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1BN3	CARBONIC ANHYDRASE II INHIBITOR Descriptor: 2-(3-METHOXYPHENYL)-2H-THIENO-[3,2-E]-1,2-THIAZINE-6-SULFINAMIDE-1,1-DIOXIDE, CARBONIC ANHYDRASE, MERCURY (II) ION, ... Authors: Boriack-Sjodin, P.A, Zeitlin, S, Christianson, D.W. Deposit date: 1998-07-31 Release date: 1999-05-18 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structural analysis of inhibitor binding to human carbonic anhydrase II. Protein Sci., 7, 1998
1BNN	CARBONIC ANHYDRASE II INHIBITOR Descriptor: 3,,4-DIHYDRO-2-(3-METHOXYPHENYL)-2H-THIENO-[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE-1,1-DIOXIDE, CARBONIC ANHYDRASE, MERCURY (II) ION, ... Authors: Boriack-Sjodin, P.A, Zeitlin, S, Christianson, D.W. Deposit date: 1998-07-30 Release date: 1999-05-18 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural analysis of inhibitor binding to human carbonic anhydrase II. Protein Sci., 7, 1998
1BNT	CARBONIC ANHYDRASE II INHIBITOR Descriptor: 3,4-DIHYDRO-4-HYDROXY-2-(4-METHOXYPHENYL)-2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE-1,1-DIOXIDE, CARBONIC ANHYDRASE, MERCURY (II) ION, ... Authors: Boriack-Sjodin, P.A, Zeitlin, S, Christianson, D.W. Deposit date: 1998-07-30 Release date: 1999-06-15 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Structural analysis of inhibitor binding to human carbonic anhydrase II. Protein Sci., 7, 1998
1HVA	ENGINEERING THE ZINC BINDING SITE OF HUMAN CARBONIC ANHYDRASE II: STRUCTURE OF THE HIS-94-> CYS APOENZYME IN A NEW CRYSTALLINE FORM Descriptor: CARBONIC ANHYDRASE II Authors: Alexander, R.S, Christianson, D.W. Deposit date: 1992-10-27 Release date: 1993-10-31 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Engineering the zinc binding site of human carbonic anhydrase II: structure of the His-94-->Cys apoenzyme in a new crystalline form. Biochemistry, 32, 1993
1BNQ	CARBONIC ANHYDRASE II INHIBITOR Descriptor: (R)-4-ETHYLAMINO-3,4-DIHYDRO-2-(2-METHOYLETHYL)-2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE-1,1-DIOXIDE, CARBONIC ANHYDRASE, MERCURY (II) ION, ... Authors: Boriack-Sjodin, P.A, Zeitlin, S, Christianson, D.W. Deposit date: 1998-07-30 Release date: 1999-06-15 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structural analysis of inhibitor binding to human carbonic anhydrase II. Protein Sci., 7, 1998
1BNV	CARBONIC ANHYDRASE II INHIBITOR Descriptor: (S)-3,4-DIHYDRO-2-(3-METHOXYPHENYL)-4-METHYLAMINO-2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE-1,1-DIOXIDE, CARBONIC ANHYDRASE, MERCURY (II) ION, ... Authors: Boriack-Sjodin, P.A, Zeitlin, S, Christianson, D.W. Deposit date: 1998-07-30 Release date: 1999-02-16 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structural analysis of inhibitor binding to human carbonic anhydrase II. Protein Sci., 7, 1998
6RZX	Carbonic Anhydrase CAIX mimic in complex with inhibitor FBSA Descriptor: 1,1,2,2,3,3,4,4,4-nonakis(fluoranyl)butane-1-sulfonamide, Carbonic anhydrase 2, ZINC ION Authors: Kugler, M, Brynda, J, Rezacova, P. Deposit date: 2019-06-13 Release date: 2020-06-03 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1 Å) Cite: Identification of Novel Carbonic Anhydrase IX Inhibitors Using High-Throughput Screening of Pooled Compound Libraries by DNA-Linked Inhibitor Antibody Assay (DIANA). SLAS Discov, 25, 2020
6S03	Carbonic Anhydrase CAIX mimic in complex with inhibitor I39LT379 Descriptor: 4-[[4-[5,5-dimethyl-2-(6-methylpyridin-2-yl)-4,6-dihydropyrrolo[1,2-b]pyrazol-3-yl]pyridin-2-yl]amino]benzenesulfonamide, Carbonic anhydrase 2, ZINC ION Authors: Kugler, M, Brynda, J, Rezacova, P. Deposit date: 2019-06-13 Release date: 2020-06-03 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.38 Å) Cite: Identification of Novel Carbonic Anhydrase IX Inhibitors Using High-Throughput Screening of Pooled Compound Libraries by DNA-Linked Inhibitor Antibody Assay (DIANA). SLAS Discov, 25, 2020
