8PC2
 
 | | SelDeg51 in complex with FKBP51FK1 domain and pVHL:EloB:EloC | | Descriptor: | Elongin-B, Elongin-C, Peptidyl-prolyl cis-trans isomerase FKBP5, ... | | Authors: | Meyners, C, Walz, M, Geiger, T.M, Hausch, F. | | Deposit date: | 2023-06-09 | | Release date: | 2023-11-15 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Discovery of a Potent Proteolysis Targeting Chimera Enables Targeting the Scaffolding Functions of FK506-Binding Protein 51 (FKBP51).
Angew.Chem.Int.Ed.Engl., 63, 2024
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8UL3
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8UVE
 | | Structure of NaDC3-Succinate complex in Coo-Ci conformation | | Descriptor: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, CHOLESTEROL, Na(+)/dicarboxylate cotransporter 3, ... | | Authors: | Li, Y, Wang, D.N, Mindell, J.A, Rice, W.J, Song, J, Mikusevic, V, Marden, J.J, Becerril, A, Kuang, H, Wang, B. | | Deposit date: | 2023-11-02 | | Release date: | 2024-12-25 | | Last modified: | 2025-04-02 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | Substrate translocation and inhibition in human dicarboxylate transporter NaDC3.
Nat.Struct.Mol.Biol., 32, 2025
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8UVF
 | | Structure of NaDC3-DMS complex in Ci-Ci conformation | | Descriptor: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, CHOLESTEROL, Na(+)/dicarboxylate cotransporter 3, ... | | Authors: | Li, Y, Wang, D.N, Mindell, J.A, Rice, W.J, Song, J, Mikusevic, V, Marden, J.J, Becerril, A, Kuang, H, Wang, B. | | Deposit date: | 2023-11-02 | | Release date: | 2024-12-25 | | Last modified: | 2025-04-02 | | Method: | ELECTRON MICROSCOPY (2.17 Å) | | Cite: | Substrate translocation and inhibition in human dicarboxylate transporter NaDC3.
Nat.Struct.Mol.Biol., 32, 2025
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8UVC
 | | Structure of NaDC3-aKG complex | | Descriptor: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-OXOGLUTARIC ACID, CHOLESTEROL, ... | | Authors: | Li, Y, Wang, D.N, Mindell, J.A, Rice, W.J, Song, J, Mikusevic, V, Marden, J.J, Becerril, A, Kuang, H, Wang, B. | | Deposit date: | 2023-11-02 | | Release date: | 2024-12-25 | | Last modified: | 2025-04-02 | | Method: | ELECTRON MICROSCOPY (2.09 Å) | | Cite: | Substrate translocation and inhibition in human dicarboxylate transporter NaDC3.
Nat.Struct.Mol.Biol., 32, 2025
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8UAG
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8UFX
 | | CAII with SLC compound | | Descriptor: | 4-{[4-(trifluoromethyl)phenyl]carbamamido}benzene-1-sulfonamide, Carbonic anhydrase 2, GLYCEROL, ... | | Authors: | Peat, T.S. | | Deposit date: | 2023-10-04 | | Release date: | 2024-12-18 | | Method: | X-RAY DIFFRACTION (1.212 Å) | | Cite: | CAII with SLC compound
To Be Published
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9MHE
 | | Native tagless Lassa virus spike complex bound to ARN-75039 at pH 8.0 | | Descriptor: | (4S)-3-(4-tert-butoxyphenyl)-7-methyl-6-{4-[(propan-2-yl)oxy]phenyl}imidazo[1,2-a]pyridine, 12.1F Heavy chain, 12.1F Light chain, ... | | Authors: | Cohen-Dvashi, H, Katz, M, Diskin, R. | | Deposit date: | 2024-12-11 | | Release date: | 2025-08-27 | | Last modified: | 2025-09-24 | | Method: | ELECTRON MICROSCOPY (2.01 Å) | | Cite: | pH-induced conformational changes and inhibition of the Lassa virus spike complex.
Cell Host Microbe, 33, 2025
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8PB1
 | | Cryo-EM structure of a pre-dimerized murine IL-12 complete extracellular signaling complex (Class 1), obtained after local refinement. | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-12 receptor subunit beta-1,Death-associated protein kinase 1, Interleukin-12 receptor subunit beta-2,Calmodulin-1, ... | | Authors: | Felix, J, Bloch, Y, Savvides, S.N. | | Deposit date: | 2023-06-08 | | Release date: | 2024-02-07 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23.
Nat.Struct.Mol.Biol., 31, 2024
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8VIS
 | | Human TMPRSS11D complexed with a disulfide-linked autoinhibitory DDDDK peptide | | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, MAGNESIUM ION, ... | | Authors: | Fraser, B.J, Dong, A, Ilyassov, O, Kenney, T, Li, Y.Y, Seitova, A, Li, Y, Hejazi, Z, Edwards, A, Benard, F, Arrowsmith, C. | | Deposit date: | 2024-01-05 | | Release date: | 2024-01-31 | | Last modified: | 2025-05-28 | | Method: | X-RAY DIFFRACTION (1.59 Å) | | Cite: | Structural basis of TMPRSS11D specificity and autocleavage activation.
Nat Commun, 16, 2025
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8VSY
 | | Bile salt hydrolase from Arthrobacter citreus with covalent inhibitor AAA-10 bound | | Descriptor: | (1R,3aS,3bR,5aR,7R,9aS,9bS,11aR)-1-[(2R)-6-fluoro-5-oxohexan-2-yl]-9a,11a-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-7-yl hydrogen sulfate (non-preferred name), Bile salt hydrolase, CHLORIDE ION, ... | | Authors: | Dhindwal, P, Ruzzini, A. | | Deposit date: | 2024-01-24 | | Release date: | 2024-02-07 | | Last modified: | 2025-04-09 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Structural and functional analysis of a bile salt hydrolase from the bison microbiome.
