8UDL
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![BU of 8udl by Molmil](/molmil-images/mine/8udl) | Human Mitochondrial DNA Polymerase Gamma Binary Complex | Descriptor: | DNA (5'-D(P*AP*AP*AP*AP*CP*GP*AP*CP*GP*GP*CP*CP*AP*GP*TP*GP*CP*CP*AP*TP*AP*C)-3'), DNA (5'-D(P*AP*GP*GP*TP*AP*TP*GP*GP*CP*AP*CP*TP*GP*GP*CP*CP*GP*TP*CP*GP*TP*TP*TP*T)-3'), DNA polymerase subunit gamma-1, ... | Authors: | Park, J, Yin, Y.W. | Deposit date: | 2023-09-28 | Release date: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (2.37 Å) | Cite: | An interaction network in the polymerase active site is a prerequisite for Watson-Crick base pairing in Pol gamma. Sci Adv, 10, 2024
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8D33
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![BU of 8d33 by Molmil](/molmil-images/mine/8d33) | |
8G5M
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![BU of 8g5m by Molmil](/molmil-images/mine/8g5m) | Cryo-EM structure of the Mismatch Locking Complex (III) of Human Mitochondrial DNA Polymerase Gamma | Descriptor: | DNA polymerase subunit gamma-1, DNA polymerase subunit gamma-2, mitochondrial, ... | Authors: | Nayak, A.R, Buchel, G, Herbine, K.H, Sarfallah, A, Sokolova, V.O, Zamudio-Ochoa, A, Temiakov, D. | Deposit date: | 2023-02-13 | Release date: | 2024-01-10 | Method: | ELECTRON MICROSCOPY (2.58 Å) | Cite: | Structural basis for DNA proofreading. Nat Commun, 14, 2023
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8G5O
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![BU of 8g5o by Molmil](/molmil-images/mine/8g5o) | Cryo-EM structure of the Guide loop Engagement Complex (IV) of Human Mitochondrial DNA Polymerase Gamma | Descriptor: | DNA polymerase subunit gamma-1, DNA polymerase subunit gamma-2, mitochondrial, ... | Authors: | Nayak, A.R, Buchel, G, Herbine, K.H, Sarfallah, A, Sokolova, V.O, Zamudio-Ochoa, A, Temiakov, D. | Deposit date: | 2023-02-13 | Release date: | 2024-01-10 | Method: | ELECTRON MICROSCOPY (2.61 Å) | Cite: | Structural basis for DNA proofreading. Nat Commun, 14, 2023
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8G5J
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![BU of 8g5j by Molmil](/molmil-images/mine/8g5j) | Cryo-EM structure of the Mismatch Uncoupling Complex (II) of Human Mitochondrial DNA Polymerase Gamma | Descriptor: | DNA polymerase subunit gamma-1, DNA polymerase subunit gamma-2, mitochondrial, ... | Authors: | Nayak, A.R, Buchel, G, Herbine, K.H, Sarfallah, A, Sokolova, V.O, Zamudio-Ochoa, A, Temiakov, D. | Deposit date: | 2023-02-13 | Release date: | 2024-01-10 | Method: | ELECTRON MICROSCOPY (2.63 Å) | Cite: | Structural basis for DNA proofreading. Nat Commun, 14, 2023
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8D37
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![BU of 8d37 by Molmil](/molmil-images/mine/8d37) | |
8G5N
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![BU of 8g5n by Molmil](/molmil-images/mine/8g5n) | Cryo-EM structure of the Guide loop Engagement Complex (VI) of Human Mitochondrial DNA Polymerase Gamma | Descriptor: | DNA polymerase subunit gamma-1, DNA polymerase subunit gamma-2, mitochondrial, ... | Authors: | Nayak, A.R, Buchel, G, Herbine, K.H, Sarfallah, A, Sokolova, V.O, Zamudio-Ochoa, A, Temiakov, D. | Deposit date: | 2023-02-13 | Release date: | 2024-01-10 | Method: | ELECTRON MICROSCOPY (2.73 Å) | Cite: | Structural basis for DNA proofreading. Nat Commun, 14, 2023
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8G5I
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![BU of 8g5i by Molmil](/molmil-images/mine/8g5i) | Cryo-EM structure of the Mismatch Sensing Complex (I) of Human Mitochondrial DNA Polymerase Gamma | Descriptor: | DNA polymerase subunit gamma-1, DNA polymerase subunit gamma-2, mitochondrial, ... | Authors: | Nayak, A.R, Buchel, G, Herbine, K.H, Sarfallah, A, Sokolova, V.O, Zamudio-Ochoa, A, Temiakov, D. | Deposit date: | 2023-02-13 | Release date: | 2024-01-10 | Method: | ELECTRON MICROSCOPY (2.75 Å) | Cite: | Structural basis for DNA proofreading. Nat Commun, 14, 2023
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8G5P
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![BU of 8g5p by Molmil](/molmil-images/mine/8g5p) | Cryo-EM structure of the Guide loop Engagement Complex (V) of Human Mitochondrial DNA Polymerase Gamma | Descriptor: | DNA polymerase subunit gamma-1, DNA polymerase subunit gamma-2, mitochondrial, ... | Authors: | Nayak, A.R, Buchel, G, Herbine, K.H, Sarfallah, A, Sokolova, V.O, Zamudio-Ochoa, A, Temiakov, D. | Deposit date: | 2023-02-13 | Release date: | 2024-01-10 | Method: | ELECTRON MICROSCOPY (2.78 Å) | Cite: | Structural basis for DNA proofreading. Nat Commun, 14, 2023
