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1H3E
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BU of 1h3e by Molmil
Tyrosyl-tRNA synthetase from Thermus thermophilus complexed with wild-type tRNAtyr(GUA) and with ATP and tyrosinol
Descriptor: 4-[(2S)-2-amino-3-hydroxypropyl]phenol, ADENOSINE-5'-TRIPHOSPHATE, TYROSYL-TRNA SYNTHETASE, ...
Authors:Cusack, S, Yaremchuk, A, Kriklivyi, I, Tukalo, M.
Deposit date:2002-08-28
Release date:2002-10-27
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Class I Tyrosyl-tRNA Synthetase Has a Class II Mode or tRNA Recognition
Embo J., 21, 2002
7AP3
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Crystal structure of E. coli tyrosyl-tRNA synthetase in complex with TyrS7HMDDA
Descriptor: SODIUM ION, Tyrosine--tRNA ligase, [(2~{R},3~{S},4~{R},5~{R})-5-[7-azanyl-5-(hydroxymethyl)benzimidazol-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl ~{N}-[(2~{S})-2-azanyl-3-(4-hydroxyphenyl)propanoyl]sulfamate
Authors:De Graef, S, Pang, L, Strelkov, S.V, Weeks, S.D.
Deposit date:2020-10-15
Release date:2020-10-28
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:Synthesis and Biological Evaluation of 1,3-Dideazapurine-Like 7-Amino-5-Hydroxymethyl-Benzimidazole Ribonucleoside Analogues as Aminoacyl-tRNA Synthetase Inhibitors.
Molecules, 25, 2020
3FOC
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BU of 3foc by Molmil
Tryptophanyl-tRNA synthetase from Giardia lamblia
Descriptor: GLYCEROL, SULFATE ION, Tryptophanyl-tRNA synthetase
Authors:Arakaki, T.L, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:2008-12-29
Release date:2009-01-13
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:The structure of tryptophanyl-tRNA synthetase from Giardia lamblia reveals divergence from eukaryotic homologs.
J.Struct.Biol., 171, 2010
1JH3
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BU of 1jh3 by Molmil
Solution structure of tyrosyl-tRNA synthetase C-terminal domain.
Descriptor: TYROSYL-TRNA SYNTHETASE
Authors:Guijarro, J.I, Pintar, A, Prochnicka-Chalufour, A, Guez, V, Gilquin, B, Bedouelle, H, Delepierre, M.
Deposit date:2001-06-27
Release date:2002-03-20
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Structure and Dynamics of the Anticodon Arm Binding Domain of Bacillus stearothermophilus Tyrosyl-tRNA Synthetase
Structure, 10, 2002
9CGU
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BU of 9cgu by Molmil
Cas9 ternary complex, 14-nt sgRNA, State II (kinked)
Descriptor: CRISPR-associated endonuclease Cas9/Csn1, Non-target strand, Target strand, ...
Authors:Kiernan, K.A, Simonovic, M.
Deposit date:2024-07-01
Release date:2024-12-04
Last modified:2025-01-22
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural basis of Cas9 DNA interrogation with a 5' truncated sgRNA.
Nucleic Acids Res., 53, 2025
1H3N
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Leucyl-tRNA synthetase from Thermus thermophilus complexed with a sulphamoyl analogue of leucyl-adenylate
Descriptor: LEUCINE, LEUCYL-TRNA SYNTHETASE, SULFATE ION, ...
Authors:Cusack, S, Yaremchuk, A, Tukalo, M.
Deposit date:2002-09-11
Release date:2002-09-27
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:The 2A Structure of Leucyl-tRNA Synthetase and its Complex with a Leucyl-Adenylate Analogue
Embo J., 19, 2000
1N75
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BU of 1n75 by Molmil
Crystal structure of Thermus thermophilus glutamyl-tRNA synthetase complexed with ATP.
