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PDB: 124 results

4U4Q
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Crystal structure of Homoharringtonine bound to the yeast 80S ribosome
Descriptor: (3beta)-O~3~-[(2R)-2,6-dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methylheptanoyl]cephalotaxine, 18S ribosomal RNA, 25S ribosomal RNA, ...
Authors:Garreau de Loubresse, N, Prokhorova, I, Yusupova, G, Yusupov, M.
Deposit date:2014-07-24
Release date:2014-10-22
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural basis for the inhibition of the eukaryotic ribosome.
Nature, 513, 2014
4U4U
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BU of 4u4u by Molmil
Crystal structure of Lycorine bound to the yeast 80S ribosome
Descriptor: (1S,2S,12bS,12cS)-2,4,5,7,12b,12c-hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol, 18S ribosomal RNA, 25S ribosomal RNA, ...
Authors:Garreau de Loubresse, N, Prokhorova, I, Yusupova, G, Yusupov, M.
Deposit date:2014-07-24
Release date:2014-10-22
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural basis for the inhibition of the eukaryotic ribosome.
Nature, 513, 2014
4V88
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The structure of the eukaryotic ribosome at 3.0 A resolution.
Descriptor: 18S RIBOSOMAL RNA, 18S rRNA, 25S rRNA, ...
Authors:Ben-Shem, A, Garreau de Loubresse, N, Melnikov, S, Jenner, L, Yusupova, G, Yusupov, M.
Deposit date:2011-10-11
Release date:2014-07-09
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (3 Å)
Cite:The structure of the eukaryotic ribosome at 3.0 angstrom resolution.
Science, 334, 2011
8K82
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BU of 8k82 by Molmil
Cryo-EM structure of the yeast 80S ribosome with tigecycline, Not5 and P-site tRNA
Descriptor: 18S rRNA, 23S rRNA, 40S ribosomal protein S1-A, ...
Authors:Buschauer, R, Beckmann, R, Cheng, J.
Deposit date:2023-07-28
Release date:2024-07-10
Last modified:2024-11-06
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.
Nat Commun, 15, 2024
8CAH
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BU of 8cah by Molmil
Cryo-EM structure of native Otu2-bound ubiquitinated 43S pre-initiation complex
Descriptor: 18S ribosomal RNA, 40S ribosomal protein S0-A, 40S ribosomal protein S1-A, ...
Authors:Ikeuchi, K, Buschauer, R, Cheng, J, Berninghausen, O, Becker, T, Beckmann, R.
Deposit date:2023-01-24
Release date:2023-05-24
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Molecular basis for recognition and deubiquitination of 40S ribosomes by Otu2.
Nat Commun, 14, 2023
7N8B
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BU of 7n8b by Molmil
Cycloheximide bound vacant 80S structure isolated from cbf5-D95A
Descriptor: 18S RIBOSOMAL RNA, 25S, 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione, ...
Authors:Rai, J, Zhao, Y, Li, H.
Deposit date:2021-06-14
Release date:2022-05-11
Last modified:2024-11-13
Method:ELECTRON MICROSCOPY (3.05 Å)
Cite:CryoEM structures of pseudouridine-free ribosome suggest impacts of chemical modifications on ribosome conformations.
Structure, 30, 2022
7MPI
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BU of 7mpi by Molmil
Stm1 bound vacant 80S structure isolated from cbf5-D95A
Descriptor: 18S rRNA, 25S rRNA, 40S ribosomal protein S0-A, ...
Authors:Rai, J, Zhao, Y, Li, H.
Deposit date:2021-05-04
Release date:2022-05-11
Last modified:2024-11-13
Method:ELECTRON MICROSCOPY (3.05 Å)
Cite:CryoEM structures of pseudouridine-free ribosome suggest impacts of chemical modifications on ribosome conformations.
Structure, 30, 2022
4U4N
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Crystal structure of Edeine bound to the yeast 80S ribosome
Descriptor: 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ...
Authors:Garreau de Loubresse, N, Prokhorova, I, Yusupova, G, Yusupov, M.
Deposit date:2014-07-24
Release date:2014-10-22
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural basis for the inhibition of the eukaryotic ribosome.
Nature, 513, 2014
4U4Z
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BU of 4u4z by Molmil
Crystal structure of Phyllanthoside bound to the yeast 80S ribosome
Descriptor: 18S ribosomal RNA, 25S ribosomal RNA, 3-O-acetyl-2-O-(3-O-acetyl-6-deoxy-beta-D-glucopyranosyl)-6-deoxy-1-O-{[(2R,2'S,3a'R,4''S,5''R,6'S,7a'S)-5''-methyl-4''-{[(2E)-3-phenylprop-2-enoyl]oxy}decahydrodispiro[oxirane-2,3'-[1]benzofuran-2',2''-pyran]-6'-yl]carbonyl}-beta-D-glucopyranose, ...
