PDB: 13252 resultsInfo pagesStatus searchChemie searchBIRD

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6UEN	Cryo-EM structure of the respiratory syncytial virus RNA polymerase Descriptor: RNA-directed RNA polymerase L, the phosphoprotein (P) of human respiratory syncytial virus Authors: Cao, D, Gao, Y, Liang, B. Deposit date: 2019-09-22 Release date: 2020-01-22 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (3.67 Å) Cite: Cryo-EM structure of the respiratory syncytial virus RNA polymerase. Nat Commun, 11, 2020
4XSZ	Crystal structure of CBR 9393 bound to Escherichia coli RNA polymerase holoenzyme Descriptor: 4-[3-(4-fluorophenyl)-1H-pyrazol-4-yl]-N-[2-(piperazin-1-yl)ethyl]-2-(trifluoromethyl)aniline, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Bae, B, Darst, S.A. Deposit date: 2015-01-22 Release date: 2015-07-22 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (3.683 Å) Cite: CBR antimicrobials inhibit RNA polymerase via at least two bridge-helix cap-mediated effects on nucleotide addition. Proc.Natl.Acad.Sci.USA, 112, 2015
4XSY	Crystal structure of CBR 9379 bound to Escherichia coli RNA polymerase holoenzyme Descriptor: 3-{[(2,6-dichlorophenyl)carbamoyl]amino}-N-hydroxy-N'-phenyl-5-(trifluoromethyl)benzenecarboximidamide, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Bae, B, Darst, S.A. Deposit date: 2015-01-22 Release date: 2015-07-22 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (4.007 Å) Cite: CBR antimicrobials inhibit RNA polymerase via at least two bridge-helix cap-mediated effects on nucleotide addition. Proc.Natl.Acad.Sci.USA, 112, 2015
4XSX	Crystal structure of CBR 703 bound to Escherichia coli RNA polymerase holoenzyme Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Bae, B, Darst, S.A. Deposit date: 2015-01-22 Release date: 2015-07-22 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (3.708 Å) Cite: CBR antimicrobials inhibit RNA polymerase via at least two bridge-helix cap-mediated effects on nucleotide addition. Proc.Natl.Acad.Sci.USA, 112, 2015
3H0G	RNA Polymerase II from Schizosaccharomyces pombe Descriptor: DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, DNA-directed RNA polymerase II subunit RPB3, ... Authors: Spahr, H, Calero, G, Bushnell, D.A, Kornberg, R.D. Deposit date: 2009-04-09 Release date: 2009-08-25 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (3.65 Å) Cite: Schizosacharomyces pombe RNA polymerase II at 3.6-A resolution. Proc.Natl.Acad.Sci.USA, 106, 2009
7NVU	RNA polymerase II core pre-initiation complex with open promoter DNA Descriptor: DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerase II subunit RPB3, ... Authors: Aibara, S, Schilbach, S, Cramer, P. Deposit date: 2021-03-16 Release date: 2021-05-05 Last modified: 2024-07-10 Method: ELECTRON MICROSCOPY (2.5 Å) Cite: Structures of mammalian RNA polymerase II pre-initiation complexes. Nature, 594, 2021
7NVT	RNA polymerase II core pre-initiation complex with closed promoter DNA in distal position Descriptor: DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerase II subunit RPB3, ... Authors: Aibara, S, Schilbach, S, Cramer, P. Deposit date: 2021-03-16 Release date: 2021-05-05 Last modified: 2024-07-10 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Structures of mammalian RNA polymerase II pre-initiation complexes. Nature, 594, 2021
7NVS	RNA polymerase II core pre-initiation complex with closed promoter DNA in proximal position Descriptor: DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerase II subunit RPB3, ... Authors: Aibara, S, Schilbach, S, Cramer, P. Deposit date: 2021-03-16 Release date: 2021-05-05 Last modified: 2024-07-10 Method: ELECTRON MICROSCOPY (2.8 Å) Cite: Structures of mammalian RNA polymerase II pre-initiation complexes. Nature, 594, 2021
8S5N	RNA polymerase II core initially transcribing complex with an ordered RNA of 12 nt Descriptor: DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB11-a, DNA-directed RNA polymerase II subunit RPB3, ... Authors: Zhan, Y, Grabbe, F, Oberbeckmann, E, Dienemann, C, Cramer, P. Deposit date: 2024-02-24 Release date: 2024-04-10 Last modified: 2024-05-15 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Three-step mechanism of promoter escape by RNA polymerase II. Mol.Cell, 84, 2024
