5V7M
 
 | | PCNA mutant L126A/I128A Protein Defective in Gene Silencing | | Descriptor: | MAGNESIUM ION, Proliferating cell nuclear antigen | | Authors: | Kondratick, C.M, Litman, J.M, Washington, M.T, Dieckman, L.M. | | Deposit date: | 2017-03-20 | | Release date: | 2018-03-14 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (1.93 Å) | | Cite: | Crystal structures of PCNA mutant proteins defective in gene silencing suggest a novel interaction site on the front face of the PCNA ring.
PLoS ONE, 13, 2018
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8CCS
 | | 80S S. cerevisiae ribosome with ligands in hybrid-1 pre-translocation (PRE-H1) complex | | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | | Authors: | Milicevic, N, Jenner, L, Myasnikov, A, Yusupov, M, Yusupova, G. | | Deposit date: | 2023-01-27 | | Release date: | 2023-09-20 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (1.97 Å) | | Cite: | mRNA reading frame maintenance during eukaryotic ribosome translocation.
Nature, 625, 2024
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6ZQH
 | | Yeast Uba1 in complex with ubiquitin | | Descriptor: | BETA-MERCAPTOETHANOL, GLYCEROL, TETRAETHYLENE GLYCOL, ... | | Authors: | Misra, M, Schindelin, H. | | Deposit date: | 2020-07-09 | | Release date: | 2020-11-04 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.032 Å) | | Cite: | Development of ADPribosyl Ubiquitin Analogues to Study Enzymes Involved in Legionella Infection.
Chemistry, 27, 2021
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8CDR
 | | Translocation intermediate 2 (TI-2) of 80S S. cerevisiae ribosome with ligands and eEF2 in the presence of sordarin | | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | | Authors: | Milicevic, N, Jenner, L, Myasnikov, A, Yusupov, M, Yusupova, G. | | Deposit date: | 2023-01-31 | | Release date: | 2023-09-20 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (2.04 Å) | | Cite: | mRNA reading frame maintenance during eukaryotic ribosome translocation.
Nature, 625, 2024
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8DQX
 | | Open state of RFC:PCNA bound to a 3' ss/dsDNA junction | | Descriptor: | DNA (5'-D(*TP*TP*TP*TP*TP*T)-3'), DNA (5'-D(P*TP*CP*CP*GP*AP*GP*CP*GP*AP*A)-3'), DNA (5'-D(P*TP*TP*TP*GP*CP*CP*CP*GP*GP*A)-3'), ... | | Authors: | Schrecker, M, Hite, R.K. | | Deposit date: | 2022-07-20 | | Release date: | 2022-08-24 | | Last modified: | 2024-02-14 | | Method: | ELECTRON MICROSCOPY (2.1 Å) | | Cite: | Multistep loading of a DNA sliding clamp onto DNA by replication factor C.
Elife, 11, 2022
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8DR1
 | | Consensus closed state of RFC:PCNA bound to a 3' ss/dsDNA junction (DNA2) | | Descriptor: | DNA (5'-D(P*CP*CP*CP*CP*CP*CP*CP*CP*CP*CP*TP*TP*T)-3'), DNA (5'-D(P*CP*CP*CP*CP*CP*CP*GP*GP*CP*CP*CP*CP*CP*CP*CP*GP*GP*C)-3'), DNA (5'-D(P*TP*TP*AP*GP*GP*GP*GP*GP*GP*GP*GP*GP*A)-3'), ... | | Authors: | Schrecker, M, Hite, R.K. | | Deposit date: | 2022-07-20 | | Release date: | 2022-08-17 | | Last modified: | 2024-02-14 | | Method: | ELECTRON MICROSCOPY (2.14 Å) | | Cite: | Multistep loading of a DNA sliding clamp onto DNA by replication factor C.
Elife, 11, 2022
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8DR3
 | | Closed state of RFC:PCNA bound to a 3' ss/dsDNA junction (DNA2) with NTD | | Descriptor: | DNA (5'-D(P*CP*CP*CP*CP*CP*CP*CP*CP*CP*CP*TP*TP*T)-3'), DNA (5'-D(P*CP*CP*CP*CP*CP*CP*GP*GP*CP*CP*CP*CP*CP*CP*CP*GP*GP*C)-3'), DNA (5'-D(P*TP*TP*AP*GP*GP*GP*GP*GP*GP*GP*GP*GP*A)-3'), ... | | Authors: | Schrecker, M, Hite, R.K. | | Deposit date: | 2022-07-20 | | Release date: | 2022-08-17 | | Last modified: | 2024-02-14 | | Method: | ELECTRON MICROSCOPY (2.2 Å) | | Cite: | Multistep loading of a DNA sliding clamp onto DNA by replication factor C.
