3L8W
 
 | | Urate oxidase from aspergillus flavus complexed with xanthin | | Descriptor: | SODIUM ION, Uricase, XANTHINE, ... | | Authors: | Prange, T, Gabison, L, Colloc'h, N, Chiadmi, M. | | Deposit date: | 2010-01-04 | | Release date: | 2010-06-02 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1 Å) | | Cite: | Near-atomic resolution structures of urate oxidase complexed with its substrate and analogues: the protonation state of the ligand.
Acta Crystallogr.,Sect.D, 66, 2010
|
|
4N9S
 | | High resolution X-RAY STRUCTURE OF URATE OXIDASE IN COMPLEX WITH 8-HYDROXYXANTHINE | | Descriptor: | 8-hydroxy-3,9-dihydro-1H-purine-2,6-dione, CHLORIDE ION, GLYCEROL, ... | | Authors: | Oksanen, E, Blakeley, M.P, Budayova-Spano, M. | | Deposit date: | 2013-10-21 | | Release date: | 2014-02-05 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.06 Å) | | Cite: | The neutron structure of urate oxidase resolves a long-standing mechanistic conundrum and reveals unexpected changes in protonation.
Plos One, 9, 2014
|
|
4POE
 | |
6IC1
 | | urate oxidase under 90 bar of krypton | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 8-AZAXANTHINE, ACETATE ION, ... | | Authors: | Prange, T, Colloc'h, N, Carpentier, P. | | Deposit date: | 2018-12-01 | | Release date: | 2019-12-18 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.1 Å) | | Cite: | Comparative study of the effects of high hydrostatic pressure per se and high argon pressure on urate oxidase ligand stabilization
Acta Cryst. D, 78, 2022
|
|
4N9V
 | | High resolution x-ray structure of urate oxidase in complex with 8-azaxanthine | | Descriptor: | 8-AZAXANTHINE, CHLORIDE ION, GLYCEROL, ... | | Authors: | Oksanen, E, Blakeley, M.P, Budayova-Spano, M. | | Deposit date: | 2013-10-21 | | Release date: | 2014-02-05 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.1 Å) | | Cite: | The neutron structure of urate oxidase resolves a long-standing mechanistic conundrum and reveals unexpected changes in protonation.
Plos One, 9, 2014
|
|
4PR8
 | |
4CW6
 | | Crystal structure of cofactor-free urate oxidase in complex with the 5-peroxo derivative of 9-metyl uric acid (X-ray dose, 92 kGy) | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, (5S)-5-(dioxidanyl)-9-methyl-7H-purine-2,6,8-trione, 9-METHYL URIC ACID, ... | | Authors: | Bui, S, Steiner, R.A. | | Deposit date: | 2014-04-01 | | Release date: | 2014-10-29 | | Last modified: | 2018-02-21 | | Method: | X-RAY DIFFRACTION (1.28 Å) | | Cite: | Direct evidence for a peroxide intermediate and a reactive enzyme-substrate-dioxygen configuration in a cofactor-free oxidase.
Angew. Chem. Int. Ed. Engl., 53, 2014
|
|
4OQC
 | |
4D13
 | |
4D17
 | | Crystal structure of cofactor-free urate oxidase in complex with its 5-peroxoisourate intermediate (X-ray dose, 106 kGy) | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 5-(HYDRO)PEROXOISOURATE, OXYGEN MOLECULE, ... | | Authors: | Bui, S, Steiner, R.A. | | Deposit date: | 2014-05-01 | | Release date: | 2014-11-05 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Direct evidence for a peroxide intermediate and a reactive enzyme-substrate-dioxygen configuration in a cofactor-free oxidase.
Angew. Chem. Int. Ed. Engl., 53, 2014
|
|
4PUV
 | | URATE OXIDASE DI-AZIDE complex | | Descriptor: | AZIDE ION, SODIUM ION, Uricase | | Authors: | Colloc'h, N, Prange, T. | | Deposit date: | 2014-03-14 | | Release date: | 2014-12-24 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Azide inhibition of urate oxidase.
Acta Crystallogr.,Sect.F, 70, 2014
|
|
4CW2
 | | Crystal structure of cofactor-free urate oxidase in complex with the 5-peroxo derivative of 9-metyl uric acid (X-ray dose, 2.5 kGy) | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, (5S)-5-(dioxidanyl)-9-methyl-7H-purine-2,6,8-trione, URICASE | | Authors: | Bui, S, Steiner, R.A. | | Deposit date: | 2014-04-01 | | Release date: | 2014-10-29 | | Last modified: | 2018-02-21 | | Method: | X-RAY DIFFRACTION (1.32 Å) | | Cite: | Direct evidence for a peroxide intermediate and a reactive enzyme-substrate-dioxygen configuration in a cofactor-free oxidase.
Angew. Chem. Int. Ed. Engl., 53, 2014
|
|
7A0L
 | | Joint neutron/X-ray room temperature structure of perdeuterated Aspergillus flavus urate oxidase in complex with the 8-azaxanthine inhibitor and catalytic water bound in the peroxo hole | | Descriptor: | 8-AZAXANTHINE, SODIUM ION, Uricase | | Authors: | McGregor, L, Bui, S, Blakeley, M.P, Steiner, R.A. | | Deposit date: | 2020-08-09 | | Release date: | 2020-12-09 | | Last modified: | 2024-05-01 | | Method: | NEUTRON DIFFRACTION (1.33 Å), X-RAY DIFFRACTION | | Cite: | Joint neutron/X-ray crystal structure of a mechanistically relevant complex of perdeuterated urate oxidase and simulations provide insight into the hydration step of catalysis.
Iucrj, 8, 2021
|
|
4CW3
 | | Crystal structure of cofactor-free urate oxidase in complex with the 5-peroxo derivative of 9-metyl uric acid (X-ray dose, 665 kGy) | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, (5S)-5-(dioxidanyl)-9-methyl-7H-purine-2,6,8-trione, 9-METHYL URIC ACID, ... | | Authors: | Bui, S, Steiner, R.A. | | Deposit date: | 2014-04-01 | | Release date: | 2014-10-29 | | Last modified: | 2018-02-21 | | Method: | X-RAY DIFFRACTION (1.34 Å) | | Cite: | Direct evidence for a peroxide intermediate and a reactive enzyme-substrate-dioxygen configuration in a cofactor-free oxidase.
Angew. Chem. Int. Ed. Engl., 53, 2014
|
|
3LD4
 | | Urate oxidase complexed with 8-nitro xanthine | | Descriptor: | 1,2-ETHANEDIOL, 8-nitro-3,7-dihydro-1H-purine-2,6-dione, SODIUM ION, ... | | Authors: | Prange, T, Colloc'h, N, Gabison, L. | | Deposit date: | 2010-01-12 | | Release date: | 2010-06-02 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.35 Å) | | Cite: | Near-atomic resolution structures of urate oxidase complexed with its substrate and analogues: the protonation state of the ligand.
Acta Crystallogr.,Sect.D, 66, 2010
|
|
4D19
 | | Crystal structure of cofactor-free urate oxidase in complex with its 5-peroxoisourate intermediate (X-ray dose, 1.75 MGy) | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 5-(HYDRO)PEROXOISOURATE, OXYGEN MOLECULE, ... | | Authors: | Bui, S, Steiner, R.A. | | Deposit date: | 2014-05-01 | | Release date: | 2014-10-29 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.35 Å) | | Cite: | Direct evidence for a peroxide intermediate and a reactive enzyme-substrate-dioxygen configuration in a cofactor-free oxidase.
