5T5X
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7D1C
| Crystal structure of mouse Cryptochrome 1 in complex with compound TH303 | Descriptor: | Cryptochrome-1, N-[2-(4-methoxyphenyl)-5,5-bis(oxidanylidene)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]-4-(phenylcarbonyl)benzamide | Authors: | Miller, S.A, Hirota, T. | Deposit date: | 2020-09-14 | Release date: | 2021-01-27 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Photopharmacological Manipulation of Mammalian CRY1 for Regulation of the Circadian Clock. J.Am.Chem.Soc., 143, 2021
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7D0M
| Crystal structure of mouse CRY1 with bound cryoprotectant | Descriptor: | Cryptochrome-1, DI(HYDROXYETHYL)ETHER, TETRAETHYLENE GLYCOL | Authors: | Miller, S.A, Aikawa, Y, Hirota, T. | Deposit date: | 2020-09-11 | Release date: | 2021-06-23 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structural differences in the FAD-binding pockets and lid loops of mammalian CRY1 and CRY2 for isoform-selective regulation. Proc.Natl.Acad.Sci.USA, 118, 2021
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6KX5
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6KX6
| Crystal structure of mouse Cryptochrome 1 in complex with KL101 compound | Descriptor: | Cryptochrome-1, ~{N}-[2-(2,4-dimethylphenyl)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]-3,4-dimethyl-benzamide | Authors: | Miller, S.A, Aikawa, Y, Hirota, T. | Deposit date: | 2019-09-10 | Release date: | 2020-04-01 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Isoform-selective regulation of mammalian cryptochromes. Nat.Chem.Biol., 16, 2020
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6KX4
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7WVA
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6LUE
| Crystal structure of mouse Cryptochrome 1 in complex with compound KL201 | Descriptor: | 2-bromanyl-N-(5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)benzamide, Cryptochrome-1 | Authors: | Miller, S, Aikawa, Y, Hirota, T. | Deposit date: | 2020-01-27 | Release date: | 2020-06-10 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | An Isoform-Selective Modulator of Cryptochrome 1 Regulates Circadian Rhythms in Mammals. Cell Chem Biol, 27, 2020
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6KX7
| Crystal structure of mouse Cryptochrome 1 in complex with TH301 compound | Descriptor: | 1-(4-chlorophenyl)-N-[2-(4-methoxyphenyl)-5,5-bis(oxidanylidene)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]cyclopentane-1-carboxamide, Cryptochrome-1 | Authors: | Miller, S.A, Aikawa, Y, Hirota, T. | Deposit date: | 2019-09-10 | Release date: | 2020-04-01 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Isoform-selective regulation of mammalian cryptochromes. Nat.Chem.Biol., 16, 2020
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7DLI
| Crystal structure of mouse CRY1 in complex with KL001 compound | Descriptor: | 1,2-ETHANEDIOL, Cryptochrome-1, N-[(2R)-3-carbazol-9-yl-2-oxidanyl-propyl]-N-(furan-2-ylmethyl)methanesulfonamide | Authors: | Miller, S.A, Aikawa, Y, Hirota, T. | Deposit date: | 2020-11-27 | Release date: | 2021-06-23 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural differences in the FAD-binding pockets and lid loops of mammalian CRY1 and CRY2 for isoform-selective regulation. Proc.Natl.Acad.Sci.USA, 118, 2021
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7D19
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4CT0
| Crystal Structure of Mouse Cryptochrome1 in Complex with Period2 | Descriptor: | CHLORIDE ION, CRYPTOCHROME-1, HEXAETHYLENE GLYCOL, ... | Authors: | Schmalen, I, Rajan Prabu, J, Benda, C, Wolf, E. | Deposit date: | 2014-03-11 | Release date: | 2014-06-04 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Interaction of Circadian Clock Proteins Cry1 and Per2 is Modulated by Zinc Binding and Disulfide Bond Formation. Cell(Cambridge,Mass.), 157, 2014
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4K0R
| Crystal structure of mouse Cryptochrome 1 | Descriptor: | Cryptochrome-1 | Authors: | Czarna, A, Wolf, E. | Deposit date: | 2013-04-04 | Release date: | 2013-06-26 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Structures of Drosophila cryptochrome and mouse cryptochrome1 provide insight into circadian function. Cell(Cambridge,Mass.), 153, 2013
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6OF7
| Crystal structure of the CRY1-PER2 complex | Descriptor: | Cryptochrome-1, Period circadian protein homolog 2 | Authors: | Michael, A.K, Fribourgh, J.L, Tripathi, S.M, Partch, C.L. | Deposit date: | 2019-03-28 | Release date: | 2020-03-04 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.11 Å) | Cite: | Dynamics at the serine loop underlie differential affinity of cryptochromes for CLOCK:BMAL1 to control circadian timing. Elife, 9, 2020
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