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PDB: 24 results

7QEQ
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BU of 7qeq by Molmil
human Connexin 26 dodecamer at 90mmHg PCO2, pH7.4
Descriptor: DODECYL-BETA-D-MALTOSIDE, Gap junction beta-2 protein, PHOSPHATIDYLETHANOLAMINE
Authors:Brotherton, D.H, Cameron, A.D, Savva, C.G, Ragan, T.J.
Deposit date:2021-12-03
Release date:2022-03-30
Last modified:2022-05-18
Method:ELECTRON MICROSCOPY (1.9 Å)
Cite:Conformational changes and CO 2 -induced channel gating in connexin26.
Structure, 30, 2022
7QEY
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BU of 7qey by Molmil
human Connexin 26 class 1 hexamer at 90mmHg PCO2, pH7.4
Descriptor: DODECYL-BETA-D-MALTOSIDE, Gap junction beta-2 protein, PHOSPHATIDYLETHANOLAMINE
Authors:Brotherton, D.H, Cameron, A.D, Savva, C.G, Ragan, T.J.
Deposit date:2021-12-03
Release date:2022-03-30
Last modified:2022-11-09
Method:ELECTRON MICROSCOPY (2 Å)
Cite:Conformational changes and CO 2 -induced channel gating in connexin26.
Structure, 30, 2022
7QEW
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BU of 7qew by Molmil
human Connexin 26 class 2 hexamer at 90mmHg PCO2, pH7.4
Descriptor: DODECYL-BETA-D-MALTOSIDE, Gap junction beta-2 protein, PHOSPHATIDYLETHANOLAMINE
Authors:Brotherton, D.H, Cameron, A.D, Savva, C.G, Ragan, T.J.
Deposit date:2021-12-03
Release date:2022-03-30
Last modified:2022-05-18
Method:ELECTRON MICROSCOPY (2.1 Å)
Cite:Conformational changes and CO 2 -induced channel gating in connexin26.
Structure, 30, 2022
7QET
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BU of 7qet by Molmil
human Connexin 26 dodecamer at 20mmHg PCO2, pH7.4
Descriptor: DODECYL-BETA-D-MALTOSIDE, Gap junction beta-2 protein, PHOSPHATIDYLETHANOLAMINE
Authors:Brotherton, D.H, Cameron, A.D, Savva, C.G, Ragan, T.J.
Deposit date:2021-12-03
Release date:2022-03-30
Last modified:2022-05-18
Method:ELECTRON MICROSCOPY (2.1 Å)
Cite:Conformational changes and CO 2 -induced channel gating in connexin26.
Structure, 30, 2022
7QER
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BU of 7qer by Molmil
human Connexin 26 dodecamer at 55mm Hg PCO2, pH7.4
Descriptor: DODECYL-BETA-D-MALTOSIDE, Gap junction beta-2 protein, PHOSPHATIDYLETHANOLAMINE
Authors:Brotherton, D.H, Cameron, A.D, Savva, C.G, Ragan, T.J.
Deposit date:2021-12-03
Release date:2022-03-30
Last modified:2022-05-18
Method:ELECTRON MICROSCOPY (2.2 Å)
Cite:Conformational changes and CO 2 -induced channel gating in connexin26.
Structure, 30, 2022
8QA2
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BU of 8qa2 by Molmil
Cryo-EM structure of Cx26 solubilised in LMNG: classification on subunit A; Nconst-mon conformation
Descriptor: Gap junction beta-2 protein, PHOSPHATIDYLETHANOLAMINE
Authors:Brotherton, D.H, Cameron, A.D.
Deposit date:2023-08-22
Release date:2024-06-12
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (2.3 Å)
Cite:Structures of wild-type and a constitutively closed mutant of connexin26 shed light on channel regulation by CO 2.
Elife, 13, 2024
8QA1
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BU of 8qa1 by Molmil
Cryo-EM structure of Cx26 solubilised in LMNG - Hemichannel classification NFlex conformation
Descriptor: Gap junction beta-2 protein, PHOSPHATIDYLETHANOLAMINE
Authors:Brotherton, D.H, Cameron, A.D.
Deposit date:2023-08-22
Release date:2024-06-12
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (2.3 Å)
Cite:Structures of wild-type and a constitutively closed mutant of connexin26 shed light on channel regulation by CO 2.
Elife, 13, 2024
8QA3
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BU of 8qa3 by Molmil
Cryo-EM structure of Cx26 solubilised in LMNG: classification on subunit A; NFlex conformation
Descriptor: Gap junction beta-2 protein, PHOSPHATIDYLETHANOLAMINE
Authors:Brotherton, D.H, Cameron, A.D.
