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PDB: 4 results
8FYZ
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BU of 8fyz by Molmil
Crystal structure of human PARP1 ART domain bound to inhibitor UKTT10 (compound 13)
Descriptor: (2P)-2-{3-[(4R)-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carbonyl]phenyl}-1H-benzimidazole-4-carboxamide, CITRIC ACID, DIMETHYL SULFOXIDE, ...
Authors:Rouleau-Turcotte, E, Pascal, J.M.
Deposit date:2023-01-27
Release date:2024-02-07
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Novel modifications of PARP inhibitor veliparib increase PARP1 binding to DNA breaks.
Biochem.J., 481, 2024
8FYY
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BU of 8fyy by Molmil
Crystal structure of human PARP1 ART domain bound to inhibitor UKTT5 (compound 10)
Descriptor: 2-(4-{[2-(1H-benzimidazol-2-yl)ethyl]carbamoyl}phenyl)-1H-benzimidazole-7-carboxamide, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ...
Authors:Rouleau-Turcotte, E, Pascal, J.M.
Deposit date:2023-01-27
Release date:2024-02-07
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Novel modifications of PARP inhibitor veliparib increase PARP1 binding to DNA breaks.
Biochem.J., 481, 2024
8G0H
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BU of 8g0h by Molmil
Human PARP1 deltaV687-E688 bound to UKTT5 (compound 10) and to a DNA double strand break.
Descriptor: 2-(4-{[2-(1H-benzimidazol-2-yl)ethyl]carbamoyl}phenyl)-1H-benzimidazole-7-carboxamide, DNA (5'-D(*CP*GP*AP*CP*G)-3'), DNA (5'-D(*CP*GP*TP*CP*G)-3'), ...
Authors:Rouleau-Turcotte, E, Pascal, J.M.
Deposit date:2023-01-31
Release date:2024-02-07
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Novel modifications of PARP inhibitor veliparib increase PARP1 binding to DNA breaks.
Biochem.J., 481, 2024
8FZ1
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BU of 8fz1 by Molmil
Crystal structure of human PARP1 ART domain bound to inhibitor UKTT22 (compound 14)
Descriptor: (2P)-2-{3-[(2-amino-4,5-dimethylphenyl)carbamoyl]phenyl}-1H-benzimidazole-4-carboxamide, 1,2-ETHANEDIOL, CITRIC ACID, ...
Authors:Rouleau-Turcotte, E, Pascal, J.M.
Deposit date:2023-01-27
Release date:2024-02-07
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Novel modifications of PARP inhibitor veliparib increase PARP1 binding to DNA breaks.
Biochem.J., 481, 2024

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PDB entries from 2024-06-19

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