7O7Y
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![BU of 7o7y by Molmil](/molmil-images/mine/7o7y) | Rabbit 80S ribosome stalled close to the mutated SARS-CoV-2 slippery site by a pseudoknot (high resolution) | Descriptor: | 18S rRNA, 28S rRNA, 40S ribosomal protein S11, ... | Authors: | Bhatt, P.R, Scaiola, A, Leibundgut, M.A, Atkins, J.F, Ban, N. | Deposit date: | 2021-04-14 | Release date: | 2021-06-02 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (2.2 Å) | Cite: | Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome. Science, 372, 2021
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7OYD
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![BU of 7oyd by Molmil](/molmil-images/mine/7oyd) | Cryo-EM structure of a rabbit 80S ribosome with zebrafish Dap1b | Descriptor: | 18S rRNA, 28S rRNA, 40S ribosomal protein S11, ... | Authors: | Leesch, F, Lorenzo-Orts, L, Grishkovskaya, I, Kandolf, S, Belacic, K, Meinhart, A, Haselbach, D, Pauli, A. | Deposit date: | 2021-06-24 | Release date: | 2022-07-20 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (2.3 Å) | Cite: | A molecular network of conserved factors keeps ribosomes dormant in the egg. Nature, 613, 2023
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7O7Z
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![BU of 7o7z by Molmil](/molmil-images/mine/7o7z) | Rabbit 80S ribosome stalled close to the mutated SARS-CoV-2 slippery site by a pseudoknot (classified for pseudoknot) | Descriptor: | 18S rRNA, 28S rRNA, 40S ribosomal protein S11, ... | Authors: | Bhatt, P.R, Scaiola, A, Leibundgut, M.A, Atkins, J.F, Ban, N. | Deposit date: | 2021-04-14 | Release date: | 2021-06-02 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (2.4 Å) | Cite: | Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome. Science, 372, 2021
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8SCB
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![BU of 8scb by Molmil](/molmil-images/mine/8scb) | Terminating ribosome with SRI-41315 | Descriptor: | (2S,4aS)-2-cyclobutyl-10-methyl-3-phenyl-2,10-dihydropyrimido[4,5-b]quinoline-4,5(3H,4aH)-dione, 18S_rRNA, 28S_rRNA, ... | Authors: | Yip, M.C.J, Coelho, J.P.L, Oltion, K, Tauton, J, Shao, S. | Deposit date: | 2023-04-05 | Release date: | 2023-12-27 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | The eRF1 degrader SRI-41315 acts as a molecular glue at the ribosomal decoding center. Nat.Chem.Biol., 20, 2024
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7JQB
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![BU of 7jqb by Molmil](/molmil-images/mine/7jqb) | SARS-CoV-2 Nsp1 and rabbit 40S ribosome complex | Descriptor: | 40S ribosomal protein S21, 40S ribosomal protein S24, 40S ribosomal protein S26, ... | Authors: | Yuan, S, Xiong, Y. | Deposit date: | 2020-08-10 | Release date: | 2020-12-02 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Nonstructural Protein 1 of SARS-CoV-2 Is a Potent Pathogenicity Factor Redirecting Host Protein Synthesis Machinery toward Viral RNA. Mol.Cell, 80, 2020
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7ZJW
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![BU of 7zjw by Molmil](/molmil-images/mine/7zjw) | Rabbit 80S ribosome as it decodes the Sec-UGA codon | Descriptor: | 18S rRNA, 28S rRNA, 40S Ribosomal protein eS19, ... | Authors: | Hilal, T, Simonovic, M, Spahn, C.M.T. | Deposit date: | 2022-04-12 | Release date: | 2022-10-19 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structure of the mammalian ribosome as it decodes the selenocysteine UGA codon. Science, 376, 2022
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7O80
