6I02
| Structure of human D-glucuronyl C5 epimerase in complex with product | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Debarnot, C, Monneau, Y.R, Roig-Zamboni, V, Le Narvor, C, Goulet, A, Fadel, F, Vives, R.R, Bonnaffe, D, Lortat-Jacob, H, Bourne, Y. | Deposit date: | 2018-10-24 | Release date: | 2019-04-03 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Substrate binding mode and catalytic mechanism of human heparan sulfate d-glucuronyl C5 epimerase. Proc.Natl.Acad.Sci.USA, 116, 2019
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6DYH
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6DYS
| C-terminal condensation domain of Ebony in complex with beta-alanyl-dopamine | Descriptor: | CALCIUM ION, Ebony, N-[2-(3,4-dihydroxyphenyl)ethyl]-beta-alaninamide | Authors: | Izore, T, Tailhades, J, Hansen, M.H, Kaczmarski, J.A, Jackson, C.J, Cryle, M.J. | Deposit date: | 2018-07-02 | Release date: | 2019-01-30 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Drosophila melanogasternonribosomal peptide synthetase Ebony encodes an atypical condensation domain. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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6HNJ
| The ligand-bound, open structure of CD0873, a substrate binding protein with adhesive properties from Clostridium difficile. | Descriptor: | 1,2-ETHANEDIOL, ABC-type transport system, sugar-family extracellular solute-binding protein, ... | Authors: | Bradshaw, W.J, Kovacs-Simon, A, Harmer, N.J, Michell, S.L, Acharya, K.R. | Deposit date: | 2018-09-15 | Release date: | 2019-08-28 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Molecular features of lipoprotein CD0873: A potential vaccine against the human pathogenClostridioides difficile. J.Biol.Chem., 294, 2019
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6DZ3
| Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with (3R,4S)-1-((4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)-4-(((3-(1-butyl-1H-1,2,3-triazol-4-yl)propyl)thio)methyl)pyrrolidin-3-ol | Descriptor: | (3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-({[3-(1-butyl-1H-1,2,3-triazol-4-yl)propyl]sulfanyl}methyl)pyrrolidin-3-ol, 1,2-ETHANEDIOL, ACETIC ACID, ... | Authors: | Harijan, R.K, Ducati, R.G, Bonanno, J.B, Almo, S.C, Schramm, V.L. | Deposit date: | 2018-07-02 | Release date: | 2019-03-20 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Selective Inhibitors of Helicobacter pylori Methylthioadenosine Nucleosidase and Human Methylthioadenosine Phosphorylase. J. Med. Chem., 62, 2019
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6DYN
| C-terminal condensation domain of Ebony in complex with Histamine | Descriptor: | CALCIUM ION, Ebony, HISTAMINE | Authors: | Izore, T, Tailhades, J, Hansen, M.H, Kaczmarski, J.A, Jackson, C.J, Cryle, M.J. | Deposit date: | 2018-07-02 | Release date: | 2019-01-30 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.102 Å) | Cite: | Drosophila melanogasternonribosomal peptide synthetase Ebony encodes an atypical condensation domain. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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6HNN
| Crystal structure of wild-type IdmH, a putative polyketide cyclase from Streptomyces antibioticus | Descriptor: | Putative polyketide cyclase IdmH | Authors: | Drulyte, I, Obajdin, J, Trinh, C, Hemsworth, G.R, Berry, A. | Deposit date: | 2018-09-16 | Release date: | 2019-11-06 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structure of the putative cyclase IdmH from the indanomycin nonribosomal peptide synthase/polyketide synthase. Iucrj, 6, 2019
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6H81
| MamM CTD E289H - Nickel form | Descriptor: | BETA-MERCAPTOETHANOL, Magnetosome protein MamM, Cation efflux protein family, ... | Authors: | Barber-Zucker, S, Zarivach, R. | Deposit date: | 2018-08-01 | Release date: | 2019-08-14 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | MMamM CTD E289H - Nickel form To Be Published
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6DZ0
| Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with (3R,4S)-1-((4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)-4-((pent-4-yn-1-ylthio)methyl)pyrrolidin-3-ol | Descriptor: | (3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-{[(pent-4-yn-1-yl)sulfanyl]methyl}pyrrolidin-3-ol, 1,2-ETHANEDIOL, CHLORIDE ION, ... | Authors: | Harijan, R.K, Ducati, R.G, Bonanno, J.B, Almo, S.C, Schramm, V.L. | Deposit date: | 2018-07-02 | Release date: | 2019-03-20 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.62 Å) | Cite: | Selective Inhibitors of Helicobacter pylori Methylthioadenosine Nucleosidase and Human Methylthioadenosine Phosphorylase. J. Med. Chem., 62, 2019
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6DYK
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6H84
| MamM CTD D249H - Cadmium form | Descriptor: | BETA-MERCAPTOETHANOL, CADMIUM ION, Magnetosome protein MamM, ... | Authors: | Barber-Zucker, S, Zarivach, R. | Deposit date: | 2018-08-01 | Release date: | 2019-08-14 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.04 Å) | Cite: | MamM CTD D249H - Cadmium form To Be Published
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6DZ8
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6H8Q
