8CQW
| Crystal structure of the Candida albicans 80S ribosome in complex with Hygromycin B | Descriptor: | 18S, 25S, 3-O-acetyl-2-O-(3-O-acetyl-6-deoxy-beta-D-glucopyranosyl)-6-deoxy-1-O-{[(2R,2'S,3a'R,4''S,5''R,6'S,7a'S)-5''-methyl-4''-{[(2E)-3-phenylprop-2-enoyl]oxy}decahydrodispiro[oxirane-2,3'-[1]benzofuran-2',2''-pyran]-6'-yl]carbonyl}-beta-D-glucopyranose, ... | Authors: | Kolosova, O, Zgadzay, Y, Yusupov, M. | Deposit date: | 2023-03-07 | Release date: | 2024-09-18 | Method: | X-RAY DIFFRACTION (3.05 Å) | Cite: | Drug-induced rotational movement of the ribosome is a key factor for read-through enhancement To Be Published
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3TQN
| Structure of the transcriptional regulator of the GntR family, from Coxiella burnetii. | Descriptor: | Transcriptional regulator, GntR family | Authors: | Rudolph, M, Cheung, J, Franklin, M.C, Cassidy, M, Gary, E, Burshteyn, F, Love, J. | Deposit date: | 2011-09-09 | Release date: | 2011-09-28 | Last modified: | 2017-11-08 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural genomics for drug design against the pathogen Coxiella burnetii. Proteins, 83, 2015
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8CQ7
| Crystal structure of phyllanthoside bound to the Candida albicans 80S ribosome | Descriptor: | 18S, 25S, 3-O-acetyl-2-O-(3-O-acetyl-6-deoxy-beta-D-glucopyranosyl)-6-deoxy-1-O-{[(2R,2'S,3a'R,4''S,5''R,6'S,7a'S)-5''-methyl-4''-{[(2E)-3-phenylprop-2-enoyl]oxy}decahydrodispiro[oxirane-2,3'-[1]benzofuran-2',2''-pyran]-6'-yl]carbonyl}-beta-D-glucopyranose, ... | Authors: | Kolosova, O, Zgadzay, Y, Yusupov, M. | Deposit date: | 2023-03-03 | Release date: | 2024-09-11 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Drug-induced rotational movement of the ribosome is a key factor for read-through enhancement To Be Published
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3WPR
| Acinetobacter sp. Tol 5 AtaA N-terminal half of C-terminal stalk fused to GCN4 adaptors (CstalkN) | Descriptor: | Trimeric autotransporter adhesin | Authors: | Koiwai, K, Hartmann, M.D, Yoshimoto, S, Nur 'Izzah, N, Suzuki, A, Linke, D, Lupas, A.N, Hori, K. | Deposit date: | 2014-01-15 | Release date: | 2015-03-04 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.899 Å) | Cite: | Structural Basis for Toughness and Flexibility in the C-terminal Passenger Domain of an Acinetobacter Trimeric Autotransporter Adhesin. J.Biol.Chem., 291, 2016
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3WWT
| Crystal Structure of the Y3:STAT1ND complex | Descriptor: | C' protein, CALCIUM ION, Signal transducer and activator of transcription 1-alpha/beta | Authors: | Oda, K, Sakaguchi, T, Matoba, Y. | Deposit date: | 2014-06-27 | Release date: | 2015-07-01 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural Basis of the Inhibition of STAT1 Activity by Sendai Virus C Protein. J.Virol., 89, 2015
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4LSN
| Crystal Structure of HIV-1 Reverse Transcriptase in Complex with (E)-3-(3-bromo-5-(4-chloro-2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (JLJ518), a non-nucleoside inhibitor | Descriptor: | (2E)-3-(3-bromo-5-{4-chloro-2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenoxy}phenyl)prop-2-enenitrile, HIV-1 reverse transcriptase, p51 subunit, ... | Authors: | Gray, W.T, Frey, K.M, Anderson, K.S. | Deposit date: | 2013-07-22 | Release date: | 2013-12-25 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structure-Based Evaluation of C5 Derivatives in the Catechol Diether Series Targeting HIV-1 Reverse Transcriptase. Chem.Biol.Drug Des., 83, 2014
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7JQM
| Crystal structure of the Thermus thermophilus 70S ribosome in complex with Bac7-002, mRNA, and deacylated P-site tRNA at 3.05A resolution | Descriptor: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Mardirossian, M, Sola, R, Beckert, B, Valencic, E, Collis, D.W.P, Borisek, J, Armas, F, Di Stasi, A, Buchmann, J, Syroegin, E.A, Polikanov, Y.S, Magistrato, A, Hilpert, K, Wilson, D.N, Scocchi, M. | Deposit date: | 2020-08-11 | Release date: | 2020-08-26 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (3.05 Å) | Cite: | Peptide Inhibitors of Bacterial Protein Synthesis with Broad Spectrum and SbmA-Independent Bactericidal Activity against Clinical Pathogens. J.Med.Chem., 63, 2020