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![BU of 7o80 by Molmil](/molmil-images/mine/7o80) | Rabbit 80S ribosome in complex with eRF1 and ABCE1 stalled at the STOP codon in the mutated SARS-CoV-2 slippery site | Descriptor: | 18S rRNA, 28S rRNA, 40S ribosomal protein S11, ... | Authors: | Bhatt, P.R, Scaiola, A, Leibundgut, M.A, Atkins, J.F, Ban, N. | Deposit date: | 2021-04-14 | Release date: | 2021-06-02 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome. Science, 372, 2021
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8P2K
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![BU of 8p2k by Molmil](/molmil-images/mine/8p2k) | Ternary complex of translating ribosome, NAC and METAP1 | Descriptor: | 18s rRNA, 28S rRNA, 40S ribosomal protein S11, ... | Authors: | Jia, M, Jaskolowski, M, Scaiola, A, Jomaa, A, Ban, N. | Deposit date: | 2023-05-16 | Release date: | 2023-07-19 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | NAC controls cotranslational N-terminal methionine excision in eukaryotes. Science, 380, 2023
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6YAL
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![BU of 6yal by Molmil](/molmil-images/mine/6yal) | Mammalian 48S late-stage initiation complex with beta-globin mRNA | Descriptor: | 18S ribosomal RNA, 40S Ribosomal protein uS3, 40S Ribosomal protein uS7, ... | Authors: | Bochler, A, Simonetti, A, Guca, E, Hashem, Y. | Deposit date: | 2020-03-12 | Release date: | 2020-04-08 | Last modified: | 2020-04-22 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural Insights into the Mammalian Late-Stage Initiation Complexes. Cell Rep, 31, 2020
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8P03
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![BU of 8p03 by Molmil](/molmil-images/mine/8p03) | 48S late-stage initiation complex with m6A mRNA | Descriptor: | 18S ribosomal RNA, 40S ribosomal protein S11, 40S ribosomal protein S12, ... | Authors: | Guca, E, Lima, L.H.F, Boissier, F, Hashem, Y. | Deposit date: | 2023-05-09 | Release date: | 2024-03-20 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (3.04 Å) | Cite: | N 6 -methyladenosine in 5' UTR does not promote translation initiation. Mol.Cell, 84, 2024
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6P4G
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![BU of 6p4g by Molmil](/molmil-images/mine/6p4g) | Structure of a mammalian small ribosomal subunit in complex with the Israeli Acute Paralysis Virus IRES (Class 1) | Descriptor: | 18S rRNA, IAPV-IRES, RACK1, ... | Authors: | Acosta-Reyes, F.J, Neupane, R, Frank, J, Fernandez, I.S. | Deposit date: | 2019-05-27 | Release date: | 2019-09-18 | Last modified: | 2020-01-08 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | The Israeli acute paralysis virus IRES captures host ribosomes by mimicking a ribosomal state with hybrid tRNAs. Embo J., 38, 2019
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7ZJX
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![BU of 7zjx by Molmil](/molmil-images/mine/7zjx) | Rabbit 80S ribosome programmed with SECIS and SBP2 | Descriptor: | 18S rRNA, 28S rRNA, 40S Ribosomal protein eS19, ... | Authors: | Hilal, T, Simonovic, M, Spahn, C.M.T. | Deposit date: | 2022-04-12 | Release date: | 2022-09-07 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structure of the mammalian ribosome as it decodes the selenocysteine UGA codon. Science, 376, 2022
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7O81
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![BU of 7o81 by Molmil](/molmil-images/mine/7o81) | Rabbit 80S ribosome colliding in another ribosome stalled by the SARS-CoV-2 pseudoknot | Descriptor: | 18S rRNA, 28S rRNA, 40S ribosomal protein S11, ... | Authors: | Bhatt, P.R, Scaiola, A, Leibundgut, M.A, Atkins, J.F, Ban, N. | Deposit date: | 2021-04-14 | Release date: | 2021-06-02 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome. Science, 372, 2021
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7NWI
