7JSJ
 
 | | Structure of the NaCT-PF2 complex | | Descriptor: | (2R)-2-[2-(4-tert-butylphenyl)ethyl]-2-hydroxybutanedioic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, SODIUM ION, ... | | Authors: | Sauer, D.B, Wang, B, Song, J, Rice, W.J, Wang, D.N. | | Deposit date: | 2020-08-14 | | Release date: | 2021-02-24 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.12 Å) | | Cite: | Structure and inhibition mechanism of the human citrate transporter NaCT.
Nature, 591, 2021
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7JSK
 | | Structure of the NaCT-Citrate complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CITRIC ACID, SODIUM ION, ... | | Authors: | Sauer, D.B, Wang, B, Song, J, Rice, W.J, Wang, D.N. | | Deposit date: | 2020-08-14 | | Release date: | 2021-02-24 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.04 Å) | | Cite: | Structure and inhibition mechanism of the human citrate transporter NaCT.
Nature, 591, 2021
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6WU1
 | | Structure of apo LaINDY | | Descriptor: | DASS family sodium-coupled anion symporter, DECANE, HEXANE, ... | | Authors: | Sauer, D.B, Marden, J.J, Cocco, N.C, Song, J.M, Wang, D.N, New York Consortium on Membrane Protein Structure (NYCOMPS) | | Deposit date: | 2020-05-04 | | Release date: | 2020-09-16 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.09 Å) | | Cite: | Structural basis for the reaction cycle of DASS dicarboxylate transporters.
Elife, 9, 2020
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6WU2
 | | Structure of the LaINDY-malate complex | | Descriptor: | DASS family sodium-coupled anion symporter, DECANE, HEXANE, ... | | Authors: | Sauer, D.B, Marden, J.J, Cocco, N, Song, J.M, Wang, D.N, New York Consortium on Membrane Protein Structure (NYCOMPS) | | Deposit date: | 2020-05-04 | | Release date: | 2020-09-16 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.36 Å) | | Cite: | Structural basis for the reaction cycle of DASS dicarboxylate transporters.
Elife, 9, 2020
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6WTW
 | | Structure of LaINDY crystallized in the presence of alpha-ketoglutarate and malate | | Descriptor: | DASS family sodium-coupled anion symporter | | Authors: | Sauer, D.B, Cocco, N, Marden, J.J, Song, J.M, Wang, D.N, New York Consortium on Membrane Protein Structure (NYCOMPS) | | Deposit date: | 2020-05-04 | | Release date: | 2020-09-16 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.86 Å) | | Cite: | Structural basis for the reaction cycle of DASS dicarboxylate transporters.
Elife, 9, 2020
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6WU4
 | | Structure of the LaINDY-alpha-ketoglutarate complex | | Descriptor: | DASS family sodium-coupled anion symporter | | Authors: | Sauer, D.B, Marden, J.J, Cocco, N, Song, J.M, Wang, D.N, New York Consortium on Membrane Protein Structure (NYCOMPS) | | Deposit date: | 2020-05-04 | | Release date: | 2020-09-16 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.71 Å) | | Cite: | Structural basis for the reaction cycle of DASS dicarboxylate transporters.
Elife, 9, 2020
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8ZKW
 | | Cryo-EM structure of the Drosophila INDY (apo-asymmetric, pH 6) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, PHOSPHATIDYLETHANOLAMINE, Protein I'm not dead yet | | Authors: | Kim, S, Park, J.G, Choi, S.H, Kim, J.W, Jin, M.S. | | Deposit date: | 2024-05-17 | | Release date: | 2025-01-29 | | Last modified: | 2025-08-13 | | Method: | ELECTRON MICROSCOPY (2.77 Å) | | Cite: | Cryo-EM structures reveal the H + /citrate symport mechanism of Drosophila INDY.
