5C8H
 
 | | Crystal structure of ORC2 C-terminal domain | | Descriptor: | Origin recognition complex subunit 2, UNKNOWN ATOM OR ION | | Authors: | Tempel, W, Xu, C, Dong, A, Loppnau, P, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | | Deposit date: | 2015-06-25 | | Release date: | 2015-07-08 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.01 Å) | | Cite: | Crystal structure of ORC2 C-terminal domain
To Be Published
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7CTE
 | | Human Origin Recognition Complex, ORC2-5 | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Origin recognition complex subunit 2, Origin recognition complex subunit 3, ... | | Authors: | Cheng, J, Li, N, Wang, X, Hu, J, Zhai, Y, Gao, N. | | Deposit date: | 2020-08-18 | | Release date: | 2021-01-06 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Structural insight into the assembly and conformational activation of human origin recognition complex.
Cell Discov, 6, 2020
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5UJ8
 | | Human Origin Recognition Complex subunits 2 and 3 | | Descriptor: | Origin recognition complex subunit 2, Origin recognition complex subunit 3 | | Authors: | Tocilj, A, On, K.F, Elkayam, E, Joshua-Tor, L. | | Deposit date: | 2017-01-17 | | Release date: | 2017-02-08 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (6 Å) | | Cite: | Structure of the active form of human Origin Recognition Complex and its ATPase motor module.
Elife, 6, 2017
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7JPQ
 | | ORC-O2-5: Human Origin Recognition Complex (ORC) with subunits 2,3,4,5 | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Origin recognition complex subunit 2, ... | | Authors: | Jaremko, M.J, Joshua-Tor, L. | | Deposit date: | 2020-08-09 | | Release date: | 2020-09-02 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | The dynamic nature of the human Origin Recognition Complex revealed through five cryoEM structures.
Elife, 9, 2020
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8ZP4
 | | Cryo-EM structure of origin recognition complex (Orc1 to 5) with ARS1 DNA bound | | Descriptor: | DNA (31-MER), MAGNESIUM ION, Origin recognition complex subunit 1, ... | | Authors: | Lam, W.H, Yu, D, Dang, S, Zhai, Y. | | Deposit date: | 2024-05-29 | | Release date: | 2025-04-16 | | Method: | ELECTRON MICROSCOPY (3.33 Å) | | Cite: | DNA bending mediated by ORC is essential for replication licensing in budding yeast.
Proc.Natl.Acad.Sci.USA, 122, 2025
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8RWV
 | | Human OCCM DNA licensing intermediate | | Descriptor: | Cell division control protein 6 homolog, DNA, DNA replication factor Cdt1, ... | | Authors: | Wells, J.N, Leber, V, Edwards, L.V, Allyjaun, S, Peach, M, Tomkins, J, Kefala-Stavridi, A, Faull, S.V, Aramayo, R, Pestana, C.M, Ranjha, L, Speck, C. | | Deposit date: | 2024-02-05 | | Release date: | 2025-02-05 | | Method: | ELECTRON MICROSCOPY (6.68 Å) | | Cite: | Reconstitution of human DNA licensing and the structural and functional analysis of key intermediates.
Nat Commun, 16, 2025
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7MCA
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4XGC
 | | Crystal structure of the eukaryotic origin recognition complex | | Descriptor: | CHLORIDE ION, Origin recognition complex subunit 1, Origin recognition complex subunit 2, ... | | Authors: | Bleichert, F, Botchan, M.R, Berger, J.M. | | Deposit date: | 2014-12-30 | | Release date: | 2015-04-01 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Crystal structure of the eukaryotic origin recognition complex.
Nature, 519, 2015
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5ZR1
 | | Saccharomyces Cerevisiae Origin Recognition Complex Bound to a 72-bp Origin DNA containing ACS and B1 element | | Descriptor: | 72bp-oring DNA, ACS305, A-rich, ... | | Authors: | Li, N, Lam, W.H, Zhai, Y, Cheng, J, Cheng, E, Zhao, Y, Gao, N, Tye, B.K. | | Deposit date: | 2018-04-21 | | Release date: | 2018-07-11 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structure of the origin recognition complex bound to DNA replication origin.
