9BC4
| Transglutaminase 2 - Intermediate State | Descriptor: | CALCIUM ION, GLYCEROL, HB-225 (gluten peptidomimetic TG2 inhibitor), ... | Authors: | Sewa, A.S, Mathews, I.I, Khosla, C. | Deposit date: | 2024-04-07 | Release date: | 2024-07-03 | Last modified: | 2024-07-17 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | Structural and mechanistic analysis of Ca 2+ -dependent regulation of transglutaminase 2 activity using a Ca 2+ -bound intermediate state. Proc.Natl.Acad.Sci.USA, 121, 2024
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2Q3Z
| Transglutaminase 2 undergoes large conformational change upon activation | Descriptor: | Polypeptide, SULFATE ION, Transglutaminase 2 | Authors: | Strop, P, Pinkas, D.M, Brunger, A.T, Khosla, C. | Deposit date: | 2007-05-30 | Release date: | 2007-10-23 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Transglutaminase 2 undergoes a large conformational change upon activation Plos Biol., 5, 2007
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3S3J
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3S3S
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3S3P
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9BC3
| Transglutaminase 2 - Alternate state | Descriptor: | CALCIUM ION, HB-225 (gluten peptidomimetic TG2 inhibitor), Protein-glutamine gamma-glutamyltransferase 2 | Authors: | Mathews, I.I, Sewa, A.S, Khosla, C. | Deposit date: | 2024-04-07 | Release date: | 2024-07-03 | Last modified: | 2024-07-17 | Method: | X-RAY DIFFRACTION (2.52 Å) | Cite: | Structural and mechanistic analysis of Ca 2+ -dependent regulation of transglutaminase 2 activity using a Ca 2+ -bound intermediate state. Proc.Natl.Acad.Sci.USA, 121, 2024
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6A8P
| Transglutaminase 2 mutant G224V in complex with GTP | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, Protein-glutamine gamma-glutamyltransferase 2 | Authors: | Park, H.H, Ha, H.J, Kwon, S. | Deposit date: | 2018-07-09 | Release date: | 2018-09-26 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.537 Å) | Cite: | Structure of natural variant transglutaminase 2 reveals molecular basis of gaining stability and higher activity. PLoS ONE, 13, 2018
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9BC2
| Transglutaminase 2 - Open State | Descriptor: | CHLORIDE ION, HB-225 (gluten peptidomimetic TG2 inhibitor), Protein-glutamine gamma-glutamyltransferase 2, ... | Authors: | Mathews, I.I, Sewa, A, Khosla, C. | Deposit date: | 2024-04-07 | Release date: | 2024-07-03 | Last modified: | 2024-07-17 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Structural and mechanistic analysis of Ca 2+ -dependent regulation of transglutaminase 2 activity using a Ca 2+ -bound intermediate state. Proc.Natl.Acad.Sci.USA, 121, 2024
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1KV3
| HUMAN TISSUE TRANSGLUTAMINASE IN GDP BOUND FORM | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Protein-glutamine gamma-glutamyltransferase | Authors: | Liu, S, Cerione, R.A, Clardy, J. | Deposit date: | 2002-01-24 | Release date: | 2002-03-13 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural basis for the guanine nucleotide-binding activity of tissue transglutaminase and its regulation of transamidation activity. Proc.Natl.Acad.Sci.USA, 99, 2002
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4PYG
| Transglutaminase2 complexed with GTP | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, Protein-glutamine gamma-glutamyltransferase 2 | Authors: | Park, H.H, Jang, T.H. | Deposit date: | 2014-03-27 | Release date: | 2015-02-11 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structure of transglutaminase 2 with GTP complex and amino acid sequence evidence of evolution of GTP binding site. Plos One, 9, 2014
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3LY6
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8TR9
| Cryo-EM structure of transglutaminase 2 bound to GDP | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Protein-glutamine gamma-glutamyltransferase 2 | Authors: | Aplin, C, Cerione, R.A. | Deposit date: | 2023-08-09 | Release date: | 2024-07-31 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Conformational activation and inhibition of transglutaminase 2 determined by static and time resolved small-angle X-ray scattering and cryoelectron microscopy To Be Published
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6KZB
| Transglutaminase2 complexed with calcium | Descriptor: | CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, Protein-glutamine gamma-glutamyltransferase 2 | Authors: | Park, H.H, Kim, C.M. | Deposit date: | 2019-09-23 | Release date: | 2020-12-09 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.55 Å) | Cite: | Competitive Binding of Magnesium to Calcium Binding Sites Reciprocally Regulates Transamidase and GTP Hydrolysis Activity of Transglutaminase 2. Int J Mol Sci, 21, 2020
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