Life Sci Alliance, 8, 2025
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8ZL1
 | | Cryo-EM structure of the Drosophila INDY (apo outward-open, pH 6) | | Descriptor: | PHOSPHATIDYLETHANOLAMINE, Protein I'm not dead yet | | Authors: | Kim, S, Park, J.G, Choi, S.H, Kim, J.W, Jin, M.S. | | Deposit date: | 2024-05-17 | | Release date: | 2025-01-29 | | Last modified: | 2025-08-13 | | Method: | ELECTRON MICROSCOPY (2.86 Å) | | Cite: | Cryo-EM structures reveal the H + /citrate symport mechanism of Drosophila INDY.
Life Sci Alliance, 8, 2025
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8ZKZ
 | | Cryo-EM structure of the Drosophila INDY (apo-asymmetric, pH8) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, PHOSPHATIDYLETHANOLAMINE, Protein I'm not dead yet | | Authors: | Kim, S, Park, J.G, Choi, S.H, Kim, J.W, Jin, M.S. | | Deposit date: | 2024-05-17 | | Release date: | 2025-01-29 | | Last modified: | 2025-08-13 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Cryo-EM structures reveal the H + /citrate symport mechanism of Drosophila INDY.
Life Sci Alliance, 8, 2025
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8ZL2
 | | Cryo-EM structure of the Drosophila INDY (DIDS-bound asymmetric, pH 6) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4,4'-Diisothiocyano-2,2'-stilbenedisulfonic acid, PHOSPHATIDYLETHANOLAMINE, ... | | Authors: | Kim, S, Park, J.G, Choi, S.H, Kim, J.W, Jin, M.S. | | Deposit date: | 2024-05-17 | | Release date: | 2025-01-29 | | Last modified: | 2025-08-13 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Cryo-EM structures reveal the H + /citrate symport mechanism of Drosophila INDY.
Life Sci Alliance, 8, 2025
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8ZL3
 | | Cryo-EM structure of the Drosophila INDY (DIDS-bound outward-open, pH 6) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4,4'-Diisothiocyano-2,2'-stilbenedisulfonic acid, PHOSPHATIDYLETHANOLAMINE, ... | | Authors: | Kim, S, Park, J.G, Choi, S.H, Kim, J.W, Jin, M.S. | | Deposit date: | 2024-05-17 | | Release date: | 2025-01-29 | | Last modified: | 2025-08-13 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Cryo-EM structures reveal the H + /citrate symport mechanism of Drosophila INDY.
Life Sci Alliance, 8, 2025
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8ZL6
 | | Cryo-EM structure of the Drosophila INDY (apo inward-open, pH 8) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, PHOSPHATIDYLETHANOLAMINE, Protein I'm not dead yet | | Authors: | Kim, S, Park, J.G, Choi, S.H, Kim, J.W, Jin, M.S. | | Deposit date: | 2024-05-17 | | Release date: | 2025-01-29 | | Last modified: | 2025-08-13 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Cryo-EM structures reveal the H + /citrate symport mechanism of Drosophila INDY.
Life Sci Alliance, 8, 2025
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8ZL4
 | | Cryo-EM structure of the Drosophila INDY (citrate-bound inward-occluded, pH 6) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CITRATE ANION, PHOSPHATIDYLETHANOLAMINE, ... | | Authors: | Kim, S, Park, J.G, Choi, S.H, Kim, J.W, Jin, M.S. | | Deposit date: | 2024-05-17 | | Release date: | 2025-01-29 | | Last modified: | 2025-08-13 | | Method: | ELECTRON MICROSCOPY (3.65 Å) | | Cite: | Cryo-EM structures reveal the H + /citrate symport mechanism of Drosophila INDY.
Life Sci Alliance, 8, 2025
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8UVF
 | | Structure of NaDC3-DMS complex in Ci-Ci conformation | | Descriptor: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, CHOLESTEROL, Na(+)/dicarboxylate cotransporter 3, ... | | Authors: | Li, Y, Wang, D.N, Mindell, J.A, Rice, W.J, Song, J, Mikusevic, V, Marden, J.J, Becerril, A, Kuang, H, Wang, B. | | Deposit date: | 2023-11-02 | | Release date: | 2024-12-25 | | Last modified: | 2025-04-02 | | Method: | ELECTRON MICROSCOPY (2.17 Å) | | Cite: | Substrate translocation and inhibition in human dicarboxylate transporter NaDC3.
