5T4K

PLP and GABA Trigger GabR-Mediated Transcription Regulation in Bacillus subsidies via External Aldimine Formation

Summary for 5T4K

• Entry DOI: 10.2210/pdb5t4k/pdb
• Related: 5T4L
• Descriptor: HTH-type transcriptional regulatory protein GabR, (4S)-5-fluoro-4-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]pentanoic acid (3 entities in total)
• Functional Keywords: gabr, mocr, plp, gaba, external aldimine, transcription
• Biological source: Bacillus subtilis
• Total number of polymer chains: 1
• Total formula weight: 42283.28

Authors

Wu, R.,Sanishvili, R.,Belitsky, B.R.,Juncosa, J.I.,Le, H.V.,Lehrer, H.J.S.,Farley, M.,Silverman, R.B.,Petsko, G.A.,Ringe, D.,Liu, D. (deposition date: 2016-08-29, release date: 2017-03-29, Last modification date: 2023-10-04)

• Primary citation: Wu, R.,Sanishvili, R.,Belitsky, B.R.,Juncosa, J.I.,Le, H.V.,Lehrer, H.J.,Farley, M.,Silverman, R.B.,Petsko, G.A.,Ringe, D.,Liu, D.; PLP and GABA trigger GabR-mediated transcription regulation in Bacillus subtilis via external aldimine formation.; Proc. Natl. Acad. Sci. U.S.A., 114:3891-3896, 2017; PubMed: 28348215; DOI: 10.1073/pnas.1703019114

Experimental method

X-RAY DIFFRACTION (2.245 Å)