8S51	RNA polymerase II core initially transcribing complex with an ordered RNA of 8 nt Descriptor: DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB11-a, DNA-directed RNA polymerase II subunit RPB3, ... Authors: Zhan, Y, Grabbe, F, Oberbeckmann, E, Dienemann, C, Cramer, P. Deposit date: 2024-02-22 Release date: 2024-04-17 Last modified: 2024-05-15 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Three-step mechanism of promoter escape by RNA polymerase II. Mol.Cell, 84, 2024
8S52	RNA polymerase II core initially transcribing complex with an ordered RNA of 10 nt Descriptor: DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB11-a, DNA-directed RNA polymerase II subunit RPB3, ... Authors: Zhan, Y, Grabbe, F, Oberbeckmann, E, Dienemann, C, Cramer, P. Deposit date: 2024-02-22 Release date: 2024-04-17 Last modified: 2024-05-15 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Three-step mechanism of promoter escape by RNA polymerase II. Mol.Cell, 84, 2024
7ROZ	Structure of RNA-dependent RNA polymerase 2 (RDR2) from Arabidopsis thaliana Descriptor: MAGNESIUM ION, RNA-dependent RNA polymerase 2 Authors: Fukudome, A, Pikaard, C.S, Takagi, Y. Deposit date: 2021-08-02 Release date: 2021-12-08 Last modified: 2024-06-05 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Structure and RNA template requirements of Arabidopsis RNA-DEPENDENT RNA POLYMERASE 2. Proc.Natl.Acad.Sci.USA, 118, 2021
7RQS	Arabidopsis RNA-dependent RNA polymerase 2 Descriptor: MAGNESIUM ION, RNA-dependent RNA polymerase 2 Authors: Fukudome, A, Pikaard, C.S, Takagi, Y. Deposit date: 2021-08-07 Release date: 2021-12-08 Last modified: 2024-06-05 Method: ELECTRON MICROSCOPY (3.57 Å) Cite: Structure and RNA template requirements of Arabidopsis RNA-DEPENDENT RNA POLYMERASE 2. Proc.Natl.Acad.Sci.USA, 118, 2021
4A3I	RNA Polymerase II binary complex with DNA Descriptor: 5'-D(*GP*GP*CP*AP*CP*AP*AP*CP*TP*GP*CP*GP*GP*CP*T)-3', DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1, DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11, ... Authors: Cheung, A.C.M, Sainsbury, S, Cramer, P. Deposit date: 2011-09-30 Release date: 2012-02-08 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (3.8 Å) Cite: Structural basis of initial RNA polymerase II transcription. EMBO J., 30, 2011
8S54	RNA polymerase II early elongation complex bound to TFIIE and TFIIF - state b (composite structure) Descriptor: DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB11-a, DNA-directed RNA polymerase II subunit RPB3, ... Authors: Zhan, Y, Grabber, F, Oberbeckmann, E, Dienemann, C, Cramer, P. Deposit date: 2024-02-22 Release date: 2024-04-17 Last modified: 2024-05-15 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Three-step mechanism of promoter escape by RNA polymerase II. Mol.Cell, 84, 2024
4A3E	RNA Polymerase II initial transcribing complex with a 5nt DNA-RNA hybrid and soaked with AMPCPP Descriptor: DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1, DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11, ... Authors: Cheung, A.C.M, Sainsbury, S, Cramer, P. Deposit date: 2011-09-30 Release date: 2011-12-07 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (3.4 Å) Cite: Structural basis of initial RNA polymerase II transcription. EMBO J., 30, 2011
4A3M	RNA Polymerase II initial transcribing complex with a 4nt DNA-RNA hybrid and soaked with AMPCPP Descriptor: 5'-D(*AP*AP*GP*TP*AP*CP*TP)-3', 5'-D(*AP*GP*CP*TP*CP*AP*AP*GP*TP*AP*CP*TP*TP*TP* TP*TP*CP*CP*BRUP*GP*GP*TP*CP*AP*TP*T)-3', 5'-R(*AP*GP*GP*A)-3', ... Authors: Cheung, A.C.M, Sainsbury, S, Cramer, P. Deposit date: 2011-09-30 Release date: 2011-12-07 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (3.9 Å) Cite: Structural basis of initial RNA polymerase II transcription. EMBO J., 30, 2011
