4UM8
 
 | | Crystal structure of alpha V beta 6 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CACODYLATE ION, ... | | Authors: | Dong, X, Springer, T.A. | | Deposit date: | 2014-05-15 | | Release date: | 2014-11-12 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.852 Å) | | Cite: | Structural Determinants of Integrin Beta-Subunit Specificity for Latent Tgf-Beta
Nat.Struct.Mol.Biol., 21, 2014
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8TCG
 | | Integrin alpha-v beta-6 in complex with minibinder B6_BP_dslf | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Integrin alpha-V heavy chain, ... | | Authors: | Campbell, M.G, Fernandez, A, Roy, A, Kraft, J, Baker, D. | | Deposit date: | 2023-06-30 | | Release date: | 2023-09-27 | | Last modified: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | De novo design of highly selective miniprotein inhibitors of integrins alpha v beta 6 and alpha v beta 8.
Nat Commun, 14, 2023
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4UM9
 | | Crystal structure of alpha V beta 6 with peptide | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Dong, X, Springer, T.A. | | Deposit date: | 2014-05-15 | | Release date: | 2014-11-12 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural Determinants of Integrin Beta-Subunit Specificity for Latent Tgf-Beta
Nat.Struct.Mol.Biol., 21, 2014
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8FSO
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5FFO
 | | Integrin alpha V beta 6 in complex with pro-TGF-beta | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Dong, X, Zhao, B, Springer, T.A. | | Deposit date: | 2015-12-18 | | Release date: | 2017-01-25 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (3.49 Å) | | Cite: | Force interacts with macromolecular structure in activation of TGF-beta.
Nature, 542, 2017
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5FFG
 | | Crystal structure of integrin alpha V beta 6 head | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Dong, X, Springer, T.A. | | Deposit date: | 2015-12-18 | | Release date: | 2017-01-25 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Force interacts with macromolecular structure in activation of TGF-beta.
Nature, 542, 2017
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5NEU
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5NER
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5NET
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5NEM
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9CZF
 | | Crystal structure of integrin avb6 headpiece in complex with compound MORF-627 | | Descriptor: | (2S)-{5-fluoro-2-[(6S)-5-oxaspiro[2.5]octan-6-yl]phenyl}{(3R)-3-[4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)butoxy]pyrrolidin-1-yl}acetic acid, 17E6 Fab heavy chain, 17E6 Fab light chain, ... | | Authors: | Monroy, M.F, Qiao, Q, Lin, F.Y. | | Deposit date: | 2024-08-05 | | Release date: | 2024-11-13 | | Last modified: | 2024-11-27 | | Method: | X-RAY DIFFRACTION (2.53 Å) | | Cite: | The Discovery of MORF-627, a Highly Selective Conformationally-Biased Zwitterionic Integrin alpha v beta 6 Inhibitor for Fibrosis.
J.Med.Chem., 67, 2024
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9CZ7
 | | Crystal structure of integrin avb6 headpiece in complex with compound 12 | | Descriptor: | (2S)-phenyl{(3S)-3-[4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)butoxy]pyrrolidin-1-yl}acetic acid, 17E6 Fab heavy chain, 17E6 Fab light chain, ... | | Authors: | Monroy, M.F, Qiao, Q, Lin, F.Y. | | Deposit date: | 2024-08-04 | | Release date: | 2024-11-13 | | Last modified: | 2024-11-27 | | Method: | X-RAY DIFFRACTION (2.57 Å) | | Cite: | The Discovery of MORF-627, a Highly Selective Conformationally-Biased Zwitterionic Integrin alpha v beta 6 Inhibitor for Fibrosis.
J.Med.Chem., 67, 2024
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9CZD
 | | Crystal structure of integrin avb6 headpiece in complex with compound 30 | | Descriptor: | (2S)-{5-fluoro-2-[(2S)-oxan-2-yl]phenyl}{(3R)-3-[4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)butoxy]pyrrolidin-1-yl}acetic acid, 17E6 Fab heavy chain, 17E6 Fab light chain, ... | | Authors: | Monroy, M.F, Qiao, Q, Lin, F.Y. | | Deposit date: | 2024-08-05 | | Release date: | 2024-11-13 | | Last modified: | 2024-11-27 | | Method: | X-RAY DIFFRACTION (2.23 Å) | | Cite: | The Discovery of MORF-627, a Highly Selective Conformationally-Biased Zwitterionic Integrin alpha v beta 6 Inhibitor for Fibrosis.
J.Med.Chem., 67, 2024
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9CZA
 | | Crystal structure of integrin avb6 headpiece in complex with compound 18 | | Descriptor: | (2S)-(2-cyclopropylphenyl){(3R)-3-[4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)butoxy]pyrrolidin-1-yl}acetic acid, 17E6 Fab heavy chain, 17E6 Fab light chain, ... | | Authors: | Monroy, M.F, Qiao, Q, Lin, F.Y. | | Deposit date: | 2024-08-05 | | Release date: | 2024-11-13 | | Last modified: | 2024-11-27 | | Method: | X-RAY DIFFRACTION (2.49 Å) | | Cite: | The Discovery of MORF-627, a Highly Selective Conformationally-Biased Zwitterionic Integrin alpha v beta 6 Inhibitor for Fibrosis.
J.Med.Chem., 67, 2024
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