7LT6
 
 | | Structure of Partial Beta-Hairpin LIR from FNIP2 Bound to GABARAP | | Descriptor: | Folliculin-interacting protein 2,Gamma-aminobutyric acid receptor-associated protein | | Authors: | Appleton, B.A. | | Deposit date: | 2021-02-18 | | Release date: | 2021-10-13 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | GABARAP sequesters the FLCN-FNIP tumor suppressor complex to couple autophagy with lysosomal biogenesis.
Sci Adv, 7, 2021
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7LSW
 | | Structure of Full Beta-Hairpin LIR from FNIP2 Bound to GABARAP | | Descriptor: | Folliculin-interacting protein 2,Gamma-aminobutyric acid receptor-associated protein, SULFATE ION | | Authors: | Appleton, B.A. | | Deposit date: | 2021-02-18 | | Release date: | 2021-10-13 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (3.05 Å) | | Cite: | GABARAP sequesters the FLCN-FNIP tumor suppressor complex to couple autophagy with lysosomal biogenesis.
Sci Adv, 7, 2021
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6ULG
 | | Cryo-EM structure of the FLCN-FNIP2-Rag-Ragulator complex | | Descriptor: | Folliculin, Folliculin-interacting protein 2, GUANOSINE-5'-DIPHOSPHATE, ... | | Authors: | Shen, K, Rogala, K.B, Yu, Z.H, Sabatini, D.M. | | Deposit date: | 2019-10-08 | | Release date: | 2019-11-20 | | Last modified: | 2019-12-11 | | Method: | ELECTRON MICROSCOPY (3.31 Å) | | Cite: | Cryo-EM Structure of the Human FLCN-FNIP2-Rag-Ragulator Complex.
Cell, 179, 2019
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8DHB
 | | Active FLCN GAP complex | | Descriptor: | BERYLLIUM TRIFLUORIDE ION, Folliculin, Folliculin-interacting protein 2, ... | | Authors: | Jansen, R.M, Hurley, J.H. | | Deposit date: | 2022-06-25 | | Release date: | 2022-09-28 | | Method: | ELECTRON MICROSCOPY (3.53 Å) | | Cite: | Structural basis for FLCN RagC GAP activation in MiT-TFE substrate-selective mTORC1 regulation.
Sci Adv, 8, 2022
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6NZD
 | | Cryo-EM Structure of the Lysosomal Folliculin Complex (FLCN-FNIP2-RagA-RagC-Ragulator) | | Descriptor: | 9-{5-O-[(S)-hydroxy{[(R)-hydroxy(thiophosphonooxy)phosphoryl]oxy}phosphoryl]-alpha-L-arabinofuranosyl}-3,9-dihydro-1H-purine-2,6-dione, Folliculin, Folliculin-interacting protein 2, ... | | Authors: | Fromm, S.A, Young, L.N, Hurley, J.H. | | Deposit date: | 2019-02-13 | | Release date: | 2019-11-06 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structural mechanism of a Rag GTPase activation checkpoint by the lysosomal folliculin complex.
Science, 366, 2019
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