1WWL
 
 | | Crystal structure of CD14 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Monocyte differentiation antigen CD14 | | Authors: | Kim, J.-I, Lee, C.J, Jin, M.S, Lee, C.-H, Paik, S.-G, Lee, H, Lee, J.-O. | | Deposit date: | 2005-01-06 | | Release date: | 2005-02-22 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal Structure of CD14 and Its Implications for Lipopolysaccharide Signaling
J.Biol.Chem., 280, 2005
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3O53
 | | Crystal Structure of LRIM1 leucine-rich repeat domain | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, COBALT (II) ION, ... | | Authors: | Baxter, R.H.G, Steinert, S, Chelliah, Y, Volohonsky, G, Levashina, E.A, Deisenhofer, J. | | Deposit date: | 2010-07-27 | | Release date: | 2010-09-22 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | A heterodimeric complex of the LRR proteins LRIM1 and APL1C regulates complement-like immunity in Anopheles gambiae.
Proc.Natl.Acad.Sci.USA, 107, 2010
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4NKH
 | | Crystal structure of SspH1 LRR domain | | Descriptor: | E3 ubiquitin-protein ligase sspH1 | | Authors: | Keszei, A.F.A, Xiaojing, T, Mccormick, C, Zeqiraj, E, Rohde, J.R, Tyers, M, Sicheri, F. | | Deposit date: | 2013-11-12 | | Release date: | 2013-12-11 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | Structure of an SspH1-PKN1 Complex Reveals the Basis for Host Substrate Recognition and Mechanism of Activation for a Bacterial E3 Ubiquitin Ligase.
Mol.Cell.Biol., 34, 2014
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5IXO
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8SUF
 | | The complex of TOL-1 ectodomain bound to LAT-1 Lectin domain | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Latrophilin-like protein 1, ... | | Authors: | Carmona Rosas, G, Li, J, Arac, D, Ozkan, E. | | Deposit date: | 2023-05-12 | | Release date: | 2024-05-15 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (4 Å) | | Cite: | Structural basis and functional roles for Toll-like receptor binding to Latrophilin adhesion-GPCR in embryo development
To Be Published
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1ZIW
 | | Human Toll-like Receptor 3 extracellular domain structure | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... | | Authors: | Wilson, I.A, Choe, J. | | Deposit date: | 2005-04-27 | | Release date: | 2005-06-28 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal structure of human toll-like receptor 3 (TLR3) ectodomain.
Science, 309, 2005
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4LXS
 | | Structure of the Toll - Spatzle complex, a molecular hub in Drosophila development and innate immunity (glycosylated form) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | | Authors: | Stelter, M, Parthier, C, Breithaupt, C, Stubbs, M.T. | | Deposit date: | 2013-07-30 | | Release date: | 2014-04-09 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Structure of the Toll-Spatzle complex, a molecular hub in Drosophila development and innate immunity.
Proc.Natl.Acad.Sci.USA, 111, 2014
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5MX0
 | | Crystal structure of human fibromodulin | | Descriptor: | CHLORIDE ION, Fibromodulin, NICKEL (II) ION, ... | | Authors: | Paracuellos, P, Hohenester, E. | | Deposit date: | 2017-01-20 | | Release date: | 2017-03-01 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2.21 Å) | | Cite: | Structural and functional analysis of two small leucine-rich repeat proteoglycans, fibromodulin and chondroadherin.
Matrix Biol., 63, 2017
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6W78
 | | crystal structure of a plant ice-binding protein | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Antifreeze polypeptide | | Authors: | Wang, Y.N, Zhang, H.Q. | | Deposit date: | 2020-03-18 | | Release date: | 2021-01-20 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.311 Å) | | Cite: | Carrot 'antifreeze' protein has an irregular ice-binding site that confers weak freezing point depression but strong inhibition of ice recrystallization.
Biochem.J., 477, 2020
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1JL5
 | | Novel Molecular Architecture of YopM-a Leucine-rich Effector Protein from Yersinia pestis | | Descriptor: | CALCIUM ION, outer protein YopM | | Authors: | Evdokimov, A.G, Anderson, D.E, Routzahn, K.M, Waugh, D.S. | | Deposit date: | 2001-07-15 | | Release date: | 2001-10-10 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Unusual molecular architecture of the Yersinia pestis cytotoxin YopM: a leucine-rich repeat protein with the shortest repeating unit.
J.Mol.Biol., 312, 2001
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1OGQ
 | | The crystal structure of PGIP (polygalacturonase inhibiting protein), a leucine rich repeat protein involved in plant defense | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, POLYGALACTURONASE INHIBITING PROTEIN | | Authors: | Di Matteo, A, Federici, L, Mattei, B, Salvi, G, Johnson, K.A, Savino, C, De Lorenzo, G, Tsernoglou, D, Cervone, F. | | Deposit date: | 2003-05-08 | | Release date: | 2003-07-24 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | The Crystal Structure of Polygalacturonase-Inhibiting Protein (Pgip), a Leucine-Rich Repeat Protein Involved in Plant Defense
Proc.Natl.Acad.Sci.USA, 100, 2003
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6NIG
 | | Crystal structure of the human TLR2-Diprovocim complex | | Descriptor: | (3S,4S,3'S,4'S)-1,1'-(1,4-phenylenedicarbonyl)bis{N~3~,N~4~-bis[(1S,2R)-2-phenylcyclopropyl]pyrrolidine-3,4-dicarboxami de}, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Zhang, H, Beutler, B.A, Tomchick, D.R, Su, L. | | Deposit date: | 2018-12-27 | | Release date: | 2019-04-17 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Structural Basis of TLR2/TLR1 Activation by the Synthetic Agonist Diprovocim.