Nature, 559, 2018
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6RQC
 | | Cryo-EM structure of an MCM loading intermediate | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, DNA (88-MER), ... | | Authors: | Miller, T.C.R, Locke, J, Costa, A. | | Deposit date: | 2019-05-15 | | Release date: | 2019-11-20 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (4.4 Å) | | Cite: | Mechanism of head-to-head MCM double-hexamer formation revealed by cryo-EM.
Nature, 575, 2019
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7CTG
 | | Human Origin Recognition Complex, ORC1-5 State I | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Origin recognition complex subunit 1, Origin recognition complex subunit 2, ... | | Authors: | Cheng, J, Li, N, Wang, X, Hu, J, Zhai, Y, Gao, N. | | Deposit date: | 2020-08-18 | | Release date: | 2021-01-06 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (5 Å) | | Cite: | Structural insight into the assembly and conformational activation of human origin recognition complex.
Cell Discov, 6, 2020
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7CTF
 | | Human origin recognition complex 1-5 State II | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Origin recognition complex subunit 1, Origin recognition complex subunit 2, ... | | Authors: | Cheng, J, Li, N, Wang, X, Hu, J, Zhai, Y, Gao, N. | | Deposit date: | 2020-08-18 | | Release date: | 2021-01-06 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (4.8 Å) | | Cite: | Structural insight into the assembly and conformational activation of human origin recognition complex.
Cell Discov, 6, 2020
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8ZPK
 | | Cryo-EM structure of origin recognition complex (Orc6 with residues 1 to 270 deleted) with ARS1 DNA bound | | Descriptor: | DNA (38-MER), DNA (40-MER), MAGNESIUM ION, ... | | Authors: | Lam, W.H, Yu, D, Dang, S, Zhai, Y. | | Deposit date: | 2024-05-30 | | Release date: | 2025-04-16 | | Method: | ELECTRON MICROSCOPY (3.21 Å) | | Cite: | DNA bending mediated by ORC is essential for replication licensing in budding yeast.
Proc.Natl.Acad.Sci.USA, 122, 2025
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8ZP5
 | | Cryo-EM structure of origin recognition complex (Orc5 basic patch mutations) with ARS1 DNA bound | | Descriptor: | DNA (34-MER), DNA (35-MER), MAGNESIUM ION, ... | | Authors: | Lam, W.H, Yu, D, Dang, S, Zhai, Y. | | Deposit date: | 2024-05-29 | | Release date: | 2025-04-16 | | Method: | ELECTRON MICROSCOPY (2.98 Å) | | Cite: | DNA bending mediated by ORC is essential for replication licensing in budding yeast.
Proc.Natl.Acad.Sci.USA, 122, 2025
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5UJM
 | | Structure of the active form of human Origin Recognition Complex and its ATPase motor module | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Origin recognition complex subunit 1, ... | | Authors: | Tocilj, A, On, K, Yuan, Z, Sun, J, Elkayam, E, Li, H, Stillman, B, Joshua-Tor, L. | | Deposit date: | 2017-01-18 | | Release date: | 2017-02-08 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (18 Å) | | Cite: | Structure of the active form of human Origin Recognition Complex and its ATPase motor module.
Elife, 6, 2017
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9BCX
 | | Cryo-EM structure of the S. cerevisiae ORC-Cdc6-Mcm2-7-DNA complex with a fully closed Mcm2-Mcm5 DNA entry gate | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 6, DNA (39-MER), ... | | Authors: | Yuan, Z, Bai, L, Li, H, Speck, C. | | Deposit date: | 2024-04-10 | | Release date: | 2025-01-01 | | Last modified: | 2025-01-15 | | Method: | ELECTRON MICROSCOPY (6.1 Å) | | Cite: | MCM2-7 ring closure involves the Mcm5 C-terminus and triggers Mcm4 ATP hydrolysis.