Nat.Struct.Mol.Biol., 32, 2025
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8UVB
 | | Structure of NaCT-PF4a complex | | Descriptor: | (2R)-2-hydroxy-2-[2-(2-methoxy-5-methylpyridin-3-yl)ethyl]butanedioic acid, SODIUM ION, Solute carrier family 13 member 5 | | Authors: | Li, Y, Wang, D.N, Mindell, J.A, Rice, W.J, Song, J, Mikusevic, V, Marden, J.J, Becerril, A, Kuang, H, Wang, B. | | Deposit date: | 2023-11-02 | | Release date: | 2024-12-25 | | Last modified: | 2025-04-02 | | Method: | ELECTRON MICROSCOPY (2.13 Å) | | Cite: | Substrate translocation and inhibition in human dicarboxylate transporter NaDC3.
Nat.Struct.Mol.Biol., 32, 2025
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8UVC
 | | Structure of NaDC3-aKG complex | | Descriptor: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-OXOGLUTARIC ACID, CHOLESTEROL, ... | | Authors: | Li, Y, Wang, D.N, Mindell, J.A, Rice, W.J, Song, J, Mikusevic, V, Marden, J.J, Becerril, A, Kuang, H, Wang, B. | | Deposit date: | 2023-11-02 | | Release date: | 2024-12-25 | | Last modified: | 2025-04-02 | | Method: | ELECTRON MICROSCOPY (2.09 Å) | | Cite: | Substrate translocation and inhibition in human dicarboxylate transporter NaDC3.
Nat.Struct.Mol.Biol., 32, 2025
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8UVE
 | | Structure of NaDC3-Succinate complex in Coo-Ci conformation | | Descriptor: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, CHOLESTEROL, Na(+)/dicarboxylate cotransporter 3, ... | | Authors: | Li, Y, Wang, D.N, Mindell, J.A, Rice, W.J, Song, J, Mikusevic, V, Marden, J.J, Becerril, A, Kuang, H, Wang, B. | | Deposit date: | 2023-11-02 | | Release date: | 2024-12-25 | | Last modified: | 2025-04-02 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | Substrate translocation and inhibition in human dicarboxylate transporter NaDC3.
Nat.Struct.Mol.Biol., 32, 2025
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8UVG
 | | Structure of NaDC3-DMS complex in Co-Ci conformation | | Descriptor: | (2R,3S)-2,3-dimethylbutanedioic acid, 1,2-Distearoyl-sn-glycerophosphoethanolamine, CHOLESTEROL, ... | | Authors: | Li, Y, Wang, D.N, Mindell, J.A, Rice, W.J, Song, J, Mikusevic, V, Marden, J.J, Becerril, A, Kuang, H, Wang, B. | | Deposit date: | 2023-11-02 | | Release date: | 2024-12-25 | | Last modified: | 2025-04-02 | | Method: | ELECTRON MICROSCOPY (2.92 Å) | | Cite: | Substrate translocation and inhibition in human dicarboxylate transporter NaDC3.
Nat.Struct.Mol.Biol., 32, 2025
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8UVH
 | | Structure of NaCT-succ complex | | Descriptor: | Solute carrier family 13 member 5 | | Authors: | Li, Y, Wang, D.N, Mindell, J.A, Rice, W.J, Song, J, Mikusevic, V, Marden, J.J, Becerril, A, Kuang, H, Wang, B. | | Deposit date: | 2023-11-02 | | Release date: | 2024-12-25 | | Last modified: | 2025-04-02 | | Method: | ELECTRON MICROSCOPY (2.33 Å) | | Cite: | Substrate translocation and inhibition in human dicarboxylate transporter NaDC3.
