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PDB: 5 results

1RV1
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BU of 1rv1 by Molmil
CRYSTAL STRUCTURE OF HUMAN MDM2 WITH AN IMIDAZOLINE INHIBITOR
Descriptor: CIS-[4,5-BIS-(4-BROMOPHENYL)-2-(2-ETHOXY-4-METHOXYPHENYL)-4,5-DIHYDROIMIDAZOL-1-YL]-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]METHANONE, Ubiquitin-protein ligase E3 Mdm2
Authors:Lukacs, C, Kammlott, U, Graves, B.
Deposit date:2003-12-12
Release date:2004-01-20
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:In vivo activation of the p53 pathway by small-molecule antagonists of MDM2.
Science, 303, 2004
4J7D
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BU of 4j7d by Molmil
The 1.25A crystal structure of humanized Xenopus MDM2 with a nutlin fragment, RO5045331
Descriptor: (4S,5R)-2-(4-tert-butyl-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethyl-4,5-dihydro-1H-imidazole, E3 ubiquitin-protein ligase Mdm2, SULFATE ION
Authors:Janson, C, Lukacs, C, Graves, B.
Deposit date:2013-02-13
Release date:2013-08-07
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Deconstruction of a nutlin: dissecting the binding determinants of a potent protein-protein interaction inhibitor.
ACS Med Chem Lett, 4, 2013
4J3E
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BU of 4j3e by Molmil
The 1.9A crystal structure of humanized Xenopus Mdm2 with nutlin-3a
Descriptor: 4-({(4S,5R)-4,5-bis(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazol-1-yl}carbonyl)piperazin-2-one, E3 ubiquitin-protein ligase Mdm2, SULFATE ION
Authors:Graves, B.J, Lukacs, C.M, Kammlott, R.U, Crowther, R.
Deposit date:2013-02-05
Release date:2013-04-24
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Discovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical Development.
ACS Med Chem Lett, 4, 2013
4J74
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BU of 4j74 by Molmil
The 1.2A crystal structure of humanized Xenopus MDM2 with RO0503918 - a nutlin fragment
Descriptor: (4S,5R)-4,5-bis(4-chlorophenyl)-2-methyl-4,5-dihydro-1H-imidazole, E3 ubiquitin-protein ligase Mdm2, SULFATE ION
Authors:Janson, C, Lukacs, C, Kammlott, U, Graves, B.
Deposit date:2013-02-12
Release date:2013-08-07
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Deconstruction of a nutlin: dissecting the binding determinants of a potent protein-protein interaction inhibitor.
ACS Med Chem Lett, 4, 2013
4J7E
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BU of 4j7e by Molmil
The 1.63A crystal structure of humanized Xenopus MDM2 with a nutlin fragment, RO5524529
Descriptor: E3 ubiquitin-protein ligase Mdm2, SULFATE ION, [(4S,5R)-4,5-bis(4-chlorophenyl)-2,4,5-trimethyl-4,5-dihydro-1H-imidazol-1-yl]{4-[3-(methylsulfonyl)propyl]piperazin-1-yl}methanone
Authors:Janson, C, Lukacs, C, Graves, B.
Deposit date:2013-02-13
Release date:2013-08-07
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Deconstruction of a nutlin: dissecting the binding determinants of a potent protein-protein interaction inhibitor.
ACS Med Chem Lett, 4, 2013

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