7MYL
Crystal structure of DfrA1 dihydrofolate reductase in complex with TRIMETHOPRIM
Summary for 7MYL
| Entry DOI | 10.2210/pdb7myl/pdb |
| Descriptor | Dihydrofolate reductase, TRIMETHOPRIM (3 entities in total) |
| Functional Keywords | trimetoprim resistant dihydrofolate reductase, dfra1, oxidoreductase |
| Biological source | Klebsiella pneumoniae |
| Total number of polymer chains | 6 |
| Total formula weight | 110405.44 |
| Authors | Erlandsen, H.,Wright, D. (deposition date: 2021-05-21, release date: 2022-06-01, Last modification date: 2023-10-18) |
| Primary citation | Krucinska, J.,Lombardo, M.N.,Erlandsen, H.,Estrada, A.,Si, D.,Viswanathan, K.,Wright, D.L. Structure-guided functional studies of plasmid-encoded dihydrofolate reductases reveal a common mechanism of trimethoprim resistance in Gram-negative pathogens. Commun Biol, 5:459-459, 2022 Cited by PubMed: 35562546DOI: 10.1038/s42003-022-03384-y PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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