6D90
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![BU of 6d90 by Molmil](/molmil-images/mine/6d90) | Mammalian 80S ribosome with a double translocated CrPV-IRES, P-site tRNA and eRF1. | Descriptor: | 18S rRNA, 28S rRNA, 5.8S rRNA, ... | Authors: | Pisareva, V.P, Pisarev, A.V, Fernandez, I.S. | Deposit date: | 2018-04-27 | Release date: | 2018-06-06 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Dual tRNA mimicry in the Cricket Paralysis Virus IRES uncovers an unexpected similarity with the Hepatitis C Virus IRES. Elife, 7, 2018
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6DLP
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![BU of 6dlp by Molmil](/molmil-images/mine/6dlp) | Crystal structure of LRRK2 WD40 domain dimer | Descriptor: | Leucine-rich repeat serine/threonine-protein kinase 2, PLATINUM (II) ION | Authors: | Zhang, P, Ru, H, Wang, L, Wu, H. | Deposit date: | 2018-06-02 | Release date: | 2019-01-09 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (4 Å) | Cite: | Crystal structure of the WD40 domain dimer of LRRK2. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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6DN8
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![BU of 6dn8 by Molmil](/molmil-images/mine/6dn8) | SPRY domain-containing SOCS box protein 2 complexed with (GZJ)VDINNN(CY3) Cyclic peptide inhibitor | Descriptor: | (GZJ)VDINNN(CY3) Cyclic peptide inhibitor, ACETATE ION, SPRY domain-containing SOCS box protein 4, ... | Authors: | Law, R.H.P, Caradoc-Davies, T.T, Norton, R.S. | Deposit date: | 2018-06-06 | Release date: | 2019-04-17 | Last modified: | 2022-04-13 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | A Cyclic Peptide Inhibitor of the iNOS-SPSB Protein-Protein Interaction as a Potential Anti-Infective Agent. ACS Chem. Biol., 13, 2018
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1A99
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![BU of 1a99 by Molmil](/molmil-images/mine/1a99) | PUTRESCINE RECEPTOR (POTF) FROM E. COLI | Descriptor: | 1,4-DIAMINOBUTANE, PUTRESCINE-BINDING PROTEIN | Authors: | Vassylyev, D.G, Tomitori, H, Kashiwagi, K, Morikawa, K, Igarashi, K. | Deposit date: | 1998-04-17 | Release date: | 1998-10-21 | Last modified: | 2020-04-01 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure and mutational analysis of the Escherichia coli putrescine receptor. Structural basis for substrate specificity. J.Biol.Chem., 273, 1998
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4W2R
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![BU of 4w2r by Molmil](/molmil-images/mine/4w2r) | Structure of Hs/AcPRC2 in complex with 5,8-dichloro-2-[(4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-7-[(R)-methoxy(oxetan-3-yl)methyl]-3,4-dihydroisoquinolin-1(2H)-one | Descriptor: | 5,8-dichloro-2-[(4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-7-[(R)-methoxy(oxetan-3-yl)methyl]-3,4-dihydroisoquinolin-1(2H)-one, Enhancer of zeste 2 polycomb repressive complex 2 subunit, Polycomb protein EED, ... | Authors: | Gajiwala, K.S, Brooun, A, Liu, W, Deng, Y, Stewart, A.E. | Deposit date: | 2017-09-25 | Release date: | 2017-12-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.81 Å) | Cite: | Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one (PF-06821497). J. Med. Chem., 61, 2018
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6DX5
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![BU of 6dx5 by Molmil](/molmil-images/mine/6dx5) | Crystal structure of the viral OTU domain protease from Farallon virus | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, RNA-dependent RNA polymerase | Authors: | Beldon, B.S, Dzimianski, J.V, Daczkowski, C.M, Goodwin, O.Y, Pegan, S.D. | Deposit date: | 2018-06-28 | Release date: | 2018-12-19 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.224 Å) | Cite: | Probing the impact of nairovirus genomic diversity on viral ovarian tumor domain protease (vOTU) structure and deubiquitinase activity. PLoS Pathog., 15, 2019
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6DY7
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![BU of 6dy7 by Molmil](/molmil-images/mine/6dy7) | WDR5 in complex with a WIN site inhibitor | Descriptor: | DIMETHYL SULFOXIDE, N-[3-(2,4-dichlorophenoxy)propyl]-1H-imidazol-2-amine, SULFATE ION, ... | Authors: | Phan, J, Wang, F, Fesik, S.W. | Deposit date: | 2018-07-01 | Release date: | 2019-03-13 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity. Cell Rep, 26, 2019
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6E1Y
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![BU of 6e1y by Molmil](/molmil-images/mine/6e1y) | |
6DYA
