6SJA
| Structure of HPV16 E6 oncoprotein in complex with IRF3 LxxLL motif | Descriptor: | Maltose/maltodextrin-binding periplasmic protein,Interferon regulatory factor 3, Protein E6, ZINC ION, ... | Authors: | Suarez, I.P, Cousido-Siah, A, Bonhoure, A, Mitschler, A, Podjarny, A, Trave, G. | Deposit date: | 2019-08-13 | Release date: | 2019-09-04 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Deciphering de molecular and structural interaction between IRF3 and HPV16 E6 To be published
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6SIV
| Structure of HPV16 E6 oncoprotein in complex with mutant IRF3 LxxLL motif | Descriptor: | Maltose/maltodextrin-binding periplasmic protein,Interferon regulatory factor 3, Protein E6, ZINC ION, ... | Authors: | Suarez, I.P, Cousido-Siah, A, Bonhoure, A, Mitschler, A, Podjarny, A, Trave, G. | Deposit date: | 2019-08-12 | Release date: | 2019-08-21 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.752 Å) | Cite: | Deciphering the molecular and structural interaction between IRF3 and HPV16 E6 To be published
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4JOP
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8B87
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6HKS
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4XR8
| Crystal structure of the HPV16 E6/E6AP/p53 ternary complex at 2.25 A resolution | Descriptor: | 1,2-ETHANEDIOL, Cellular tumor antigen p53, DI(HYDROXYETHYL)ETHER, ... | Authors: | Martinez-Zapien, D, Ruiz, F.X, Mitschler, A, Podjarny, A, Trave, G, Zanier, K. | Deposit date: | 2015-01-20 | Release date: | 2016-02-03 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53. Nature, 529, 2016
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6TWX
| MAGI1_2 complexed with a phosphorylated 16E6 peptide | Descriptor: | 16E6 peptide, CALCIUM ION, CITRIC ACID, ... | Authors: | Gogl, G, Cousido-Siah, A, Trave, G. | Deposit date: | 2020-01-13 | Release date: | 2020-04-01 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Dual Specificity PDZ- and 14-3-3-Binding Motifs: A Structural and Interactomics Study. Structure, 28, 2020
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6TWU
| MAGI1_2 complexed with a phosphomimetic 16E6 peptide | Descriptor: | CALCIUM ION, CITRIC ACID, GLYCEROL, ... | Authors: | Gogl, G, Cousido-Siah, A, Trave, G. | Deposit date: | 2020-01-13 | Release date: | 2020-04-01 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Dual Specificity PDZ- and 14-3-3-Binding Motifs: A Structural and Interactomics Study. Structure, 28, 2020
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8B9T
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4GIZ
| Crystal structure of full-length human papillomavirus oncoprotein E6 in complex with LXXLL peptide of ubiquitin ligase E6AP at 2.55 A resolution | Descriptor: | Maltose-binding periplasmic protein, UBIQUITIN LIGASE EA6P: chimeric protein, Protein E6, ... | Authors: | McEwen, A.G, Zanier, K, Charbonnier, S, Poussin, P, Cura, V, Vande Pol, S, Trave, G, Cavarelli, J. | Deposit date: | 2012-08-09 | Release date: | 2013-01-23 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Structural basis for hijacking of cellular LxxLL motifs by papillomavirus E6 oncoproteins. Science, 339, 2013
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8JRN
| Structure of E6AP-E6 complex in Att1 state | Descriptor: | Protein E6, Ubiquitin-protein ligase E3A, ZINC ION | Authors: | Wang, Z, Yu, X. | Deposit date: | 2023-06-17 | Release date: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Structural insights into the functional mechanism of the ubiquitin ligase E6AP. Nat Commun, 15, 2024
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6TWQ
| MAGI1_2 complexed with a 16E6 peptide | Descriptor: | CALCIUM ION, CITRIC ACID, GLYCEROL, ... | Authors: | Gogl, G, Cousido-Siah, A, Trave, G. | Deposit date: | 2020-01-13 | Release date: | 2020-04-01 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Dual Specificity PDZ- and 14-3-3-Binding Motifs: A Structural and Interactomics Study. Structure, 28, 2020
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7VZE
| Crystal structure of PTPN4 PDZ bound to the PBM of HPV16 E6 | Descriptor: | Tyrosine-protein phosphatase non-receptor type 4, the PDZ-binding motif of HPV16 E6 | Authors: | Lee, H.S, Yun, H.-Y, Ku, B. | Deposit date: | 2021-11-16 | Release date: | 2022-03-02 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.882 Å) | Cite: | Structural and biochemical analysis of the PTPN4 PDZ domain bound to the C-terminal tail of the human papillomavirus E6 oncoprotein. J.Microbiol, 60, 2022
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8JRO
| Structure of E6AP-E6 complex in Att2 state | Descriptor: | Protein E6, Ubiquitin-protein ligase E3A, ZINC ION | Authors: | Wang, Z, Yu, X. | Deposit date: | 2023-06-17 | Release date: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.01 Å) | Cite: | Structural insights into the functional mechanism of the ubiquitin ligase E6AP. Nat Commun, 15, 2024