Deposit date:2023-08-22
Release date:2024-06-12
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (2.3 Å)
Cite:Structures of wild-type and a constitutively closed mutant of connexin26 shed light on channel regulation by CO 2.
Elife, 13, 2024
8QA0
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BU of 8qa0 by Molmil
Cryo-EM structure of Cx26 solubilised in LMNG - hemichannel classification - NConst conformation
Descriptor: Gap junction beta-2 protein, PHOSPHATIDYLETHANOLAMINE
Authors:Brotherton, D.H, Cameron, A.D.
Deposit date:2023-08-22
Release date:2024-06-12
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (2.3 Å)
Cite:Structures of wild-type and a constitutively closed mutant of connexin26 shed light on channel regulation by CO 2.
Elife, 13, 2024
8Q9Z
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BU of 8q9z by Molmil
Cryo-EM structure of Cx26 gap junction K125E mutant in bicarbonate buffer (classification on hemichannel)
Descriptor: DODECYL-BETA-D-MALTOSIDE, Gap junction beta-2 protein, PHOSPHATIDYLETHANOLAMINE
Authors:Brotherton, D.H, Cameron, A.D.
Deposit date:2023-08-22
Release date:2024-06-12
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (2.4 Å)
Cite:Structures of wild-type and a constitutively closed mutant of connexin26 shed light on channel regulation by CO 2.
Elife, 13, 2024
7QES
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BU of 7qes by Molmil
human Connexin 26 at 55mm Hg PCO2, pH7.4: two masked subunits, class A
Descriptor: DODECYL-BETA-D-MALTOSIDE, Gap junction beta-2 protein, PHOSPHATIDYLETHANOLAMINE
Authors:Brotherton, D.H, Cameron, A.D, Savva, C.G, Ragan, T.J.
Deposit date:2021-12-03
Release date:2022-06-15
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Conformational changes and CO 2 -induced channel gating in connexin26.
Structure, 30, 2022
7QEU
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BU of 7qeu by Molmil
human Connexin 26 at 55mmHg PCO2, pH7.4: two masked subunits, class B
Descriptor: DODECYL-BETA-D-MALTOSIDE, Gap junction beta-2 protein, PHOSPHATIDYLETHANOLAMINE
Authors:Brotherton, D.H, Cameron, A.D, Savva, C.G, Ragan, T.J.
Deposit date:2021-12-03
Release date:2022-06-15
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Conformational changes and CO 2 -induced channel gating in connexin26.
Structure, 30, 2022
7QEO
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BU of 7qeo by Molmil
human Connexin 26 at 55mm Hg PCO2, pH7.4: two masked subunits, class C
Descriptor: DODECYL-BETA-D-MALTOSIDE, Gap junction beta-2 protein, PHOSPHATIDYLETHANOLAMINE
Authors:Brotherton, D.H, Cameron, A.D, Savva, C.G, Ragan, T.J.
Deposit date:2021-12-03
Release date:2022-06-22
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Conformational changes and CO 2 -induced channel gating in connexin26.
Structure, 30, 2022
7QEV
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BU of 7qev by Molmil
human Connexin 26 at 55mm Hg PCO2, pH7.4:two masked subunits, class D
Descriptor: DODECYL-BETA-D-MALTOSIDE, Gap junction beta-2 protein, PHOSPHATIDYLETHANOLAMINE
Authors:Brotherton, D.H, Cameron, A.D, Savva, C.G, Ragan, T.J.
Deposit date:2021-12-03
Release date:2022-06-15
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Conformational changes and CO 2 -induced channel gating in connexin26.
Structure, 30, 2022
5ER7
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BU of 5er7 by Molmil
Connexin-26 Bound to Calcium
Descriptor: CALCIUM ION, Gap junction beta-2 protein
Authors:Purdy, M.D, Bennett, B.C, Baker, K.A, Yeager, M.J.
Deposit date:2015-11-13
Release date:2016-01-27
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (3.286 Å)
Cite:An electrostatic mechanism for Ca(2+)-mediated regulation of gap junction channels.
Nat Commun, 7, 2016
2ZW3
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BU of 2zw3 by Molmil
Structure of the connexin-26 gap junction channel at 3.5 angstrom resolution
Descriptor: Gap junction beta-2 protein
Authors:Maeda, S, Nakagawa, S, Suga, M, Yamashita, E, Oshima, A, Fujiyoshi, Y, Tsukihara, T.
