7KWD
 
 | | Crystal structure of Thermus thermophilus alkaline phosphatase | | Descriptor: | Alkaline phosphatase, L(+)-TARTARIC ACID, MAGNESIUM ION, ... | | Authors: | Gallo, G, Coelho, C, Borges, B, Negri, N, Maiello, F, Hardy, L, Wurtele, M. | | Deposit date: | 2020-11-30 | | Release date: | 2021-04-14 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Dynamic cross correlation analysis of Thermus thermophilus alkaline phosphatase and determinants of thermostability.
Biochim Biophys Acta Gen Subj, 1865, 2021
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6T26
 | | X-ray crystal structure of Vibrio alkaline phosphatase with the non-competitive inhibitor cyclohexylamine | | Descriptor: | Alkaline phosphatase, CHLORIDE ION, CYCLOHEXYLAMMONIUM ION, ... | | Authors: | Asgeirsson, B, Hjorleifsson, J.G, Markusson, S, Helland, R. | | Deposit date: | 2019-10-07 | | Release date: | 2020-10-21 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.265 Å) | | Cite: | X-ray crystal structure of Vibrio alkaline phosphatase with the non-competitive inhibitor cyclohexylamine.
Biochem Biophys Rep, 24, 2020
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7TM9
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3WBH
 | | Structural characteristics of alkaline phosphatase from a moderately halophilic bacteria Halomonas sp.593 | | Descriptor: | Alkaline phosphatase, CHLORIDE ION, MAGNESIUM ION, ... | | Authors: | Arai, S, Yonezawa, Y, Ishibashi, M, Matsumoto, F, Tamada, T, Tokunaga, H, Tokunaga, M, Kuroki, R. | | Deposit date: | 2013-05-17 | | Release date: | 2014-03-12 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structural characteristics of alkaline phosphatase from the moderately halophilic bacterium Halomonas sp. 593.
Acta Crystallogr.,Sect.D, 70, 2014
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4YR1
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5TPQ
 | | E. coli alkaline phosphatase D101A, D153A, R166S, E322A, K328A mutant | | Descriptor: | Alkaline phosphatase, PHOSPHATE ION, ZINC ION | | Authors: | Sunden, F, AlSadhan, I, Lyubimov, A.Y, Doukov, T, Swan, J, Herschlag, D. | | Deposit date: | 2016-10-20 | | Release date: | 2017-11-01 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | Differential catalytic promiscuity of the alkaline phosphatase superfamily bimetallo core reveals mechanistic features underlying enzyme evolution.
J. Biol. Chem., 292, 2017
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5C66
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3TG0
 | | E. coli alkaline phosphatase with bound inorganic phosphate | | Descriptor: | Alkaline phosphatase, MAGNESIUM ION, PHOSPHATE ION, ... | | Authors: | Bobyr, E, Lassila, J.K, Wiersma-Koch, H.I, Fenn, T.D, Lee, J.J, Nikolic-Hughes, I, Hodgson, K.O, Rees, D.C, Hedman, B, Herschlag, D. | | Deposit date: | 2011-08-16 | | Release date: | 2011-11-09 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.2 Å) | | Cite: | High-resolution analysis of Zn(2+) coordination in the alkaline phosphatase superfamily by EXAFS and x-ray crystallography.
J.Mol.Biol., 415, 2012
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2IUC
 | | Structure of alkaline phosphatase from the Antarctic bacterium TAB5 | | Descriptor: | ALKALINE PHOSPHATASE, CACODYLATE ION, MAGNESIUM ION, ... | | Authors: | Wang, E, Koutsioulis, D, Leiros, H.K.S, Andersen, O.A, Bouriotis, V, Hough, E, Heikinheimo, P. | | Deposit date: | 2006-06-01 | | Release date: | 2006-11-28 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Crystal Structure of Alkaline Phosphatase from the Antarctic Bacterium Tab5.
J.Mol.Biol., 366, 2007
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6QSQ
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7QOW
 | | Crystal structure of Vibrio alkaline phosphatase in 1.0 M NaCl | | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Alkaline phosphatase, ... | | Authors: | Markusson, S, Hjorleifsson, J.G, Kursula, P, Asgeirsson, B. | | Deposit date: | 2021-12-29 | | Release date: | 2022-11-02 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.2 Å) | | Cite: | Structural Characterization of Functionally Important Chloride Binding Sites in the Marine Vibrio Alkaline Phosphatase.
Biochemistry, 61, 2022
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7QP8
 | | Crystal structure of Vibrio alkaline phosphatase with bound HEPES | | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Alkaline phosphatase, CHLORIDE ION, ... | | Authors: | Markusson, S, Hjorleifsson, J.G, Kursula, P, Asgeirsson, B. | | Deposit date: | 2022-01-03 | | Release date: | 2022-11-02 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structural Characterization of Functionally Important Chloride Binding Sites in the Marine Vibrio Alkaline Phosphatase.
Biochemistry, 61, 2022
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2MLZ
 | | NMR structure of E. coli Trigger Factor in complex with unfolded PhoA365-471 | | Descriptor: | Alkaline phosphatase, Trigger factor | | Authors: | Saio, T, Guan, X, Rossi, P, Economou, A, Kalodimos, C.G. | | Deposit date: | 2014-03-05 | | Release date: | 2014-05-21 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | Structural basis for protein antiaggregation activity of the trigger factor chaperone.
