4V06
 
 | | Crystal structure of human tryptophan hydroxylase 2 (TPH2), catalytic domain | | Descriptor: | FE (III) ION, IMIDAZOLE, TRYPTOPHAN 5-HYDROXYLASE 2 | | Authors: | Kopec, J, Oberholzer, A, Fitzpatrick, F, Newman, J, Tallant, C, Kiyani, W, Shrestha, L, Burgess-Brown, N, von Delft, F, Arrowsmith, C, Edwards, A, Bountra, C, Yue, W.W. | | Deposit date: | 2014-09-11 | | Release date: | 2014-10-15 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.63 Å) | | Cite: | Crystal Structure of Human Tryptophane Hydroxylase 2 (Tph2), Catalytic Domain
To be Published
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7WIY
 | | Cryo-EM structure of human TPH2 tetramer | | Descriptor: | FE (III) ION, IMIDAZOLE, Tryptophan 5-hydroxylase 2 | | Authors: | Zhu, K.F, Liu, C, Zhang, H.W, Wang, D.P. | | Deposit date: | 2022-01-05 | | Release date: | 2022-10-05 | | Last modified: | 2024-06-26 | | Method: | ELECTRON MICROSCOPY (3.09 Å) | | Cite: | Cryo-EM Structure and Activator Screening of Human Tryptophan Hydroxylase 2.
Front Pharmacol, 13, 2022
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7QRI
 | | Regulatory domain dimer of tryptophan hydroxylase 2 in complex with L-Phe | | Descriptor: | PHENYLALANINE, Tryptophan 5-hydroxylase 2 | | Authors: | Vedel, I.M, Prestel, A, Harris, P, Peters, G.H.J, Kragelund, B.B. | | Deposit date: | 2022-01-11 | | Release date: | 2023-05-03 | | Last modified: | 2024-06-19 | | Method: | SOLUTION NMR | | Cite: | Structural characterization of human tryptophan hydroxylase 2 reveals that L-Phe is superior to L-Trp as the regulatory domain ligand.
Structure, 31, 2023
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