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![BU of 6dya by Molmil](/molmil-images/mine/6dya) | WDR5 in complex with a WIN site inhibitor | Descriptor: | DIMETHYL SULFOXIDE, N-[(3,5-dichlorophenyl)methyl]-3-[(1H-imidazol-1-yl)methyl]benzamide, SULFATE ION, ... | Authors: | Phan, J, Wang, F, Fesik, S.W. | Deposit date: | 2018-07-01 | Release date: | 2019-03-13 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.56 Å) | Cite: | Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity. Cell Rep, 26, 2019
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2JU0
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![BU of 2ju0 by Molmil](/molmil-images/mine/2ju0) | Structure of Yeast Frequenin bound to PdtIns 4-kinase | Descriptor: | CALCIUM ION, Calcium-binding protein NCS-1, Phosphatidylinositol 4-kinase PIK1 | Authors: | Ames, J. | Deposit date: | 2007-08-11 | Release date: | 2007-08-28 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Structural insights into activation of phosphatidylinositol 4-kinase (Pik1) by yeast frequenin (Frq1). J.Biol.Chem., 282, 2007
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6LQS
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![BU of 6lqs by Molmil](/molmil-images/mine/6lqs) | |
1BBR
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![BU of 1bbr by Molmil](/molmil-images/mine/1bbr) | |
2RMU
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![BU of 2rmu by Molmil](/molmil-images/mine/2rmu) | THREE-DIMENSIONAL STRUCTURES OF DRUG-RESISTANT MUTANTS OF HUMAN RHINOVIRUS 14 | Descriptor: | HUMAN RHINOVIRUS 14 COAT PROTEIN (SUBUNIT VP1), HUMAN RHINOVIRUS 14 COAT PROTEIN (SUBUNIT VP2), HUMAN RHINOVIRUS 14 COAT PROTEIN (SUBUNIT VP3), ... | Authors: | Badger, J, Krishnaswamy, S, Kremer, M.J, Oliveira, M.A, Rossmann, M.G, Heinz, B.A, Rueckert, R.R, Dutko, F.J, Mckinlay, M.A. | Deposit date: | 1988-10-03 | Release date: | 1990-01-15 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Three-dimensional structures of drug-resistant mutants of human rhinovirus 14. J.Mol.Biol., 207, 1989
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2VOW
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![BU of 2vow by Molmil](/molmil-images/mine/2vow) | An oxidized tryptophan facilitates copper-binding in Methylococcus capsulatus secreted protein MopE. The structure of recombinant MopE to 1.65AA | Descriptor: | CALCIUM ION, GLYCEROL, SURFACE-ASSOCIATED PROTEIN | Authors: | Helland, R, Fjellbirkeland, A, Karlsen, O.A, Ve, T, Lillehaug, J.R, Jensen, H.B. | Deposit date: | 2008-02-22 | Release date: | 2008-03-18 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | An Oxidized Tryptophan Facilitates Copper Binding in Methylococcus Capsulatus-Secreted Protein Mope. J.Biol.Chem., 283, 2008
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1CMU
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![BU of 1cmu by Molmil](/molmil-images/mine/1cmu) | THE ROLE OF ASPARTATE-235 IN THE BINDING OF CATIONS TO AN ARTIFICIAL CAVITY AT THE RADICAL SITE OF CYTOCHROME C PEROXIDASE | Descriptor: | CYTOCHROME C PEROXIDASE, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Fitzgerald, M.M, Trester, M.L, Jensen, G.M, Mcree, D.E, Goodin, D.B. | Deposit date: | 1995-04-10 | Release date: | 1995-07-10 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The role of aspartate-235 in the binding of cations to an artificial cavity at the radical site of cytochrome c peroxidase. Protein Sci., 4, 1995
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1CMT
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![BU of 1cmt by Molmil](/molmil-images/mine/1cmt) | THE ROLE OF ASPARTATE-235 IN THE BINDING OF CATIONS TO AN ARTIFICIAL CAVITY AT THE RADICAL SITE OF CYTOCHROME C PEROXIDASE | Descriptor: | CYTOCHROME C PEROXIDASE, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Fitzgerald, M.M, Trester, M.L, Jensen, G.M, Mcree, D.E, Goodin, D.B. | Deposit date: | 1995-04-11 | Release date: | 1995-07-10 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The role of aspartate-235 in the binding of cations to an artificial cavity at the radical site of cytochrome c peroxidase. Protein Sci., 4, 1995
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2VOV
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![BU of 2vov by Molmil](/molmil-images/mine/2vov) | An oxidized tryptophan facilitates copper-binding in Methylococcus capsulatus secreted protein MopE. The structure of wild-type MopE to 1.35AA | Descriptor: | CALCIUM ION, COPPER (II) ION, SURFACE-ASSOCIATED PROTEIN | Authors: | Helland, R, Fjellbirkeland, A, Karlsen, O.A, Ve, T, Lillehaug, J.R, Jensen, H.B. | Deposit date: | 2008-02-22 | Release date: | 2008-03-18 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | An Oxidized Tryptophan Facilitates Copper Binding in Methylococcus Capsulatus-Secreted Protein Mope. J.Biol.Chem., 283, 2008
