5J9P
| KcsA in vitro | Descriptor: | Fab, POTASSIUM ION, pH-gated potassium channel KcsA | Authors: | Matulef, K, Valiyaveetil, F.I. | Deposit date: | 2016-04-10 | Release date: | 2016-07-20 | Last modified: | 2019-12-04 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Combining in Vitro Folding with Cell Free Protein Synthesis for Membrane Protein Expression. Biochemistry, 55, 2016
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4UUJ
| POTASSIUM CHANNEL KCSA-FAB WITH TETRAHEXYLAMMONIUM | Descriptor: | ANTIBODY FAB FRAGMENT HEAVY CHAIN, ANTIBODY FAB FRAGMENT LIGHT CHAIN, COBALT (II) ION, ... | Authors: | Lenaeus, M.J, Burdette, D, Wagner, T, Focia, P.J, Gross, A. | Deposit date: | 2014-07-29 | Release date: | 2014-08-27 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structures of Kcsa in Complex with Symmetrical Quaternary Ammonium Compounds Reveal a Hydrophobic Binding Site. Biochemistry, 53, 2014
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1BL8
| POTASSIUM CHANNEL (KCSA) FROM STREPTOMYCES LIVIDANS | Descriptor: | POTASSIUM ION, PROTEIN (POTASSIUM CHANNEL PROTEIN) | Authors: | Doyle, D.A, Cabral, J.M, Pfuetzner, R.A, Kuo, A, Gulbis, J.M, Cohen, S.L, Chait, B.T, Mackinnon, R. | Deposit date: | 1998-07-23 | Release date: | 1998-07-29 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | The structure of the potassium channel: molecular basis of K+ conduction and selectivity. Science, 280, 1998
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8THN
| KcsA M96V mutant with Y78ester in High K+ | Descriptor: | KcsA Fab Heavy Chain, KcsA Fab Light Chain, POTASSIUM ION, ... | Authors: | Reddi, R, Valiyaveetil, F.I. | Deposit date: | 2023-07-17 | Release date: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | A facile approach for incorporating tyrosine esters to probe ion-binding sites and backbone hydrogen bonds. J.Biol.Chem., 300, 2023
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1F6G
| POTASSIUM CHANNEL (KCSA) FULL-LENGTH FOLD | Descriptor: | VOLTAGE-GATED POTASSIUM CHANNEL | Authors: | Cortes, D.M, Perozo, E. | Deposit date: | 2000-06-21 | Release date: | 2001-02-21 | Last modified: | 2021-11-03 | Method: | SOLUTION NMR | Cite: | Molecular architecture of full-length KcsA: role of cytoplasmic domains in ion permeation and activation gating. J.Gen.Physiol., 117, 2001
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1J95
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6BY3
| Open and conductive conformation of KcsA-T75A mutant | Descriptor: | Antibody Heavy Chain, Antibody Light Chain, DIACYL GLYCEROL, ... | Authors: | Labro, A.J, Cortes, D.M, Tilegenova, C, Cuello, L.G. | Deposit date: | 2017-12-19 | Release date: | 2018-05-09 | Last modified: | 2020-01-01 | Method: | X-RAY DIFFRACTION (2.37 Å) | Cite: | Inverted allosteric coupling between activation and inactivation gates in K+channels. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6BY2
| Closed and deep-inactivated conformation of KcsA-T75A mutant | Descriptor: | Antibody Heavy Chain, Antibody Light Chain, DIACYL GLYCEROL, ... | Authors: | Labro, A.J, Cortes, D.M, Tilegenova, C, Cuello, L.G. | Deposit date: | 2017-12-19 | Release date: | 2018-05-09 | Last modified: | 2020-01-01 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Inverted allosteric coupling between activation and inactivation gates in K+channels. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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3UM7
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3UKM
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3VOU
