1H3E
 
 | Tyrosyl-tRNA synthetase from Thermus thermophilus complexed with wild-type tRNAtyr(GUA) and with ATP and tyrosinol | Descriptor: | 4-[(2S)-2-amino-3-hydroxypropyl]phenol, ADENOSINE-5'-TRIPHOSPHATE, TYROSYL-TRNA SYNTHETASE, ... | Authors: | Cusack, S, Yaremchuk, A, Kriklivyi, I, Tukalo, M. | Deposit date: | 2002-08-28 | Release date: | 2002-10-27 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Class I Tyrosyl-tRNA Synthetase Has a Class II Mode or tRNA Recognition Embo J., 21, 2002
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7AP3
 
 | Crystal structure of E. coli tyrosyl-tRNA synthetase in complex with TyrS7HMDDA | Descriptor: | SODIUM ION, Tyrosine--tRNA ligase, [(2~{R},3~{S},4~{R},5~{R})-5-[7-azanyl-5-(hydroxymethyl)benzimidazol-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl ~{N}-[(2~{S})-2-azanyl-3-(4-hydroxyphenyl)propanoyl]sulfamate | Authors: | De Graef, S, Pang, L, Strelkov, S.V, Weeks, S.D. | Deposit date: | 2020-10-15 | Release date: | 2020-10-28 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Synthesis and Biological Evaluation of 1,3-Dideazapurine-Like 7-Amino-5-Hydroxymethyl-Benzimidazole Ribonucleoside Analogues as Aminoacyl-tRNA Synthetase Inhibitors. Molecules, 25, 2020
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3FOC
 
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1JH3
 
 | Solution structure of tyrosyl-tRNA synthetase C-terminal domain. | Descriptor: | TYROSYL-TRNA SYNTHETASE | Authors: | Guijarro, J.I, Pintar, A, Prochnicka-Chalufour, A, Guez, V, Gilquin, B, Bedouelle, H, Delepierre, M. | Deposit date: | 2001-06-27 | Release date: | 2002-03-20 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Structure and Dynamics of the Anticodon Arm Binding Domain of Bacillus stearothermophilus
Tyrosyl-tRNA Synthetase Structure, 10, 2002
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9CGU
 
 | Cas9 ternary complex, 14-nt sgRNA, State II (kinked) | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, Non-target strand, Target strand, ... | Authors: | Kiernan, K.A, Simonovic, M. | Deposit date: | 2024-07-01 | Release date: | 2024-12-04 | Last modified: | 2025-01-22 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural basis of Cas9 DNA interrogation with a 5' truncated sgRNA. Nucleic Acids Res., 53, 2025
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1H3N
 
 | Leucyl-tRNA synthetase from Thermus thermophilus complexed with a sulphamoyl analogue of leucyl-adenylate | Descriptor: | LEUCINE, LEUCYL-TRNA SYNTHETASE, SULFATE ION, ... | Authors: | Cusack, S, Yaremchuk, A, Tukalo, M. | Deposit date: | 2002-09-11 | Release date: | 2002-09-27 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The 2A Structure of Leucyl-tRNA Synthetase and its Complex with a Leucyl-Adenylate Analogue Embo J., 19, 2000
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1N75
 
 | Crystal structure of Thermus thermophilus glutamyl-tRNA synthetase complexed with ATP. | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Glutamyl-tRNA synthetase, MAGNESIUM ION | Authors: | Sekine, S, Nureki, O, Dubois, D.Y, Bernier, S, Chenevert, R, Lapointe, J, Vassylyev, D.G, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2002-11-12 | Release date: | 2003-02-25 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | ATP binding by glutamyl-tRNA synthetase is switched to the productive mode by tRNA binding EMBO J., 22, 2003
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8POT
 
 | Ternary complex of E. coli leucyl-tRNA synthetase, tRNA(leu) and the benzoxaborole cmpd9 in the editing conformation | Descriptor: | 1,2-ETHANEDIOL, Leucine--tRNA ligase, [(1R,3'S,5S,6R,8R)-3'-(aminomethyl)-8-(6-aminopurin-9-yl)-4'-bromanyl-7'-[3-[methyl-(phenylmethyl)amino]propoxy]spiro[2,4,7-trioxa-3$l^{4}-borabicyclo[3.3.0]octane-3,1'-3H-2,1$l^{4}-benzoxaborole]-6-yl]methyl dihydrogen phosphate, ... | Authors: | Palencia, A, Hoffmann, G. | Deposit date: | 2023-07-05 | Release date: | 2024-06-12 | Last modified: | 2024-07-24 | Method: | X-RAY DIFFRACTION (2.149 Å) | Cite: | Targeting a microbiota Wolbachian aminoacyl-tRNA synthetase to block its pathogenic host. Sci Adv, 10, 2024
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5W6M
 
