1K8K
 
 | | Crystal Structure of Arp2/3 Complex | | Descriptor: | ACTIN-LIKE PROTEIN 2, ACTIN-LIKE PROTEIN 3, ARP2/3 COMPLEX 16 KDA SUBUNIT, ... | | Authors: | Robinson, R.C, Turbedsky, K, Kaiser, D.A, Higgs, H.N, Marchand, J.-B, Choe, S, Pollard, T.D. | | Deposit date: | 2001-10-24 | | Release date: | 2001-12-07 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal Structure of Arp2/3 Complex
Science, 294, 2001
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2P9I
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3UKR
 | | Crystal structure of Bos taurus Arp2/3 complex with bound inhibitor CK-666 | | Descriptor: | 2-fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide, Actin-related protein 2, Actin-related protein 2/3 complex subunit 1B, ... | | Authors: | Nolen, B.J, Han, M. | | Deposit date: | 2011-11-09 | | Release date: | 2013-02-13 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.48 Å) | | Cite: | Structural characterization and computer-aided optimization of a small-molecule inhibitor of the Arp2/3 complex, a key regulator of the actin cytoskeleton.
Chemmedchem, 7, 2012
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3ULE
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1U2V
 | | Crystal structure of Arp2/3 complex with bound ADP and calcium | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin-Related Protein 2, Actin-Related Protein 3, ... | | Authors: | Nolen, B.J, Littlefield, R.S, Pollard, T.D. | | Deposit date: | 2004-07-20 | | Release date: | 2004-11-09 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | Crystal structures of actin-related protein 2/3 complex with bound ATP or ADP
Proc.Natl.Acad.Sci.Usa, 101, 2004
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1TYQ
 | | Crystal structure of Arp2/3 complex with bound ATP and calcium | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Actin-related Protein 2, Actin-related protein 3, ... | | Authors: | Nolen, B.J, Littlefield, R.S, Pollard, T.D. | | Deposit date: | 2004-07-08 | | Release date: | 2004-11-09 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | Crystal structures of actin-related protein 2/3 complex with bound ATP or ADP
Proc.Natl.Acad.Sci.Usa, 101, 2004
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2P9K
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2P9L
 | | Crystal Structure of bovine Arp2/3 complex | | Descriptor: | Actin-like protein 2, Actin-like protein 3, Actin-related protein 2/3 complex subunit 1B, ... | | Authors: | Nolen, B.J, Pollard, T.D. | | Deposit date: | 2007-03-26 | | Release date: | 2007-05-29 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | Insights into the Influence of Nucleotides on Actin Family Proteins from Seven Structures of Arp2/3 Complex.
Mol.Cell, 26, 2007
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3RSE
 | | Structural and biochemical characterization of two binding sites for nucleation promoting factor WASp-VCA on Arp2/3 complex | | Descriptor: | Actin-related protein 2, Actin-related protein 2/3 complex subunit 1B, Actin-related protein 2/3 complex subunit 2, ... | | Authors: | Pollard, T.D, Jurgenson, C.T, Ti, S, Nolen, B.J. | | Deposit date: | 2011-05-02 | | Release date: | 2011-06-01 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | Structural and biochemical characterization of two binding sites for nucleation-promoting factor WASp-VCA on Arp2/3 complex.
