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PDB: 3 results

5ECC
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BU of 5ecc by Molmil
Klebsiella pneumoniae DfrA1 complexed with NADPH and 6-ethyl-5-(3-(2-methoxy-5-(pyridin-4-yl)phenyl)prop-1-yn-1-yl)pyrimidine-2,4-diamine
Descriptor: 6-ethyl-5-{3-[2-methoxy-5-(pyridin-4-yl)phenyl]prop-1-yn-1-yl}pyrimidine-2,4-diamine, CALCIUM ION, Dehydrofolate reductase type I, ...
Authors:Lombardo, M.N, Anderson, A.C.
Deposit date:2015-10-20
Release date:2016-05-18
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Crystal Structures of Trimethoprim-Resistant DfrA1 Rationalize Potent Inhibition by Propargyl-Linked Antifolates.
ACS Infect Dis, 2, 2016
5ECX
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BU of 5ecx by Molmil
Klebsiella pneumoniae DfrA1 complexed with NADPH and 6-ethyl-5-(3-(6-(pyridin-4-yl)benzo[d][1,3]dioxol-4-yl)but-1-yn-1-yl)pyrimidine-2,4-diamine
Descriptor: 6-ethyl-5-[(3~{S})-3-(6-pyridin-4-yl-1,3-benzodioxol-4-yl)but-1-ynyl]pyrimidine-2,4-diamine, Dehydrofolate reductase type I, GLYCEROL, ...
Authors:Lombardo, M.N, Anderson, A.C.
Deposit date:2015-10-20
Release date:2016-05-18
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal Structures of Trimethoprim-Resistant DfrA1 Rationalize Potent Inhibition by Propargyl-Linked Antifolates.
ACS Infect Dis, 2, 2016
7MYL
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BU of 7myl by Molmil
Crystal structure of DfrA1 dihydrofolate reductase in complex with TRIMETHOPRIM
Descriptor: Dihydrofolate reductase, TRIMETHOPRIM
Authors:Erlandsen, H, Wright, D.
Deposit date:2021-05-21
Release date:2022-06-01
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structure-guided functional studies of plasmid-encoded dihydrofolate reductases reveal a common mechanism of trimethoprim resistance in Gram-negative pathogens.
Commun Biol, 5, 2022

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