Nat Commun, 16, 2025
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6WGI
 | | Atomic model of the mutant OCCM (ORC-Cdc6-Cdt1-Mcm2-7 with Mcm6 WHD truncation) loaded on DNA at 10.5 A resolution | | Descriptor: | Cell division control protein 6, Cell division cycle protein CDT1, DNA (34-MER), ... | | Authors: | Yuan, Z, Schneider, S, Dodd, T, Riera, A, Bai, L, Yan, C, Magdalou, I, Ivanov, I, Stillman, B, Li, H, Speck, C. | | Deposit date: | 2020-04-05 | | Release date: | 2020-07-15 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (10 Å) | | Cite: | Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6.
Proc.Natl.Acad.Sci.USA, 117, 2020
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9GJP
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9GJW
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9GM5
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6WGG
 | | Atomic model of pre-insertion mutant OCCM-DNA complex(ORC-Cdc6-Cdt1-Mcm2-7 with Mcm6 WHD truncation) | | Descriptor: | Cell division control protein 6, Cell division cycle protein CDT1, DNA (41-MER), ... | | Authors: | Yuan, Z, Schneider, S, Dodd, T, Riera, A, Bai, L, Yan, C, Magdalou, I, Ivanov, I, Stillman, B, Li, H, Speck, C. | | Deposit date: | 2020-04-05 | | Release date: | 2020-07-15 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (8.1 Å) | | Cite: | Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6.
Proc.Natl.Acad.Sci.USA, 117, 2020
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6WGC
 | | Atomic model of semi-attached mutant OCCM-DNA complex (ORC-Cdc6-Cdt1-Mcm2-7 with Mcm6 WHD truncation) | | Descriptor: | Cell division control protein 6, DNA (41-MER), DNA replication licensing factor MCM3, ... | | Authors: | Yuan, Z, Schneider, S, Dodd, T, Riera, A, Bai, L, Yan, C, Magdalou, I, Ivanov, I, Stillman, B, Li, H, Speck, C. | | Deposit date: | 2020-04-05 | | Release date: | 2020-07-15 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (4.3 Å) | | Cite: | Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6.
Proc.Natl.Acad.Sci.USA, 117, 2020
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5V8F
 | | Structural basis of MCM2-7 replicative helicase loading by ORC-Cdc6 and Cdt1 | | Descriptor: | Cell division control protein 6, Cell division cycle protein CDT1, DNA (39-MER), ... | | Authors: | Yuan, Z, Riera, A, Bai, L, Sun, J, Spanos, C, Chen, Z.A, Barbon, M, Rappsilber, J, Stillman, B, Speck, C, Li, H. | | Deposit date: | 2017-03-21 | | Release date: | 2017-05-10 | | Last modified: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Structural basis of Mcm2-7 replicative helicase loading by ORC-Cdc6 and Cdt1.
Nat. Struct. Mol. Biol., 24, 2017
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8S0C
 | | H. sapiens ORC1-5 bound to double stranded DNA as part of the MCM-ORC complex | | Descriptor: | DNA (26-mer), Isoform 2 of Origin recognition complex subunit 3, MAGNESIUM ION, ... | | Authors: | Greiwe, J.F, Weissmann, F, Diffley, J.F.X, Costa, A. | | Deposit date: | 2024-02-13 | | Release date: | 2024-10-02 | | Last modified: | 2024-12-25 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | MCM double hexamer loading visualized with human proteins.
Nature, 636, 2024
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8S0F
 | | H. sapiens OC1M bound to double stranded DNA | | Descriptor: | DNA (39-mer), DNA replication factor Cdt1, DNA replication licensing factor MCM2, ... | | Authors: | Greiwe, J.F, Weissmann, F, Diffley, J.F.X, Costa, A. | | Deposit date: | 2024-02-13 | | Release date: | 2024-10-02 | | Last modified: | 2024-12-25 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | MCM double hexamer loading visualized with human proteins.
Nature, 636, 2024
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