Proc.Natl.Acad.Sci.USA, 108, 2011
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2P9S
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3DXK
 | | Structure of Bos Taurus Arp2/3 Complex with Bound Inhibitor CK0944636 | | Descriptor: | Actin-related protein 2, Actin-related protein 2/3 complex subunit 1B, Actin-related protein 2/3 complex subunit 2, ... | | Authors: | Nolen, B.J, Tomasevic, N, Russell, A, Pierce, D.W, Jia, Z, Hartman, J, Sakowicz, R, Pollard, T.D. | | Deposit date: | 2008-07-24 | | Release date: | 2009-07-28 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Characterization of two classes of small molecule inhibitors of Arp2/3 complex
Nature, 460, 2009
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3UKU
 | | Structure of Arp2/3 complex with bound inhibitor CK-869 | | Descriptor: | (2S)-2-(3-bromophenyl)-3-(2,4-dimethoxyphenyl)-1,3-thiazolidin-4-one, ACTIN-LIKE PROTEIN 2, ACTIN-LIKE PROTEIN 3, ... | | Authors: | Nolen, B.J, Han, M. | | Deposit date: | 2011-11-09 | | Release date: | 2013-02-13 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | Structure of Arp2/3 complex with bound inhibitor CK-869
To be Published
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2P9U
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3DXM
 | | Structure of Bos taurus Arp2/3 Complex with Bound Inhibitor CK0993548 | | Descriptor: | (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one, Actin-related protein 2, Actin-related protein 2/3 complex subunit 1B, ... | | Authors: | Nolen, B.J, Tomasevic, N, Russell, A, Pierce, D.W, Jia, Z, Hartman, J, Sakowicz, R, Pollard, T.D. | | Deposit date: | 2008-07-24 | | Release date: | 2009-07-28 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | Characterization of two classes of small molecule inhibitors of Arp2/3 complex
Nature, 460, 2009
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2P9N
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8TAH
 | | Cryo-EM structure of Cortactin-bound to Arp2/3 complex | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Actin-related protein 2, Actin-related protein 2/3 complex subunit 1A, ... | | Authors: | Fregoso, F.E, van Eeuwen, T, Dominguez, R. | | Deposit date: | 2023-06-27 | | Release date: | 2023-09-27 | | Last modified: | 2024-01-31 | | Method: | ELECTRON MICROSCOPY (2.89 Å) | | Cite: | Mechanism of synergistic activation of Arp2/3 complex by cortactin and WASP-family proteins.
Nat Commun, 14, 2023
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2P9P
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4JD2
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7JPN
 | | Cryo-EM structure of Arpin-bound Arp2/3 complex | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Actin-related protein 2, Actin-related protein 2/3 complex subunit 1B, ... | | Authors: | van Eeuwen, T, Fregoso, F.E, Dominguez, R, Zimmet, A, Boczkowska, M, Rebowski, G. | | Deposit date: | 2020-08-09 | | Release date: | 2022-02-09 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (3.24 Å) | | Cite: | Molecular mechanism of Arp2/3 complex inhibition by Arpin.
Nat Commun, 13, 2022
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7T5Q
 | | Cryo-EM Structure of a Transition State of Arp2/3 Complex Activation | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... | | Authors: | Rebowski, G, van Eeuwen, T, Boczkowska, M, Dominguez, R. | | Deposit date: | 2021-12-13 | | Release date: | 2023-06-14 | | Last modified: | 2023-08-02 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Cryo-EM structure of an Arp2/3 complex mini-branch capped by capping protein (CapZ)
To Be Published
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4XEI
 | | Orthorhombic isomorph of bovine Arp2/3 complex | | Descriptor: | Actin-related protein 2, Actin-related protein 2/3 complex subunit 1B, Actin-related protein 2/3 complex subunit 2, ... | | Authors: | Jurgenson, C.J, Pollard, T.P. | | Deposit date: | 2014-12-23 | | Release date: | 2015-09-02 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (3.874 Å) | | Cite: | Crystals of the Arp2/3 complex in two new space groups with structural information about actin-related protein 2 and potential WASP binding sites.
Acta Crystallogr.,Sect.F, 71, 2015
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7TPT
 | | Single-particle Cryo-EM structure of Arp2/3 complex at branched-actin junction. | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | | Authors: | Ding, B, Narvaez-Ortiz, H.Y, Nolen, B.J, Chowdhury, S. | | Deposit date: | 2022-01-26 | | Release date: | 2022-05-25 | | Last modified: | 2022-06-08 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Structure of Arp2/3 complex at a branched actin filament junction resolved by single-particle cryo-electron microscopy.
Proc.Natl.Acad.Sci.USA, 119, 2022
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6DEC
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4XF2
 | | Tetragonal structure of Arp2/3 complex | | Descriptor: | Actin-related protein 2, Actin-related protein 2/3 complex subunit 1B, Actin-related protein 2/3 complex subunit 2, ... | | Authors: | Jurgenson, C.T, Pollard, T.P. | | Deposit date: | 2014-12-25 | | Release date: | 2015-11-18 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (5 Å) | | Cite: | Crystals of the Arp2/3 complex in two new space groups with structural information about actin-related protein 2 and potential WASP binding sites.
Acta Crystallogr.,Sect.F, 71, 2015
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