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2VOX
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![BU of 2vox by Molmil](/molmil-images/mine/2vox) | An oxidized tryptophan facilitates copper-binding in Methylococcus capsulatus secreted protein MopE. The structure of mercury soaked MopE to 1.9AA | Descriptor: | CALCIUM ION, COPPER (II) ION, MERCURY (II) ION, ... | Authors: | Helland, R, Fjellbirkeland, A, Karlsen, O.A, Ve, T, Lillehaug, J.R, Jensen, H.B. | Deposit date: | 2008-02-22 | Release date: | 2008-03-18 | Last modified: | 2013-04-17 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | An Oxidized Tryptophan Facilitates Copper Binding in Methylococcus Capsulatus-Secreted Protein Mope. J.Biol.Chem., 283, 2008
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2GP9
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![BU of 2gp9 by Molmil](/molmil-images/mine/2gp9) | Crystal structure of the slow form of thrombin in a self-inhibited conformation | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Prothrombin | Authors: | Pineda, A, Chen, Z, Mathews, F.S, Di Cera, E. | Deposit date: | 2006-04-17 | Release date: | 2006-09-12 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.87 Å) | Cite: | Crystal structure of thrombin in a self-inhibited conformation. J.Biol.Chem., 281, 2006
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2LR9
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![BU of 2lr9 by Molmil](/molmil-images/mine/2lr9) | |
3U82
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![BU of 3u82 by Molmil](/molmil-images/mine/3u82) | Binding of herpes simplex virus glycoprotein D to nectin-1 exploits host cell adhesion | Descriptor: | Envelope glycoprotein D, Poliovirus receptor-related protein 1 | Authors: | Zhang, N, Yan, J, Lu, G, Guo, Z, Fan, Z, Wang, J, Shi, Y, Qi, J, Gao, G.F. | Deposit date: | 2011-10-15 | Release date: | 2012-03-21 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3.164 Å) | Cite: | Binding of herpes simplex virus glycoprotein D to nectin-1 exploits host cell adhesion. Nat Commun, 2, 2011
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3U96
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![BU of 3u96 by Molmil](/molmil-images/mine/3u96) | Crystal Structure of YopHQ357F(Catalytic Domain, Residues 163-468) in complex with pNCS | Descriptor: | N,4-DIHYDROXY-N-OXO-3-(SULFOOXY)BENZENAMINIUM, SULFATE ION, Tyrosine-protein phosphatase yopH | Authors: | Ho, M.C, Ke, S. | Deposit date: | 2011-10-17 | Release date: | 2012-08-29 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Investigation of catalytic loop structure, dynamics, and function relationship of Yersinia protein tyrosine phosphatase by temperature-jump relaxation spectroscopy and X-ray structural determination. J.Phys.Chem.B, 116, 2012
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3U3U
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![BU of 3u3u by Molmil](/molmil-images/mine/3u3u) | Crystal structure of the tablysin-15-leukotriene E4 complex | Descriptor: | (5S,7E,9E,11Z,14Z)-5-hydroxyicosa-7,9,11,14-tetraenoic acid, CITRIC ACID, PRASEODYMIUM ION, ... | Authors: | Andersen, J.F. | Deposit date: | 2011-10-06 | Release date: | 2012-02-15 | Last modified: | 2015-01-28 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure of protein having inhibitory disintegrin and leukotriene scavenging functions contained in single domain. J.Biol.Chem., 287, 2012
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3TLT
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![BU of 3tlt by Molmil](/molmil-images/mine/3tlt) | The GLIC pentameric Ligand-Gated Ion Channel H11'F mutant in a locally-closed conformation (LC1 subtype) | Descriptor: | CHLORIDE ION, DODECYL-BETA-D-MALTOSIDE, Glr4197 protein | Authors: | Sauguet, L, Nury, H, Corringer, P.J, Delarue, M. | Deposit date: | 2011-08-30 | Release date: | 2012-05-16 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | A locally closed conformation of a bacterial pentameric proton-gated ion channel. Nat.Struct.Mol.Biol., 19, 2012
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4JSP
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![BU of 4jsp by Molmil](/molmil-images/mine/4jsp) | structure of mTORDeltaN-mLST8-ATPgammaS-Mg complex | Descriptor: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase mTOR, ... | Authors: | Pavletich, N.P, Yang, H. | Deposit date: | 2013-03-22 | Release date: | 2013-05-01 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | mTOR kinase structure, mechanism and regulation. Nature, 497, 2013
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