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Glutamyl-tRNA synthetase, MAGNESIUM ION
Authors:Sekine, S, Nureki, O, Dubois, D.Y, Bernier, S, Chenevert, R, Lapointe, J, Vassylyev, D.G, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2002-11-12
Release date:2003-02-25
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:ATP binding by glutamyl-tRNA synthetase is switched to the productive mode by tRNA binding
EMBO J., 22, 2003
8POT
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BU of 8pot by Molmil
Ternary complex of E. coli leucyl-tRNA synthetase, tRNA(leu) and the benzoxaborole cmpd9 in the editing conformation
Descriptor: 1,2-ETHANEDIOL, Leucine--tRNA ligase, [(1R,3'S,5S,6R,8R)-3'-(aminomethyl)-8-(6-aminopurin-9-yl)-4'-bromanyl-7'-[3-[methyl-(phenylmethyl)amino]propoxy]spiro[2,4,7-trioxa-3$l^{4}-borabicyclo[3.3.0]octane-3,1'-3H-2,1$l^{4}-benzoxaborole]-6-yl]methyl dihydrogen phosphate, ...
Authors:Palencia, A, Hoffmann, G.
Deposit date:2023-07-05
Release date:2024-06-12
Last modified:2024-07-24
Method:X-RAY DIFFRACTION (2.149 Å)
Cite:Targeting a microbiota Wolbachian aminoacyl-tRNA synthetase to block its pathogenic host.
Sci Adv, 10, 2024
5W6M
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BU of 5w6m by Molmil
Crystal structure of the human histidyl-tRNA synthetase mutant D175E
Descriptor: Histidine--tRNA ligase, cytoplasmic
Authors:Blocquel, D, Yang, X.L.
Deposit date:2017-06-16
Release date:2018-06-20
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.696 Å)
Cite:CMT disease severity correlates with mutation-induced open conformation of histidyl-tRNA synthetase, not aminoacylation loss, in patient cells.
Proc.Natl.Acad.Sci.USA, 2019
6YKQ
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BU of 6ykq by Molmil
Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with Compound 11c
Descriptor: 1,2-ETHANEDIOL, Leucine--tRNA ligase, MAGNESIUM ION, ...
Authors:Pang, L, Strelkov, S.V, Weeks, S.D.
Deposit date:2020-04-06
Release date:2020-12-02
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors.
Eur.J.Med.Chem., 211, 2021
6YKN
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Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with Compound 11b
Descriptor: 1,2-ETHANEDIOL, Leucine--tRNA ligase, MAGNESIUM ION, ...
Authors:Pang, L, Strelkov, S.V, Weeks, S.D.
Deposit date:2020-04-06
Release date:2020-12-02
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.63 Å)
Cite:Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors.
Eur.J.Med.Chem., 211, 2021
6YKW
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BU of 6ykw by Molmil
Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with Compound 11h
Descriptor: 1,2-ETHANEDIOL, Leucine--tRNA ligase, MAGNESIUM ION, ...
Authors:Pang, L, Strelkov, S.V, Weeks, S.D.
Deposit date:2020-04-06
Release date:2020-12-02
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors.
Eur.J.Med.Chem., 211, 2021
6YKX
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BU of 6ykx by Molmil
Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with Compound 11j
Descriptor: 1,2-ETHANEDIOL, Leucine--tRNA ligase, MAGNESIUM ION, ...
Authors:Pang, L, Strelkov, S.V, Weeks, S.D.
Deposit date:2020-04-06
Release date:2020-12-02
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors.
Eur.J.Med.Chem., 211, 2021
6YKK
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BU of 6ykk by Molmil
Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with Compound 15
Descriptor: 1,2-ETHANEDIOL, Leucine--tRNA ligase, MAGNESIUM ION, ...
Authors:Pang, L, Strelkov, S.V, Weeks, S.D.
Deposit date:2020-04-06
Release date:2020-12-02
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.236 Å)
Cite:Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors.
Eur.J.Med.Chem., 211, 2021
6YKV
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BU of 6ykv by Molmil
Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with Compound 11g
Descriptor: 1,2-ETHANEDIOL, Leucine--tRNA ligase, MAGNESIUM ION, ...
Authors:Pang, L, Strelkov, S.V, Weeks, S.D.
Deposit date:2020-04-06
Release date:2020-12-02
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors.
Eur.J.Med.Chem., 211, 2021
6YKO
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BU of 6yko by Molmil
Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with Compound 11a
Descriptor: 1,2-ETHANEDIOL, Leucine--tRNA ligase, MAGNESIUM ION, ...
Authors:Pang, L, Strelkov, S.V, Weeks, S.D.
Deposit date:2020-04-06
Release date:2020-12-02
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors.