J.Biol.Chem., 300, 2024
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8VR7
 | | crystal structure of the Pcryo_0619 N-acetyltransferase from Psychrobacter cryohalolentis K5 int he presence of acetyl coenzyme A | | Descriptor: | 1,2-ETHANEDIOL, 3'-PHOSPHATE-ADENOSINE-5'-DIPHOSPHATE, 3-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]PROPANE-1-SULFONIC ACID, ... | | Authors: | Dunsirn, M.M, Bockhaus, N.J, Thoden, J.B, Holden, H.M. | | Deposit date: | 2024-01-20 | | Release date: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Biochemical Investigation of the Enzymes Required for the Production of 2,3,4-triacetoamido-2,3,4-trideoxy-l-arabinose in Psychrobacter cryohalolentis K5
To Be Published
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8VEX
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8VEW
 | | Crystal structure of PRMT5:MEP50 in complex with MTA and oxamide compound 24 | | Descriptor: | 5'-DEOXY-5'-METHYLTHIOADENOSINE, 5-{2-[(2R,5S)-5-methyl-2-phenylpiperidin-1-yl](oxo)acetamido}pyridine-3-carboxamide, CHLORIDE ION, ... | | Authors: | Whittington, D.A. | | Deposit date: | 2023-12-20 | | Release date: | 2024-04-24 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.69 Å) | | Cite: | Discovery of TNG908: A Selective, Brain Penetrant, MTA-Cooperative PRMT5 Inhibitor That Is Synthetically Lethal with MTAP -Deleted Cancers.
J.Med.Chem., 67, 2024
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6OJP
 | | Structure of glycolipid alpha-GSA[8,6P] in complex with mouse CD1d | | Descriptor: | (5R,6S,7S)-5,6-dihydroxy-7-(octanoylamino)-N-(6-phenylhexyl)-8-{[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}octanamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, Antigen-presenting glycoprotein CD1d1, ... | | Authors: | Zajonc, D.M, Bitra, A. | | Deposit date: | 2019-04-11 | | Release date: | 2019-08-21 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.17 Å) | | Cite: | A molecular switch in mouse CD1d modulates natural killer T cell activation by alpha-galactosylsphingamides.
J.Biol.Chem., 294, 2019
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8VLS
 | | Structure of VCP in complex with an ATPase activator (D2 domains only, dodecameric form) | | Descriptor: | (3R)-N-[2-(ethylsulfanyl)phenyl]-3-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)butanamide, Transitional endoplasmic reticulum ATPase | | Authors: | Jones, N.H, Urnivicius, L, Kapoor, T.M. | | Deposit date: | 2024-01-12 | | Release date: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Allosteric activation of VCP, an AAA unfoldase, by small molecule mimicry.
Proc.Natl.Acad.Sci.USA, 121, 2024
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8VOV
 | | Structure of VCP in complex with an ATPase activator and ADP (D2 domains only, hexameric form) | | Descriptor: | (3R)-N-[2-(ethylsulfanyl)phenyl]-3-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)butanamide, ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase | | Authors: | Jones, N.H, Urnivicius, L, Kapoor, T.M. | | Deposit date: | 2024-01-16 | | Release date: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Allosteric activation of VCP, an AAA unfoldase, by small molecule mimicry.
Proc.Natl.Acad.Sci.USA, 121, 2024
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8VII
 | | EgtB-IV from Crocosphaera subtropica, an ergothioneine-biosynthetic type IV sulfoxide synthase in complex with cysteine and hercynine | | Descriptor: | 1,2-ETHANEDIOL, CYSTEINE, MANGANESE (II) ION, ... | | Authors: | Ireland, K.A, Davis, K.M. | | Deposit date: | 2024-01-04 | | Release date: | 2024-08-07 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (1.621 Å) | | Cite: | Structural insights into the convergent evolution of sulfoxide synthase EgtB-IV, an ergothioneine-biosynthetic homolog of ovothiol synthase OvoA.
Structure, 32, 2024
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6NHQ
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8VDR
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8VDP
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8VH1
 | | CH235.12 Fab bound to the HIV-1 CH505.M5 SOSIP | | Descriptor: | CH235.I60 Fab Heavy Chain, CH235.I60 Fab Light Chain, CH505.M5 SOSIP gp120, ... | | Authors: | Henderson, R, Acharya, P. | | Deposit date: | 2023-12-30 | | Release date: | 2024-10-02 | | Last modified: | 2024-11-20 | | Method: | ELECTRON MICROSCOPY (4.08 Å) | | Cite: | Engineering immunogens that select for specific mutations in HIV broadly neutralizing antibodies.
Nat Commun, 15, 2024
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8VDO
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8VH2
 | | CH235.12 Fab bound to the HIV-1 CH505.M5 SOSIP | | Descriptor: | CH235.12 Fab Heavy Chain, CH235.12 Fab Light Chain, CH505.M5.G458Y SOSIP gp120, ... | | Authors: | Henderson, R, Acharya, P. | | Deposit date: | 2023-12-30 | | Release date: | 2024-10-02 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (4.31 Å) | | Cite: | Engineering immunogens that select for specific mutations in HIV broadly neutralizing antibodies.
Nat Commun, 15, 2024
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8VDQ
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