PDB: 364 resultsInfo pagesStatus searchChemie searchBIRD

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7KTR	Cryo-EM structure of the human SAGA coactivator complex (TRRAP, core) Descriptor: Ataxin-7, INOSITOL HEXAKISPHOSPHATE, Isoform 3 of Transcription factor SPT20 homolog, ... Authors: Herbst, D.A, Esbin, M.N, Nogales, E. Deposit date: 2020-11-24 Release date: 2021-11-10 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (2.93 Å) Cite: Structure of the human SAGA coactivator complex. Nat.Struct.Mol.Biol., 28, 2021
7N6Z	Crystal Structure of PI5P4KIIAlpha Descriptor: Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha, SULFATE ION Authors: Chen, S, Ha, Y. Deposit date: 2021-06-09 Release date: 2021-06-30 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Pharmacological inhibition of PI5P4K alpha / beta disrupts cell energy metabolism and selectively kills p53-null tumor cells. Proc.Natl.Acad.Sci.USA, 118, 2021
7N7N	Crystal Structure of PI5P4KIIAlpha complex with Volasertib Descriptor: N-{trans-4-[4-(cyclopropylmethyl)piperazin-1-yl]cyclohexyl}-4-{[(7R)-7-ethyl-5-methyl-8-(1-methylethyl)-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxybenzamide, Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha, SULFATE ION Authors: Chen, S, Ha, Y. Deposit date: 2021-06-10 Release date: 2021-06-30 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Pharmacological inhibition of PI5P4K alpha / beta disrupts cell energy metabolism and selectively kills p53-null tumor cells. Proc.Natl.Acad.Sci.USA, 118, 2021
7N81	Crystal Structure of PI5P4KIIBeta complex with CC260 Descriptor: (7R)-8-cyclopentyl-7-(cyclopentylmethyl)-2-[(3,5-dichloro-4-hydroxyphenyl)amino]-5-methyl-7,8-dihydropteridin-6(5H)-one, Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Authors: Chen, S, Ha, Y. Deposit date: 2021-06-11 Release date: 2021-06-30 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Pharmacological inhibition of PI5P4K alpha / beta disrupts cell energy metabolism and selectively kills p53-null tumor cells. Proc.Natl.Acad.Sci.USA, 118, 2021
7N7O	Crystal Structure of PI5P4KIIAlpha complex with Palbociclib Descriptor: 6-ACETYL-8-CYCLOPENTYL-5-METHYL-2-[(5-PIPERAZIN-1-YLPYRIDIN-2-YL)AMINO]PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE, Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha, SULFATE ION Authors: Chen, S, Ha, Y. Deposit date: 2021-06-10 Release date: 2021-06-30 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Pharmacological inhibition of PI5P4K alpha / beta disrupts cell energy metabolism and selectively kills p53-null tumor cells. Proc.Natl.Acad.Sci.USA, 118, 2021
7N7J	Crystal Structure of PI5P4KIIAlpha complex with AMPPNP Descriptor: MANGANESE (II) ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha, ... Authors: Chen, S, Ha, Y. Deposit date: 2021-06-10 Release date: 2021-06-30 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Pharmacological inhibition of PI5P4K alpha / beta disrupts cell energy metabolism and selectively kills p53-null tumor cells. Proc.Natl.Acad.Sci.USA, 118, 2021
7N80	Crystal Structure of PI5P4KIIBeta Descriptor: Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Authors: Chen, S, Ha, Y. Deposit date: 2021-06-11 Release date: 2021-06-30 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Pharmacological inhibition of PI5P4K alpha / beta disrupts cell energy metabolism and selectively kills p53-null tumor cells. Proc.Natl.Acad.Sci.USA, 118, 2021
7N7M	Crystal Structure of PI5P4KIIAlpha complex with BI-2536 Descriptor: 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide, Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha, SULFATE ION Authors: Chen, S, Ha, Y. Deposit date: 2021-06-10 Release date: 2021-06-30 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Pharmacological inhibition of PI5P4K alpha / beta disrupts cell energy metabolism and selectively kills p53-null tumor cells. Proc.Natl.Acad.Sci.USA, 118, 2021
7N7K	Crystal Structure of PI5P4KIIAlpha complex with AMPPNP Descriptor: MANGANESE (II) ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha, ... Authors: Chen, S, Ha, Y. Deposit date: 2021-06-10 Release date: 2021-06-30 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2 Å) Cite: Pharmacological inhibition of PI5P4K alpha / beta disrupts cell energy metabolism and selectively kills p53-null tumor cells. Proc.Natl.Acad.Sci.USA, 118, 2021
7N7L	Crystal Structure of PI5P4KIIAlpha complex with BI-D1870 Descriptor: (7R)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-7,8-dihydropteridin-6(5H)-one, Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha, SULFATE ION Authors: Chen, S, Ha, Y. Deposit date: 2021-06-10 Release date: 2021-06-30 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Pharmacological inhibition of PI5P4K alpha / beta disrupts cell energy metabolism and selectively kills p53-null tumor cells. Proc.Natl.Acad.Sci.USA, 118, 2021
8TXS	Solution NMR structure of designed peptide BH26 (RGVTVPHNGESKDYSV) Descriptor: BH26 peptide Authors: McShan, A.C, Torres, M.P. Deposit date: 2023-08-24 Release date: 2023-09-06 Last modified: 2024-09-18 Method: SOLUTION NMR Cite: Generative beta-hairpin design using a residue-based physicochemical property landscape. Biophys.J., 123, 2024
7N71	Crystal Structure of PI5P4KIIAlpha Descriptor: Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha, SULFATE ION Authors: Chen, S, Ha, Y. Deposit date: 2021-06-09 Release date: 2021-07-07 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Pharmacological inhibition of PI5P4K alpha / beta disrupts cell energy metabolism and selectively kills p53-null tumor cells. Proc.Natl.Acad.Sci.USA, 118, 2021
4L3L	Crystal structures of human p70S6K1 kinase domain (Zinc anomalous) Descriptor: 2-{[4-(5-ethylpyrimidin-4-yl)piperazin-1-yl]methyl}-5-(trifluoromethyl)-1H-benzimidazole, RPS6KB1 protein, ZINC ION Authors: Wang, J, Zhong, C, Ding, J. Deposit date: 2013-06-06 Release date: 2013-07-24 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Crystal structures of S6K1 provide insights into the regulation mechanism of S6K1 by the hydrophobic motif Biochem.J., 454, 2013
4L3J	Crystal structures of human p70S6K1 kinase domain Descriptor: 2-{[4-(5-ethylpyrimidin-4-yl)piperazin-1-yl]methyl}-5-(trifluoromethyl)-1H-benzimidazole, RPS6KB1 protein, ZINC ION Authors: Wang, J, Zhong, C, Ding, J. Deposit date: 2013-06-06 Release date: 2013-07-24 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Crystal structures of S6K1 provide insights into the regulation mechanism of S6K1 by the hydrophobic motif Biochem.J., 454, 2013

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