4A3F	RNA Polymerase II initial transcribing complex with a 6nt DNA-RNA hybrid and soaked with AMPCPP Descriptor: 5'-D(*AP*GP*CP*TP*CP*AP*AP*GP*TP*AP*CP*TP*TP*DTP *TP*TP*CP*C BRU*GP*GP*TP*CP*AP*TP*T)-3', DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1, ... Authors: Cheung, A.C.M, Sainsbury, S, Cramer, P. Deposit date: 2011-09-30 Release date: 2011-12-07 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (3.5 Å) Cite: Structural basis of initial RNA polymerase II transcription. EMBO J., 30, 2011
4A3J	RNA Polymerase II initial transcribing complex with a 2nt DNA-RNA hybrid and soaked with GMPCPP Descriptor: 5'-D(*AP*GP*CP*TP*AP*GP*CP*TP*TP*TP*CP*BRUP*AP*CP*CP *TP*GP*AP*AP*CP*AP*AP*CP*TP*AP*AP*CP)-3', 5'-D(*GP*TP*AP*GP*AP*AP*AP*GP*CP*TP*AP*GP*CP*TP)-3', 5'-R(*CP*AP)-3', ... Authors: Cheung, A.C.M, Sainsbury, S, Cramer, P. Deposit date: 2011-09-30 Release date: 2011-12-07 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (3.7 Å) Cite: Structural Basis of Initial RNA Polymerase II Transcription. Embo J., 30, 2011
4A3B	RNA Polymerase II initial transcribing complex with a 4nt DNA-RNA hybrid Descriptor: DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1, DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11, DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2, ... Authors: Cheung, A.C.M, Sainsbury, S, Cramer, P. Deposit date: 2011-09-30 Release date: 2011-12-07 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (3.5 Å) Cite: Structural basis of initial RNA polymerase II transcription. EMBO J., 30, 2011
8S55	RNA polymerase II early elongation complex bound to TFIIE and TFIIF - state a (composite structure) Descriptor: DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB11-a, DNA-directed RNA polymerase II subunit RPB3, ... Authors: Zhan, Y, Grabbe, F, Oberbeckmann, E, Dienemann, C, Cramer, P. Deposit date: 2024-02-22 Release date: 2024-04-17 Last modified: 2024-05-15 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Three-step mechanism of promoter escape by RNA polymerase II. Mol.Cell, 84, 2024
4A3K	RNA Polymerase II initial transcribing complex with a 7nt DNA-RNA hybrid Descriptor: 5'-D(*AP*GP*CP*TP*CP*AP*AP*GP*TP*AP*CP*TP*TP*DTP *TP*TP*CP*CP*BRU*GP*GP*TP*CP*AP*TP*T)-3', 5'-D(*TP*AP*AP*GP*TP*AP*CP*TP*TP*GP*AP)-3', 5'-R(*AP*CP*CP*AP*GP*GP*AP)-3', ... Authors: Cheung, A.C.M, Sainsbury, S, Cramer, P. Deposit date: 2011-09-30 Release date: 2011-12-07 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (3.5 Å) Cite: Structural Basis of Initial RNA Polymerase II Transcription. Embo J., 30, 2011
4A3L	RNA Polymerase II initial transcribing complex with a 7nt DNA-RNA hybrid and soaked with AMPCPP Descriptor: 5'-D(*AP*AP*GP*TP*AP*CP*TP)-3', 5'-D(*AP*GP*CP*TP*CP*AP*AP*GP*TP*AP*CP*TP*TP*TP *TP*TP*CP*CP*BRU*GP*GP*TP*CP*AP*TP*T)-3', 5'-R(*AP*CP*CP*AP*GP*GP*AP)-3', ... Authors: Cheung, A.C.M, Sainsbury, S, Cramer, P. Deposit date: 2011-09-30 Release date: 2011-12-07 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (3.5 Å) Cite: Structural basis of initial RNA polymerase II transcription. EMBO J., 30, 2011
4A3C	RNA Polymerase II initial transcribing complex with a 5nt DNA-RNA hybrid Descriptor: DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1, DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11, DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2, ... Authors: Cheung, A.C.M, Sainsbury, S, Cramer, P. Deposit date: 2011-09-30 Release date: 2011-11-16 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (3.5 Å) Cite: Structural basis of initial RNA polymerase II transcription. EMBO J., 30, 2011
4A3D	RNA Polymerase II initial transcribing complex with a 6nt DNA-RNA hybrid Descriptor: DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1, DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11, DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2, ... Authors: Cheung, A.C.M, Sainsbury, S, Cramer, P. Deposit date: 2011-09-30 Release date: 2011-12-07 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (3.4 Å) Cite: Structural basis of initial RNA polymerase II transcription. EMBO J., 30, 2011

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