3UE2
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![BU of 3ue2 by Molmil](/molmil-images/mine/3ue2) | |
3US5
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7Z3X
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![BU of 7z3x by Molmil](/molmil-images/mine/7z3x) | Crystal structure of FIR RRM1-2 Y115F mutant bound to FUSE ssDNA | Descriptor: | 1,2-ETHANEDIOL, DNA (5'-D(*TP*TP*T)-3'), DNA (5'-D(P*GP*TP*())-3'), ... | Authors: | Ni, X, Chaikuad, A, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2022-03-02 | Release date: | 2022-11-09 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Crystal structure of FIR RRM1-2 Y115F mutant bound to FUSE ssDNA To Be Published
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5KW6
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![BU of 5kw6 by Molmil](/molmil-images/mine/5kw6) | Two Tandem RRM Domains of PUF60 Bound to an AdML Pre-mRNA 3' Splice Site Analogue with a Modified Binding-Site Nucleic Acid Base | Descriptor: | DNA (30-MER), Poly(U)-binding-splicing factor PUF60 | Authors: | Crichlow, G.V, Hsiao, H.-H, Albright, R, Lolis, E.J, Braddock, D.T. | Deposit date: | 2016-07-15 | Release date: | 2017-08-23 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Unraveling the mechanism of recognition of the 3' splice site of the adenovirus major late promoter intron by the alternative splicing factor PUF60. Plos One, 15, 2020
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6SLO
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![BU of 6slo by Molmil](/molmil-images/mine/6slo) | Crystal structure of PUF60 UHM domain in complex with 7,8 dimethoxyperphenazine | Descriptor: | 2-[4-[3-(8-chloranyl-2,3-dimethoxy-phenothiazin-10-yl)propyl]piperazin-1-yl]ethanol, MAGNESIUM ION, Thioredoxin,Poly(U)-binding-splicing factor PUF60 | Authors: | Jagtap, P.K.A, Kubelka, T, Bach, T, Sattler, M. | Deposit date: | 2019-08-20 | Release date: | 2020-09-09 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | Identification of phenothiazine derivatives as UHM-binding inhibitors of early spliceosome assembly. Nat Commun, 11, 2020
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5KVY
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![BU of 5kvy by Molmil](/molmil-images/mine/5kvy) | CRYSTAL STRUCTURE OF THE TWO TANDEM RRM DOMAINS OF PUF60 BOUND TO A PORTION OF AN ADML PRE-MRNA 3' SPLICE SITE ANALOG | Descriptor: | CHLORIDE ION, DNA (30-MER), Poly(U)-binding-splicing factor PUF60 | Authors: | Hsiao, H.-H, Crichlow, G.V, Albright, R.A, Murphy, J.W, Lolis, E.J, Braddock, D.T. | Deposit date: | 2016-07-15 | Release date: | 2017-08-23 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Unraveling the mechanism of recognition of the 3' splice site of the adenovirus major late promoter intron by the alternative splicing factor PUF60. Plos One, 15, 2020
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6LUR
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7Q8A
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![BU of 7q8a by Molmil](/molmil-images/mine/7q8a) | Crystal structure of tandem domain RRM1-2 of FUBP-interacting repressor (FIR) bound to FUSE ssDNA fragment | Descriptor: | 1,2-ETHANEDIOL, DNA (5'-D(P*GP*T)-3'), Poly(U)-binding-splicing factor PUF60, ... | Authors: | Ni, X, Joerger, A.C, Chaikuad, A, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2021-11-10 | Release date: | 2022-11-09 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Crystal structure of tandem domain RRM1-2 of FIR bound to FUSE ssDNA fragment To Be Published
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5KW1
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![BU of 5kw1 by Molmil](/molmil-images/mine/5kw1) | Crystal Structure of the Two Tandem RRM Domains of PUF60 Bound to a Modified AdML Pre-mRNA 3' Splice Site Analogue | Descriptor: | CHLORIDE ION, DNA/RNA (30-MER), Poly(U)-binding-splicing factor PUF60 | Authors: | Crichlow, G.V, Hsiao, H.-H, Albright, R, Lolis, E.J, Braddock, D.T. | Deposit date: | 2016-07-15 | Release date: | 2017-08-23 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Unraveling the mechanism of recognition of the 3' splice site of the adenovirus major late promoter intron by the alternative splicing factor PUF60. Plos One, 15, 2020
