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PDB: 10 results

6V4G
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BU of 6v4g by Molmil
Crystal Structure Analysis of Zebra fish MDMX
Descriptor: Protein Mdm4, SULFATE ION, Stapled peptide QSQQTF(0EH)NLWRLE(MK8)QN(NH2)
Authors:Seo, H.-S, Dhe-Paganon, S.
Deposit date:2019-11-27
Release date:2020-04-22
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Identification of a Structural Determinant for Selective Targeting of HDMX.
Structure, 28, 2020
8EBK
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Crystal Structure Analysis of xHDMX in complex with the stapled peptide PROTAC analog
Descriptor: ACE-LEU-THR-PHE-0EH-GLU-TYR-TRP-ALA-GLN-LEU-MK8-SER-ALA-ALA, HDMX
Authors:Seo, H.-S, Dhe-Paganon, S.
Deposit date:2022-08-31
Release date:2023-10-04
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.29 Å)
Cite:Crystal Structure Analysis of xHDMX in complex with the stapled peptide PROTAC analog
To Be Published
6V4F
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Crystal Structure Analysis of Zebra Fish MDMX
Descriptor: Protein Mdm4, SULFATE ION, Stapled Peptide LSQETF(0EH)DLWKLE(MK8)EN(NH2)
Authors:Seo, H.-S, Dhe-Paganon, S.
Deposit date:2019-11-27
Release date:2020-04-22
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Identification of a Structural Determinant for Selective Targeting of HDMX.
Structure, 28, 2020
6V4H
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BU of 6v4h by Molmil
Crystal Structure Analysis of Zebra Fish MDMX
Descriptor: Protein Mdm4, Stapled Peptide LSQETF(0EH)DLWKLL(MK8)EN(NH2)
Authors:Seo, H.-S, Dhe-Paganon, S.
Deposit date:2019-11-27
Release date:2020-04-22
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Identification of a Structural Determinant for Selective Targeting of HDMX.
Structure, 28, 2020
6V4E
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BU of 6v4e by Molmil
Crystal Structure Analysis of Zebra Fish MDM
Descriptor: Protein Mdm4, Stapled peptide QSQQTF(0EH)NLWRLL(MK8)QN(NH2)
Authors:Seo, H.-S, Dhe-Paganon, S.
Deposit date:2019-11-27
Release date:2020-04-22
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Identification of a Structural Determinant for Selective Targeting of HDMX.
Structure, 28, 2020
4N5T
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The 1.7A Crystal Structure of MDMX with a Stapled Peptide, ATSP-7041
Descriptor: ATSP-7041 stapled-peptide, Protein Mdm4
Authors:Graves, B.J, Lukacs, C, Janson, C.A.
Deposit date:2013-10-10
Release date:2013-11-20
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Stapled alpha-helical peptide drug development: a potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy.
Proc.Natl.Acad.Sci.USA, 110, 2013
8GJS
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BU of 8gjs by Molmil
Stapled Peptide ALRN-6924 Bound to MDMX
Descriptor: ACE-LEU-THR-PHE-ALA-GLU-TYR-TRP-ALA-GLN-LEU-DAL-ALA-ALA-ALA-ALA-ALA-DAL, Protein Mdm4
Authors:Graves, B.J, Janson, C, Lukacs, C.
Deposit date:2023-03-16
Release date:2023-07-26
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Discovery of Sulanemadlin (ALRN-6924), the First Cell-Permeating, Stabilized alpha-Helical Peptide in Clinical Development.
J.Med.Chem., 66, 2023
3DAC
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BU of 3dac by Molmil
Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain
Descriptor: Cellular tumor antigen p53, Mdm4 protein
Authors:Popowicz, G.M, Czarna, A, Holak, T.A.
Deposit date:2008-05-29
Release date:2008-09-02
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain.
Cell Cycle, 7, 2008
2Z5S
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Molecular basis for the inhibition of p53 by Mdmx
Descriptor: Cellular tumor antigen p53, Mdm4 protein
Authors:Popowicz, G.M, Czarna, A, Rothweiler, U, Szwagierczak, A, Holak, T.A.
Deposit date:2007-07-17
Release date:2007-11-06
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Molecular basis for the inhibition of p53 by Mdmx.
Cell Cycle, 6, 2007
2Z5T
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BU of 2z5t by Molmil
Molecular basis for the inhibition of p53 by Mdmx
Descriptor: Cellular tumor antigen p53, Mdm4 protein
Authors:Popowicz, G.M, Czarna, A, Rothweiler, U, Szwagierczak, A, Holak, T.A.
Deposit date:2007-07-17
Release date:2007-11-06
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Molecular basis for the inhibition of p53 by Mdmx.
Cell Cycle, 6, 2007

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