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3UKR

Crystal structure of Bos taurus Arp2/3 complex with bound inhibitor CK-666

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0003779molecular_functionactin binding
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005885cellular_componentArp2/3 protein complex
A0010592biological_processpositive regulation of lamellipodium assembly
A0030030biological_processcell projection organization
A0034314biological_processArp2/3 complex-mediated actin nucleation
A0035861cellular_componentsite of double-strand break
A0042995cellular_componentcell projection
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0051015molecular_functionactin filament binding
A0060271biological_processcilium assembly
B0000166molecular_functionnucleotide binding
B0003779molecular_functionactin binding
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005885cellular_componentArp2/3 protein complex
B0010592biological_processpositive regulation of lamellipodium assembly
B0034314biological_processArp2/3 complex-mediated actin nucleation
B0035861cellular_componentsite of double-strand break
B0042995cellular_componentcell projection
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0051015molecular_functionactin filament binding
B1905168biological_processpositive regulation of double-strand break repair via homologous recombination
B2001032biological_processregulation of double-strand break repair via nonhomologous end joining
C0003779molecular_functionactin binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005885cellular_componentArp2/3 protein complex
C0015629cellular_componentactin cytoskeleton
C0034314biological_processArp2/3 complex-mediated actin nucleation
C0051015molecular_functionactin filament binding
D0003779molecular_functionactin binding
D0005200molecular_functionstructural constituent of cytoskeleton
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005856cellular_componentcytoskeleton
D0005885cellular_componentArp2/3 protein complex
D0015629cellular_componentactin cytoskeleton
D0030041biological_processactin filament polymerization
D0034314biological_processArp2/3 complex-mediated actin nucleation
D0035861cellular_componentsite of double-strand break
D0042995cellular_componentcell projection
D0043005cellular_componentneuron projection
D0045202cellular_componentsynapse
D0051015molecular_functionactin filament binding
E0003779molecular_functionactin binding
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0005856cellular_componentcytoskeleton
E0005885cellular_componentArp2/3 protein complex
E0030833biological_processregulation of actin filament polymerization
E0034314biological_processArp2/3 complex-mediated actin nucleation
E0035861cellular_componentsite of double-strand break
E0042995cellular_componentcell projection
E0051015molecular_functionactin filament binding
F0003779molecular_functionactin binding
F0005634cellular_componentnucleus
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0005856cellular_componentcytoskeleton
F0005885cellular_componentArp2/3 protein complex
F0015629cellular_componentactin cytoskeleton
F0030041biological_processactin filament polymerization
F0034314biological_processArp2/3 complex-mediated actin nucleation
F0035861cellular_componentsite of double-strand break
F0042995cellular_componentcell projection
F0051015molecular_functionactin filament binding
G0003779molecular_functionactin binding
G0005634cellular_componentnucleus
G0005737cellular_componentcytoplasm
G0005829cellular_componentcytosol
G0005856cellular_componentcytoskeleton
G0005885cellular_componentArp2/3 protein complex
G0015629cellular_componentactin cytoskeleton
G0016477biological_processcell migration
G0030833biological_processregulation of actin filament polymerization
G0034314biological_processArp2/3 complex-mediated actin nucleation
G0035861cellular_componentsite of double-strand break
G0042995cellular_componentcell projection
G0051015molecular_functionactin filament binding
Functional Information from PDB Data
site_idAC1
Number of Residues10
DetailsBINDING SITE FOR RESIDUE CKH B 401
ChainResidue
ALEU117
BILE252
BTYR202
BALA203
BPHE204
BASP209
BLEU246
BPRO247
BASP248
BARG250

Functional Information from PROSITE/UniProt
site_idPS01132
Number of Residues13
DetailsACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEPpMNPtkNR
ChainResidueDetails
BLEU108-ARG120
ALEU111-ARG123

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N-acetylserine => ECO:0000250|UniProtKB:O15511
ChainResidueDetails
GSER2
DLYS295
BGLY305

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:O15145
ChainResidueDetails
ELYS56
ELYS61
ALYS251
ALYS254

site_idSWS_FT_FI3
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0000250|UniProtKB:O15145
ChainResidueDetails
ELYS14
BLYS322

218853

PDB entries from 2024-04-24

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