Authors:Garreau de Loubresse, N, Prokhorova, I, Yusupova, G, Yusupov, M.
Deposit date:2014-07-24
Release date:2014-10-22
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural basis for the inhibition of the eukaryotic ribosome.
Nature, 513, 2014
4U6F
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BU of 4u6f by Molmil
Crystal structure of T-2 toxin bound to the yeast 80S ribosome
Descriptor: 12,13-Epoxytrichothec-9-ene-3,4,8,15-tetrol-4,15-diacetate-8-isovalerate, 18S ribosomal RNA, 25S ribosomal RNA, ...
Authors:Garreau de Loubresse, N, Prokhorova, I, Yusupova, G, Yusupov, M.
Deposit date:2014-07-28
Release date:2014-10-22
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural basis for the inhibition of the eukaryotic ribosome.
Nature, 513, 2014
6T7T
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BU of 6t7t by Molmil
Structure of yeast 80S ribosome stalled on poly(A) tract.
Descriptor: 18S rRNA, 25S rRNA, 40S ribosomal protein S0-A, ...
Authors:Tesina, P, Buschauer, R, Cheng, J, Berninghausen, O, Becker, R, Beckmann, R.
Deposit date:2019-10-23
Release date:2019-12-25
Last modified:2024-11-13
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Molecular mechanism of translational stalling by inhibitory codon combinations and poly(A) tracts.
Embo J., 39, 2020
6TNU
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BU of 6tnu by Molmil
Yeast 80S ribosome in complex with eIF5A and decoding A-site and P-site tRNAs.
Descriptor: 18S rRNA, 25S rRNA, 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione, ...
Authors:Buschauer, R, Cheng, J, Berninghausen, O, Tesina, P, Becker, T, Beckmann, R.
Deposit date:2019-12-10
Release date:2020-04-22
Last modified:2024-11-06
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:The Ccr4-Not complex monitors the translating ribosome for codon optimality.
Science, 368, 2020
5FCJ
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BU of 5fcj by Molmil
Structure of the anisomycin-containing uL3 W255C mutant 80S yeast ribosome
Descriptor: 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ...
Authors:Mailliot, J, Garreau de Loubresse, N, Yusupova, G, Dinman, J.D, Yusupov, M.
Deposit date:2015-12-15
Release date:2016-05-11
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Crystal Structures of the uL3 Mutant Ribosome: Illustration of the Importance of Ribosomal Proteins for Translation Efficiency.
J.Mol.Biol., 428, 2016
5DGV
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BU of 5dgv by Molmil
Complex of yeast 80S ribosome with hypusine-containing/non-modified eIF5A and/or a peptidyl-tRNA analog
Descriptor: 25S ribosomal RNA, 40S ribosomal protein S0-A, 40S ribosomal protein S1-A, ...
Authors:Melnikov, S, Mailliot, J, Shin, B.-S, Rigger, L, Yusupova, G, Micura, R, Dever, T.E, Yusupov, M.
Deposit date:2015-08-28
Release date:2016-12-14
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Coping with proline stalling: structural basis of hypusine-induced protein synthesis by the eukaryotic ribosome
To Be Published
8CKU
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BU of 8cku by Molmil
Translocation intermediate 1 (TI-1*) of 80S S. cerevisiae ribosome with ligands and eEF2 in the absence of sordarin
Descriptor: 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ...
Authors:Milicevic, N, Jenner, L, Myasnikov, A, Yusupov, M, Yusupova, G.
Deposit date:2023-02-16
Release date:2023-09-20
Last modified:2024-04-24
Method:ELECTRON MICROSCOPY (3.11 Å)
Cite:mRNA reading frame maintenance during eukaryotic ribosome translocation.
Nature, 625, 2024
8UTI
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BU of 8uti by Molmil
Eukaryotic 80S ribosome with Reh1 and A/P site tRNA
Descriptor: 18S rRNA, 25S rRNA, 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione, ...
Authors:Yelland, J.N, Taylor, D.W, Johnson, A.W.
Deposit date:2023-10-31
Release date:2024-11-06
Method:ELECTRON MICROSCOPY (3.13 Å)
Cite:The Ribosome Assembly Factor Reh1 is Released from the Polypeptide Exit Tunnel in the Pioneer Round of Translation
To Be Published
5DAT
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BU of 5dat by Molmil
Complex of yeast 80S ribosome with hypusine-containing eIF5A
Descriptor: 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ...
