1EK9
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![BU of 1ek9 by Molmil](/molmil-images/mine/1ek9) | 2.1A X-RAY STRUCTURE OF TOLC: AN INTEGRAL OUTER MEMBRANE PROTEIN AND EFFLUX PUMP COMPONENT FROM ESCHERICHIA COLI | Descriptor: | OUTER MEMBRANE PROTEIN TOLC | Authors: | Koronakis, V, Sharff, A.J, Koronakis, E, Luisi, B, Hughes, C. | Deposit date: | 2000-03-07 | Release date: | 2000-06-28 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of the bacterial membrane protein TolC central to multidrug efflux and protein export. Nature, 405, 2000
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1TQQ
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![BU of 1tqq by Molmil](/molmil-images/mine/1tqq) | Structure of TolC in complex with hexamminecobalt | Descriptor: | COBALT HEXAMMINE(III), Outer membrane protein tolC | Authors: | Higgins, M.K, Eswaran, J, Edwards, P.C, Schertler, G.F, Hughes, C, Koronakis, V. | Deposit date: | 2004-06-18 | Release date: | 2004-07-20 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Structure of the ligand-blocked periplasmic entrance of the bacterial multidrug effllux protein TolC J.Mol.Biol., 342, 2004
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6WXI
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![BU of 6wxi by Molmil](/molmil-images/mine/6wxi) | Colicin E1 fragment in nanodisc-embedded TolC | Descriptor: | Outer membrane protein TolC | Authors: | Kaelber, J.T, Budiardjo, S.J, Firlar, E, Ikujuni, A.P, Slusky, J.S.G. | Deposit date: | 2020-05-10 | Release date: | 2021-05-12 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (2.84 Å) | Cite: | Colicin E1 opens its hinge to plug TolC. Elife, 11, 2022
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2XMN
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![BU of 2xmn by Molmil](/molmil-images/mine/2xmn) | High resolution snapshots of defined TolC open states present an iris- like movement of periplasmic entrance helices | Descriptor: | CHLORIDE ION, DODECYL-BETA-D-MALTOSIDE, Outer membrane protein TolC | Authors: | Pei, X.Y, Koronakis, E, Hughes, C, Koronakis, V. | Deposit date: | 2010-07-28 | Release date: | 2011-01-26 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Structures of sequential open states in a symmetrical opening transition of the TolC exit duct. Proc. Natl. Acad. Sci. U.S.A., 108, 2011
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2WMZ
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![BU of 2wmz by Molmil](/molmil-images/mine/2wmz) | Structure of a mutated TolC | Descriptor: | CHLORIDE ION, OUTER MEMBRANE PROTEIN TOLC, SODIUM ION, ... | Authors: | Hinchliffe, P, Pei, X.Y, Symmons, M.F, Koronakis, E, Hughes, C, Koronakis, V. | Deposit date: | 2009-07-03 | Release date: | 2011-01-26 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structures of Sequential Open States in a Symmetrical Opening Transition of the Tolc Exit Duct. Proc.Natl.Acad.Sci.USA, 108, 2011
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6WXH
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![BU of 6wxh by Molmil](/molmil-images/mine/6wxh) | Colicin E1 fragment in nanodisc-embedded TolC | Descriptor: | Colicin-E1, Outer membrane protein TolC | Authors: | Kaelber, J.T, Budiardjo, S.J, Firlar, E, Case, D.A, Ikujuni, A.P, Slusky, J.S.G. | Deposit date: | 2020-05-10 | Release date: | 2021-05-12 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.09 Å) | Cite: | Colicin E1 opens its hinge to plug TolC. Elife, 11, 2022
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2VDE
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![BU of 2vde by Molmil](/molmil-images/mine/2vde) | Crystal Structure of the Open State of TolC Outer Membrane Component of Mutlidrug Efflux Pumps | Descriptor: | CHLORIDE ION, OUTER MEMBRANE PROTEIN TOLC | Authors: | Bavro, V.N, Pietras, Z, Furnham, N, Perez-Cano, L, Fernandez-Recio, J, Pei, X.Y, Truer, R, Misra, R, Luisi, B. | Deposit date: | 2007-10-04 | Release date: | 2008-04-22 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Assembly and Channel Opening in a Bacterial Drug Efflux Machine. Mol.Cell, 30, 2008
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2VDD