| Structural basis for Scc3-dependent cohesin recruitment to chromatin | Descriptor: | Cohesin subunit SCC3, DNA (5'-D(P*CP*TP*TP*TP*CP*GP*TP*TP*TP*CP*CP*TP*TP*GP*AP*AP*AP*AP*A)-3'), DNA (5'-D(P*TP*TP*TP*TP*TP*CP*AP*AP*GP*GP*AP*AP*AP*CP*GP*AP*AP*AP*G)-3'), ... | Authors: | Li, Y, Muir, K, Panne, D. | Deposit date: | 2018-08-03 | Release date: | 2018-08-29 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.631 Å) | Cite: | Structural basis for Scc3-dependent cohesin recruitment to chromatin. Elife, 7, 2018
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6H9U
| Crystal structure of the BiP NBD and MANF SAP complex | Descriptor: | D-MALATE, Endoplasmic reticulum chaperone BiP, Mesencephalic astrocyte-derived neurotrophic factor, ... | Authors: | Yan, Y, Ron, D. | Deposit date: | 2018-08-06 | Release date: | 2019-02-06 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.57 Å) | Cite: | MANF antagonizes nucleotide exchange by the endoplasmic reticulum chaperone BiP. Nat Commun, 10, 2019
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6E0D
| X-ray structure of a complex of thaumatin with xylene cyanol | Descriptor: | (1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside, L(+)-TARTARIC ACID, Thaumatin I | Authors: | McPherson, A. | Deposit date: | 2018-07-06 | Release date: | 2018-09-19 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.24 Å) | Cite: | Investigation into the binding of dyes within protein crystals. Acta Crystallogr F Struct Biol Commun, 74, 2018
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6HPF
| Structure of Inactive E165Q mutant of fungal non-CBM carrying GH26 endo-b-mannanase from Yunnania penicillata in complex with alpha-62-61-di-galactosyl-mannotriose | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETIC ACID, CHLORIDE ION, ... | Authors: | von Freiesleben, P, Moroz, O.V, Blagova, E, Wiemann, M, Spodsberg, N, Agger, J.W, Davies, G.J, Wilson, K.S, Stalbrand, H, Meyer, A.S, Krogh, K.B.R.M. | Deposit date: | 2018-09-20 | Release date: | 2019-03-06 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.36 Å) | Cite: | Crystal structure and substrate interactions of an unusual fungal non-CBM carrying GH26 endo-beta-mannanase from Yunnania penicillata. Sci Rep, 9, 2019
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6HA2
| MamM CTD D249H-H285D | Descriptor: | BETA-MERCAPTOETHANOL, Magnetosome protein MamM, Cation efflux protein family | Authors: | Barber-Zucker, S, Zarivach, R. | Deposit date: | 2018-08-07 | Release date: | 2019-08-21 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | MamM CTD D249H-H285D To Be Published
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6HPP
| X-ray structure of GLIC in complex with propionate | Descriptor: | CHLORIDE ION, DODECYL-BETA-D-MALTOSIDE, PROPANOIC ACID, ... | Authors: | Fourati, Z, Delarue, M. | Deposit date: | 2018-09-21 | Release date: | 2019-10-09 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural evidence for the binding of monocarboxylates and dicarboxylates at pharmacologically relevant extracellular sites of a pentameric ligand-gated ion channel. Acta Crystallogr D Struct Biol, 76, 2020
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6E08
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6HAA
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6HAH
| Crystal structure of PAF - p-sulfonatocalix[6]arene complex | Descriptor: | 2-[2-(2-ethoxyethoxy)ethoxy]ethanol, GLYCEROL, Pc24g00380 protein, ... | Authors: | Alex, J.M, Rennie, M, Engilberge, S, Batta, G, Crowley, P.B. | Deposit date: | 2018-08-07 | Release date: | 2019-02-13 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Calixarene-mediated assembly of a small antifungal protein. Iucrj, 6, 2019
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6HQG
| Cytochrome P450-153 from Phenylobacterium zucineum | Descriptor: | Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Fiorentini, F, Mattevi, A. | Deposit date: | 2018-09-25 | Release date: | 2018-12-12 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | The Extreme Structural Plasticity in the CYP153 Subfamily of P450s Directs Development of Designer Hydroxylases. Biochemistry, 57, 2018
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6HAK
| Crystal structure of HIV-1 reverse transcriptase (RT) in complex with a double stranded RNA represents the RT transcription initiation complex prior to nucleotide incorporation | Descriptor: | Gag-Pol polyprotein, MAGNESIUM ION, RNA (5'-R(P*AP*GP*UP*GP*GP*CP*GP*GP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*C)-3'), ... | Authors: | Das, K, Martinez, S.E, Arnold, E. | Deposit date: | 2018-08-07 | Release date: | 2019-04-03 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.95 Å) | Cite: | Structure of HIV-1 RT/dsRNA initiation complex prior to nucleotide incorporation. Proc.Natl.Acad.Sci.USA, 116, 2019
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6DZ6
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6HQU
| Humanised RadA mutant HumRadA22 in complex with a recombined BRC repeat 8-2 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Breast cancer type 2 susceptibility, DNA repair and recombination protein RadA, ... | Authors: | Pantelejevs, T, Lindenburg, L, Hyvonen, M, Hollfelder, F. | Deposit date: | 2018-09-25 | Release date: | 2019-10-09 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | Improved RAD51 binders through motif shuffling based on the modularity of BRC repeats. Proc.Natl.Acad.Sci.USA, 118, 2021
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