6R72
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![BU of 6r72 by Molmil](/molmil-images/mine/6r72) | Crystal structure of BmrA-E504A in an outward-facing conformation | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Multidrug exporter ATP-binding cassette | Authors: | Chaptal, V, Zampieri, V, Kilburg, A, Magnard, S, Falson, P. | Deposit date: | 2019-03-28 | Release date: | 2020-05-06 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.95 Å) | Cite: | Substrate-bound and substrate-free outward-facing structures of a multidrug ABC exporter. Sci Adv, 8, 2022
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1OY8
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![BU of 1oy8 by Molmil](/molmil-images/mine/1oy8) | Structural Basis of Multiple Drug Binding Capacity of the AcrB Multidrug Efflux Pump | Descriptor: | Acriflavine resistance protein B, RHODAMINE 6G | Authors: | Yu, E.W, McDermott, G, Zgurskaya, H.I, Nikaido, H, Koshland Jr, D.E. | Deposit date: | 2003-04-03 | Release date: | 2003-05-13 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3.63 Å) | Cite: | Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump. Science, 300, 2003
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1OY6
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![BU of 1oy6 by Molmil](/molmil-images/mine/1oy6) | Structural Basis of the Multiple Binding Capacity of the AcrB Multidrug Efflux Pump | Descriptor: | Acriflavine resistance protein B | Authors: | Yu, E.W, McDermott, G, Zgurskaya, H.I, Nikaido, H, Koshland Jr, D.E. | Deposit date: | 2003-04-03 | Release date: | 2003-05-13 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3.68 Å) | Cite: | Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump. Science, 300, 2003
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6BZS
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![BU of 6bzs by Molmil](/molmil-images/mine/6bzs) | Human ABCC6 NBD1 in Apo state | Descriptor: | Multidrug resistance-associated protein 6, SULFATE ION | Authors: | Zheng, A, Thibodeau, P.H. | Deposit date: | 2017-12-26 | Release date: | 2018-09-05 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.29990458 Å) | Cite: | Structural analysis reveals pathomechanisms associated with pseudoxanthoma elasticum-causing mutations in the ABCC6 transporter. J. Biol. Chem., 293, 2018
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4ZLL
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![BU of 4zll by Molmil](/molmil-images/mine/4zll) | |
4ZLJ
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![BU of 4zlj by Molmil](/molmil-images/mine/4zlj) | |
4ZLN
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![BU of 4zln by Molmil](/molmil-images/mine/4zln) | |
8HW4
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![BU of 8hw4 by Molmil](/molmil-images/mine/8hw4) | Cryo-EM structure of dehydroepiandrosterone sulfate-bound human ABC transporter ABCC3 in nanodiscs | Descriptor: | 17-oxoandrost-5-en-3beta-yl hydrogen sulfate, ATP-binding cassette sub-family C member 3 | Authors: | Wang, J, Wang, F.F, Chen, Y.X, Zhou, C.Z. | Deposit date: | 2022-12-28 | Release date: | 2023-06-07 | Last modified: | 2023-10-11 | Method: | ELECTRON MICROSCOPY (3.52 Å) | Cite: | Placing steroid hormones within the human ABCC3 transporter reveals a compatible amphiphilic substrate-binding pocket. Embo J., 42, 2023
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8HVH
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![BU of 8hvh by Molmil](/molmil-images/mine/8hvh) | Cryo-EM structure of ABC transporter ABCC3 | Descriptor: | ATP-binding cassette sub-family C member 3 | Authors: | Wang, J, Wang, F.F, Chen, Y.X, Zhou, C.Z. | Deposit date: | 2022-12-26 | Release date: | 2023-06-07 | Last modified: | 2023-10-11 | Method: | ELECTRON MICROSCOPY (3.07 Å) | Cite: | Placing steroid hormones within the human ABCC3 transporter reveals a compatible amphiphilic substrate-binding pocket. Embo J., 42, 2023
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8HW2
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![BU of 8hw2 by Molmil](/molmil-images/mine/8hw2) | Cryo-EM structure of beta-estradiol 17-(beta-D-glucuronide)-bound human ABC transporter ABCC3 in nanodiscs | Descriptor: | ATP-binding cassette sub-family C member 3, Estradiol-17beta-glucuronide | Authors: | Wang, J, Wang, F.F, Chen, Y.X, Zhou, C.Z. | Deposit date: | 2022-12-28 | Release date: | 2023-06-07 | Last modified: | 2023-10-11 | Method: | ELECTRON MICROSCOPY (3.65 Å) | Cite: | Placing steroid hormones within the human ABCC3 transporter reveals a compatible amphiphilic substrate-binding pocket. Embo J., 42, 2023
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7M33
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5NIK
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![BU of 5nik by Molmil](/molmil-images/mine/5nik) | Structure of the MacAB-TolC ABC-type tripartite multidrug efflux pump | Descriptor: | Macrolide export ATP-binding/permease protein MacB, Macrolide export protein MacA, Outer membrane protein TolC | Authors: | Fitzpatrick, A.W.P, Llabres, S, Neuberger, A, Blaza, J.N, Bai, X.-C, Okada, U, Murakami, S, van Veen, H.W, Zachariae, U, Scheres, S.H.W, Luisi, B.F, Du, D. | Deposit date: | 2017-03-24 | Release date: | 2017-05-24 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structure of the MacAB-TolC ABC-type tripartite multidrug efflux pump. Nat Microbiol, 2, 2017
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5NIL