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![BU of 2vdd by Molmil](/molmil-images/mine/2vdd) | Crystal Structure of the Open State of TolC Outer Membrane Component of Mutlidrug Efflux Pumps | Descriptor: | CHLORIDE ION, OUTER MEMBRANE PROTEIN TOLC, POTASSIUM ION | Authors: | Bavro, V.N, Pietras, Z, Furnham, N, Perez-Cano, L, Fernandez-Recio, J, Pei, X.Y, Truer, R, Misra, R, Luisi, B. | Deposit date: | 2007-10-04 | Release date: | 2008-04-22 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Assembly and Channel Opening in a Bacterial Drug Efflux Machine. Mol.Cell, 30, 2008
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5NIK
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![BU of 5nik by Molmil](/molmil-images/mine/5nik) | Structure of the MacAB-TolC ABC-type tripartite multidrug efflux pump | Descriptor: | Macrolide export ATP-binding/permease protein MacB, Macrolide export protein MacA, Outer membrane protein TolC | Authors: | Fitzpatrick, A.W.P, Llabres, S, Neuberger, A, Blaza, J.N, Bai, X.-C, Okada, U, Murakami, S, van Veen, H.W, Zachariae, U, Scheres, S.H.W, Luisi, B.F, Du, D. | Deposit date: | 2017-03-24 | Release date: | 2017-05-24 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structure of the MacAB-TolC ABC-type tripartite multidrug efflux pump. Nat Microbiol, 2, 2017
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5NIL
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![BU of 5nil by Molmil](/molmil-images/mine/5nil) | Structure of the MacAB-TolC ABC-type tripartite multidrug efflux pump-MacB section | Descriptor: | Macrolide export ATP-binding/permease protein MacB, Macrolide export protein MacA, Outer membrane protein TolC | Authors: | Fitzpatrick, A.W.P, Llabres, S, Neuberger, A, Blaza, J.N, Bai, X.-C, Okada, U, Murakami, S, van Veen, H.W, Zachariae, U, Scheres, S.H.W, Luisi, B.F, Du, D. | Deposit date: | 2017-03-24 | Release date: | 2017-05-24 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (5.3 Å) | Cite: | Structure of the MacAB-TolC ABC-type tripartite multidrug efflux pump. Nat Microbiol, 2, 2017
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5O66
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![BU of 5o66 by Molmil](/molmil-images/mine/5o66) | Asymmetric AcrABZ-TolC | Descriptor: | Multidrug efflux pump accessory protein AcrZ, Multidrug efflux pump subunit AcrA, Multidrug efflux pump subunit AcrB, ... | Authors: | Du, D, Luisi, B.F. | Deposit date: | 2017-06-05 | Release date: | 2017-06-14 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (5.9 Å) | Cite: | An allosteric transport mechanism for the AcrAB-TolC multidrug efflux pump. Elife, 6, 2017
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5NG5
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![BU of 5ng5 by Molmil](/molmil-images/mine/5ng5) | multi-drug efflux; membrane transport; RND superfamily; Drug resistance | Descriptor: | 6-[2-(3,4-dimethoxyphenyl)ethylsulfanyl]-8-[4-(2-methoxyethyl)piperazin-1-yl]-3,3-dimethyl-1,4-dihydropyrano[3,4-c]pyridine-5-carbonitrile, Multidrug efflux pump accessory protein AcrZ, Multidrug efflux pump subunit AcrA, ... | Authors: | Wang, Z, Fan, G, Hryc, C.F, Blaza, J.N, Serysheva, I.I, Schmid, M.F, Chiu, W, Luisi, B.F, Du, D. | Deposit date: | 2017-03-16 | Release date: | 2017-04-19 | Last modified: | 2017-08-02 | Method: | ELECTRON MICROSCOPY (6.5 Å) | Cite: | An allosteric transport mechanism for the AcrAB-TolC Multidrug Efflux Pump. Elife, 6, 2017
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5V5S
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![BU of 5v5s by Molmil](/molmil-images/mine/5v5s) | multi-drug efflux; membrane transport; RND superfamily; Drug resistance | Descriptor: | Multidrug efflux pump subunit AcrA, Multidrug efflux pump subunit AcrB, Outer membrane protein TolC | Authors: | wang, Z, fan, G, Hryc, C.F, Blaza, J.N, Serysheva, I.I, Schmid, M.F, Chiu, W, Luisi, B.F, Du, D. | Deposit date: | 2017-03-15 | Release date: | 2017-04-19 | Last modified: | 2019-10-23 | Method: | ELECTRON MICROSCOPY (6.5 Å) | Cite: | An allosteric transport mechanism for the AcrAB-TolC Multidrug Efflux Pump. Elife, 6, 2017
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