02-14
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.899 Å)
Cite:Memory B Cells that Cross-React with Group 1 and Group 2 Influenza A Viruses Are Abundant in Adult Human Repertoires.
Immunity, 48, 2018
3PWU
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BU of 3pwu by Molmil
An immmunodominant CTL epitope from rinderpest virus presented by cattle MHC class I molecule N*01801(BoLA-A11)
Descriptor: Beta-2-microglobulin, IPA from Hemagglutinin glycoprotein, MHC class I antigen
Authors:Li, X, Liu, J, Qi, J, Gao, F, Li, Q, Li, X, Zhang, N, Xia, C, Gao, G.F.
Deposit date:2010-12-09
Release date:2011-08-24
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.899 Å)
Cite:Two distinct conformations of a rinderpest virus epitope presented by bovine major histocompatibility complex class I N*01801: a host strategy to present featured peptides
J.Virol., 85, 2011
3VJ6
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BU of 3vj6 by Molmil
Structure of the MHC class Ib molecule Qa-1b
Descriptor: Beta-2-microglobulin, H-2 class I histocompatibility antigen, D-37 alpha chain, ...
Authors:Zeng, L, Clements, C.S, Rossjohn, J.
Deposit date:2011-10-12
Release date:2012-03-14
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A structural basis for antigen presentation by the MHC class Ib molecule, Qa-1b
J.Immunol., 188, 2012
6UJ7
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BU of 6uj7 by Molmil
Crystal structure of HLA-B*07:02 with R140Q mutant IDH2 peptide
Descriptor: Beta-2-microglobulin, HLA class I histocompatibility antigen, B-7 alpha chain, ...
Authors:Miller, M.S, Thirawatananond, P, Gabelli, S.B.
Deposit date:2019-10-02
Release date:2021-05-05
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural engineering of chimeric antigen receptors targeting HLA-restricted neoantigens.
Nat Commun, 12, 2021

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