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8C93
| Cryo-EM captures early ribosome assembly in action | Descriptor: | 23S rRNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ... | Authors: | Lauer, S, Nikolay, R, Qin, B. | Deposit date: | 2023-01-21 | Release date: | 2023-04-05 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (4.17 Å) | Cite: | Cryo-EM captures early ribosome assembly in action. Nat Commun, 14, 2023
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8C96
| Cryo-EM captures early ribosome assembly in action | Descriptor: | 23S rRNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ... | Authors: | Lauer, S, Nikolay, R, Qin, B. | Deposit date: | 2023-01-21 | Release date: | 2023-04-05 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (4.43 Å) | Cite: | Cryo-EM captures early ribosome assembly in action. Nat Commun, 14, 2023
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8C99
| Cryo-EM captures early ribosome assembly in action | Descriptor: | 23S rRNA, 50S ribosomal protein L13, 50S ribosomal protein L15, ... | Authors: | Nikolay, R, Qin, B, Lauer, S. | Deposit date: | 2023-01-21 | Release date: | 2023-04-05 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.29 Å) | Cite: | Cryo-EM captures early ribosome assembly in action. Nat Commun, 14, 2023
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8C9B
| Cryo-EM captures early ribosome assembly in action | Descriptor: | 23S rRNA, 50S ribosomal protein L22, 50S ribosomal protein L24, ... | Authors: | Nikolay, R, Qin, B, Lauer, S. | Deposit date: | 2023-01-21 | Release date: | 2023-04-05 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (5.9 Å) | Cite: | Cryo-EM captures early ribosome assembly in action. Nat Commun, 14, 2023
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8C8Z
| Cryo-EM captures early ribosome assembly in action | Descriptor: | 23S rRNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ... | Authors: | Lauer, S, Nikolay, R, Qin, B. | Deposit date: | 2023-01-21 | Release date: | 2023-04-05 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.12 Å) | Cite: | Cryo-EM captures early ribosome assembly in action. Nat Commun, 14, 2023
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8C92
| Cryo-EM captures early ribosome assembly in action | Descriptor: | 23S rRNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ... | Authors: | Lauer, S, Nikolay, R, Qin, B. | Deposit date: | 2023-01-21 | Release date: | 2023-04-05 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.79 Å) | Cite: | Cryo-EM captures early ribosome assembly in action. Nat Commun, 14, 2023
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8C98
| Cryo-EM captures early ribosome assembly in action | Descriptor: | 23S rRNA, 50S ribosomal protein L13, 50S ribosomal protein L15, ... | Authors: | Lauer, S, Nikolay, R, Qin, B. | Deposit date: | 2023-01-21 | Release date: | 2023-04-05 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.66 Å) | Cite: | Cryo-EM captures early ribosome assembly in action. Nat Commun, 14, 2023
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8C94
| Cryo-EM captures early ribosome assembly in action | Descriptor: | 23S rRNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ... | Authors: | Lauer, S, Nikolay, R, Qin, B. | Deposit date: | 2023-01-21 | Release date: | 2023-04-05 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Cryo-EM captures early ribosome assembly in action. Nat Commun, 14, 2023
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8C9A
| Cryo-EM captures early ribosome assembly in action | Descriptor: | 23S rRNA, 50S ribosomal protein L22, 50S ribosomal protein L23, ... | Authors: | Lauer, S, Nikolay, R, Qin, B. | Deposit date: | 2023-01-21 | Release date: | 2023-04-05 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (4.86 Å) | Cite: | Cryo-EM captures early ribosome assembly in action. Nat Commun, 14, 2023
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8C97
| Cryo-EM captures early ribosome assembly in action | Descriptor: | 23S rRNA, 50S ribosomal protein L14, 50S ribosomal protein L17, ... | Authors: | Lauer, S, Nikolay, R, Qin, B. | Deposit date: | 2023-01-21 | Release date: | 2023-04-05 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (4.07 Å) | Cite: | Cryo-EM captures early ribosome assembly in action. Nat Commun, 14, 2023