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8G5K
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![BU of 8g5k by Molmil](/molmil-images/mine/8g5k) | Cryo-EM structure of the Wedge Alignment Complex (VIII) of Human Mitochondrial DNA Polymerase Gamma | Descriptor: | DNA polymerase subunit gamma-1, DNA polymerase subunit gamma-2, mitochondrial, ... | Authors: | Nayak, A.R, Buchel, G, Herbine, K.H, Sarfallah, A, Sokolova, V.O, Zamudio-Ochoa, A, Temiakov, D. | Deposit date: | 2023-02-13 | Release date: | 2024-01-10 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural basis for DNA proofreading. Nat Commun, 14, 2023
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8D42
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![BU of 8d42 by Molmil](/molmil-images/mine/8d42) | |
8G5L
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![BU of 8g5l by Molmil](/molmil-images/mine/8g5l) | Cryo-EM structure of the Primer Separation Complex (IX) of Human Mitochondrial DNA Polymerase Gamma | Descriptor: | DNA polymerase subunit gamma-1, DNA polymerase subunit gamma-2, mitochondrial, ... | Authors: | Nayak, A.R, Buchel, G, Herbine, K.H, Sarfallah, A, Sokolova, V.O, Zamudio-Ochoa, A, Temiakov, D. | Deposit date: | 2023-02-13 | Release date: | 2024-01-10 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural basis for DNA proofreading. Nat Commun, 14, 2023
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8V5D
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![BU of 8v5d by Molmil](/molmil-images/mine/8v5d) | Human mitochondrial DNA polymerase catalytic subunit, PolG, in an APO conformation | Descriptor: | DNA polymerase subunit gamma-1 | Authors: | Riccio, A.A, Brannon, A.J, Krahn, J.M, Bouvette, J, Borgnia, J.M, Copeland, W.C. | Deposit date: | 2023-11-30 | Release date: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Coordinated DNA polymerization by Pol gamma and the region of LonP1 regulated proteolysis. Nucleic Acids Res., 2024
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8V5R
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![BU of 8v5r by Molmil](/molmil-images/mine/8v5r) | Active conformation of DNA polymerase gamma bound to DNA | Descriptor: | 2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATE, DNA polymerase subunit gamma-1, DNA polymerase subunit gamma-2, ... | Authors: | Riccio, A.A, Krahn, J.M, Bouvette, J, Borgnia, J.M, Copeland, W.C. | Deposit date: | 2023-11-30 | Release date: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Coordinated DNA polymerization by Pol gamma and the region of LonP1 regulated proteolysis. Nucleic Acids Res., 2024
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8D3R
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![BU of 8d3r by Molmil](/molmil-images/mine/8d3r) | |
8T7E
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![BU of 8t7e by Molmil](/molmil-images/mine/8t7e) | Cryo-EM structure of the Backtracking Initiation Complex (VII) of Human Mitochondrial DNA Polymerase Gamma | Descriptor: | DNA polymerase subunit gamma-1, DNA polymerase subunit gamma-2, mitochondrial, ... | Authors: | Nayak, A.R, Buchel, G, Herbine, K.H, Sarfallah, A, Sokolova, V.O, Zamudio-Ochoa, A, Temiakov, D. | Deposit date: | 2023-06-20 | Release date: | 2024-01-10 | Method: | ELECTRON MICROSCOPY (3.08 Å) | Cite: | Structural basis for DNA proofreading. Nat Commun, 14, 2023
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3IKM
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![BU of 3ikm by Molmil](/molmil-images/mine/3ikm) | |
4ZTU
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![BU of 4ztu by Molmil](/molmil-images/mine/4ztu) | Structural basis for processivity and antiviral drug toxicity in human mitochondrial DNA replicase | Descriptor: | 2',3'-DIDEOXYCYTIDINE 5'-TRIPHOSPHATE, DNA (25-MER), DNA (5'-D(P*AP*AP*GP*AP*CP*GP*AP*GP*GP*GP*CP*CP*AP*GP*TP*GP*CP*CP*GP*TP*AP*C)-3'), ... | Authors: | Szymanski, M.R, Kuznestov, V.B, Shumate, C.K, Meng, Q, Lee, Y.-S, Patel, G, Patel, S.S, Yin, Y.W. | Deposit date: | 2015-05-15 | Release date: | 2015-09-23 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (3.299 Å) | Cite: | Structural basis for processivity and antiviral drug toxicity