Authors:Melnikov, S, Mailliot, J, Shin, B.-S, Rigger, L, Yusupova, G, Micura, R, Dever, T.E, Yusupov, M.
Deposit date:2015-08-20
Release date:2016-08-31
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Coping with proline stalling: structural basis of hypusine-induced protein synthesis by the eukaryotic ribosome
To Be Published
4U51
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BU of 4u51 by Molmil
Crystal structure of Narciclasine bound to the yeast 80S ribosome
Descriptor: (2S,3R,4S,4aR)-2,3,4,7-tetrahydroxy-3,4,4a,5-tetrahydro[1,3]dioxolo[4,5-j]phenanthridin-6(2H)-one, 18S ribosomal RNA, 25S ribosomal RNA, ...
Authors:Garreau de Loubresse, N, Prokhorova, I, Yusupova, G, Yusupov, M.
Deposit date:2014-07-24
Release date:2014-10-22
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural basis for the inhibition of the eukaryotic ribosome.
Nature, 513, 2014
4U3N
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BU of 4u3n by Molmil
Crystal structure of CCA trinucleotide bound to the yeast 80S ribosome
Descriptor: 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ...
Authors:Garreau de Loubresse, N, Prokhorova, I, Yusupova, G, Yusupov, M.
Deposit date:2014-07-22
Release date:2014-10-22
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural basis for the inhibition of the eukaryotic ribosome.
Nature, 513, 2014
4U55
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BU of 4u55 by Molmil
Crystal structure of Cryptopleurine bound to the yeast 80S ribosome
Descriptor: (14aR)-2,3,6-trimethoxy-11,12,13,14,14a,15-hexahydro-9H-dibenzo[f,h]pyrido[1,2-b]isoquinoline, 18S ribosomal RNA, 25S ribosomal RNA, ...
Authors:Garreau de Loubresse, N, Prokhorova, I, Yusupova, G, Yusupov, M.
Deposit date:2014-07-24
Release date:2014-10-22
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural basis for the inhibition of the eukaryotic ribosome.
Nature, 513, 2014
8K2D
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BU of 8k2d by Molmil
Cryo-EM structure of the yeast 80S ribosome with tigecycline, eEF2, Stm1 and eIF5A
Descriptor: 18S rRNA, 23S rRNA, 40S ribosomal protein S1-A, ...
Authors:Buschauer, R, Beckmann, R, Cheng, J.
Deposit date:2023-07-12
Release date:2024-07-10
Last modified:2024-10-30
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.
Nat Commun, 15, 2024
6T7I
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BU of 6t7i by Molmil
Structure of yeast 80S ribosome stalled on the CGA-CGA inhibitory codon combination.
Descriptor: 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ...
Authors:Tesina, P, Buschauer, R, Cheng, J, Berninghausen, O, Becker, R, Beckmann, R.
Deposit date:2019-10-22
Release date:2019-12-25
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Molecular mechanism of translational stalling by inhibitory codon combinations and poly(A) tracts.
Embo J., 39, 2020
6LQP
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BU of 6lqp by Molmil
Cryo-EM structure of 90S small subunit preribosomes in transition states (State A)
Descriptor: 13 kDa ribonucleoprotein-associated protein, 18S pre-rRNA, 40S ribosomal protein S1-A, ...
Authors:Du, Y, Ye, K.
Deposit date:2020-01-14
Release date:2020-09-16
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-EM structure of 90 S small ribosomal subunit precursors in transition states.
Science, 369, 2020
4U50
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BU of 4u50 by Molmil
Crystal structure of Verrucarin bound to the yeast 80S ribosome
Descriptor: (4S,5R,10E,12Z,16R,16aS,17S,18R,19aR,23aR)-4-hydroxy-5,16a,21-trimethyl-4,5,6,7,16,16a,22,23-octahydro-3H,18H,19aH-spiro[16,18-methano[1,6,12]trioxacyclooctadecino[3,4-d]chromene-17,2'-oxirane]-3,9,14-trione, 18S ribosomal RNA, 25S ribosomal RNA, ...
Authors:Garreau de Loubresse, N, Prokhorova, I, Yusupova, G, Yusupov, M.
Deposit date:2014-07-24
Release date:2014-10-22
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural basis for the inhibition of the eukaryotic ribosome.
Nature, 513, 2014
4U4Y
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BU of 4u4y by Molmil
Crystal structure of Pactamycin bound to the yeast 80S ribosome
Descriptor: 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ...
Authors:Garreau de Loubresse, N, Prokhorova, I, Yusupova, G, Yusupov, M.
Deposit date:2014-07-24
Release date:2014-10-22
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural basis for the inhibition of the eukaryotic ribosome.
Nature, 513, 2014

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