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![BU of 7nwi by Molmil](/molmil-images/mine/7nwi) | Mammalian pre-termination 80S ribosome with Empty-A site bound by Blasticidin S | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA+BlaS, 40S ribosomal protein S11, ... | Authors: | Powers, K.T, Yadav, S.K.N, Bufton, J.C, Schaffitzel, C. | Deposit date: | 2021-03-16 | Release date: | 2021-07-07 | Last modified: | 2023-01-11 | Method: | ELECTRON MICROSCOPY (3.13 Å) | Cite: | Blasticidin S inhibits mammalian translation and enhances production of protein encoded by nonsense mRNA. Nucleic Acids Res., 49, 2021
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6P4H
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![BU of 6p4h by Molmil](/molmil-images/mine/6p4h) | Structure of a mammalian small ribosomal subunit in complex with the Israeli Acute Paralysis Virus IRES (Class 2) | Descriptor: | 18S rRNA, IAPV-IRES, RACK1, ... | Authors: | Acosta-Reyes, F.J, Neupane, R, Frank, J, Fernandez, I.S. | Deposit date: | 2019-05-27 | Release date: | 2019-09-18 | Last modified: | 2020-01-08 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | The Israeli acute paralysis virus IRES captures host ribosomes by mimicking a ribosomal state with hybrid tRNAs. Embo J., 38, 2019
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7MDZ
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![BU of 7mdz by Molmil](/molmil-images/mine/7mdz) | 80S rabbit ribosome stalled with benzamide-CHX | Descriptor: | 18S rRNA, 28S rRNA, 40S ribosomal protein S21, ... | Authors: | Koga, Y, Hoang, E.M, Park, Y, Keszei, A.F.A, Murray, J, Shao, S, Liau, B.B. | Deposit date: | 2021-04-06 | Release date: | 2021-09-01 | Last modified: | 2021-09-15 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Discovery of C13-Aminobenzoyl Cycloheximide Derivatives that Potently Inhibit Translation Elongation. J.Am.Chem.Soc., 143, 2021
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6D90
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![BU of 6d90 by Molmil](/molmil-images/mine/6d90) | Mammalian 80S ribosome with a double translocated CrPV-IRES, P-site tRNA and eRF1. | Descriptor: | 18S rRNA, 28S rRNA, 5.8S rRNA, ... | Authors: | Pisareva, V.P, Pisarev, A.V, Fernandez, I.S. | Deposit date: | 2018-04-27 | Release date: | 2018-06-06 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Dual tRNA mimicry in the Cricket Paralysis Virus IRES uncovers an unexpected similarity with the Hepatitis C Virus IRES. Elife, 7, 2018
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8P09
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![BU of 8p09 by Molmil](/molmil-images/mine/8p09) | 48S late-stage initiation complex with non methylated mRNA | Descriptor: | 18S ribosomal RNA, 40S ribosomal protein S11, 40S ribosomal protein S12, ... | Authors: | Guca, E, Lima, L.H.F, Boissier, F, Hashem, Y. | Deposit date: | 2023-05-09 | Release date: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | N 6 -methyladenosine in 5' UTR does not promote translation initiation. Mol.Cell, 84, 2024
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7JQC
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![BU of 7jqc by Molmil](/molmil-images/mine/7jqc) | SARS-CoV-2 Nsp1, CrPV IRES and rabbit 40S ribosome complex | Descriptor: | 40S ribosomal protein S21, 40S ribosomal protein S24, 40S ribosomal protein S26, ... | Authors: | Yuan, S, Xiong, Y. | Deposit date: | 2020-08-10 | Release date: | 2020-12-02 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Nonstructural Protein 1 of SARS-CoV-2 Is a Potent Pathogenicity Factor Redirecting Host Protein Synthesis Machinery toward Viral RNA. Mol.Cell, 80, 2020
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6W2T
