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3U7C	crystal structure of the V143I mutant of human carbonic anhydrase II Descriptor: BICARBONATE ION, CARBON DIOXIDE, Carbonic anhydrase 2, ... Authors: West, D.M, Kim, C.U, Robbins, A.H, Mckenna, R. Deposit date: 2011-10-13 Release date: 2013-02-13 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (0.93 Å) Cite: crystal structure of the V143I mutant of human carbonic anhydrase II To be Published
3V3H	Kinetic and structural studies of thermostabilized mutants of HCA II. Descriptor: CHLORIDE ION, Carbonic anhydrase 2, ZINC ION Authors: Boone, C.D, Fisher, S.Z, McKenna, R. Deposit date: 2011-12-13 Release date: 2012-06-20 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Kinetic and structural characterization of thermostabilized mutants of human carbonic anhydrase II. Protein Eng.Des.Sel., 25, 2012
3V7X	Complex of human carbonic anhydrase II with N-[2-(3,4-dimethoxyphenyl)ethyl]-4-sulfamoylbenzamide Descriptor: Carbonic anhydrase 2, GLYCEROL, MERCURIBENZOIC ACID, ... Authors: Mader, P, Brynda, J, Rezacova, P. Deposit date: 2011-12-22 Release date: 2012-04-04 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.03 Å) Cite: Synthesis, Structure-Activity Relationship Studies, and X-ray Crystallographic Analysis of Arylsulfonamides as Potent Carbonic Anhydrase Inhibitors. J.Med.Chem., 55, 2012
6OE1	Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects Descriptor: 2-(2,4-dioxo-1,3-diazaspiro[4.5]decan-3-yl)-N-(4-sulfamoylphenyl)acetamide, Carbonic anhydrase 2, GLYCEROL, ... Authors: Peat, T.S. Deposit date: 2019-03-27 Release date: 2019-06-12 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects. Eur.J.Med.Chem., 177, 2019
6OUM	Carbonic Anhydrase IX mimic complexed with benzene sulfonamide MB10-580B Descriptor: (2Z)-2-(hydroxyimino)-2,3-dihydro-1,3-benzoxazole-5-sulfonamide, Carbonic anhydrase 2, GLYCEROL, ... Authors: Kota, A, McKenna, R. Deposit date: 2019-05-04 Release date: 2020-05-06 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.559 Å) Cite: Carbonic Anhydrase IX mimic complexed with ureido benzene sulfonamide MB10-580B To Be Published
6OE0	Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects Descriptor: 2-(2,4-dioxo-1,3-diazaspiro[4.6]undecan-3-yl)-N-(4-sulfamoylphenyl)acetamide, Carbonic anhydrase 2, GLYCEROL, ... Authors: Peat, T.S. Deposit date: 2019-03-27 Release date: 2019-06-12 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects. Eur.J.Med.Chem., 177, 2019
6OUD	Carbonic Anhydrase IX mimic complexed with benzene sulfonamide MB11-694B Descriptor: 4-{[(2-hydroxyethyl)carbamoyl]amino}benzene-1-sulfonamide, Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ... Authors: Kota, A, McKenna, R. Deposit date: 2019-05-04 Release date: 2020-05-06 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.256 Å) Cite: Carbonic Anhydrase IX mimic complexed with benzene sulfonamide MB11-694B To Be Published
6OUF	Carbonic Anhydrase IX mimic complexed with benzene sulfonamide MB11-707A Descriptor: 4-{[(4-hydroxybutyl)carbamoyl]amino}benzene-1-sulfonamide, Carbonic anhydrase 2, GLYCEROL, ... Authors: Kota, A, McKenna, R. Deposit date: 2019-05-04 Release date: 2020-05-06 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.358 Å) Cite: Carbonic Anhydrase IX mimic complexed with ureido benzene sulfonamide MB9-561B To Be Published
6OTK	Carbonic Anhydrase IX mimic complexed with ureido benzene sulfonamide MB10-596B Descriptor: 4-hydroxy-3-{[(4-hydroxybutyl)carbamoyl]amino}benzene-1-sulfonamide, Carbonic anhydrase 2, GLYCEROL, ... Authors: Kota, A, McKenna, R. Deposit date: 2019-05-03 Release date: 2020-05-06 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.123 Å) Cite: Carbonic Anhydrase IX mimic complexed with ureido benzene sulfonamide MB9-561B To Be Published