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![BU of 5nil by Molmil](/molmil-images/mine/5nil) | Structure of the MacAB-TolC ABC-type tripartite multidrug efflux pump-MacB section | Descriptor: | Macrolide export ATP-binding/permease protein MacB, Macrolide export protein MacA, Outer membrane protein TolC | Authors: | Fitzpatrick, A.W.P, Llabres, S, Neuberger, A, Blaza, J.N, Bai, X.-C, Okada, U, Murakami, S, van Veen, H.W, Zachariae, U, Scheres, S.H.W, Luisi, B.F, Du, D. | Deposit date: | 2017-03-24 | Release date: | 2017-05-24 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (5.3 Å) | Cite: | Structure of the MacAB-TolC ABC-type tripartite multidrug efflux pump. Nat Microbiol, 2, 2017
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8F4B
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6SGR
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![BU of 6sgr by Molmil](/molmil-images/mine/6sgr) | Cryo-EM structure of Escherichia coli AcrBZ and DARPin in Saposin A-nanodisc with cardiolipin | Descriptor: | DARPin, Multidrug efflux pump accessory protein AcrZ, Multidrug efflux pump subunit AcrB | Authors: | Szewczak-Harris, A, Du, D, Newman, C, Neuberger, A, Luisi, B.F. | Deposit date: | 2019-08-05 | Release date: | 2020-05-13 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.17 Å) | Cite: | Interactions of a Bacterial RND Transporter with a Transmembrane Small Protein in a Lipid Environment. Structure, 28, 2020
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6SGS
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![BU of 6sgs by Molmil](/molmil-images/mine/6sgs) | Cryo-EM structure of Escherichia coli AcrBZ and DARPin in Saposin A-nanodisc | Descriptor: | DARPin, Multidrug efflux pump accessory protein AcrZ, Multidrug efflux pump subunit AcrB | Authors: | Szewczak-Harris, A, Du, D, Newman, C, Neuberger, A, Luisi, B.F. | Deposit date: | 2019-08-05 | Release date: | 2020-05-13 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Interactions of a Bacterial RND Transporter with a Transmembrane Small Protein in a Lipid Environment. Structure, 28, 2020
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1IWG
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![BU of 1iwg by Molmil](/molmil-images/mine/1iwg) | |
8SX9
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![BU of 8sx9 by Molmil](/molmil-images/mine/8sx9) | |
8SXA
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5XJJ
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![BU of 5xjj by Molmil](/molmil-images/mine/5xjj) | Crystal structure of a MATE family protein | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, multi drug efflux transporter | Authors: | Tanaka, Y, Tsukazaki, T, Iwaki, S. | Deposit date: | 2017-05-02 | Release date: | 2017-09-20 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Crystal Structure of a Plant Multidrug and Toxic Compound Extrusion Family Protein Structure, 25, 2017
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7OUK
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![BU of 7ouk by Molmil](/molmil-images/mine/7ouk) | BDM88855 inhibitor bound to the transmembrane domain of AcrB | Descriptor: | (2S)-3-hydroxypropane-1,2-diyl didecanoate, (2S)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-hydroxypropyl hexadecanoate, 1,2-ETHANEDIOL, ... | Authors: | Tam, H.K, Foong, W.E, Pos, K.M. | Deposit date: | 2021-06-12 | Release date: | 2021-12-29 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Pyridylpiperazine-based allosteric inhibitors of RND-type multidrug efflux pumps. Nat Commun, 13, 2022
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7OUL
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![BU of 7oul by Molmil](/molmil-images/mine/7oul) | BDM88832 inhibitor bound to the transmembrane domain of AcrB-R971A | Descriptor: | (2S)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-hydroxypropyl hexadecanoate, 1,2-ETHANEDIOL, 1-(3-chloranyl-5-iodanyl-pyridin-2-yl)piperazine, ... | Authors: | Tam, H.K, Foong, W.E, Pos, K.M. | Deposit date: | 2021-06-12 | Release date: | 2021-12-29 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Pyridylpiperazine-based allosteric inhibitors of RND-type multidrug efflux pumps. Nat Commun, 13, 2022
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7OUM
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![BU of 7oum by Molmil](/molmil-images/mine/7oum) | BDM88855 inhibitor bound to the transmembrane domain of AcrB-R971A | Descriptor: | (2S)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-hydroxypropyl hexadecanoate, 1,2-ETHANEDIOL, 3-chloranyl-2-piperazin-1-yl-quinoline, ... | Authors: | Tam, H.K, Foong, W.E, Pos, K.M. | Deposit date: | 2021-06-12 | Release date: | 2021-12-29 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Pyridylpiperazine-based allosteric inhibitors of RND-type multidrug efflux pumps. Nat Commun, 13, 2022
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7DQK
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![BU of 7dqk by Molmil](/molmil-images/mine/7dqk) | A nicotine MATE transporter, Nicotiana tabacum MATE2 (NtMATE2) | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Tanaka, Y, Tsukazaki, T, Sasaki, A, Iwaki, S. | Deposit date: | 2020-12-24 | Release date: | 2021-06-09 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Crystal structures of a nicotine MATE transporter provide insight into its mechanism of substrate transport. Febs Lett., 595, 2021
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6SGU
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![BU of 6sgu by Molmil](/molmil-images/mine/6sgu) | Cryo-EM structure of Escherichia coli AcrB and DARPin in Saposin A-nanodisc | Descriptor: | DARPin, Multidrug efflux pump subunit AcrB | Authors: | Szewczak-Harris, A, Du, D, Newman, C, Neuberger, A, Luisi, B.F. | Deposit date: | 2019-08-05 | Release date: | 2020-05-13 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.27 Å) | Cite: | Interactions of a Bacterial RND Transporter with a Transmembrane Small Protein in a Lipid Environment. Structure, 28, 2020
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