Elife, 11, 2022
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5L6H
 | | Uba1 in complex with Ub-ABPA3 covalent adduct | | Descriptor: | ACETATE ION, CHLORIDE ION, GLYCEROL, ... | | Authors: | Misra, M, Schindelin, H. | | Deposit date: | 2016-05-30 | | Release date: | 2017-06-14 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Dissecting the Specificity of Adenosyl Sulfamate Inhibitors Targeting the Ubiquitin-Activating Enzyme.
Structure, 25, 2017
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1PLQ
 | | CRYSTAL STRUCTURE OF THE EUKARYOTIC DNA POLYMERASE PROCESSIVITY FACTOR PCNA | | Descriptor: | MERCURY (II) ION, PROLIFERATING CELL NUCLEAR ANTIGEN (PCNA) | | Authors: | Krishna, T.S.R, Kong, X.-P, Gary, S, Burgers, P.M, Kuriyan, J. | | Deposit date: | 1995-01-02 | | Release date: | 1995-03-31 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal structure of the eukaryotic DNA polymerase processivity factor PCNA.
Cell(Cambridge,Mass.), 79, 1994
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8DR6
 | | Closed state of RFC:PCNA bound to a nicked dsDNA | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DNA (32-MER), DNA (5'-D(P*CP*CP*CP*CP*CP*CP*GP*GP*CP*CP*CP*CP*CP*CP*CP*GP*GP*C)-3'), ... | | Authors: | Schrecker, M, Hite, R.K. | | Deposit date: | 2022-07-20 | | Release date: | 2022-08-24 | | Last modified: | 2024-02-14 | | Method: | ELECTRON MICROSCOPY (2.39 Å) | | Cite: | Multistep loading of a DNA sliding clamp onto DNA by replication factor C.
Elife, 11, 2022
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7ZW0
 | | FAP-80S Complex - Rotated state | | Descriptor: | 18S ribosomal RNA (RDN18-1), 25S ribosomal RNA (RDN25-1), 40S ribosomal protein S0-A, ... | | Authors: | Ikeuchi, K, Buschauer, R, Berninghausen, O, Becker, T, Beckmann, R. | | Deposit date: | 2022-05-17 | | Release date: | 2022-10-05 | | Method: | ELECTRON MICROSCOPY (2.4 Å) | | Cite: | Sensing of individual stalled 80S ribosomes by Fap1 for nonfunctional rRNA turnover.
Mol.Cell, 82, 2022
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8DR0
 | | Closed state of RFC:PCNA bound to a 3' ss/dsDNA junction | | Descriptor: | DNA (5'-D(P*CP*CP*CP*CP*GP*GP*GP*GP*CP*CP*CP*CP*CP*CP*CP*GP*GP*C)-3'), DNA (5'-D(P*TP*TP*TP*TP*TP*TP*CP*GP*GP*GP*GP*GP*GP*GP*CP*CP*CP*CP*GP*GP*GP*G)-3'), GUANOSINE-5'-DIPHOSPHATE, ... | | Authors: | Schrecker, M, Hite, R.K. | | Deposit date: | 2022-07-20 | | Release date: | 2022-08-24 | | Last modified: | 2024-02-14 | | Method: | ELECTRON MICROSCOPY (2.42 Å) | | Cite: | Multistep loading of a DNA sliding clamp onto DNA by replication factor C.
Elife, 11, 2022
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8DR4
 | | Open state of RFC:PCNA bound to a 3' ss/dsDNA junction (DNA2) without NTD | | Descriptor: | DNA (5'-D(P*AP*AP*GP*GP*GP*GP*GP*GP*GP*GP*GP*G)-3'), DNA (5'-D(P*CP*CP*CP*CP*CP*CP*CP*CP*CP*CP*TP*TP*T)-3'), DNA (5'-D(P*CP*CP*CP*CP*CP*CP*GP*GP*CP*CP*CP*CP*CP*CP*CP*GP*GP*C)-3'), ... | | Authors: | Schrecker, M, Hite, R.K. | | Deposit date: | 2022-07-20 | | Release date: | 2022-08-17 | | Last modified: | 2024-02-14 | | Method: | ELECTRON MICROSCOPY (2.45 Å) | | Cite: | Multistep loading of a DNA sliding clamp onto DNA by replication factor C.
Elife, 11, 2022
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3GPN
 | | Structure of the non-trimeric form of the E113G PCNA mutant protein | | Descriptor: | Proliferating cell nuclear antigen | | Authors: | Freudenthal, B.D, Gakhar, L, Ramaswamy, S, Washington, M.T. | | Deposit date: | 2009-03-23 | | Release date: | 2009-06-16 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | A charged residue at the subunit interface of PCNA promotes trimer formation by destabilizing alternate subunit interactions.