J. Med. Chem., 62, 2019
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3J0A
 | | Homology model of human Toll-like receptor 5 fitted into an electron microscopy single particle reconstruction | | Descriptor: | Toll-like receptor 5, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | | Authors: | Modis, Y, Zhou, K, Kanai, R, Lee, P, Wang, H.W. | | Deposit date: | 2011-06-02 | | Release date: | 2011-12-28 | | Last modified: | 2024-11-20 | | Method: | ELECTRON MICROSCOPY (26 Å) | | Cite: | Toll-like receptor 5 forms asymmetric dimers in the absence of flagellin.
J.Struct.Biol., 177, 2012
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5JFK
 | | Crystal structure of a TDR receptor | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Leucine-rich repeat receptor-like protein kinase TDR | | Authors: | Li, Z, Xu, G. | | Deposit date: | 2016-04-19 | | Release date: | 2017-03-29 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.647 Å) | | Cite: | Crystal structure of a TDR receptor
To Be Published
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1G9U
 | | CRYSTAL STRUCTURE OF YOPM-LEUCINE RICH EFFECTOR PROTEIN FROM YERSINIA PESTIS | | Descriptor: | ACETATE ION, CALCIUM ION, MERCURY (II) ION, ... | | Authors: | Evdokimov, A.G, Anderson, D.E, Routzahn, K.M, Waugh, D.S. | | Deposit date: | 2000-11-28 | | Release date: | 2001-10-10 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Unusual molecular architecture of the Yersinia pestis cytotoxin YopM: a leucine-rich repeat protein with the shortest repeating unit.
J.Mol.Biol., 312, 2001
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2A0Z
 | | The molecular structure of toll-like receptor 3 ligand binding domain | | Descriptor: | 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Bell, J.K, Botos, I, Hall, P.R, Askins, J, Shiloach, J, Segal, D.M, Davies, D.R. | | Deposit date: | 2005-06-17 | | Release date: | 2005-08-02 | | Last modified: | 2025-03-26 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | The molecular structure of the Toll-like receptor 3 ligand-binding domain
Proc.Natl.Acad.Sci.USA, 102, 2005
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8ZGD
 | | The Crystal Structure of the NLRP1_LRR domain from Biortus. | | Descriptor: | GLYCEROL, NACHT, LRR and PYD domains-containing protein 1, ... | | Authors: | Wang, F, Cheng, W, Yuan, Z, Qi, J, Pan, W. | | Deposit date: | 2024-05-09 | | Release date: | 2024-06-26 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | The Crystal Structure of the NLRP1_LRR domain from Biortus.
To Be Published
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6S6Q
 | | Crystal structure of the LRR ectodomain of the plant membrane receptor kinase GASSHO1/SCHENGEN3 from Arabidopsis thaliana in complex with CASPARIAN STRIP INTEGRITY FACTOR 2. | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, LRR receptor-like serine/threonine-protein kinase GSO1, ... | | Authors: | Okuda, S, Moretti, A, Hothorn, M. | | Deposit date: | 2019-07-03 | | Release date: | 2020-01-29 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2.95 Å) | | Cite: | Molecular mechanism for the recognition of sequence-divergent CIF peptides by the plant receptor kinases GSO1/SGN3 and GSO2.
Proc.Natl.Acad.Sci.USA, 117, 2020
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8YN1
 | | Cryo-EM structure of NRG1A(LRR) in complex with EDS1-SAG101-(ADPr-ATP) | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, ADENOSINE-5-DIPHOSPHORIBOSE, Probable disease resistance protein At5g66900, ... | | Authors: | Huang, S, Xiao, Y, Chai, J. | | Deposit date: | 2024-03-10 | | Release date: | 2024-12-11 | | Last modified: | 2025-03-26 | | Method: | ELECTRON MICROSCOPY (3.09 Å) | | Cite: | Balanced plant helper NLR activation by a modified host protein complex.
Nature, 639, 2025
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7YJW
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6G3W
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6FIF
 | | Crystal structure of the BRI1 Gly644-Asp (bri1-6) mutant from Arabidopsis thaliana. | | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Hothorn, M, Santiago, J, Hohmann, U. | | Deposit date: | 2018-01-18 | | Release date: | 2018-01-31 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.54 Å) | | Cite: | Mechanistic basis for the activation of plant membrane receptor kinases by SERK-family coreceptors.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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3CIY
 | | Mouse Toll-like receptor 3 ectodomain complexed with double-stranded RNA | | Descriptor: | 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Liu, L, Botos, I, Wang, Y, Leonard, J.N, Shiloach, J, Segal, D.M, Davies, D.R. | | Deposit date: | 2008-03-12 | | Release date: | 2008-05-06 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (3.41 Å) | | Cite: | Structural basis of toll-like receptor 3 signaling with double-stranded RNA.
Science, 320, 2008
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6FG7
 | | Crystal structure of the BIR2 ectodomain from Arabidopsis thaliana. | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Inactive LRR receptor-like serine/threonine-protein kinase BIR2, ... | | Authors: | Hothorn, M, Hohmann, U. | | Deposit date: | 2018-01-10 | | Release date: | 2018-01-24 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | The SERK3 elongated allele defines a role for BIR ectodomains in brassinosteroid signalling.
Nat Plants, 4, 2018
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3CIG
 | | Crystal structure of mouse TLR3 ectodomain | | Descriptor: | 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Liu, L, Botos, I, Wang, Y, Leonard, J.N, Shiloach, J, Segal, D.M, Davies, D.R. | | Deposit date: | 2008-03-11 | | Release date: | 2008-05-06 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.66 Å) | | Cite: | Structural basis of toll-like receptor 3 signaling with double-stranded RNA.
Science, 320, 2008
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