7WU5
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![BU of 7wu5 by Molmil](/molmil-images/mine/7wu5) | Cryo-EM structure of the adhesion GPCR ADGRF1(H565A/T567A) in complex with miniGi | Descriptor: | Adhesion G-protein coupled receptor F1, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Qu, X, Qiu, N, Wang, M, Zhao, Q, Wu, B. | Deposit date: | 2022-02-05 | Release date: | 2022-04-27 | Last modified: | 2022-05-11 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural basis of tethered agonism of the adhesion GPCRs ADGRD1 and ADGRF1. Nature, 604, 2022
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7WU4
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![BU of 7wu4 by Molmil](/molmil-images/mine/7wu4) | Cryo-EM structure of the adhesion GPCR ADGRF1 in complex with miniGi | Descriptor: | Adhesion G-protein coupled receptor F1, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Qu, X, Qiu, N, Wang, M, Zhao, Q, Wu, B. | Deposit date: | 2022-02-05 | Release date: | 2022-04-27 | Last modified: | 2022-05-11 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural basis of tethered agonism of the adhesion GPCRs ADGRD1 and ADGRF1. Nature, 604, 2022
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1V3O
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![BU of 1v3o by Molmil](/molmil-images/mine/1v3o) | Crystal structure of d(GCGAGAGC): the DNA quadruplex structure split from the octaplex | Descriptor: | 5'-D(*GP*(C38)P*GP*AP*GP*AP*GP*C)-3', POTASSIUM ION | Authors: | Kondo, J, Umeda, S, Sunami, T, Takenaka, A. | Deposit date: | 2003-11-03 | Release date: | 2004-06-08 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal structures of a DNA octaplex with I-motif of G-quartets and its splitting into two quadruplexes suggest a folding mechanism of eight tandem repeats Nucleic Acids Res., 32, 2004
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1Y74
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![BU of 1y74 by Molmil](/molmil-images/mine/1y74) | Solution Structure of mLin-2/mLin-7 L27 Domain Complex | Descriptor: | Peripheral plasma membrane protein CASK, lin 7 homolog b | Authors: | Feng, W, Long, J.-F, Zhang, M. | Deposit date: | 2004-12-08 | Release date: | 2005-04-19 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | A unified assembly mode revealed by the structures of tetrameric L27 domain complexes formed by mLin-2/mLin-7 and Patj/Pals1 scaffold proteins. Proc.Natl.Acad.Sci.Usa, 102, 2005
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1V3N
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![BU of 1v3n by Molmil](/molmil-images/mine/1v3n) | Crystal structure of d(GCGAGAGC): the DNA quadruplex structure split from the octaplex | Descriptor: | 5'-D(*GP*(CBR)P*GP*AP*GP*AP*GP*C)-3', POTASSIUM ION | Authors: | Kondo, J, Umeda, S, Sunami, T, Takenaka, A. | Deposit date: | 2003-11-03 | Release date: | 2004-06-08 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structures of a DNA octaplex with I-motif of G-quartets and its splitting into two quadruplexes suggest a folding mechanism of eight tandem repeats Nucleic Acids Res., 32, 2004
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1Y76
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![BU of 1y76 by Molmil](/molmil-images/mine/1y76) | Solution Structure of Patj/Pals1 L27 Domain Complex | Descriptor: | MAGUK p55 subfamily member 5, protein associated to tight junctions | Authors: | Feng, W, Long, J.-F, Zhang, M. | Deposit date: | 2004-12-08 | Release date: | 2005-04-19 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | A unified assembly mode revealed by the structures of tetrameric L27 domain complexes formed by mLin-2/mLin-7 and Patj/Pals1 scaffold proteins. Proc.Natl.Acad.Sci.Usa, 102, 2005
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1QX8
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![BU of 1qx8 by Molmil](/molmil-images/mine/1qx8) | Crystal structure of a five-residue deletion mutant of the Rop protein | Descriptor: | Regulatory protein ROP | Authors: | Glykos, N.M, Vlassi, M, Papanikolaou, Y, Kotsifaki, D, Cesareni, G, Kokkinidis, M. | Deposit date: | 2003-09-04 | Release date: | 2004-09-28 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.02 Å) | Cite: | Loopless Rop: structure and dynamics of an engineered homotetrameric variant of the repressor of primer protein. Biochemistry, 45, 2006
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1XOE