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6YKQ
 
 | Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with Compound 11c | Descriptor: | 1,2-ETHANEDIOL, Leucine--tRNA ligase, MAGNESIUM ION, ... | Authors: | Pang, L, Strelkov, S.V, Weeks, S.D. | Deposit date: | 2020-04-06 | Release date: | 2020-12-02 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors. Eur.J.Med.Chem., 211, 2021
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6YKN
 
 | Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with Compound 11b | Descriptor: | 1,2-ETHANEDIOL, Leucine--tRNA ligase, MAGNESIUM ION, ... | Authors: | Pang, L, Strelkov, S.V, Weeks, S.D. | Deposit date: | 2020-04-06 | Release date: | 2020-12-02 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.63 Å) | Cite: | Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors. Eur.J.Med.Chem., 211, 2021
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6YKW
 
 | Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with Compound 11h | Descriptor: | 1,2-ETHANEDIOL, Leucine--tRNA ligase, MAGNESIUM ION, ... | Authors: | Pang, L, Strelkov, S.V, Weeks, S.D. | Deposit date: | 2020-04-06 | Release date: | 2020-12-02 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.46 Å) | Cite: | Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors. Eur.J.Med.Chem., 211, 2021
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6YKX
 
 | Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with Compound 11j | Descriptor: | 1,2-ETHANEDIOL, Leucine--tRNA ligase, MAGNESIUM ION, ... | Authors: | Pang, L, Strelkov, S.V, Weeks, S.D. | Deposit date: | 2020-04-06 | Release date: | 2020-12-02 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors. Eur.J.Med.Chem., 211, 2021
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6YKK
 
 | Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with Compound 15 | Descriptor: | 1,2-ETHANEDIOL, Leucine--tRNA ligase, MAGNESIUM ION, ... | Authors: | Pang, L, Strelkov, S.V, Weeks, S.D. | Deposit date: | 2020-04-06 | Release date: | 2020-12-02 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.236 Å) | Cite: | Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors. Eur.J.Med.Chem., 211, 2021
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6YKV
 
 | Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with Compound 11g | Descriptor: | 1,2-ETHANEDIOL, Leucine--tRNA ligase, MAGNESIUM ION, ... | Authors: | Pang, L, Strelkov, S.V, Weeks, S.D. | Deposit date: | 2020-04-06 | Release date: | 2020-12-02 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.43 Å) | Cite: | Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors. Eur.J.Med.Chem., 211, 2021
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6YKO
 
 | Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with Compound 11a | Descriptor: | 1,2-ETHANEDIOL, Leucine--tRNA ligase, MAGNESIUM ION, ... | Authors: | Pang, L, Strelkov, S.V, Weeks, S.D. | Deposit date: | 2020-04-06 | Release date: | 2020-12-02 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors. Eur.J.Med.Chem., 211, 2021
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3TEH
 
 | Crystal structure of Thermus thermophilus Phenylalanyl-tRNA synthetase complexed with L-dopa | Descriptor: | 3,4-DIHYDROXYPHENYLALANINE, Phenylalanyl-tRNA synthetase alpha chain, Phenylalanyl-tRNA synthetase beta chain | Authors: | Safro, M, Klipcan, L, Moor, N. | Deposit date: | 2011-08-14 | Release date: | 2011-11-23 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.8524 Å) | Cite: | Bacterial and Eukaryotic Phenylalanyl-tRNA Synthetases Catalyze Misaminoacylation of tRNA(Phe) with 3,4-Dihydroxy-L-Phenylalanine. Chem.Biol., 18, 2011
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6YKL
 
 | Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with Compound 11k | Descriptor: | 1,2-ETHANEDIOL, Leucine--tRNA ligase, MAGNESIUM ION, ... | Authors: | Pang, L, Strelkov, S.V, Weeks, S.D. | Deposit date: | 2020-04-06 | Release date: | 2020-12-02 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.27 Å) | Cite: | Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors. Eur.J.Med.Chem., 211, 2021
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6YKU
 
 | Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with Compound 11f | Descriptor: | 1,2-ETHANEDIOL, Leucine--tRNA ligase, MAGNESIUM ION, ... | Authors: | Pang, L, Strelkov, S.V, Weeks, S.D. | Deposit date: | 2020-04-06 | Release date: | 2020-12-02 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.14 Å) | Cite: | Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors. Eur.J.Med.Chem., 211, 2021
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6YKS
 
 | Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with Compound 11d | Descriptor: | 1,2-ETHANEDIOL, Leucine--tRNA ligase, MAGNESIUM ION, ... | Authors: | Pang, L, Strelkov, S.V, Weeks, S.D. | Deposit date: | 2020-04-06 | Release date: | 2020-12-02 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors. Eur.J.Med.Chem., 211, 2021
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6YKT
 
 | Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with Compound 11e | Descriptor: | 1,2-ETHANEDIOL, Leucine--tRNA ligase, MAGNESIUM ION, ... | Authors: | Pang, L, Strelkov, S.V, Weeks, S.D. | Deposit date: | 2020-04-06 | Release date: | 2020-12-02 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.32 Å) | Cite: | Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors. Eur.J.Med.Chem., 211, 2021
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5XGQ
 
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1N9W
 
 | Crystal structure of the non-discriminating and archaeal-type aspartyl-tRNA synthetase from Thermus thermophilus | Descriptor: | aspartyl-tRNA synthetase 2 | Authors: | Charron, C, Roy, H, Blaise, M, Giege, R, Kern, D. | Deposit date: | 2002-11-26 | Release date: | 2003-04-08 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Non-discriminating and discriminating aspartyl-tRNA synthetases differ in
the anticodon-binding domain EMBO J., 22, 2003
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1VS3
 
 | Crystal Structure of the tRNA Pseudouridine Synthase TruA From Thermus thermophilus HB8 | Descriptor: | tRNA pseudouridine synthase A | Authors: | Dong, X, Bessho, Y, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2006-06-28 | Release date: | 2006-12-12 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Crystal structure of tRNA pseudouridine synthase TruA from Thermus thermophilus HB8. Rna Biol., 3, 2006
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4G6Z
 
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