Deposit date:2008-12-01
Release date:2009-04-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structure of the connexin 26 gap junction channel at 3.5 A resolution
Nature, 458, 2009
5ERA
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BU of 5era by Molmil
Human Connexin-26 (Calcium-free)
Descriptor: Gap junction beta-2 protein
Authors:Purdy, M.D, Bennett, B.C, Baker, K.A, Yeager, M.J.
Deposit date:2015-11-13
Release date:2016-01-27
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:An electrostatic mechanism for Ca(2+)-mediated regulation of gap junction channels.
Nat Commun, 7, 2016
6UVR
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BU of 6uvr by Molmil
Human Connexin-26 (Neutral pH open conformation)
Descriptor: Gap junction beta-2 protein
Authors:Khan, A.K, Jagielnicki, M, Purdy, M.D, Yeager, M.
Deposit date:2019-11-04
Release date:2020-04-29
Last modified:2020-05-06
Method:ELECTRON MICROSCOPY (4 Å)
Cite:A Steric "Ball-and-Chain" Mechanism for pH-Mediated Regulation of Gap Junction Channels.
Cell Rep, 31, 2020
6UVS
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BU of 6uvs by Molmil
Human Connexin-26 (Low pH open conformation)
Descriptor: Gap junction beta-2 protein
Authors:Khan, A.K, Jagielnicki, M, Purdy, M.D, Yeager, M.
Deposit date:2019-11-04
Release date:2020-04-29
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:A Steric "Ball-and-Chain" Mechanism for pH-Mediated Regulation of Gap Junction Channels.
Cell Rep, 31, 2020
3IZ1
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BU of 3iz1 by Molmil
C-alpha model fitted into the EM structure of Cx26M34A
Descriptor: Gap junction beta-2 protein
Authors:Oshima, A, Tani, K, Toloue, M.M, Hiroaki, Y, Smock, A, Inukai, S, Cone, A, Nicholson, B.J, Sosinsky, G.E, Fujiyoshi, Y.
Deposit date:2010-08-19
Release date:2010-11-03
Last modified:2024-02-21
Method:ELECTRON CRYSTALLOGRAPHY (6 Å)
Cite:Asymmetric configurations and N-terminal rearrangements in connexin26 gap junction channels.
J.Mol.Biol., 405, 2011
6UVT
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BU of 6uvt by Molmil
Human Connexin-26 (Low pH closed conformation)
Descriptor: Gap junction beta-2 protein
Authors:Khan, A.K, Jagielnicki, M, Purdy, M.D, Yeager, M.
Deposit date:2019-11-04
Release date:2020-04-29
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (7.5 Å)
Cite:A Steric 'Ball-and-Chain' Mechanism for pH-Mediated Regulation of Gap Junction Channels
Cell Rep, 31, 2020
3IZ2
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BU of 3iz2 by Molmil
C-alpha model fitted into the EM structure of Cx26M34Adel2-7
Descriptor: Gap junction beta-2 protein
Authors:Oshima, A, Tani, K, Toloue, M.M, Hiroaki, Y, Smock, A, Inukai, S, Cone, A, Nicholson, B.J, Sosinsky, G.E, Fujiyoshi, Y.
Deposit date:2010-08-19
Release date:2010-11-03
Last modified:2024-02-21
Method:ELECTRON CRYSTALLOGRAPHY (10 Å)
Cite:Asymmetric configurations and N-terminal rearrangements in connexin26 gap junction channels.
J.Mol.Biol., 405, 2011
5KJ3
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BU of 5kj3 by Molmil
Connexin 26 WT peptide NMR Structure
Descriptor: Gap junction beta-2 protein
Authors:Dowd, T.L, Bargiello, T.A.
Deposit date:2016-06-17
Release date:2016-09-28
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structural studies of N-terminal mutants of Connexin 26 and Connexin 32 using (1)H NMR spectroscopy.
Arch.Biochem.Biophys., 608, 2016
5KJG
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BU of 5kjg by Molmil
Connexin 26 G12R mutant NMR structure
Descriptor: Gap junction beta-2 protein
Authors:Dowd, T.L, Bargiello, T.A.
Deposit date:2016-06-19
Release date:2016-09-28
Last modified:2019-12-25
Method:SOLUTION NMR
Cite:Structural studies of N-terminal mutants of Connexin 26 and Connexin 32 using (1)H NMR spectroscopy.
Arch.Biochem.Biophys., 608, 2016

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