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![BU of 1xoe by Molmil](/molmil-images/mine/1xoe) | N9 Tern influenza neuraminidase complexed with (2R,4R,5R)-5-(1-Acetylamino-3-methyl-butyl-pyrrolidine-2, 4-dicarobyxylic acid 4-methyl esterdase complexed with | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-[1-(ACETYLAMINO)-3-METHYLBUTYL]-4-(METHOXYCARBONYL)PROLINE, Neuraminidase, ... | Authors: | Wang, G.T, Wang, S, Gentles, R, Sowin, T, Maring, C.J, Kempf, D.J, Kati, W.M, Stoll, V, Stewart, K.D, Laver, G. | Deposit date: | 2004-10-06 | Release date: | 2005-01-11 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Design, synthesis, and structural analysis of inhibitors of influenza neuraminidase
containing a 2,3-disubstituted tetrahydrofuran-5-carboxylic acid core. Bioorg.Med.Chem.Lett., 15, 2005
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2PES
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![BU of 2pes by Molmil](/molmil-images/mine/2pes) | Urate Oxidase in complex with tris-dipicolinate Lutetium | Descriptor: | 8-AZAXANTHINE, LUTETIUM (III) ION, PYRIDINE-2,6-DICARBOXYLIC ACID, ... | Authors: | Pompidor, G, Vicat, J, Kahn, R. | Deposit date: | 2007-04-03 | Release date: | 2008-04-22 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | A dipicolinate lanthanide complex for solving protein structures using anomalous diffraction. Acta Crystallogr.,Sect.D, 66, 2010
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2FIK
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![BU of 2fik by Molmil](/molmil-images/mine/2fik) | Structure of a microbial glycosphingolipid bound to mouse CD1d | Descriptor: | (2S,3R)-3-HYDROXY-2-(TETRADECANOYLAMINO)OCTADECYL ALPHA-D-GALACTOPYRANOSIDURONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Wu, D, Zajonc, D.M. | Deposit date: | 2005-12-29 | Release date: | 2006-03-21 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Design of natural killer T cell activators: structure and function of a microbial glycosphingolipid bound to mouse CD1d. Proc.Natl.Acad.Sci.Usa, 103, 2006
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1RWO
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![BU of 1rwo by Molmil](/molmil-images/mine/1rwo) | Crystal structure of human caspase-1 in complex with 4-oxo-3-{6-[4-(quinoxalin-2-ylamino)-benzoylamino]-2-thiophen-2-yl-hexanoylamino}-pentanoic acid | Descriptor: | 4-OXO-3-{6-[4-(QUINOXALIN-2-YLAMINO)-BENZOYLAMINO]-2-THIOPHEN-2-YL-HEXANOYLAMINO}-PENTANOIC ACID, Interleukin-1 beta convertase | Authors: | Romanowski, M.J, Waal, N.D, Fahr, B.T, O'Brien, T. | Deposit date: | 2003-12-16 | Release date: | 2004-12-28 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural analysis of caspase-1 inhibitors derived from Tethering. Acta Crystallogr.,Sect.F, 61, 2005
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1RWP
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![BU of 1rwp by Molmil](/molmil-images/mine/1rwp) | |
1JVQ
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![BU of 1jvq by Molmil](/molmil-images/mine/1jvq) | Crystal structure at 2.6A of the ternary complex between antithrombin, a P14-P8 reactive loop peptide, and an exogenous tetrapeptide | Descriptor: | 2-acetamido-2-deoxy-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ANTITHROMBIN-III, ... | Authors: | Zhou, A, Huntington, J.A, Lomas, D.A, Carrell, R.W, Stein, P.E. | Deposit date: | 2001-08-31 | Release date: | 2003-06-03 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | How small peptides block and reverse serpin polymerisation J.Mol.Biol., 342, 2004
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1RWN
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1RWM
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![BU of 1rwm by Molmil](/molmil-images/mine/1rwm) | Crystal structure of human caspase-1 in complex with 4-oxo-3-[2-(5-{[4-(quinoxalin-2-ylamino)-benzoylamino]-methyl}-thiophen-2-yl)-acetylamino]-pentanoic acid | Descriptor: | 4-OXO-3-[2-(5-{[4-(QUINOXALIN-2-YLAMINO)-BENZOYLAMINO]-METHYL}-THIOPHEN-2-YL)-ACETYLAMINO]-PENTANOIC ACID, Interleukin-1 beta convertase | Authors: | Romanowski, M.J, Waal, N.D, Fahr, B.T, O'Brien, T. | Deposit date: | 2003-12-16 | Release date: | 2004-12-28 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural analysis of caspase-1 inhibitors derived from Tethering. Acta Crystallogr.,Sect.F, 61, 2005
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1RWK
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![BU of 1rwk by Molmil](/molmil-images/mine/1rwk) | Crystal structure of human caspase-1 in complex with 3-(2-mercapto-acetylamino)-4-oxo-pentanoic acid | Descriptor: | 3-(2-MERCAPTO-ACETYLAMINO)-4-OXO-PENTANOIC ACID, Interleukin-1 beta convertase | Authors: | Romanowski, M.J, Lam, J.W, Fahr, B.T, O'Brien, T. | Deposit date: | 2003-12-16 | Release date: | 2004-12-28 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural analysis of caspase-1 inhibitors derived from Tethering. Acta Crystallogr.,Sect.F, 61, 2005
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1VAR
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![BU of 1var by Molmil](/molmil-images/mine/1var) | |