1ZSB	CARBONIC ANHYDRASE II MUTANT E117Q, TRANSITION STATE ANALOGUE ACETAZOLAMIDE Descriptor: 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE, CARBONIC ANHYDRASE II, ZINC ION Authors: Lesburg, C.A, Christianson, D.W. Deposit date: 1996-01-09 Release date: 1996-07-11 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2 Å) Cite: Reversal of the hydrogen bond to zinc ligand histidine-119 dramatically diminishes catalysis and enhances metal equilibration kinetics in carbonic anhydrase II. Biochemistry, 35, 1996
12CA	ALTERING THE MOUTH OF A HYDROPHOBIC POCKET. STRUCTURE AND KINETICS OF HUMAN CARBONIC ANHYDRASE II MUTANTS AT RESIDUE VAL-121 Descriptor: CARBONIC ANHYDRASE II, MERCURY (II) ION, ZINC ION Authors: Nair, S.K, Christianson, D.W. Deposit date: 1991-10-01 Release date: 1992-10-15 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Altering the mouth of a hydrophobic pocket. Structure and kinetics of human carbonic anhydrase II mutants at residue Val-121. J.Biol.Chem., 266, 1991
1CAL	STRUCTURAL ANALYSIS OF THE ZINC HYDROXIDE-THR 199-GLU 106 HYDROGEN BONDING NETWORK IN HUMAN CARBONIC ANHYDRASE II Descriptor: CARBONIC ANHYDRASE II, ZINC ION Authors: Xue, Y, Liljas, A, Jonsson, B.-H, Lindskog, S. Deposit date: 1992-09-17 Release date: 1993-10-31 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structural analysis of the zinc hydroxide-Thr-199-Glu-106 hydrogen-bond network in human carbonic anhydrase II. Proteins, 17, 1993
1CVB	STRUCTURAL AND FUNCTIONAL IMPORTANCE OF A CONSERVED HYDROGEN BOND NETWORK IN HUMAN CARBONIC ANHYDRASE II Descriptor: CARBONIC ANHYDRASE II, SULFATE ION, ZINC ION Authors: Ippolito, J.A, Christianson, D.W. Deposit date: 1993-02-04 Release date: 1993-10-31 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structural and functional importance of a conserved hydrogen bond network in human carbonic anhydrase II. J.Biol.Chem., 268, 1993
1CNY	SECONDARY INTERACTIONS SIGNIFICANTLY REMOVED FROM THE SULFONAMIDE BINDING POCKET OF CARBONIC ANHYDRASE II INFLUENCE BINDING CONSTANTS Descriptor: CARBONIC ANHYDRASE II, MERCURY (II) ION, PHENYLALANYLAMINODI(ETHYLOXY)ETHYL BENZENESULFONAMIDEAMINOCARBONYLBENZENESULFONAMIDE, ... Authors: Boriack, P.A, Christianson, D.W. Deposit date: 1995-07-21 Release date: 1995-11-14 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Secondary interactions significantly removed from the sulfonamide binding pocket of carbonic anhydrase II influence inhibitor binding constants. J.Med.Chem., 38, 1995
1DCA	STRUCTURE OF AN ENGINEERED METAL BINDING SITE IN HUMAN CARBONIC ANHYDRASE II REVEALS THE ARCHITECTURE OF A REGULATORY CYSTEINE SWITCH Descriptor: CARBONIC ANHYDRASE II, ZINC ION Authors: Ippolito, J.A, Christianson, D.W. Deposit date: 1992-12-18 Release date: 1993-07-15 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structure of an engineered His3Cys zinc binding site in human carbonic anhydrase II. Biochemistry, 32, 1993
1DCB	STRUCTURE OF AN ENGINEERED METAL BINDING SITE IN HUMAN CARBONIC ANHYDRASE II REVEALS THE ARCHITECTURE OF A REGULATORY CYSTEINE SWITCH Descriptor: CARBONIC ANHYDRASE II, ZINC ION Authors: Ippolito, J.A, Christianson, D.W. Deposit date: 1993-03-10 Release date: 1993-07-15 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structure of an engineered His3Cys zinc binding site in human carbonic anhydrase II. Biochemistry, 32, 1993
6QN2	Three dimensional structure of human carbonic anhydrase IX in complex with benzenesulfonamide Descriptor: Carbonic anhydrase 9, ZINC ION, methyl 4-[(4-chloranyl-2-cyclohexylsulfanyl-5-sulfamoyl-phenyl)carbonylamino]butanoate Authors: Leitans, J, Tars, K. Deposit date: 2019-02-08 Release date: 2020-02-26 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Halogenated and di-substituted benzenesulfonamides as selective inhibitors of carbonic anhydrase isoforms. Eur.J.Med.Chem., 185, 2020