Eur.J.Med.Chem., 211, 2021
3TEH
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BU of 3teh by Molmil
Crystal structure of Thermus thermophilus Phenylalanyl-tRNA synthetase complexed with L-dopa
Descriptor: 3,4-DIHYDROXYPHENYLALANINE, Phenylalanyl-tRNA synthetase alpha chain, Phenylalanyl-tRNA synthetase beta chain
Authors:Safro, M, Klipcan, L, Moor, N.
Deposit date:2011-08-14
Release date:2011-11-23
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.8524 Å)
Cite:Bacterial and Eukaryotic Phenylalanyl-tRNA Synthetases Catalyze Misaminoacylation of tRNA(Phe) with 3,4-Dihydroxy-L-Phenylalanine.
Chem.Biol., 18, 2011
6YKL
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BU of 6ykl by Molmil
Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with Compound 11k
Descriptor: 1,2-ETHANEDIOL, Leucine--tRNA ligase, MAGNESIUM ION, ...
Authors:Pang, L, Strelkov, S.V, Weeks, S.D.
Deposit date:2020-04-06
Release date:2020-12-02
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors.
Eur.J.Med.Chem., 211, 2021
6YKU
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BU of 6yku by Molmil
Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with Compound 11f
Descriptor: 1,2-ETHANEDIOL, Leucine--tRNA ligase, MAGNESIUM ION, ...
Authors:Pang, L, Strelkov, S.V, Weeks, S.D.
Deposit date:2020-04-06
Release date:2020-12-02
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors.
Eur.J.Med.Chem., 211, 2021
6YKS
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BU of 6yks by Molmil
Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with Compound 11d
Descriptor: 1,2-ETHANEDIOL, Leucine--tRNA ligase, MAGNESIUM ION, ...
Authors:Pang, L, Strelkov, S.V, Weeks, S.D.
Deposit date:2020-04-06
Release date:2020-12-02
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors.
Eur.J.Med.Chem., 211, 2021
6YKT
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BU of 6ykt by Molmil
Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with Compound 11e
Descriptor: 1,2-ETHANEDIOL, Leucine--tRNA ligase, MAGNESIUM ION, ...
Authors:Pang, L, Strelkov, S.V, Weeks, S.D.
Deposit date:2020-04-06
Release date:2020-12-02
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors.
Eur.J.Med.Chem., 211, 2021
5XGQ
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BU of 5xgq by Molmil
Crystal structure of apo form (free-state) Mycobacterium tuberculosis methionyl-tRNA synthetase
Descriptor: Methionine-tRNA ligase
Authors:Wang, W, Wang, M, Wojdyla, J.A, Cui, S.
Deposit date:2017-04-15
Release date:2018-07-11
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.899 Å)
Cite:Structural characterization of free-state and product-stateMycobacterium tuberculosismethionyl-tRNA synthetase reveals an induced-fit ligand-recognition mechanism
IUCrJ, 5, 2018
1N9W
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BU of 1n9w by Molmil
Crystal structure of the non-discriminating and archaeal-type aspartyl-tRNA synthetase from Thermus thermophilus
Descriptor: aspartyl-tRNA synthetase 2
Authors:Charron, C, Roy, H, Blaise, M, Giege, R, Kern, D.
Deposit date:2002-11-26
Release date:2003-04-08
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Non-discriminating and discriminating aspartyl-tRNA synthetases differ in the anticodon-binding domain
EMBO J., 22, 2003
1VS3
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BU of 1vs3 by Molmil
Crystal Structure of the tRNA Pseudouridine Synthase TruA From Thermus thermophilus HB8
Descriptor: tRNA pseudouridine synthase A
Authors:Dong, X, Bessho, Y, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2006-06-28
Release date:2006-12-12
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystal structure of tRNA pseudouridine synthase TruA from Thermus thermophilus HB8.
Rna Biol., 3, 2006
4G6Z
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Crystal structure of a glutamyl-tRNA synthetase GluRS from Burkholderia thailandensis bound to L-glutamate
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, GLUTAMIC ACID, ...
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2012-07-19
Release date:2012-08-01
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Ligand co-crystallization of aminoacyl-tRNA synthetases from infectious disease organisms.
Sci Rep, 7, 2017

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