5QT3
| Ground state model of human erythroid-specific 5'-aminolevulinate synthase, ALAS2 - SGC Diamond Xchem fragment screening | Descriptor: | 5-aminolevulinate synthase, erythroid-specific, mitochondrial, ... | Authors: | Bezerra, G.A, Foster, W, Bailey, H, Shrestha, L, Krojer, T, Talon, R, Brandao-Neto, J, Douangamath, A, Nicola, B.B, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Brennan, P.E, Yue, W.W. | Deposit date: | 2019-06-28 | Release date: | 2019-08-07 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | PanDDA analysis group deposition of ground-state model To Be Published
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1C7N
| CRYSTAL STRUCTURE OF CYSTALYSIN FROM TREPONEMA DENTICOLA CONTAINS A PYRIDOXAL 5'-PHOSPHATE COFACTOR | Descriptor: | CYSTALYSIN, PYRIDOXAL-5'-PHOSPHATE | Authors: | Krupka, H.I, Huber, R, Holt, S.C, Clausen, T. | Deposit date: | 2000-03-16 | Release date: | 2000-07-26 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure of cystalysin from Treponema denticola: a pyridoxal 5'-phosphate-dependent protein acting as a haemolytic enzyme. EMBO J., 19, 2000
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1C9C
| ASPARTATE AMINOTRANSFERASE COMPLEXED WITH C3-PYRIDOXAL-5'-PHOSPHATE | Descriptor: | ALANYL-PYRIDOXAL-5'-PHOSPHATE, ASPARTATE AMINOTRANSFERASE | Authors: | Ishijima, J, Nakai, T, Kawaguchi, S, Hirotsu, K, Kuramitsu, S. | Deposit date: | 1999-08-02 | Release date: | 2000-12-20 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Free energy requirement for domain movement of an enzyme J.Biol.Chem., 275, 2000
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1C7O
| CRYSTAL STRUCTURE OF CYSTALYSIN FROM TREPONEMA DENTICOLA CONTAINS A PYRIDOXAL 5'-PHOSPHATE-L-AMINOETHOXYVINYLGLYCINE COMPLEX | Descriptor: | (2E,3E)-4-(2-aminoethoxy)-2-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)imino]but-3-enoic acid, CYSTALYSIN | Authors: | Krupka, H.I, Huber, R, Holt, S.C, Clausen, T. | Deposit date: | 2000-03-16 | Release date: | 2000-07-26 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of cystalysin from Treponema denticola: a pyridoxal 5'-phosphate-dependent protein acting as a haemolytic enzyme. EMBO J., 19, 2000
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1CQ7
| ASPARTATE AMINOTRANSFERASE (E.C. 2.6.1.1) COMPLEXED WITH C5-PYRIDOXAL-5P-PHOSPHATE | Descriptor: | 2-[O-PHOSPHONOPYRIDOXYL]-AMINO-PENTANOIC ACID, ASPARTATE AMINOTRANSFERASE | Authors: | Ishijima, J, Nakai, T, Kawaguchi, S, Hirotsu, K, Kuramitsu, S. | Deposit date: | 1999-08-06 | Release date: | 2000-12-20 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Free energy requirement for domain movement of an enzyme J.Biol.Chem., 275, 2000
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1BJW
| ASPARTATE AMINOTRANSFERASE FROM THERMUS THERMOPHILUS | Descriptor: | ASPARTATE AMINOTRANSFERASE, PHOSPHATE ION | Authors: | Nakai, T, Okada, K, Kuramitsu, S, Hirotsu, K, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 1998-06-30 | Release date: | 1999-07-22 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure of Thermus thermophilus HB8 aspartate aminotransferase and its complex with maleate. Biochemistry, 38, 1999
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1CQ6
| ASPARTATE AMINOTRANSFERASE COMPLEX WITH C4-PYRIDOXAL-5P-PHOSPHATE | Descriptor: | 2-[O-PHOSPHONOPYRIDOXYL]-AMINO- BUTYRIC ACID, ASPARTATE AMINOTRANSFERASE | Authors: | Ishijima, J, Nakai, T, Kawaguchi, S, Hirotsu, K, Kuramitsu, S. | Deposit date: | 1999-08-06 | Release date: | 2000-12-20 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Free energy requirement for domain movement of an enzyme J.Biol.Chem., 275, 2000
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1DJU
| CRYSTAL STRUCTURE OF AROMATIC AMINOTRANSFERASE FROM PYROCOCCUS HORIKOSHII OT3 | Descriptor: | AROMATIC AMINOTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE | Authors: | Matsui, I, Matsui, E, Sakai, Y, Kikuchi, H, Kawarabayashi, H. | Deposit date: | 1999-12-06 | Release date: | 2001-04-11 | Last modified: | 2018-04-18 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The molecular structure of hyperthermostable aromatic aminotransferase with novel substrate specificity from Pyrococcus horikoshii. J.Biol.Chem., 275, 2000
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1FG7
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1FC4