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2QFJ
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![BU of 2qfj by Molmil](/molmil-images/mine/2qfj) | Crystal Structure of First Two RRM Domains of FIR Bound to ssDNA from a Portion of FUSE | Descriptor: | DNA (5'-D(*DTP*DCP*DGP*DGP*DGP*DAP*DTP*DTP*DTP*DTP*DTP*DTP*DAP*DTP*DTP*DTP*DTP*DGP*DTP*DGP*DTP*DTP*DAP*DTP*DT)-3'), FBP-interacting repressor | Authors: | Crichlow, G.V, Yang, Y, Fan, C, Lolis, E, Braddock, D. | Deposit date: | 2007-06-27 | Release date: | 2008-03-04 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Dimerization of FIR upon FUSE DNA binding suggests a mechanism of c-myc inhibition EMBO J., 27, 2007
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3DXB
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![BU of 3dxb by Molmil](/molmil-images/mine/3dxb) | Structure of the UHM domain of Puf60 fused to thioredoxin | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, thioredoxin N-terminally fused to Puf60(UHM) | Authors: | Corsini, L, Hothorn, M, Scheffzek, K, Stier, G, Sattler, M. | Deposit date: | 2008-07-24 | Release date: | 2008-10-28 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Dimerization and Protein Binding Specificity of the U2AF Homology Motif of the Splicing Factor Puf60. J.Biol.Chem., 284, 2009
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3UWT
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![BU of 3uwt by Molmil](/molmil-images/mine/3uwt) | |
5KWQ
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![BU of 5kwq by Molmil](/molmil-images/mine/5kwq) | Two Tandem RRM Domains of FBP-Interacting Repressor (FIR), also Known as PUF60 | Descriptor: | Poly(U)-binding-splicing factor PUF60 | Authors: | Crichlow, G.V, Yang, Y, Zhou, H, Lolis, E.J, Braddock, D.T. | Deposit date: | 2016-07-18 | Release date: | 2017-08-23 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Unraveling the mechanism of recognition of the 3' splice site of the adenovirus major late promoter intron by the alternative splicing factor PUF60. Plos One, 15, 2020
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2KXH
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![BU of 2kxh by Molmil](/molmil-images/mine/2kxh) | Solution structure of the first two RRM domains of FIR in the complex with FBP Nbox peptide | Descriptor: | Poly(U)-binding-splicing factor PUF60, peptide of Far upstream element-binding protein 1 | Authors: | Cukier, C.D, Ramos, A, Hollingworth, D, Diaz-Moreno, I, Kelly, G. | Deposit date: | 2010-05-05 | Release date: | 2010-08-18 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Molecular basis of FIR-mediated c-myc transcriptional control. Nat.Struct.Mol.Biol., 17, 2010
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2KXF
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![BU of 2kxf by Molmil](/molmil-images/mine/2kxf) | Solution structure of the first two RRM domains of FBP-interacting repressor (FIR) | Descriptor: | Poly(U)-binding-splicing factor PUF60 | Authors: | Cukier, C.D, Ramos, A, Hollingworth, D, Diaz-Moreno, I, Kelly, G. | Deposit date: | 2010-05-04 | Release date: | 2010-08-18 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Molecular basis of FIR-mediated c-myc transcriptional control. Nat.Struct.Mol.Biol., 17, 2010
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2DNY
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![BU of 2dny by Molmil](/molmil-images/mine/2dny) | Solution structure of the third RNA binding domain of FBP-interacting repressor, SIAHBP1 | Descriptor: | Fuse-binding protein-interacting repressor, isoform b | Authors: | Suzuki, S, Nagata, T, Muto, Y, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2006-04-27 | Release date: | 2007-04-17 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution structure of the third RNA binding domain of FBP-interacting repressor, SIAHBP1 To be Published
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