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3UKR

Crystal structure of Bos taurus Arp2/3 complex with bound inhibitor CK-666

Summary for 3UKR
Entry DOI10.2210/pdb3ukr/pdb
Related3UKU 3ULE
DescriptorActin-related protein 3, Actin-related protein 2, Actin-related protein 2/3 complex subunit 1B, ... (9 entities in total)
Functional Keywordsbeta-propeller actin fold, structural protein, atp binding
Biological sourceBos taurus (bovine,cow,domestic cattle,domestic cow)
More
Cellular locationCytoplasm, cytoskeleton (By similarity): P61157 A7MB62 Q58CQ2 Q3MHR7 Q3T035 Q148J6 Q3SYX9
Total number of polymer chains7
Total formula weight224496.91
Authors
Nolen, B.J.,Han, M. (deposition date: 2011-11-09, release date: 2013-02-13, Last modification date: 2024-02-28)
Primary citationBaggett, A.W.,Cournia, Z.,Han, M.S.,Patargias, G.,Glass, A.C.,Liu, S.Y.,Nolen, B.J.
Structural characterization and computer-aided optimization of a small-molecule inhibitor of the Arp2/3 complex, a key regulator of the actin cytoskeleton.
Chemmedchem, 7:1286-1294, 2012
Cited by
PubMed: 22623398
DOI: 10.1002/cmdc.201200104
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.48 Å)
Structure validation

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