5ECX
Klebsiella pneumoniae DfrA1 complexed with NADPH and 6-ethyl-5-(3-(6-(pyridin-4-yl)benzo[d][1,3]dioxol-4-yl)but-1-yn-1-yl)pyrimidine-2,4-diamine
Summary for 5ECX
Entry DOI | 10.2210/pdb5ecx/pdb |
Related | 5ECC |
Descriptor | Dehydrofolate reductase type I, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 6-ethyl-5-[(3~{S})-3-(6-pyridin-4-yl-1,3-benzodioxol-4-yl)but-1-ynyl]pyrimidine-2,4-diamine, ... (6 entities in total) |
Functional Keywords | antifolates, dfra1, plasmid borne resistance, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Klebsiella pneumoniae |
Total number of polymer chains | 2 |
Total formula weight | 37611.85 |
Authors | Lombardo, M.N.,Anderson, A.C. (deposition date: 2015-10-20, release date: 2016-05-18, Last modification date: 2024-03-06) |
Primary citation | Lombardo, M.N.,G-Dayanandan, N.,Wright, D.L.,Anderson, A.C. Crystal Structures of Trimethoprim-Resistant DfrA1 Rationalize Potent Inhibition by Propargyl-Linked Antifolates. ACS Infect Dis, 2:149-156, 2016 Cited by PubMed: 27624966DOI: 10.1021/acsinfecdis.5b00129 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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