6UZ8
| Cryo-EM structure of human TRPC6 in complex with agonist AM-0883 | Descriptor: | (5-chloro-1'H-spiro[indole-3,4'-piperidin]-1'-yl)[(2R)-2,3-dihydro-1,4-benzodioxin-2-yl]methanone, 2-[[(2~{S})-2-decanoyloxy-3-dodecanoyloxy-propoxy]-oxidanyl-phosphoryl]oxyethyl-trimethyl-azanium, CHOLESTEROL HEMISUCCINATE, ... | Authors: | Bai, Y, Yu, X, Huang, X, Chen, H. | Deposit date: | 2019-11-14 | Release date: | 2020-03-18 | Method: | ELECTRON MICROSCOPY (2.84 Å) | Cite: | Structural basis for pharmacological modulation of the TRPC6 channel. Elife, 9, 2020
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6UZA
| Cryo-EM structure of human TRPC6 in complex with antagonist AM-1473 | Descriptor: | 2-[[(2~{S})-2-decanoyloxypropoxy]-oxidanyl-phosphoryl]oxyethyl-trimethyl-azanium, 4-({(1R,2R)-2-[(3R)-3-aminopiperidin-1-yl]-2,3-dihydro-1H-inden-1-yl}oxy)benzonitrile, CHOLESTEROL HEMISUCCINATE, ... | Authors: | Bai, Y, Yu, X, Huang, X, Chen, H. | Deposit date: | 2019-11-14 | Release date: | 2020-03-18 | Method: | ELECTRON MICROSCOPY (3.08 Å) | Cite: | Structural basis for pharmacological modulation of the TRPC6 channel. Elife, 9, 2020
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