6OTQ	Carbonic Anhydrase II complexed with ureic benzene sulfonamide MB10-596B Descriptor: 4-hydroxy-3-{[(4-hydroxybutyl)carbamoyl]amino}benzene-1-sulfonamide, Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ... Authors: Kota, A, McKenna, R. Deposit date: 2019-05-03 Release date: 2020-05-06 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.467 Å) Cite: Carbonic Anhydrase II complexed with benzene sulfonamide MB9-561B To Be Published
6OUH	Carbonic Anhydrase II mimic complexed with benzene sulfonamide MB11-710A Descriptor: 3-{[(4-hydroxybutyl)carbamoyl]amino}benzene-1-sulfonamide, Carbonic anhydrase 2, GLYCEROL, ... Authors: Kota, A, McKenna, R. Deposit date: 2019-05-04 Release date: 2020-05-06 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.449 Å) Cite: Carbonic Anhydrase II mimic complexed with benzene sulfonamide MB11-710A To Be Published
6OTI	Carbonic Anhydrase IX mimic complexed with ureic benzene sulfonamide MB9-561B Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 4-hydroxy-3-({[(pyridin-4-yl)methyl]carbamoyl}amino)benzene-1-sulfonamide, Carbonic anhydrase 2, ... Authors: Kota, A, McKenna, R. Deposit date: 2019-05-03 Release date: 2020-05-06 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2 Å) Cite: Carbonic Anhydrase IX mimic complexed with ureido benzene sulfonamide MB9-561B To Be Published
6OTM	Carbonic Anhydrase IX mimic complexed with ureic benzene sulfonamide MB10-586B Descriptor: 4-hydroxy-3-({[2-(pyridin-2-yl)ethyl]carbamoyl}amino)benzene-1-sulfonamide, Carbonic anhydrase 2, GLYCEROL, ... Authors: Kota, A, McKenna, R. Deposit date: 2019-05-03 Release date: 2020-05-06 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.307 Å) Cite: Carbonic Anhydrase IX mimic complexed with ureido benzene sulfonamide MB9-561B To Be Published
6OTP	Carbonic Anhydrase II complexed with ureic benzene sulfonamide MB10-586B Descriptor: 4-hydroxy-3-({[2-(pyridin-2-yl)ethyl]carbamoyl}amino)benzene-1-sulfonamide, Carbonic anhydrase 2, ZINC ION Authors: Kota, A, McKenna, R. Deposit date: 2019-05-03 Release date: 2020-05-06 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.466 Å) Cite: Carbonic Anhydrase IX mimic complexed with ureido benzene sulfonamide MB9-561B To Be Published
6OUI	Carbonic Anhydrase IX mimic complexed with benzene sulfonamide MB11-710A Descriptor: 3-{[(4-hydroxybutyl)carbamoyl]amino}benzene-1-sulfonamide, Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ... Authors: Kota, A, McKenna, R. Deposit date: 2019-05-04 Release date: 2020-05-06 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.528 Å) Cite: Carbonic Anhydrase IX mimic complexed with ureido benzene sulfonamide MB11-710A To Be Published
3VBD	Complex of human carbonic anhydrase II with 4-(6-methoxy-3,4-dihydroisoquinolin-1-yl)benzenesulfonamide Descriptor: 4-(6-methoxy-3,4-dihydroisoquinolin-1-yl)benzenesulfonamide, Carbonic anhydrase 2, GLYCEROL, ... Authors: Mader, P, Brynda, J, Rezacova, P. Deposit date: 2012-01-02 Release date: 2012-04-04 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.05 Å) Cite: Synthesis, Structure-Activity Relationship Studies, and X-ray Crystallographic Analysis of Arylsulfonamides as Potent Carbonic Anhydrase Inhibitors. J.Med.Chem., 55, 2012
6ODZ	Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects Descriptor: 2-(2,4-dioxo-1,3-diazaspiro[4.4]nonan-3-yl)-N-(4-sulfamoylphenyl)acetamide, Carbonic anhydrase 2, GLYCEROL, ... Authors: Peat, T.S. Deposit date: 2019-03-27 Release date: 2019-06-12 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects. Eur.J.Med.Chem., 177, 2019
