1ZIW

Human Toll-like Receptor 3 extracellular domain structure

Summary for 1ZIW

• Entry DOI: 10.2210/pdb1ziw/pdb
• Descriptor: Toll-like receptor 3, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: innate immunity, immune system
• Biological source: Homo sapiens (human)
• Cellular location: Endoplasmic reticulum membrane; Single-pass type I membrane protein: O15455
• Total number of polymer chains: 1
• Total formula weight: 80828.40

Authors

Wilson, I.A.,Choe, J. (deposition date: 2005-04-27, release date: 2005-06-28, Last modification date: 2024-11-13)

Primary citation

Choe, J.,Kelker, M.S.,Wilson, I.A.
Crystal structure of human toll-like receptor 3 (TLR3) ectodomain.
Science, 309:581-585, 2005

PubMed Abstract: Toll-like receptors (TLRs) play key roles in activating immune responses during infection. The human TLR3 ectodomain structure at 2.1 angstroms reveals a large horseshoe-shaped solenoid assembled from 23 leucine-rich repeats (LRRs). Asparagines conserved in the 24-residue LRR motif contribute extensive hydrogen-bonding networks for solenoid stabilization. TLR3 is largely masked by carbohydrate, but one face is glycosylation-free, which suggests its potential role in ligand binding and oligomerization. Highly conserved surface residues and a TLR3-specific LRR insertion form a homodimer interface in the crystal, whereas two patches of positively charged residues and a second insertion would provide an appropriate binding site for double-stranded RNA.

PubMed: 15961631
DOI: 10.1126/science.1115253

Experimental method

X-RAY DIFFRACTION (2.1 Å)