in human mitochondrial DNA replicase EMBO J., 34, 2015
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5C51
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![BU of 5c51 by Molmil](/molmil-images/mine/5c51) | Probing the Structural and Molecular Basis of Nucleotide Selectivity by Human Mitochondrial DNA Polymerase gamma | Descriptor: | DNA, DNA (5'-D(*(AD)P*AP*AP*AP*CP*GP*AP*GP*GP*GP*CP*CP*AP*GP*TP*GP*CP*CP*GP*TP*AP*C)-3'), DNA polymerase subunit gamma-1, ... | Authors: | Sohl, C.D, Szymanski, M.R, Mislak, A.C, Shumate, C.K, Amiralaei, S, Schinazi, R.F, Anderson, K.S, Whitney, Y.Y. | Deposit date: | 2015-06-19 | Release date: | 2016-05-11 | Last modified: | 2016-05-18 | Method: | X-RAY DIFFRACTION (3.426 Å) | Cite: | Probing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA polymerase gamma. Proc.Natl.Acad.Sci.USA, 112, 2015
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8UDK
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![BU of 8udk by Molmil](/molmil-images/mine/8udk) | Human Mitochondrial DNA Polymerase gamma R853A Ternary Complex | Descriptor: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, DNA (24-MER), DNA (28-MER), ... | Authors: | Park, J, Herrmann, G.K, Yin, Y.W. | Deposit date: | 2023-09-28 | Release date: | 2024-06-05 | Method: | X-RAY DIFFRACTION (3.43 Å) | Cite: | An interaction network in the polymerase active site is a prerequisite for Watson-Crick base pairing in Pol gamma. Sci Adv, 10, 2024
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4ZTZ
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![BU of 4ztz by Molmil](/molmil-images/mine/4ztz) | |
5C53
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![BU of 5c53 by Molmil](/molmil-images/mine/5c53) | Probing the Structural and Molecular Basis of Nucleotide Selectivity by Human Mitochondrial DNA Polymerase gamma | Descriptor: | 2',3'-DIDEOXYCYTIDINE-5'-MONOPHOSPHATE, DNA (26-MER), DNA (5'-D(*AP*AP*AP*AP*CP*GP*AP*GP*GP*GP*CP*CP*AP*GP*TP*GP*CP*CP*GP*TP*AP*C)-3'), ... | Authors: | Sohl, C.D, Szymanski, M.R, Mislak, A.C, Shumate, C.K, Amiralaei, S, Schinazi, R.F, Anderson, K.S, Yin, Y.W. | Deposit date: | 2015-06-19 | Release date: | 2016-01-27 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (3.567 Å) | Cite: | Probing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA polymerase gamma. Proc.Natl.Acad.Sci.USA, 112, 2015
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5C52
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![BU of 5c52 by Molmil](/molmil-images/mine/5c52) | Probing the Structural and Molecular Basis of Nucleotide Selectivity by Human Mitochondrial DNA Polymerase gamma | Descriptor: | DNA (26-MER), DNA (5'-D(*AP*AP*AP*AP*CP*GP*AP*GP*GP*GP*CP*CP*AP*GP*TP*GP*CP*CP*GP*TP*AP*C)-3'), DNA polymerase subunit gamma-1, ... | Authors: | Sohl, C.D, Szymanski, M.R, Mislak, A.C, Shumate, C.K, Amiralaei, S, Schinazi, R.F, Anderson, K.S, Yin, Y.W. | Deposit date: | 2015-06-19 | Release date: | 2016-05-11 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (3.637 Å) | Cite: | Probing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA polymerase gamma. Proc.Natl.Acad.Sci.USA, 112, 2015
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8V54
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![BU of 8v54 by Molmil](/molmil-images/mine/8v54) | Engaged conformation of the human mitochondrial DNA polymerase gamma bound to DNA | Descriptor: | DNA (25-MER), DNA (44-MER), DNA polymerase subunit gamma-1, ... | Authors: | Riccio, A.A, Krahn, J.M, Bouvette, J, Borgnia, J.M, Copeland, W.C. | Deposit date: | 2023-11-30 | Release date: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Coordinated DNA polymerization by Pol gamma and the region of LonP1 regulated proteolysis. Nucleic Acids Res., 2024
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8V55
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![BU of 8v55 by Molmil](/molmil-images/mine/8v55) | Human mitochondrial DNA polymerase gamma bound to a replication fork in an open conformation | Descriptor: | DNA polymerase subunit gamma-1, DNA polymerase subunit gamma-2, mitochondrial, ... | Authors: | Riccio, A.A, Krahn, J.M, Bouvette, J, Borgnia, M.J, Copeland, W.C. | Deposit date: | 2023-11-30 | Release date: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Coordinated DNA polymerization by Pol gamma and the region of LonP1 regulated proteolysis. Nucleic Acids Res., 2024
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