| The crystal structure of NaK-NavSulP chimera channel | Descriptor: | COBALT (II) ION, Ion transport 2 domain protein, Voltage-gated sodium channel, ... | Authors: | Irie, K, Shimomura, T, Fujiyoshi, Y. | Deposit date: | 2012-02-10 | Release date: | 2012-05-02 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | The C-terminal helical bundle of the tetrameric prokaryotic sodium channel accelerates the inactivation rate Nat Commun, 3, 2012
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6W88
| K2P2.1 (TREK-1):ML335 complex, 30 mM K+ | Descriptor: | CADMIUM ION, DECANE, DODECANE, ... | Authors: | Lolicato, M, Minor, D.L. | Deposit date: | 2020-03-20 | Release date: | 2021-01-27 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | K 2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions. Sci Adv, 6, 2020
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6W7C
| K2P2.1 (TREK-1), 1 mM K+ | Descriptor: | CADMIUM ION, DECANE, DODECANE, ... | Authors: | Lolicato, M, Minor, D.L. | Deposit date: | 2020-03-19 | Release date: | 2021-01-27 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | K 2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions. Sci Adv, 6, 2020
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6W0F
| Closed-gate KcsA soaked in 0mM KCl/5mM BaCl2 | Descriptor: | Fab Heavy Chain, Fab Light Chain, POTASSIUM ION, ... | Authors: | Rohaim, A, Gong, L, Li, J. | Deposit date: | 2020-02-29 | Release date: | 2020-07-08 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Open and Closed Structures of a Barium-Blocked Potassium Channel. J.Mol.Biol., 432, 2020
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6WLV
| TASK2 in MSP1D1 lipid nanodisc at pH 6.5 | Descriptor: | POTASSIUM ION, Potassium channel TASK2 | Authors: | Li, B, Brohawn, S.G. | Deposit date: | 2020-04-20 | Release date: | 2020-07-15 | Last modified: | 2020-10-28 | Method: | ELECTRON MICROSCOPY (3.45 Å) | Cite: | Structural basis for pH gating of the two-pore domain K + channel TASK2. Nature, 586, 2020
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6WM0
| TASK2 in MSP1D1 lipid nanodisc at pH 8.5 | Descriptor: | POTASSIUM ION, Potassium channel TASK2 | Authors: | Li, B, Brohawn, S.G. | Deposit date: | 2020-04-20 | Release date: | 2020-07-15 | Last modified: | 2020-10-28 | Method: | ELECTRON MICROSCOPY (3.52 Å) | Cite: | Structural basis for pH gating of the two-pore domain K + channel TASK2. Nature, 586, 2020
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6PA0
| Structure of the G77A mutant in Sodium Chloride | Descriptor: | Antibody HEAVY fragment, Antibody LIGHT fragment, DIACYL GLYCEROL, ... | Authors: | Cuello, L.G, Guan, L. | Deposit date: | 2019-06-11 | Release date: | 2019-08-07 | Last modified: | 2019-12-18 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Structure, function, and ion-binding properties of a K+channel stabilized in the 2,4-ion-bound configuration. Proc.Natl.Acad.Sci.USA, 116, 2019
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6PIS
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8DE9
| Cryo-EM structure of the zebrafish two pore domain K+ channel TREK1 (K2P2.1) in DDM/POPE mixed micelles | Descriptor: | (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, POTASSIUM ION, Potassium channel, ... | Authors: | Schmidpeter, P.A.M, Nimigean, C.M, Riegelhaupt, P.M. | Deposit date: | 2022-06-20 | Release date: | 2023-03-08 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Membrane phospholipids control gating of the mechanosensitive potassium leak channel TREK1. Nat Commun, 14, 2023
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8DE8