Nat.Struct.Mol.Biol., 32, 2025
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8UVI
 | | Structure of NaDC3-Succinate complex in Coo-Coo conformation | | Descriptor: | CHOLESTEROL, Na(+)/dicarboxylate cotransporter 3, SODIUM ION, ... | | Authors: | Li, Y, Wang, D.N, Mindell, J.A, Rice, W.J, Song, J, Mikusevic, V, Marden, J.J, Becerril, A, Kuang, H, Wang, B. | | Deposit date: | 2023-11-03 | | Release date: | 2024-12-25 | | Last modified: | 2025-04-02 | | Method: | ELECTRON MICROSCOPY (2.53 Å) | | Cite: | Substrate translocation and inhibition in human dicarboxylate transporter NaDC3.
Nat.Struct.Mol.Biol., 32, 2025
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8UVD
 | | Structure of NaDC3-PF4a complex | | Descriptor: | (2R)-2-hydroxy-2-[2-(2-methoxy-5-methylpyridin-3-yl)ethyl]butanedioic acid, 1,2-Distearoyl-sn-glycerophosphoethanolamine, CHOLESTEROL, ... | | Authors: | Li, Y, Wang, D.N, Mindell, J.A, Rice, W.J, Song, J, Mikusevic, V, Marden, J.J, Becerril, A, Kuang, H, Wang, B. | | Deposit date: | 2023-11-02 | | Release date: | 2024-12-25 | | Last modified: | 2025-04-02 | | Method: | ELECTRON MICROSCOPY (2.16 Å) | | Cite: | Substrate translocation and inhibition in human dicarboxylate transporter NaDC3.
Nat.Struct.Mol.Biol., 32, 2025
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8W6D
 | | CryoEM structure of NaDC1 in apo state | | Descriptor: | 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, CHOLESTEROL HEMISUCCINATE, SODIUM ION, ... | | Authors: | Chi, X, Chen, Y, Li, Y, Zhang, Y, Shen, Y, Chen, Y, Wang, Z, Yan, R. | | Deposit date: | 2023-08-28 | | Release date: | 2024-04-17 | | Method: | ELECTRON MICROSCOPY (2.5 Å) | | Cite: | Cryo-EM structures of the human NaS1 and NaDC1 transporters revealed the elevator transport and allosteric regulation mechanism.
Sci Adv, 10, 2024
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8W6N
 | | NaS1 with sulfate in IN/OUT state | | Descriptor: | SODIUM ION, SULFATE ION, Solute carrier family 13 member 1 | | Authors: | Chi, X, Chen, Y, Li, Y, Zhang, Y, Shen, Y, Chen, Y, Wang, Z, Yan, R. | | Deposit date: | 2023-08-29 | | Release date: | 2024-04-17 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Cryo-EM structures of the human NaS1 and NaDC1 transporters revealed the elevator transport and allosteric regulation mechanism.
Sci Adv, 10, 2024
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8W6O
 | | NaS1 in IN/IN state | | Descriptor: | CHOLESTEROL, SODIUM ION, Solute carrier family 13 member 1 | | Authors: | Chi, X, Chen, Y, Li, Y, Zhang, Y, Shen, Y, Chen, Y, Wang, Z, Yan, R. | | Deposit date: | 2023-08-29 | | Release date: | 2024-04-17 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Cryo-EM structures of the human NaS1 and NaDC1 transporters revealed the elevator transport and allosteric regulation mechanism.
Sci Adv, 10, 2024
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8W6G
 | | NaDC1 with inhibitor ACA | | Descriptor: | 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, 2-[[(~{E})-3-(4-pentylphenyl)prop-2-enoyl]amino]benzoic acid, CHOLESTEROL HEMISUCCINATE, ... | | Authors: | Chi, X, Chen, Y, Li, Y, Zhang, Y, Shen, Y, Chen, Y, Wang, Z, Yan, R. | | Deposit date: | 2023-08-28 | | Release date: | 2024-04-17 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Cryo-EM structures of the human NaS1 and NaDC1 transporters revealed the elevator transport and allosteric regulation mechanism.
Sci Adv, 10, 2024
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