5ECC
Klebsiella pneumoniae DfrA1 complexed with NADPH and 6-ethyl-5-(3-(2-methoxy-5-(pyridin-4-yl)phenyl)prop-1-yn-1-yl)pyrimidine-2,4-diamine
Summary for 5ECC
Entry DOI | 10.2210/pdb5ecc/pdb |
Related | 5ECX |
Descriptor | Dehydrofolate reductase type I, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 6-ethyl-5-{3-[2-methoxy-5-(pyridin-4-yl)phenyl]prop-1-yn-1-yl}pyrimidine-2,4-diamine, ... (6 entities in total) |
Functional Keywords | oxidoreductase, antifolates, dfra1, plasmid borne resistance, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Klebsiella pneumoniae |
Total number of polymer chains | 2 |
Total formula weight | 38412.97 |
Authors | Lombardo, M.N.,Anderson, A.C. (deposition date: 2015-10-20, release date: 2016-05-18, Last modification date: 2024-03-06) |
Primary citation | Lombardo, M.N.,G-Dayanandan, N.,Wright, D.L.,Anderson, A.C. Crystal Structures of Trimethoprim-Resistant DfrA1 Rationalize Potent Inhibition by Propargyl-Linked Antifolates. ACS Infect Dis, 2:149-156, 2016 Cited by PubMed: 27624966DOI: 10.1021/acsinfecdis.5b00129 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.87 Å) |
Structure validation
Download full validation report