6QN0	Three dimensional structure of human carbonic anhydrase XII in complex with benzenesulfonamide Descriptor: Carbonic anhydrase 12, ZINC ION, ~{N}-butyl-4-chloranyl-2-(2-phenylethylsulfanyl)-5-sulfamoyl-benzamide Authors: Dvinskis, E, Leitans, J, Tars, K. Deposit date: 2019-02-08 Release date: 2020-02-26 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.89 Å) Cite: Halogenated and di-substituted benzenesulfonamides as selective inhibitors of carbonic anhydrase isoforms. Eur.J.Med.Chem., 185, 2020
6QN6	Three dimensional structure of human carbonic anhydrase IX in complex with benzenesulfonamide Descriptor: Carbonic anhydrase 9, ZINC ION, ~{N}-butyl-4-chloranyl-2-(2-phenylethylsulfanyl)-5-sulfamoyl-benzamide Authors: Leitans, J, Tars, K. Deposit date: 2019-02-09 Release date: 2020-02-26 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Halogenated and di-substituted benzenesulfonamides as selective inhibitors of carbonic anhydrase isoforms. Eur.J.Med.Chem., 185, 2020
6QNL	Three dimensional structure of human carbonic anhydrase XII in complex with benzenesulfonamide Descriptor: Carbonic anhydrase 12, ZINC ION, methyl 4-[(4-chloranyl-2-cyclohexylsulfanyl-5-sulfamoyl-phenyl)carbonylamino]butanoate Authors: Dvinskis, E, Leitans, J, Tars, K. Deposit date: 2019-02-11 Release date: 2020-03-04 Last modified: 2021-10-06 Method: X-RAY DIFFRACTION (1.53 Å) Cite: Halogenated and di-substituted benzenesulfonamides as selective inhibitors of carbonic anhydrase isoforms. Eur.J.Med.Chem., 185, 2020
3UK8	The crystal structure of the cd-bound domain 3 of the cadmium carbonic anhydrase from marine diatom Thalassiosira weissflogii Descriptor: ACETATE ION, CADMIUM ION, Cadmium-specific carbonic anhydrase Authors: Alterio, V, De Simone, G. Deposit date: 2011-11-09 Release date: 2012-07-11 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural and inhibition insights into carbonic anhydrase CDCA1 from the marine diatom Thalassiosira weissflogii. Biochimie, 94, 2012
1H9Q	H119Q CARBONIC ANHYDRASE II Descriptor: CARBONIC ANHYDRASE II, ZINC ION Authors: Lesburg, C.A, Christianson, D.W. Deposit date: 1997-05-29 Release date: 1997-09-17 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Histidine --> carboxamide ligand substitutions in the zinc binding site of carbonic anhydrase II alter metal coordination geometry but retain catalytic activity. Biochemistry, 36, 1997
1H9N	H119N CARBONIC ANHYDRASE II Descriptor: CARBONIC ANHYDRASE II, ZINC ION Authors: Lesburg, C.A, Christianson, D.W. Deposit date: 1997-05-29 Release date: 1997-09-17 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Histidine --> carboxamide ligand substitutions in the zinc binding site of carbonic anhydrase II alter metal coordination geometry but retain catalytic activity. Biochemistry, 36, 1997
1CAI	STRUCTURAL ANALYSIS OF THE ZINC HYDROXIDE-THR 199-GLU 106 HYDROGEN BONDING NETWORK IN HUMAN CARBONIC ANHYDRASE II Descriptor: CARBONIC ANHYDRASE II, SULFATE ION, ZINC ION Authors: Xue, Y, Liljas, A, Jonsson, B.-H, Lindskog, S. Deposit date: 1992-09-17 Release date: 1993-10-31 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural analysis of the zinc hydroxide-Thr-199-Glu-106 hydrogen-bond network in human carbonic anhydrase II. Proteins, 17, 1993
1CAK	STRUCTURAL ANALYSIS OF THE ZINC HYDROXIDE-THR 199-GLU 106 HYDROGEN BONDING NETWORK IN HUMAN CARBONIC ANHYDRASE II Descriptor: CARBONIC ANHYDRASE II, SULFATE ION, ZINC ION Authors: Xue, Y, Liljas, A, Jonsson, B.-H, Lindskog, S. Deposit date: 1992-09-17 Release date: 1993-10-31 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural analysis of the zinc hydroxide-Thr-199-Glu-106 hydrogen-bond network in human carbonic anhydrase II. Proteins, 17, 1993
1CAJ	STRUCTURAL ANALYSIS OF THE ZINC HYDROXIDE-THR 199-GLU 106 HYDROGEN BONDING NETWORK IN HUMAN CARBONIC ANHYDRASE II Descriptor: CARBONIC ANHYDRASE II, SULFATE ION, ZINC ION Authors: Xue, Y, Liljas, A, Jonsson, B.-H, Lindskog, S. Deposit date: 1992-09-17 Release date: 1993-10-31 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural analysis of the zinc hydroxide-Thr-199-Glu-106 hydrogen-bond network in human carbonic anhydrase II. Proteins, 17, 1993

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