6OUJ	Carbonic Anhydrase II complexed with benzene sulfonamide MB11-689A Descriptor: 3-[(1S)-1-(4-nitrophenyl)ethyl]-2-oxo-2,3-dihydro-1,3-benzoxazole-5-sulfonamide, Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ... Authors: Kota, A, McKenna, R. Deposit date: 2019-05-04 Release date: 2020-05-06 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.466 Å) Cite: Carbonic Anhydrase II complexed with benzene sulfonamide MB11-689A To Be Published
6OTO	Carbonic Anhydrase II complexed with ureic benzene sulfonamide MB9-561B Descriptor: 4-hydroxy-3-({[(pyridin-4-yl)methyl]carbamoyl}amino)benzene-1-sulfonamide, Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ... Authors: Kota, A, McKenna, R. Deposit date: 2019-05-03 Release date: 2020-05-06 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.496 Å) Cite: Carbonic Anhydrase II complexed with ureido benzene sulfonamide MB9-561B To Be Published
6OUB	Carbonic Anhydrase II complexed with benzene sulfonamide MB11-694B Descriptor: 4-{[(2-hydroxyethyl)carbamoyl]amino}benzene-1-sulfonamide, Carbonic anhydrase 2, GLYCEROL, ... Authors: Kota, A, McKenna, R. Deposit date: 2019-05-04 Release date: 2020-05-06 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.418 Å) Cite: Carbonic Anhydrase II complexed with ureido benzene sulfonamide MB11-694B To Be Published
6OUE	Carbonic Anhydrase II complexed with benzene sulfonamide MB11-707A Descriptor: 4-{[(4-hydroxybutyl)carbamoyl]amino}benzene-1-sulfonamide, Carbonic anhydrase 2, GLYCEROL, ... Authors: Kota, A, McKenna, R. Deposit date: 2019-05-04 Release date: 2020-05-06 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.415 Å) Cite: Carbonic Anhydrase II complexed with ureido benzene sulfonamide MB11-707A To Be Published
3W6H	Crystal structure of 19F probe-labeled hCAI in complex with acetazolamide Descriptor: 1-(2-ethoxyethoxy)-3,5-bis(trifluoromethyl)benzene, 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE, Carbonic anhydrase 1, ... Authors: Takaoka, Y, Kioi, Y, Morito, A, Otani, J, Arita, K, Ashihara, E, Ariyoshi, M, Tochio, H, Shirakawa, M, Hamachi, I. Deposit date: 2013-02-14 Release date: 2013-03-13 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.964 Å) Cite: Quantitative Comparison of Protein Dynamics in Live Cells and In Vitro by In-Cell 19F-NMR To be published
3W6I	Crystal structure of 19F probe-labeled hCAI Descriptor: 1-(2-ethoxyethoxy)-3,5-bis(trifluoromethyl)benzene, Carbonic anhydrase 1, ZINC ION Authors: Takaoka, Y, Kioi, Y, Morito, A, Otani, J, Arita, K, Ashihara, E, Ariyoshi, M, Tochio, H, Shirakawa, M, Hamachi, I. Deposit date: 2013-02-14 Release date: 2013-03-13 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.693 Å) Cite: Quantitative Comparison of Protein Dynamics in Live Cells and In Vitro by In-Cell 19F-NMR To be published
6PDV	Cu-Carbonic Anhydrase II, A Nitrite Reductase Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, COPPER (II) ION, Carbonic anhydrase 2, ... Authors: Andring, J.T, McKenna, R. Deposit date: 2019-06-19 Release date: 2020-03-11 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.23 Å) Cite: Structure and mechanism of copper-carbonic anhydrase II: a nitrite reductase. Iucrj, 7, 2020
6PGX	Synthesis of novel tellurides bearing benzensulfonamide moiety as carbonic anhydrase inhibitors with antitumor activity Descriptor: 4-[(2S)-2-hydroxy-3-{[(2R)-2-hydroxy-3-(4-sulfamoylphenoxy)propyl]tellanyl}propoxy]benzene-1-sulfonamide, Carbonic anhydrase 2, GLYCEROL, ... Authors: Peat, T.S. Deposit date: 2019-06-25 Release date: 2019-08-21 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.36 Å) Cite: Synthesis of novel tellurides bearing benzensulfonamide moiety as carbonic anhydrase inhibitors with antitumor activity. Eur.J.Med.Chem., 181, 2019

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