PDB: 46188 resultsInfo pagesStatus searchChemie searchBIRD

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4I3I	Structures of IT intermediate of photoactive yellow protein E46Q mutant from time-resolved laue crystallography collected at 14ID APS Descriptor: 4'-HYDROXYCINNAMIC ACID, Photoactive yellow protein Authors: Jung, Y.O, Lee, J.H, Kim, J, Schmidt, M, Vukica, S, Moffat, K, Ihee, H. Deposit date: 2012-11-26 Release date: 2013-03-20 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Volume-conserving trans-cis isomerization pathways in photoactive yellow protein visualized by picosecond X-ray crystallography NAT.CHEM., 5, 2013
7NC4	Crystal structure of human carbonic anhydrase VII (hCA VII) in complex with a 4-(4-aroylpiperazine-1-carbonyl)benzenesulfonamide derivative. Descriptor: 4-[4-(2-chlorophenyl)carbonylpiperazin-1-yl]carbonylbenzenesulfonamide, Carbonic anhydrase 7, GLYCEROL, ... Authors: Di Fiore, A, De Simone, G. Deposit date: 2021-01-28 Release date: 2021-07-14 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Design, synthesis and biochemical evaluation of novel carbonic anhydrase inhibitors triggered by structural knowledge on hCA VII. Bioorg.Med.Chem., 44, 2021
4I8O	Crystal structure of the toxin RnlA from Escherichia coli Descriptor: TOXIN RNLA Authors: Wei, Y, Gao, Z.Q, Zhang, H, Dong, Y.H. Deposit date: 2012-12-04 Release date: 2013-10-23 Last modified: 2017-11-15 Method: X-RAY DIFFRACTION (2.104 Å) Cite: Structure-function studies of Escherichia coli RnlA reveal a novel toxin structure involved in bacteriophage resistance. Mol.Microbiol., 90, 2013
2CR7	Solution structure of the first PAH domain of the mouse transcriptional repressor SIN3B Descriptor: Paired amphipathic helix protein Sin3b Authors: Nagashima, K, Hayashi, F, Yoshida, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2005-05-20 Release date: 2005-11-20 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: Solution structure of the first PAH domain of the mouse transcriptional repressor SIN3B to be published
4I9S	Crystal Structure of the R111K:R132L:Y134F:T54V:R59W Mutant of the Cellular Retinoic Acid Binding Protein Type II in Complex with All-Trans Retinal at 2.58 Angstrom Resolution Descriptor: Cellular retinoic acid-binding protein 2, RETINAL Authors: Nosrati, M, Geiger, J.H. Deposit date: 2012-12-05 Release date: 2013-10-09 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.58 Å) Cite: Rational Design of a Colorimetric pH Sensor from a Soluble Retinoic Acid Chaperone. J.Am.Chem.Soc., 135, 2013
4I9R	Crystal Structure of the R111K:R132L:Y134F:T54V:R59W:A32W Mutant of the Cellular Retinoic Acid Binding Protein Type II in Complex with All-Trans Retinal at 2.6 Angstrom Resolution Descriptor: Cellular retinoic acid-binding protein 2, RETINAL Authors: Nosrati, M, Geiger, J.H. Deposit date: 2012-12-05 Release date: 2013-10-09 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Rational Design of a Colorimetric pH Sensor from a Soluble Retinoic Acid Chaperone. J.Am.Chem.Soc., 135, 2013
3C2W	Crystal structure of the photosensory core domain of P. aeruginosa bacteriophytochrome PaBphP in the Pfr state Descriptor: BILIVERDINE IX ALPHA, Bacteriophytochrome Authors: Yang, X, Kuk, J, Moffat, K. Deposit date: 2008-01-25 Release date: 2008-09-23 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Crystal structure of Pseudomonas aeruginosa bacteriophytochrome: photoconversion and signal transduction. Proc.Natl.Acad.Sci.USA, 105, 2008
4LY7	Ancestral RNase H Descriptor: Ribonuclease H, SULFATE ION Authors: Hart, K.M, Harms, M.J, Schmidt, B.H, Elya, C, Thornton, J.W, Marqusee, S. Deposit date: 2013-07-30 Release date: 2014-11-19 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.36 Å) Cite: Thermodynamic system drift in protein evolution. Plos Biol., 12, 2014
7RWS	Structure of SAVED domain of Cap5 from Lactococcus lactis in complex with cGAMP Descriptor: 3'2'-cGAMP, SAVED domain-containing protein Authors: Huang, R.H, Chakravarti, A, Fatma, S. Deposit date: 2021-08-20 Release date: 2021-11-10 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Molecular mechanisms of the CdnG-Cap5 antiphage defense system employing 3',2'-cGAMP as the second messenger. Nat Commun, 12, 2021