| 2-AMINO-3-KETOBUTYRATE COA LIGASE | Descriptor: | 2-AMINO-3-KETOBUTYRATE CONENZYME A LIGASE, 2-AMINO-3-KETOBUTYRIC ACID, PYRIDOXAL-5'-PHOSPHATE | Authors: | Schmidt, A, Matte, A, Li, Y, Sivaraman, J, Larocque, R, Schrag, J.D, Smith, C, Sauve, V, Cygler, M, Montreal-Kingston Bacterial Structural Genomics Initiative (BSGI) | Deposit date: | 2000-07-17 | Release date: | 2001-05-02 | Last modified: | 2018-01-31 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Three-dimensional structure of 2-amino-3-ketobutyrate CoA ligase from Escherichia coli complexed with a PLP-substrate intermediate: inferred reaction mechanism. Biochemistry, 40, 2001
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5T4J
| PLP and GABA Trigger GabR-Mediated Transcription Regulation in Bacillus subsidies via External Aldimine Formation | Descriptor: | GAMMA-AMINO-BUTANOIC ACID, HTH-type transcriptional regulatory protein GabR, PYRIDOXAL-5'-PHOSPHATE | Authors: | Wu, R, Sanishvili, R, Belitsky, B.R, Juncosa, J.I, Le, H.V, Lehrer, H.J.S, Farley, M, Silverman, R.B, Petsko, G.A, Ringe, D, Liu, D. | Deposit date: | 2016-08-29 | Release date: | 2017-03-29 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.231 Å) | Cite: | PLP and GABA trigger GabR-mediated transcription regulation in Bacillus subtilis via external aldimine formation. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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1FG3
| CRYSTAL STRUCTURE OF L-HISTIDINOL PHOSPHATE AMINOTRANSFERASE COMPLEXED WITH L-HISTIDINOL | Descriptor: | HISTIDINOL PHOSPHATE AMINOTRANSFERASE, PHOSPHORIC ACID MONO-[2-AMINO-3-(3H-IMIDAZOL-4-YL)-PROPYL]ESTER, PYRIDOXAL-5'-PHOSPHATE | Authors: | Sivaraman, J, Cygler, M. | Deposit date: | 2000-07-27 | Release date: | 2001-08-22 | Last modified: | 2017-10-04 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of histidinol phosphate aminotransferase (HisC) from Escherichia coli, and its covalent complex with pyridoxal-5'-phosphate and l-histidinol phosphate. J.Mol.Biol., 311, 2001
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5T4K
| PLP and GABA Trigger GabR-Mediated Transcription Regulation in Bacillus subsidies via External Aldimine Formation | Descriptor: | (4S)-5-fluoro-4-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]pentanoic acid, HTH-type transcriptional regulatory protein GabR | Authors: | Wu, R, Sanishvili, R, Belitsky, B.R, Juncosa, J.I, Le, H.V, Lehrer, H.J.S, Farley, M, Silverman, R.B, Petsko, G.A, Ringe, D, Liu, D. | Deposit date: | 2016-08-29 | Release date: | 2017-03-29 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.245 Å) | Cite: | PLP and GABA trigger GabR-mediated transcription regulation in Bacillus subtilis via external aldimine formation. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5T4L
| PLP and GABA Trigger GabR-Mediated Transcription Regulation in Bacillus subsidies via External Aldimine Formation | Descriptor: | (4R)-4-amino-6-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}hexanoic acid, Aspartate aminotransferase | Authors: | Wu, R, Sanishvili, R, Belitsky, B.R, Juncosa, J.I, Le, H.V, Lehrer, H.J.S, Farley, M, Silverman, R.B, Petsko, G.A, Ringe, D, Liu, D. | Deposit date: | 2016-08-29 | Release date: | 2017-03-29 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.53 Å) | Cite: | PLP and GABA trigger GabR-mediated transcription regulation in Bacillus subtilis via external aldimine formation. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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1DJE
| CRYSTAL STRUCTURE OF THE PLP-BOUND FORM OF 8-AMINO-7-OXONANOATE SYNTHASE | Descriptor: | 8-AMINO-7-OXONANOATE SYNTHASE, PYRIDOXAL-5'-PHOSPHATE, SULFATE ION | Authors: | Webster, S.P, Alexeev, D, Campopiano, D.J, Watt, R.M, Alexeeva, M, Sawyer, L, Baxter, R.L. | Deposit date: | 1999-12-02 | Release date: | 2000-12-04 | Last modified: | 2018-01-24 | Method: | X-RAY DIFFRACTION (1.71 Å) | Cite: | Mechanism of 8-amino-7-oxononanoate synthase: spectroscopic, kinetic, and crystallographic studies. Biochemistry, 39, 2000
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5TF5
| CRYSTAL STRUCTURE OF HUMAN KAT-2 IN COMPLEX WITH A REVERSIBLE INHIBITOR | Descriptor: | (2R)-2-(5,6-dichloro-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpropanoic acid, Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | Authors: | Nematollahi, A, Sun, G, Church, W.B. | Deposit date: | 2016-09-24 | Release date: | 2016-10-05 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.807 Å) | Cite: | Crystal structure and mechanistic analysis of a novel human kynurenine aminotransferase-2 reversible inhibitor Med.Chem.Res., 2017
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1GD9
| CRYSTALL STRUCTURE OF PYROCOCCUS PROTEIN-A1 | Descriptor: | ASPARTATE AMINOTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE | Authors: | Ura, H, Harata, K, Matsui, I, Kuramitsu, S. | Deposit date: | 2000-09-22 | Release date: | 2001-09-22 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Temperature dependence of the enzyme-substrate recognition mechanism. J.Biochem., 129, 2001