Acta Crystallogr.,Sect.D, 65, 2009
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7ZUX
 | | Collided ribosome in a disome unit from S. cerevisiae | | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | | Authors: | Best, K.M, Ikeuchi, K, Kater, L, Best, D.M, Musial, J, Matsuo, Y, Berninghausen, O, Becker, T, Inada, T, Beckmann, R. | | Deposit date: | 2022-05-13 | | Release date: | 2023-02-22 | | Last modified: | 2023-03-01 | | Method: | ELECTRON MICROSCOPY (2.5 Å) | | Cite: | Structural basis for clearing of ribosome collisions by the RQT complex.
Nat Commun, 14, 2023
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5U4P
 | | Protein-protein complex between 26S proteasome regulatory subunit RPN8, RPN11, and Ubiquitin S31 | | Descriptor: | 26S proteasome regulatory subunit RPN11, 26S proteasome regulatory subunit RPN8, Ubiquitin-40S ribosomal protein S31, ... | | Authors: | Worden, E.J, Dong, K.C, Martin, A. | | Deposit date: | 2016-12-05 | | Release date: | 2017-09-06 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | An AAA Motor-Driven Mechanical Switch in Rpn11 Controls Deubiquitination at the 26S Proteasome.
Mol. Cell, 67, 2017
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6T4Q
 | | Structure of yeast 80S ribosome stalled on the CGA-CCG inhibitory codon combination. | | Descriptor: | 18S rRNA, 25S rRNA, 40S ribosomal protein S0-A, ... | | Authors: | Tesina, P, Buschauer, R, Cheng, J, Berninghausen, O, Becker, R, Beckmann, R. | | Deposit date: | 2019-10-14 | | Release date: | 2019-12-25 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | Molecular mechanism of translational stalling by inhibitory codon combinations and poly(A) tracts.
Embo J., 39, 2020
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3V60
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6W9W
 | | R80A PCNA mutant defective in BIR | | Descriptor: | Proliferating cell nuclear antigen | | Authors: | Ripley, B.M, Washington, M.T. | | Deposit date: | 2020-03-23 | | Release date: | 2020-09-23 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | Structural analysis of PCNA mutant proteins defective in BIR, FF248-249AA and R80A
To be Published
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5L6J
 | | Uba1 in complex with Ub-MLN7243 covalent adduct | | Descriptor: | CHLORIDE ION, GLYCEROL, SULFATE ION, ... | | Authors: | Misra, M, Schindelin, H. | | Deposit date: | 2016-05-30 | | Release date: | 2017-06-14 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.68 Å) | | Cite: | Dissecting the Specificity of Adenosyl Sulfamate Inhibitors Targeting the Ubiquitin-Activating Enzyme.
Structure, 25, 2017
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4L6P
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7MPJ
 | | Stm1 bound vacant 80S structure isolated from wild-type | | Descriptor: | 18S rRNA, 25S rRNA, 40S ribosomal protein S0-A, ... | | Authors: | Rai, J, Zhao, Y, Li, H. | | Deposit date: | 2021-05-04 | | Release date: | 2022-05-11 | | Last modified: | 2023-12-13 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | CryoEM structures of pseudouridine-free ribosome suggest impacts of chemical modifications on ribosome conformations.
Structure, 30, 2022
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3CMM
 | | Crystal Structure of the Uba1-Ubiquitin Complex | | Descriptor: | PROLINE, Ubiquitin, Ubiquitin-activating enzyme E1 1 | | Authors: | Lee, I, Schindelin, H. | | Deposit date: | 2008-03-23 | | Release date: | 2008-08-05 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structural insights into E1-catalyzed ubiquitin activation and transfer to conjugating enzymes.
Cell(Cambridge,Mass.), 134, 2008
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8DR7
 | | Open state of RFC:PCNA bound to a nicked dsDNA | | Descriptor: | DNA (26-MER), DNA (5'-D(P*AP*GP*GP*GP*GP*GP*GP*GP*GP*GP*G)-3'), DNA (5'-D(P*GP*GP*CP*CP*CP*CP*CP*CP*CP*GP*GP*C)-3'), ... | | Authors: | Schrecker, M, Hite, R.K. | | Deposit date: | 2022-07-20 | | Release date: | 2022-08-17 | | Last modified: | 2024-02-14 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Multistep loading of a DNA sliding clamp onto DNA by replication factor C.
Elife, 11, 2022
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8CDL
 | | 80S S. cerevisiae ribosome with ligands in hybrid-2 pre-translocation (PRE-H2) complex | | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | | Authors: | Milicevic, N, Jenner, L, Myasnikov, A, Yusupov, M, Yusupova, G. | | Deposit date: | 2023-01-31 | | Release date: | 2023-09-20 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (2.72 Å) | | Cite: | mRNA reading frame maintenance during eukaryotic ribosome translocation.
Nature, 625, 2024
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