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7UAJ
| Crystal structure of apo HPV16 E6 | Descriptor: | Maltose/maltodextrin-binding periplasmic protein,Protein E6, ZINC ION, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | Authors: | Shen, Q, Leonard, P.G, Cross, J.B. | Deposit date: | 2022-03-13 | Release date: | 2023-03-15 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (3.25 Å) | Cite: | Disorder-to-order transition of the interdomain linker of HPV E6 upon E6AP binding reshapes p53 binding pocket To Be Published
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8GCR
| HPV16 E6-E6AP-p53 complex | Descriptor: | Cellular tumor antigen p53, Maltose/maltodextrin-binding periplasmic protein,Protein E6, Ubiquitin-protein ligase E3A, ... | Authors: | Bratkowski, M.A, Wang, J.C.K, Hao, Q, Nile, A.H. | Deposit date: | 2023-03-02 | Release date: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.38 Å) | Cite: | Structure of the p53 degradation complex from HPV16. Nat Commun, 15, 2024
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8JRP
| Structure of E6AP-E6 complex in Att3 state | Descriptor: | Protein E6, Ubiquitin-protein ligase E3A, ZINC ION | Authors: | Wang, Z, Yu, X. | Deposit date: | 2023-06-17 | Release date: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.58 Å) | Cite: | Structural insights into the functional mechanism of the ubiquitin ligase E6AP. Nat Commun, 15, 2024
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8R1F
| Monomeric E6AP-E6-p53 ternary complex | Descriptor: | Cellular tumor antigen p53, Ubiquitin-like protein SMT3,Protein E6, Ubiquitin-protein ligase E3A, ... | Authors: | Sandate, C.R, Chakraborty, D, Kater, L, Kempf, G, Thoma, N.H. | Deposit date: | 2023-11-01 | Release date: | 2023-12-06 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.67 Å) | Cite: | Structural insights into viral hijacking of p53 by E6 and E6AP Biorxiv, 2023
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8R1G
| Dimeric ternary structure of E6AP-E6-p53 | Descriptor: | Cellular tumor antigen p53, Ubiquitin-like protein SMT3,Protein E6, Ubiquitin-protein ligase E3A, ... | Authors: | Sandate, C.R, Chakrabory, D, Kater, L, Kempf, G, Thoma, N.H. | Deposit date: | 2023-11-01 | Release date: | 2023-12-06 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.99 Å) | Cite: | Structural insights into viral hijacking of p53 by E6 and E6AP Biorxiv, 2023
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8JRQ
| Structure of E6AP-E6 complex in Det1 state | Descriptor: | Protein E6, Ubiquitin-protein ligase E3A, ZINC ION | Authors: | Wang, Z, Yu, X. | Deposit date: | 2023-06-17 | Release date: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (4.15 Å) | Cite: | Structural insights into the functional mechanism of the ubiquitin ligase E6AP. Nat Commun, 15, 2024
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8JRR
| Structure of E6AP-E6 complex in Det2 state | Descriptor: | Protein E6, Ubiquitin-protein ligase E3A, ZINC ION | Authors: | Wang, Z, Yu, X. | Deposit date: | 2023-06-17 | Release date: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (4.35 Å) | Cite: | Structural insights into the functional mechanism of the ubiquitin ligase E6AP. Nat Commun, 15, 2024
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2LJX
| Structure of the monomeric N-terminal domain of HPV16 E6 oncoprotein | Descriptor: | Protein E6, ZINC ION | Authors: | Zanier, K, Muhamed Sidi, A, Boulade-Ladame, C, Rybin, V, Chappelle, A, Atkinson, A, Kieffer, B, Trave, G. | Deposit date: | 2011-09-30 | Release date: | 2012-04-04 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution Structure Analysis of the HPV16 E6 Oncoprotein Reveals a Self-Association Mechanism Required for E6-Mediated Degradation of p53. Structure, 20, 2012
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2LJZ
| Structure of the C-terminal domain of HPV16 E6 oncoprotein | Descriptor: | Protein E6, ZINC ION | Authors: | Zanier, K, Muhamed Sidi, A, Boulade-Ladame, C, Rybin, V, Chappelle, A, Atkinson, A, Kieffer, B, Trave, G. | Deposit date: | 2011-09-30 | Release date: | 2012-04-04 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution Structure Analysis of the HPV16 E6 Oncoprotein Reveals a Self-Association Mechanism Required for E6-Mediated Degradation of p53. Structure, 20, 2012
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2FK4
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2LJY
| Haddock model structure of the N-terminal domain dimer of HPV16 E6 | Descriptor: | Protein E6, ZINC ION | Authors: | Zanier, K, Muhamed Sidi, A, Boulade-Ladame, C, Rybin, V, Chappelle, A, Atkinson, A, Kieffer, B, Trave, G. | Deposit date: | 2011-09-30 | Release date: | 2012-04-04 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Solution Structure Analysis of the HPV16 E6 Oncoprotein Reveals a Self-Association Mechanism Required for E6-Mediated Degradation of p53. Structure, 20, 2012
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