1TT0
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![BU of 1tt0 by Molmil](/molmil-images/mine/1tt0) | Crystal Structure of Pyranose 2-Oxidase | Descriptor: | ACETATE ION, DODECAETHYLENE GLYCOL, FLAVIN-ADENINE DINUCLEOTIDE, ... | Authors: | Hallberg, B.M, Leitner, C, Haltrich, D, Divne, C. | Deposit date: | 2004-06-21 | Release date: | 2005-06-21 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of the 270 kDa homotetrameric lignin-degrading enzyme pyranose 2-oxidase J.Mol.Biol., 341, 2004
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1I33
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![BU of 1i33 by Molmil](/molmil-images/mine/1i33) | LEISHMANIA MEXICANA GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE IN COMPLEX WITH INHIBITORS | Descriptor: | GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE, N-1,2,3,4-TETRAHYDRONAPHTH-1-YL-2'-[3,5-DIMETHOXYBENZAMIDO]-2'-DEOXY-ADENOSINE | Authors: | Suresh, S, Bressi, J.C, Kennedy, K.J, Verlinde, C.L.M.J, Gelb, M.H, Hol, W.G.J. | Deposit date: | 2001-02-12 | Release date: | 2001-10-03 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Conformational changes in Leishmania mexicana glyceraldehyde-3-phosphate dehydrogenase induced by designed inhibitors. J.Mol.Biol., 309, 2001
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1SN0
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![BU of 1sn0 by Molmil](/molmil-images/mine/1sn0) | Crystal Structure Of Sea Bream Transthyretin in complex with thyroxine At 1.9A Resolution | Descriptor: | 3,5,3',5'-TETRAIODO-L-THYRONINE, SULFATE ION, transthyretin | Authors: | Eneqvist, T, Lundberg, E, Karlsson, A, Huang, S, Santos, C.R, Power, D.M, Sauer-Eriksson, A.E. | Deposit date: | 2004-03-10 | Release date: | 2004-08-03 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | High resolution crystal structures of piscine transthyretin reveal different binding modes for triiodothyronine and thyroxine. J.Biol.Chem., 279, 2004
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1SQL
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![BU of 1sql by Molmil](/molmil-images/mine/1sql) | Crystal structure of 7,8-dihydroneopterin aldolase in complex with guanine | Descriptor: | GUANINE, dihydroneopterin aldolase | Authors: | Bauer, S, Schott, A.K, Illarionova, V, Bacher, A, Huber, R, Fischer, M. | Deposit date: | 2004-03-19 | Release date: | 2004-06-08 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Biosynthesis of Tetrahydrofolate in Plants: Crystal Structure of 7,8-Dihydroneopterin Aldolase from Arabidopsis thaliana Reveals a Novel Adolase Class. J.Mol.Biol., 339, 2004
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6X4Q
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![BU of 6x4q by Molmil](/molmil-images/mine/6x4q) | Human cyclophilin A bound to a series of acylcic and macrocyclic inhibitors: (2R,5S,11S,14S,18E)-14-cyclobutyl-2,11,17,17-tetramethyl-15-oxa-3,9,12,26,29-pentaazatetracyclo[18.5.3.1~5,9~.0~23,27~]nonacosa-1(25),18,20(28),21,23,26-hexaene-4,10,13,16-tetrone (compound 33) | Descriptor: | (2R,5S,11S,14S,18E)-14-cyclobutyl-2,11,17,17-tetramethyl-15-oxa-3,9,12,26,29-pentaazatetracyclo[18.5.3.1~5,9~.0~23,27~]nonacosa-1(25),18,20(28),21,23,26-hexaene-4,10,13,16-tetrone, Peptidyl-prolyl cis-trans isomerase A | Authors: | Appleby, T.C, Paulsen, J.L, Schmitz, U, Shivakumar, D. | Deposit date: | 2020-05-22 | Release date: | 2020-06-24 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Evaluation of Free Energy Calculations for the Prioritization of Macrocycle Synthesis. J.Chem.Inf.Model., 60, 2020
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1JVM
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![BU of 1jvm by Molmil](/molmil-images/mine/1jvm) | |
1XCE
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![BU of 1xce by Molmil](/molmil-images/mine/1xce) | |
7AOT
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![BU of 7aot by Molmil](/molmil-images/mine/7aot) | The Fk1 domain of FKBP51 in complex with (2R,5S,12R)-12-cyclohexyl-2-[2-(3,4-dimethoxyphenyl)ethyl]-3,19-dioxa-10,13,16-triazatricyclo[18.3.1.0-5,10]tetracosa- 1(24),20,22-triene-4,11,14,17-tetrone | Descriptor: | (2R,5S,12R)-12-cyclohexyl-2-[2-(3,4-dimethoxyphenyl)ethyl]-3,19-dioxa-10,13,16-triazatricyclo[18.3.1.0-5,10]tetracosa- 1(24),20,22-triene-4,11,14,17-tetrone, Peptidyl-prolyl cis-trans isomerase FKBP5 | Authors: | Voll, A.M, Meyners, C, Heymann, T, Merz, S, Purder, P, Bracher, A, Hausch, F. | Deposit date: | 2020-10-15 | Release date: | 2021-04-21 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (0.85 Å) | Cite: | Macrocyclic FKBP51 Ligands Define a Transient Binding Mode with Enhanced Selectivity. Angew.Chem.Int.Ed.Engl., 60, 2021
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