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1TH8
| Crystal Structures of the ADP and ATP bound forms of the Bacillus Anti-sigma factor SpoIIAB in complex with the Anti-anti-sigma SpoIIAA: inhibitory complex with ADP, crystal form II | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Anti-sigma F factor, Anti-sigma F factor antagonist, ... | Authors: | Masuda, S, Murakami, K.S, Wang, S, Olson, C.A, Donigian, J, Leon, F, Darst, S.A, Campbell, E.A. | Deposit date: | 2004-06-01 | Release date: | 2004-06-15 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal Structures of the ADP and ATP Bound Forms of the Bacillus Anti-sigma Factor SpoIIAB in Complex with the Anti-anti-sigma SpoIIAA. J.Mol.Biol., 340, 2004
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8C90
| Cryo-EM captures early ribosome assembly in action | Descriptor: | 23S rRNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ... | Authors: | Lauer, S, Nikolay, R, Qin, B. | Deposit date: | 2023-01-21 | Release date: | 2023-04-05 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.15 Å) | Cite: | Cryo-EM captures early ribosome assembly in action. Nat Commun, 14, 2023
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8C95
| Cryo-EM captures early ribosome assembly in action | Descriptor: | 23S rRNA, 50S ribosomal protein L13, 50S ribosomal protein L15, ... | Authors: | Lauer, S, Nikolay, R, Qin, B. | Deposit date: | 2023-01-21 | Release date: | 2023-04-05 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (4.92 Å) | Cite: | Cryo-EM captures early ribosome assembly in action. Nat Commun, 14, 2023
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8CVL
| Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-NH-tRNAphe, peptidyl P-site fMTHSMRC-NH-tRNAmet, and deacylated E-site tRNAphe at 2.30A resolution | Descriptor: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Syroegin, E.A, Aleksandrova, E.V, Polikanov, Y.S. | Deposit date: | 2022-05-18 | Release date: | 2022-10-19 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Insights into the ribosome function from the structures of non-arrested ribosome-nascent chain complexes. Nat.Chem., 15, 2023
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8EKB
| Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, deacylated P-site tRNAmet, and thermorubin at 2.70A resolution | Descriptor: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Paranjpe, M.N, Polikanov, Y.S. | Deposit date: | 2022-09-20 | Release date: | 2022-12-21 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Insights into the molecular mechanism of translation inhibition by the ribosome-targeting antibiotic thermorubin. Nucleic Acids Res., 51, 2023
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6GBM
| Solution structure of FUS-RRM bound to stem-loop RNA | Descriptor: | RNA (5'-R(*GP*GP*CP*AP*GP*AP*UP*UP*AP*CP*AP*AP*UP*UP*CP*UP*AP*UP*UP*UP*GP*CP*C)-3'), RNA-binding protein FUS | Authors: | Loughlin, F.E, Allain, F.H.-T. | Deposit date: | 2018-04-15 | Release date: | 2019-02-20 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | The Solution Structure of FUS Bound to RNA Reveals a Bipartite Mode of RNA Recognition with Both Sequence and Shape Specificity. Mol. Cell, 73, 2019
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4ALW
| Benzofuropyrimidinone Inhibitors of Pim-1 | Descriptor: | 8-BROMANYL-2-[(4-METHYLPIPERAZIN-1-YL)METHYL]-3H-[1]BENZOFURO[3,2-D]PYRIMIDIN-4-ONE, IMIDAZOLE, PIM-1 KINASE | Authors: | Stout, T.J, Adams, L. | Deposit date: | 2012-03-05 | Release date: | 2013-01-16 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | The Design, Synthesis, and Biological Evaluation of Pim Kinase Inhibitors. Bioorg.Med.Chem.Lett., 22, 2012
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4ALU
| Benzofuropyrimidinone Inhibitors of Pim-1 | Descriptor: | 8-bromo-2-(2-chlorophenyl)[1]benzofuro[3,2-d]pyrimidin-4(3H)-one, IMIDAZOLE, SERINE/THREONINE-PROTEIN KINASE PIM-1 | Authors: | Stout, T.J, Adams, L. | Deposit date: | 2012-03-05 | Release date: | 2013-01-16 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | The Design, Synthesis, and Biological Evaluation of Pim Kinase Inhibitors. Bioorg.Med.Chem.Lett., 22, 2012
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