2CXC	Crystal structure of archaeal transcription termination factor NusA Descriptor: NusA Authors: Shibata, R, Bessho, Y, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2005-06-28 Release date: 2005-12-28 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structure and RNA-binding analysis of the archaeal transcription factor NusA Biochem.Biophys.Res.Commun., 355, 2007
7JVU	Crystal structure of human histone deacetylase 8 (HDAC8) I45T mutation complexed with SAHA Descriptor: 1,2-ETHANEDIOL, Histone deacetylase 8, OCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDE, ... Authors: Osko, J.D, Christianson, D.W, Decroos, C, Porter, N.J, Lee, M. Deposit date: 2020-08-24 Release date: 2020-12-16 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.5004766 Å) Cite: Structural analysis of histone deacetylase 8 mutants associated with Cornelia de Lange Syndrome spectrum disorders. J.Struct.Biol., 213, 2020
2FV2	Crystal Structure Analysis of human Rcd-1 conserved region Descriptor: MANGANESE (II) ION, RCD1 required for cell differentiation1 homolog Authors: Garces, R.G, Gillon, W, Pai, E.F. Deposit date: 2006-01-28 Release date: 2007-01-09 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Atomic model of human Rcd-1 reveals an armadillo-like-repeat protein with in vitro nucleic acid binding properties. Protein Sci., 16, 2007
7JVW	Crystal structure of human histone deacetylase 8 (HDAC8) G320R mutation complexed with M344 Descriptor: 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide, Histone deacetylase 8, POTASSIUM ION, ... Authors: Osko, J.D, Christianson, D.W, Decroos, C, Porter, N.J, Lee, M. Deposit date: 2020-08-24 Release date: 2020-12-16 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.40301776 Å) Cite: Structural analysis of histone deacetylase 8 mutants associated with Cornelia de Lange Syndrome spectrum disorders. J.Struct.Biol., 213, 2020
2FRS	Crystal structure of the f15w mutant of apo-cellular retinoic acid binding protein type ii at 1.51 angstroms resolution Descriptor: Cellular retinoic acid-binding protein 2, SODIUM ION Authors: Vaezeslami, S, Geiger, J.H. Deposit date: 2006-01-20 Release date: 2006-09-19 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.51 Å) Cite: The structure of Apo-wild-type cellular retinoic acid binding protein II at 1.4 A and its relationship to ligand binding and nuclear translocation. J.Mol.Biol., 363, 2006
3BRL	Crystal Structure of LC8 S88E / Swa Descriptor: Dynein light chain 1, cytoplasmic, Protein swallow 10-resiude peptide Authors: Benison, G.C, Karplus, P.A, Barbar, E.J, Chiodo, M. Deposit date: 2007-12-21 Release date: 2008-12-30 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.9 Å) Cite: The Interplay of Ligand Binding and Phosphorylation in the Regulation of Dynein Light Chain LC8 To be Published
3BSN	Norwalk Virus polymerase bound to 5-nitrocytidine triphosphate and primer-template RNA Descriptor: 5-nitrocytidine 5'-(tetrahydrogen triphosphate), GLYCEROL, MANGANESE (II) ION, ... Authors: Zamyatkin, D.F, Ng, K.K.S. Deposit date: 2007-12-26 Release date: 2008-01-08 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural insights into mechanisms of catalysis and inhibition in norwalk virus polymerase. J.Biol.Chem., 283, 2008
3BP3	Crystal structure of EIIB Descriptor: Glucose-specific phosphotransferase enzyme IIB component, SULFATE ION Authors: Cha, S.S, Jung, H.I, An, Y.J. Deposit date: 2007-12-18 Release date: 2008-11-04 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Analyses of Mlc-IIBGlc interaction and a plausible molecular mechanism of Mlc inactivation by membrane sequestration. Proc.Natl.Acad.Sci.Usa, 105, 2008
4NYD	Crystal structure of the E. coli thiM riboswitch in complex with hypoxanthine Descriptor: HYPOXANTHINE, MAGNESIUM ION, MANGANESE (II) ION, ... Authors: Warner, K.D, Homan, P, Weeks, K.M, Smith, A.G, Abell, C, Ferre-D'Amare, A.R. Deposit date: 2013-12-10 Release date: 2014-06-04 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Validating Fragment-Based Drug Discovery for Biological RNAs: Lead Fragments Bind and Remodel the TPP Riboswitch Specifically. Chem.Biol., 21, 2014
