8S0R
 
 | | Cryo-EM structure of CAK modified by covalent inhibitor SY-1365 | | Descriptor: | CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... | | Authors: | Feng, J, Koh, A.F, Kotecha, A, Greber, B.J. | | Deposit date: | 2024-02-14 | | Release date: | 2024-12-25 | | Last modified: | 2025-07-09 | | Method: | ELECTRON MICROSCOPY (2.4 Å) | | Cite: | TFIIH kinase CDK7 drives cell proliferation through a common core transcription factor network.
Sci Adv, 11, 2025
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8S0T
 | | Cryo-EM structure of CAK in complex with SY-5609 | | Descriptor: | 7-dimethylphosphoryl-3-[2-[[(3~{S})-6,6-dimethylpiperidin-3-yl]amino]-5-(trifluoromethyl)pyrimidin-4-yl]-1~{H}-indole-6-carbonitrile, CDK-activating kinase assembly factor MAT1, Cyclin-H, ... | | Authors: | Feng, J, Cronin, N.B, Marineau, J.J, Greber, B.J. | | Deposit date: | 2024-02-14 | | Release date: | 2024-12-25 | | Last modified: | 2025-07-09 | | Method: | ELECTRON MICROSCOPY (2.3 Å) | | Cite: | TFIIH kinase CDK7 drives cell proliferation through a common core transcription factor network.
Sci Adv, 11, 2025
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