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1G7X
| ASPARTATE AMINOTRANSFERASE ACTIVE SITE MUTANT N194A/R292L/R386L | Descriptor: | ASPARTATE AMINOTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE | Authors: | Mizuguchi, H, Hayashi, H, Okada, K, Miyahara, I, Hirotsu, K, Kagamiyama, H. | Deposit date: | 2000-11-15 | Release date: | 2000-11-29 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Strain is more important than electrostatic interaction in controlling the pKa of the catalytic group in aspartate aminotransferase. Biochemistry, 40, 2001
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1BKG
| ASPARTATE AMINOTRANSFERASE FROM THERMUS THERMOPHILUS WITH MALEATE | Descriptor: | 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, ASPARTATE AMINOTRANSFERASE, MALEIC ACID | Authors: | Nakai, T, Okada, K, Kuramitsu, S, Hirotsu, K, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 1998-07-07 | Release date: | 1999-07-22 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structure of Thermus thermophilus HB8 aspartate aminotransferase and its complex with maleate. Biochemistry, 38, 1999
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5TOQ
| High resolution crystal structure of AAT | Descriptor: | Aspartate aminotransferase, cytoplasmic | Authors: | Mueser, T.C, Dajnowicz, S, Kovalevsky, A. | Deposit date: | 2016-10-18 | Release date: | 2017-03-01 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Direct evidence that an extended hydrogen-bonding network influences activation of pyridoxal 5'-phosphate in aspartate aminotransferase. J. Biol. Chem., 292, 2017
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5TXR
| Structure of ALAS from S. cerevisiae non-covalently bound to PLP cofactor | Descriptor: | 5-aminolevulinate synthase, mitochondrial, FORMIC ACID, ... | Authors: | Brown, B.L, Grant, R.A, Kardon, J.R, Sauer, R.T, Baker, T.A. | Deposit date: | 2016-11-17 | Release date: | 2018-03-28 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure of the Mitochondrial Aminolevulinic Acid Synthase, a Key Heme Biosynthetic Enzyme. Structure, 26, 2018
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1GC4
| THERMUS THERMOPHILUS ASPARTATE AMINOTRANSFERASE TETRA MUTANT 2 COMPLEXED WITH ASPARTATE | Descriptor: | ASPARTATE AMINOTRANSFERASE, ASPARTIC ACID, PYRIDOXAL-5'-PHOSPHATE | Authors: | Ura, H, Nakai, T, Hirotsu, K, Kuramitsu, S. | Deposit date: | 2000-07-19 | Release date: | 2001-09-05 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Substrate recognition mechanism of thermophilic dual-substrate enzyme. J.Biochem., 130, 2001
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1GEY
| CRYSTAL STRUCTURE OF HISTIDINOL-PHOSPHATE AMINOTRANSFERASE COMPLEXED WITH N-(5'-PHOSPHOPYRIDOXYL)-L-GLUTAMATE | Descriptor: | 4-[(1,3-DICARBOXY-PROPYLAMINO)-METHYL]-3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDINIUM, HISTIDINOL-PHOSPHATE AMINOTRANSFERASE | Authors: | Haruyama, K, Nakai, T, Miyahara, I, Hirotsu, K, Mizuguchi, H, Hayashi, H, Kagamiyama, H. | Deposit date: | 2000-11-30 | Release date: | 2001-04-18 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structures of Escherichia coli histidinol-phosphate aminotransferase and its complexes with histidinol-phosphate and N-(5'-phosphopyridoxyl)-L-glutamate: double substrate recognition of the enzyme. Biochemistry, 40, 2001
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1G4X
| ASPARTATE AMINOTRANSFERASE ACTIVE SITE MUTANT N194A/R292L | Descriptor: | ASPARTATE AMINOTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE | Authors: | Mizuguchi, H. | Deposit date: | 2000-10-29 | Release date: | 2000-11-22 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Strain is more important than electrostatic interaction in controlling the pKa of the catalytic group in aspartate aminotransferase. Biochemistry, 40, 2001
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1G4V
| ASPARTATE AMINOTRANSFERASE ACTIVE SITE MUTANT N194A/Y225F | Descriptor: | ASPARTATE AMINOTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE | Authors: | Mizuguchi, H, Hayashi, H, Okada, K, Miyahara, I, Hirotsu, K, Kagamiyama, H. | Deposit date: | 2000-10-28 | Release date: | 2000-11-22 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Strain is more important than electrostatic interaction in controlling the pKa of the catalytic group in aspartate aminotransferase. Biochemistry, 40, 2001
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