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![BU of 6w2t by Molmil](/molmil-images/mine/6w2t) | Structure of the Cricket Paralysis Virus 5-UTR IRES (CrPV 5-UTR-IRES) bound to the small ribosomal subunit in the closed state (Class 2) | Descriptor: | 18S rRNA, CrPV 5'-UTR IRES, Eukaryotic translation initiation factor 3 subunit A, ... | Authors: | Neupane, R, Pisareva, V, Rodriguez, C.F, Pisarev, A, Fernandez, I.S. | Deposit date: | 2020-03-08 | Release date: | 2020-04-22 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.36 Å) | Cite: | A complex IRES at the 5'-UTR of a viral mRNA assembles a functional 48S complex via an uAUG intermediate. Elife, 9, 2020
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6W2S
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![BU of 6w2s by Molmil](/molmil-images/mine/6w2s) | Structure of the Cricket Paralysis Virus 5-UTR IRES (CrPV 5-UTR-IRES) bound to the small ribosomal subunit in the open state (Class 1) | Descriptor: | 18S rRNA, CrPV 5'-UTR IRES, Eukaryotic translation initiation factor 3 subunit A, ... | Authors: | Neupane, R, Pisareva, V, Rodriguez, C.F, Pisarev, A, Fernandez, I.S. | Deposit date: | 2020-03-08 | Release date: | 2020-04-22 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.47 Å) | Cite: | A complex IRES at the 5'-UTR of a viral mRNA assembles a functional 48S complex via an uAUG intermediate. Elife, 9, 2020
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6YAN
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![BU of 6yan by Molmil](/molmil-images/mine/6yan) | Mammalian 48S late-stage translation initiation complex with histone 4 mRNA | Descriptor: | 18S ribosomal RNA, 40S ribosomal protein S12, 40S ribosomal protein S21, ... | Authors: | Bochler, A, Simonetti, A, Guca, E, Hashem, Y. | Deposit date: | 2020-03-12 | Release date: | 2020-04-08 | Last modified: | 2020-04-22 | Method: | ELECTRON MICROSCOPY (3.48 Å) | Cite: | Structural Insights into the Mammalian Late-Stage Initiation Complexes. Cell Rep, 31, 2020
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7SYS
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![BU of 7sys by Molmil](/molmil-images/mine/7sys) | Structure of the delta dII IRES eIF2-containing 48S initiation complex, closed conformation. Structure 12(delta dII). | Descriptor: | 18S rRNA, Eukaryotic translation initiation factor 1A, X-chromosomal, ... | Authors: | Brown, Z.P, Abaeva, I.S, De, S, Hellen, C.U.T, Pestova, T.V, Frank, J. | Deposit date: | 2021-11-25 | Release date: | 2022-07-27 | Last modified: | 2022-08-24 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES. Embo J., 41, 2022
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8BTK
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![BU of 8btk by Molmil](/molmil-images/mine/8btk) | Structure of the TRAP complex with the Sec translocon and a translating ribosome | Descriptor: | 18S rRNA, 28S rRNA, 40S ribosomal protein S11, ... | Authors: | Jaskolowski, M, Jomaa, A, Gamerdinger, M, Shrestha, S, Leibundgut, M, Deuerling, E, Ban, N. | Deposit date: | 2022-11-29 | Release date: | 2023-05-24 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Molecular basis of the TRAP complex function in ER protein biogenesis. Nat.Struct.Mol.Biol., 30, 2023
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7SYR
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![BU of 7syr by Molmil](/molmil-images/mine/7syr) | Structure of the wt IRES eIF2-containing 48S initiation complex, closed conformation. Structure 12(wt). | Descriptor: | 18S rRNA, Eukaryotic translation initiation factor 1A, X-chromosomal, ... | Authors: | Brown, Z.P, Abaeva, I.S, De, S, Hellen, C.U.T, Pestova, T.V, Frank, J. | Deposit date: | 2021-11-25 | Release date: | 2022-07-27 | Last modified: | 2022-08-24 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES. Embo J., 41, 2022
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