7NC4

Crystal structure of human carbonic anhydrase VII (hCA VII) in complex with a 4-(4-aroylpiperazine-1-carbonyl)benzenesulfonamide derivative.

Summary for 7NC4

Entry DOI	10.2210/pdb7nc4/pdb
Descriptor	Carbonic anhydrase 7, ZINC ION, 4-[4-(2-chlorophenyl)carbonylpiperazin-1-yl]carbonylbenzenesulfonamide, ... (5 entities in total)
Functional Keywords	protein-inhibitor adduct, lyase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	31583.16
Authors	Di Fiore, A.,De Simone, G. (deposition date: 2021-01-28, release date: 2021-07-14, Last modification date: 2024-01-31)
Primary citation	Mancuso, F.,Di Fiore, A.,De Luca, L.,Angeli, A.,De Simone, G.,Supuran, C.T.,Gitto, R. Design, synthesis and biochemical evaluation of novel carbonic anhydrase inhibitors triggered by structural knowledge on hCA VII. Bioorg.Med.Chem., 44:116279-116279, 2021 Cited by PubMed: 34216985 DOI: 10.1016/j.bmc.2021.116279 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation