4D12

Crystal Structure of Cofactor-free Urate Oxidase Anaerobically Complexed with Uric Acid

Summary for 4D12

Entry DOI	10.2210/pdb4d12/pdb
Related	4D13 4D17
Descriptor	URICASE, (4S)-2-METHYL-2,4-PENTANEDIOL, URIC ACID, ... (4 entities in total)
Functional Keywords	oxidoreductase, cofactor-free oxidase
Biological source	ASPERGILLUS FLAVUS
Cellular location	Peroxisome: Q00511
Total number of polymer chains	1
Total formula weight	34575.03
Authors	Bui, S.,Steiner, R.A. (deposition date: 2014-05-01, release date: 2014-10-29, Last modification date: 2018-02-21)
Primary citation	Bui, S.,von Stetten, D.,Jambrina, P.G.,Prange, T.,Colloc'h, N.,de Sanctis, D.,Royant, A.,Rosta, E.,Steiner, R.A. Direct evidence for a peroxide intermediate and a reactive enzyme-substrate-dioxygen configuration in a cofactor-free oxidase. Angew. Chem. Int. Ed. Engl., 53:13710-13714, 2014 Cited by PubMed: 25314114 DOI: 10.1002/anie.201405485 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.4 Å)

Structure validation