| Cryo-EM structure of the zebrafish two pore domain K+ channel TREK1 (K2P2.1) in DDM/POPA mixed micelles | Descriptor: | (2R)-1-(hexadecanoyloxy)-3-(phosphonooxy)propan-2-yl (9Z)-octadec-9-enoate, POTASSIUM ION, Potassium channel, ... | Authors: | Schmidpeter, P.A.M, Nimigean, C.M, Riegelhaupt, P.M. | Deposit date: | 2022-06-20 | Release date: | 2023-03-08 | Method: | ELECTRON MICROSCOPY (2.82 Å) | Cite: | Membrane phospholipids control gating of the mechanosensitive potassium leak channel TREK1. Nat Commun, 14, 2023
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8DE7
| Cryo-EM structure of the zebrafish two pore domain K+ channel TREK1 (K2P2.1) in DDM detergent | Descriptor: | DODECYL-BETA-D-MALTOSIDE, POTASSIUM ION, Potassium channel, ... | Authors: | Schmidpeter, P.A.M, Nimigean, C.M, Riegelhaupt, P.M. | Deposit date: | 2022-06-20 | Release date: | 2023-03-08 | Method: | ELECTRON MICROSCOPY (3.27 Å) | Cite: | Membrane phospholipids control gating of the mechanosensitive potassium leak channel TREK1. Nat Commun, 14, 2023
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6RV3
| Crystal structure of the human two pore domain potassium ion channel TASK-1 (K2P3.1) in a closed conformation with a bound inhibitor BAY 1000493 | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CHOLESTEROL HEMISUCCINATE, DECYL-BETA-D-MALTOPYRANOSIDE, ... | Authors: | Rodstrom, K.E.J, Pike, A.C.W, Zhang, W, Quigley, A, Speedman, D, Mukhopadhyay, S.M.M, Shrestha, L, Chalk, R, Venkaya, S, Bushell, S.R, Tessitore, A, Burgess-Brown, N, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Carpenter, E.P, Structural Genomics Consortium (SGC) | Deposit date: | 2019-05-30 | Release date: | 2019-08-07 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | A lower X-gate in TASK channels traps inhibitors within the vestibule. Nature, 582, 2020
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1S5H
| Potassium Channel Kcsa-Fab Complex T75C mutant in K+ | Descriptor: | ANTIBODY FAB FRAGMENT HEAVY CHAIN, ANTIBODY FAB FRAGMENT LIGHT CHAIN, DIACYL GLYCEROL, ... | Authors: | Mackinnon, R, Zhou, M. | Deposit date: | 2004-01-20 | Release date: | 2004-05-18 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | A mutant KcsA K(+) channel with altered conduction properties and selectivity filter ion distribution. J.Mol.Biol., 338, 2004
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6RV4
| Crystal structure of the human two pore domain potassium ion channel TASK-1 (K2P3.1) in a closed conformation with a bound inhibitor BAY 2341237 | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CHOLESTEROL HEMISUCCINATE, POTASSIUM ION, ... | Authors: | Rodstrom, K.E.J, Pike, A.C.W, Zhang, W, Quigley, A, Speedman, D, Mukhopadhyay, S.M.M, Shrestha, L, Chalk, R, Venkaya, S, Bushell, S.R, Tessitore, A, Burgess-Brown, N, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Carpenter, E.P, Structural Genomics Consortium (SGC) | Deposit date: | 2019-05-30 | Release date: | 2019-08-07 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | A lower X-gate in TASK channels traps inhibitors within the vestibule. Nature, 582, 2020
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6RV2
| Crystal structure of the human two pore domain potassium ion channel TASK-1 (K2P3.1) in a closed conformation | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CHOLESTEROL HEMISUCCINATE, DECYL-BETA-D-MALTOPYRANOSIDE, ... | Authors: | Rodstrom, K.E.J, Pike, A.C.W, Zhang, W, Quigley, A, Speedman, D, Mukhopadhyay, S.M.M, Shrestha, L, Chalk, R, Venkaya, S, Bushell, S.R, Tessitore, A, Burgess-Brown, N, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Carpenter, E.P, Structural Genomics Consortium (SGC) | Deposit date: | 2019-05-30 | Release date: | 2019-08-07 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | A lower X-gate in TASK channels traps inhibitors within the vestibule. Nature, 582, 2020
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