4NWL	Crystal structure of hepatis c virus protease (ns3) complexed with bms-650032 aka n-(tert-butoxycarbonyl)-3-me thyl-l-valyl-(4r)-4-((7-chloro-4-methoxy-1-isoquinolinyl)o xy)-n-((1r,2s)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylc yclopropyl)-l-prolinamide Descriptor: HCV NS3 1a Protease, N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-4-[(7-chloro-4-methoxyisoquinolin-1-yl)oxy]-N-{(1R,2S)-1-[(cyclopropylsulfonyl)carbamoyl]-2-ethenylcyclopropyl}-L-prolinamide, ZINC ION Authors: Muckelbauer, J.K, Klei, H.E. Deposit date: 2013-12-06 Release date: 2014-03-26 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Discovery and Early Clinical Evaluation of BMS-605339, a Potent and Orally Efficacious Tripeptidic Acylsulfonamide NS3 Protease Inhibitor for the Treatment of Hepatitis C Virus Infection. J.Med.Chem., 57, 2014
7JVV	Crystal structure of human histone deacetylase 8 (HDAC8) E66D/Y306F double mutation complexed with a tetrapeptide substrate Descriptor: 1,2-ETHANEDIOL, ACE-ARG-HIS-ALY-ALY-MCM, GLYCEROL, ... Authors: Osko, J.D, Christianson, D.W, Decroos, C, Porter, N.J, Lee, M. Deposit date: 2020-08-24 Release date: 2020-12-16 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.84 Å) Cite: Structural analysis of histone deacetylase 8 mutants associated with Cornelia de Lange Syndrome spectrum disorders. J.Struct.Biol., 213, 2020
7NH4	Co-Crystal Structure of Akt1 in Complex with Covalent-Allosteric Akt Inhibitor 3 Descriptor: ACETATE ION, RAC-alpha serine/threonine-protein kinase, ~{N}-[3-[1-[[4-[5-(hydroxymethyl)-3-phenyl-pyridin-2-yl]phenyl]methyl]piperidin-4-yl]-2-oxidanylidene-1~{H}-benzimidazol-5-yl]propanamide Authors: Landel, I, Mueller, M.P, Rauh, D. Deposit date: 2021-02-10 Release date: 2021-09-08 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Cellular model system to dissect the isoform-selectivity of Akt inhibitors. Nat Commun, 12, 2021
7NH5	Co-Crystal Structure of Akt1 in Complex with Covalent-Allosteric Akt Inhibitor 6 Descriptor: ACETATE ION, RAC-alpha serine/threonine-protein kinase, ~{N}-methyl-6-[4-[[4-[2-oxidanylidene-6-(propanoylamino)-3~{H}-benzimidazol-1-yl]piperidin-1-yl]methyl]phenyl]-5-phenyl-pyridine-3-carboxamide Authors: Landel, I, Mueller, M.P, Rauh, D. Deposit date: 2021-02-10 Release date: 2021-09-08 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Cellular model system to dissect the isoform-selectivity of Akt inhibitors. Nat Commun, 12, 2021
4MD6	Crystal structure of PDE5 in complex with inhibitor 5R Descriptor: 3-(4-hydroxybenzyl)-1-(thiophen-2-yl)chromeno[2,3-c]pyrrol-9(2H)-one, MAGNESIUM ION, SULFATE ION, ... Authors: Cui, W, Huang, M, Shao, Y, Luo, H. Deposit date: 2013-08-22 Release date: 2014-07-09 Method: X-RAY DIFFRACTION (2 Å) Cite: Discovery of 3-(4-hydroxybenzyl)-1-(thiophen-2-yl)chromeno[2,3-c]pyrrol-9(2H)-one as a phosphodiesterase-5 inhibitor and its complex crystal structure. Biochem Pharmacol, 89, 2014
2FS6	Crystal Structure of Apo-Cellular Retinoic Acid Binding Protein Type II At 1.35 Angstroms Resolution Descriptor: ACETATE ION, CHLORIDE ION, Cellular retinoic acid-binding protein 2, ... Authors: Vaezeslami, S, Geiger, J.H. Deposit date: 2006-01-21 Release date: 2006-09-19 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.35 Å) Cite: The structure of Apo-wild-type cellular retinoic acid binding protein II at 1.4 A and its relationship to ligand binding and nuclear translocation. J.Mol.Biol., 363, 2006
2FMM	Crystal Structure of EMSY-HP1 complex Descriptor: Chromobox protein homolog 1, Protein EMSY, SULFATE ION Authors: Huang, Y. Deposit date: 2006-01-09 Release date: 2006-05-23 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystal structure of the HP1-EMSY complex reveals an unusual mode of HP1 binding. Structure, 14, 2006

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