Angew. Chem. Int. Ed. Engl., 53, 2014
|
|
4D12
 | |
5FRC
 | | Structure of urate oxidase prepared by the 'soak-and-freeze' method under 42 bar of oxygen pressure | | Descriptor: | 8-AZAXANTHINE, OXYGEN MOLECULE, SODIUM ION, ... | | Authors: | Lafumat, B, Mueller-Dieckmann, C, Colloc'h, N, Prange, T, Royant, A, van der Linden, P, Carpentier, P. | | Deposit date: | 2015-12-16 | | Release date: | 2016-10-26 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.443 Å) | | Cite: | Gas-Sensitive Biological Crystals Processed in Pressurized Oxygen and Krypton Atmospheres: Deciphering Gas Channels in Proteins Using a Novel `Soak-and-Freeze' Methodology.
J.Appl.Crystallogr., 49, 2016
|
|
3P9O
 | | Aerobic ternary complex of urate oxidase with azide and chloride | | Descriptor: | AZIDE ION, CHLORIDE ION, SODIUM ION, ... | | Authors: | Gabison, L, Colloc'H, N, El Hajji, M, Castro, B, Chiadmi, M, Prange, T. | | Deposit date: | 2010-10-18 | | Release date: | 2011-08-31 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.45 Å) | | Cite: | Azide and Cyanide Show Different Inhibition Modes to Urate Oxidase
To be Published
|
|
6RGM
 | | urate oxidase under 130 bar of krypton | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 8-AZAXANTHINE, ACETATE ION, ... | | Authors: | Prange, T, Colloc'h, N, Carpentier, P. | | Deposit date: | 2019-04-17 | | Release date: | 2020-05-13 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Comparative study of the effects of high hydrostatic pressure per se and high argon pressure on urate oxidase ligand stabilization
Acta Cryst. D, 78, 2022
|
|
3LBG
 | | Urate oxidase complexed with 8-thio xanthine | | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 8-thioxo-3,7,8,9-tetrahydro-1H-purine-2,6-dione, ... | | Authors: | Prange, T, Colloc'h, N, Gabison, L. | | Deposit date: | 2010-01-08 | | Release date: | 2010-06-02 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Near-atomic resolution structures of urate oxidase complexed with its substrate and analogues: the protonation state of the ligand.
Acta Crystallogr.,Sect.D, 66, 2010
|
|
4CW0
 | |
3OBP
 | | Anaerobic complex of urate oxidase with uric acid | | Descriptor: | SODIUM ION, URIC ACID, Uricase | | Authors: | Gabison, L, Chopard, C, Colloc'h, N, El Hajji, M, Castro, B, Chiadmi, M, Prange, T. | | Deposit date: | 2010-08-08 | | Release date: | 2011-06-22 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | X-ray, ESR, and quantum mechanics studies unravel a spin well in the cofactor-less urate oxidase.
Proteins, 79, 2011
|
|
2IBA
 | | Urate oxidase from Aspergillus flavus complexed with its inhibitor 8-azaxanthine | | Descriptor: | 8-AZAXANTHINE, SODIUM ION, Uricase | | Authors: | Colloc'h, N, Retailleau, P, Sopkova-de Oliveira Santos, J, Prange, T. | | Deposit date: | 2006-09-11 | | Release date: | 2007-02-06 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Protein Crystallography under Xenon and Nitrous Oxide Pressure: Comparison with In Vivo Pharmacology Studies and Implications for the Mechanism of Inhaled Anesthetic Action
Biophys.J., 92, 2007
|
|
4OP9
 | | Urate OXIDASE IN COMPLEX WITH 8-AZAXANTHINE | | Descriptor: | 8-AZAXANTHINE, SODIUM ION, Uricase | | Authors: | Colloc'h, N, Prange, T. | | Deposit date: | 2014-02-05 | | Release date: | 2014-03-19 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.58 Å) | | Cite: | Functional relevance of the internal hydrophobic cavity of urate oxidase.
Febs Lett., 588, 2014
|
|