Science, 344, 2014
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4KJD
 | | RatIntestinal AP expressed in E. coli | | Descriptor: | GLYCEROL, Intestinal-type alkaline phosphatase 1, MAGNESIUM ION | | Authors: | Ghosh, K, Anumula, R.K, Laksmaiah, B.K. | | Deposit date: | 2013-05-03 | | Release date: | 2013-10-16 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.21 Å) | | Cite: | Crystal structure of rat intestinal alkaline phosphatase - Role of crown domain in mammalian alkaline phosphatases.
J.Struct.Biol., 184, 2013
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4KJG
 | | Structure of Rat Intestinal Alkaline Phosphatase expressed in insect cell | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Ghosh, K, Anumula, R.K, Laksmaiah, B.K. | | Deposit date: | 2013-05-03 | | Release date: | 2013-10-16 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.38 Å) | | Cite: | Crystal structure of rat intestinal alkaline phosphatase - Role of crown domain in mammalian alkaline phosphatases.
J.Struct.Biol., 184, 2013
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4KM4
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3MK1
 | | Refinement of placental alkaline phosphatase complexed with nitrophenyl | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, Alkaline phosphatase, ... | | Authors: | Stec, B, Cheltsov, A, Millan, J.L. | | Deposit date: | 2010-04-13 | | Release date: | 2011-01-19 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (1.57 Å) | | Cite: | Refined structures of placental alkaline phosphatase show a consistent pattern of interactions at the peripheral site.
Acta Crystallogr.,Sect.F, 66, 2010
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3MK0
 | | Refinement of placental alkaline phosphatase complexed with nitrophenyl | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, Alkaline phosphatase, ... | | Authors: | Stec, B, Cheltsov, A, Millan, J.L. | | Deposit date: | 2010-04-13 | | Release date: | 2011-01-19 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Refined structures of placental alkaline phosphatase show a consistent pattern of interactions at the peripheral site.
Acta Crystallogr.,Sect.F, 66, 2010
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3MK2
 | | Placental alkaline phosphatase complexed with Phe | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, Alkaline phosphatase, ... | | Authors: | Stec, B, Cheltsov, A, Millan, J.L. | | Deposit date: | 2010-04-13 | | Release date: | 2011-01-19 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (1.89 Å) | | Cite: | Refined structures of placental alkaline phosphatase show a consistent pattern of interactions at the peripheral site.
Acta Crystallogr.,Sect.F, 66, 2010
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2W5W
 | | Structure of TAB5 alkaline phosphatase mutant His 135 Asp with Zn bound in the M3 site. | | Descriptor: | ALKALINE PHOSPHATASE, ZINC ION | | Authors: | Koutsioulis, D, Lyskowski, A, Maki, S, Guthrie, E, Feller, G, Bouriotis, V, Heikinheimo, P. | | Deposit date: | 2008-12-15 | | Release date: | 2009-11-24 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.79 Å) | | Cite: | Coordination Sphere of the Third Metal Site is Essential to the Activity and Metal Selectivity of Alkaline Phosphatases.
Protein Sci., 19, 2010
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2W5X
 | | Structure of TAB5 alkaline phosphatase mutant His 135 Glu with Mg bound in the M3 site. | | Descriptor: | ALKALINE PHOSPHATASE, MAGNESIUM ION, ZINC ION | | Authors: | Koutsioulis, D, Lyskowski, A, Maki, S, Guthrie, E, Feller, G, Bouriotis, V, Heikinheimo, P. | | Deposit date: | 2008-12-15 | | Release date: | 2009-11-24 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.99 Å) | | Cite: | Coordination Sphere of the Third Metal Site is Essential to the Activity and Metal Selectivity of Alkaline Phosphatases.
Protein Sci., 19, 2010
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2W5V
 | | Structure of TAB5 alkaline phosphatase mutant His 135 Asp with Mg bound in the M3 site. | | Descriptor: | ALKALINE PHOSPHATASE, MAGNESIUM ION, ZINC ION | | Authors: | Koutsioulis, D, Lyskowski, A, Maki, S, Guthrie, E, Feller, G, Bouriotis, V, Heikinheimo, P. | | Deposit date: | 2008-12-15 | | Release date: | 2009-11-24 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.78 Å) | | Cite: | Coordination Sphere of the Third Metal Site is Essential to the Activity and Metal Selectivity of Alkaline Phosphatases.
Protein Sci., 19, 2010
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2ANH
 | | ALKALINE PHOSPHATASE (D153H) | | Descriptor: | ALKALINE PHOSPHATASE, PHOSPHATE ION, ZINC ION | | Authors: | Murphy, J.E, Tibbitts, T.T, Kantrowitz, E.R. | | Deposit date: | 1995-09-06 | | Release date: | 1996-01-29 | | Last modified: | 2021-11-03 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Mutations at positions 153 and 328 in Escherichia coli alkaline phosphatase provide insight towards the structure and function of mammalian and yeast alkaline phosphatases.
J.Mol.Biol., 253, 1995
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3CMR
 | | E. coli alkaline phosphatase mutant R166S in complex with phosphate | | Descriptor: | Alkaline phosphatase, MAGNESIUM ION, PHOSPHATE ION, ... | | Authors: | O'Brien, P.J, Lassila, J.K, Fenn, T.D, Zalatan, J.G, Herschlag, D. | | Deposit date: | 2008-03-24 | | Release date: | 2008-07-29 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Arginine coordination in enzymatic phosphoryl transfer: evaluation of the effect of Arg166 mutations in Escherichia coli alkaline phosphatase
Biochemistry, 47, 2008
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3DPC
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