8GJS

Stapled Peptide ALRN-6924 Bound to MDMX

Summary for 8GJS

Entry DOI	10.2210/pdb8gjs/pdb
Descriptor	Protein Mdm4, ACE-LEU-THR-PHE-ALA-GLU-TYR-TRP-ALA-GLN-LEU-DAL-ALA-ALA-ALA-ALA-ALA-DAL (3 entities in total)
Functional Keywords	stapled peptide inhibitor complex, mdmx, apoptosis
Biological source	Danio rerio (zebrafish) More
Total number of polymer chains	2
Total formula weight	12241.35
Authors	Graves, B.J.,Janson, C.,Lukacs, C. (deposition date: 2023-03-16, release date: 2023-07-26, Last modification date: 2023-11-15)
Primary citation	Guerlavais, V.,Sawyer, T.K.,Carvajal, L.,Chang, Y.S.,Graves, B.,Ren, J.G.,Sutton, D.,Olson, K.A.,Packman, K.,Darlak, K.,Elkin, C.,Feyfant, E.,Kesavan, K.,Gangurde, P.,Vassilev, L.T.,Nash, H.M.,Vukovic, V.,Aivado, M.,Annis, D.A. Discovery of Sulanemadlin (ALRN-6924), the First Cell-Permeating, Stabilized alpha-Helical Peptide in Clinical Development. J.Med.Chem., 66:9401-9417, 2023 Cited by PubMed: 37439511 DOI: 10.1021/acs.jmedchem.3c00623 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.75 Å)

Structure validation